GRP75 Regulates Mitochondrial-Supercomplex Turnover to Modulate Insulin Sensitivity

Mitochondrial DNA in inflammation and immunity

(2020) Joel S Riley et al.   EMBO REPORTS

Systematic analysis of a mitochondrial disease‐causing ND6 mutation in mitochondrial deficiency

(2020) Deyu Chen et al.   Molecular Genetics & Genomic Medicine

Mucosal-associated invariant T cells promote inflammation and intestinal dysbiosis leading to metabolic dysfunction during obesity

(2020) Amine Toubal et al.   Nature Communications

Mitochondrial stress-activated cGAS-STING pathway inhibits thermogenic program and contributes to overnutrition-induced obesity in mice

(2020) Juli Bai et al.   Communications Biology

Insulin resistance is mechanistically linked to hepatic mitochondrial remodeling in non-alcoholic fatty liver disease

(2020) Chris E. Shannon et al.   Molecular Metabolism

STING-mediated intestinal barrier dysfunction contributes to lethal sepsis

(2019) Qiongyuan Hu et al.   EBioMedicine

Mitochondrial (Dys)function and Insulin Resistance: From Pathophysiological Molecular Mechanisms to the Impact of Diet

(2019) Domenico Sergi et al.   Frontiers in Physiology

Plasma mitochondrial DNA is elevated in obese type 2 diabetes mellitus patients and correlates positively with insulin resistance

(2019) Larysa V. Yuzefovych et al.   PLoS One

Repairing Mitochondrial Dysfunction in Disease

(2018) Vincenzo Sorrentino et al.   Annual Review of Pharmacology and Toxicology

Hsp70 at the membrane: driving protein translocation

(2018) Elizabeth A. Craig   BMC BIOLOGY

Disruption of Mitochondria-Associated Endoplasmic Reticulum Membrane (MAM) Integrity Contributes to Muscle Insulin Resistance in Mice and Humans

(2018) Emily Tubbs et al.   DIABETES

HMGB1-induced asthmatic airway inflammation through GRP75-mediated enhancement of ER-mitochondrial Ca2+ transfer and ROS increased

(2018) Yanhua Lv et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Oncogenic HSP60 regulates mitochondrial oxidative phosphorylation to support Erk1/2 activation during pancreatic cancer cell growth

(2018) Chao Zhou et al.   Cell Death & Disease

Exercise, Obesity and CNS Control of Metabolic Homeostasis: A Review

(2018) John K. Smith   Frontiers in Physiology

Altered mitochondrial function in insulin-deficient and insulin-resistant states

(2018) Gregory N. Ruegsegger et al.   JOURNAL OF CLINICAL INVESTIGATION

PDK4 Augments ER-Mitochondria Contact to Dampen Skeletal Muscle Insulin Signaling During Obesity

(2018) Themis Thoudam et al.   DIABETES

Downregulation of macrophage Irs2 by hyperinsulinemia impairs IL-4-indeuced M2a-subtype macrophage activation in obesity

(2018) Tetsuya Kubota et al.   Nature Communications

DsbA-L prevents obesity-induced inflammation and insulin resistance by suppressing the mtDNA release-activated cGAS-cGAMP-STING pathway

(2017) Juli Bai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondria-Associated Membranes Response to Nutrient Availability and Role in Metabolic Diseases

(2017) Pierre Theurey et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Lost region in amyloid precursor protein (APP) through TALEN-mediated genome editing alters mitochondrial morphology

(2016) Yajie Wang et al.   Scientific Reports

MICOS coordinates with respiratory complexes and lipids to establish mitochondrial inner membrane architecture

(2015) Jonathan R Friedman et al.   eLife

Mitochondria-Associated Endoplasmic Reticulum Membrane (MAM) Integrity Is Required for Insulin Signaling and Is Implicated in Hepatic Insulin Resistance

(2014) E. Tubbs et al.   DIABETES

Mortalin/GRP75 Binds to Complement C9 and Plays a Role in Resistance to Complement-dependent Cytotoxicity

(2014) Moran Saar Ray et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cytosolic-DNA-Mediated, STING-Dependent Proinflammatory Gene Induction Necessitates Canonical NF- B Activation through TBK1

(2014) T. Abe et al.   JOURNAL OF VIROLOGY

Chronic enrichment of hepatic endoplasmic reticulum–mitochondria contact leads to mitochondrial dysfunction in obesity

(2014) Ana Paula Arruda et al.   NATURE MEDICINE

Mitochondrial retrograde signaling at the crossroads of tumor bioenergetics, genetics and epigenetics

(2013) Manti Guha et al.   MITOCHONDRION

Bridging the gap between qualitative and quantitative colocalization results in fluorescence microscopy studies

(2013) Vadim Zinchuk et al.   Scientific Reports

Chaperone–protease networks in mitochondrial protein homeostasis

(2012) Wolfgang Voos   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Where the endoplasmic reticulum and the mitochondrion tie the knot: The mitochondria-associated membrane (MAM)

(2012) Arun Raturi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Complexome Profiling Identifies TMEM126B as a Component of the Mitochondrial Complex I Assembly Complex

(2012) Heinrich Heide et al.   Cell Metabolism

Effect of losartan on the glomerular protein expression profile of type 2 diabetic KKAy mice

(2012) Qiu-Ling Fan et al.   JOURNAL OF NEPHROLOGY

Mitochondrial DNA Mutations Provoke Dominant Inhibition of Mitochondrial Inner Membrane Fusion

(2012) Cécile Sauvanet et al.   PLoS One

Knockdown of Hspa9, a del(5q31.2) gene, results in a decrease in hematopoietic progenitors in mice

(2010) T. H.- P. Chen et al.   BLOOD

Dissecting the role of the mitochondrial chaperone mortalin in Parkinson's disease: functional impact of disease-related variants on mitochondrial homeostasis

(2010) Lena F. Burbulla et al.   HUMAN MOLECULAR GENETICS

Five Entry Points of the Mitochondrially Encoded Subunits in Mammalian Complex I Assembly

(2010) E. Perales-Clemente et al.   MOLECULAR AND CELLULAR BIOLOGY

Exercise training and experimental diabetes modulate heat shock protein response in brain

(2010) Z. Lappalainen et al.   SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS

Insulin resistance is a cellular antioxidant defense mechanism

(2009) K. L. Hoehn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of Mitochondrial Dysfunction in Insulin Resistance

(2008) Jeong-a Kim et al.   CIRCULATION RESEARCH

Identification by a differential proteomic approach of the induced stress and redox proteins by resveratrol in the normal and diabetic rat heart

(2008) D. H. W. Dekkers et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Overexpression of Mitochondrial Hsp70/Hsp75 in Rat Brain Protects Mitochondria, Reduces Oxidative Stress, and Protects from Focal Ischemia

(2008) Lijun Xu et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Exercise training with dietary counselling increases mitochondrial chaperone expression in middle-aged subjects with impaired glucose tolerance

(2008) Mika Venojärvi et al.   BMC Endocrine Disorders