A non-canonical cGAS–STING–PERK pathway facilitates the translational program critical for senescence and organ fibrosis
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Title
A non-canonical cGAS–STING–PERK pathway facilitates the translational program critical for senescence and organ fibrosis
Authors
Keywords
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Journal
NATURE CELL BIOLOGY
Volume 24, Issue 5, Pages 766-782
Publisher
Springer Science and Business Media LLC
Online
2022-05-03
DOI
10.1038/s41556-022-00894-z
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Note: Only part of the references are listed.- Induced phase separation of mutant NF2 imprisons the cGAS-STING machinery to abrogate antitumor immunity
- (2021) Fansen Meng et al. MOLECULAR CELL
- Endoplasmic reticulum stress promotes epithelial‑mesenchymal transition via the PERK signaling pathway in paraquat‑induced pulmonary fibrosis
- (2021) Xiaoxiao Meng et al. Molecular Medicine Reports
- The Unfolded Protein Response Mediator PERK Governs Myeloid Cell-Driven Immunosuppression in Tumors through Inhibition of STING Signaling
- (2020) Eslam Mohamed et al. IMMUNITY
- TBK1-Mediated DRP1 Targeting Confers Nucleic Acid Sensing to Reprogram Mitochondrial Dynamics and Physiology
- (2020) Shasha Chen et al. MOLECULAR CELL
- The STING agonist 5,6-dimethylxanthenone-4-acetic acid (DMXAA) stimulates an antiviral state and protects mice against herpes simplex virus-induced neurological disease
- (2019) Stacey Cerón et al. VIROLOGY
- Activation of GCN2 by the ribosomal P-stalk
- (2019) Alison J. Inglis et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structural basis of STING binding with and phosphorylation by TBK1
- (2019) Conggang Zhang et al. NATURE
- Cryo-EM structures of STING reveal its mechanism of activation by cyclic GMP–AMP
- (2019) Guijun Shang et al. NATURE
- Autophagy induction via STING trafficking is a primordial function of the cGAS pathway
- (2019) Xiang Gui et al. NATURE
- Viral and metazoan poxins are cGAMP-specific nucleases that restrict cGAS–STING signalling
- (2019) James B. Eaglesham et al. NATURE
- Spatiotemporal Control of ULK1 Activation by NDP52 and TBK1 during Selective Autophagy
- (2019) Jose Norberto S. Vargas et al. MOLECULAR CELL
- STING-mediated disruption of calcium homeostasis chronically activates ER stress and primes T cell death
- (2019) Jianjun Wu et al. JOURNAL OF EXPERIMENTAL MEDICINE
- STING-associated lung disease in mice relies on T cells but not type I interferon
- (2019) Hella Luksch et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- TUDCA-Treated Mesenchymal Stem Cells Protect against ER Stress in the Hippocampus of a Murine Chronic Kidney Disease Model
- (2019) Jun Lee et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Hierarchy of clinical manifestations in SAVI N153S and V154M mouse models
- (2019) Mona Motwani et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- HER2 recruits AKT1 to disrupt STING signalling and suppress antiviral defence and antitumour immunity
- (2019) Shiying Wu et al. NATURE CELL BIOLOGY
- TUDCA attenuates intestinal injury and inhibits endoplasmic reticulum stress-mediated intestinal cell apoptosis in necrotizing enterocolitis
- (2019) Peng Li et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- Mitochondrial Damage and Activation of the STING Pathway Lead to Renal Inflammation and Fibrosis
- (2019) Ki Wung Chung et al. Cell Metabolism
- Aberrant ER-stress induced neuronal-IFNβ elicits white matter injury due to microglial activation and T-cell infiltration after TBI
- (2019) Tanusree Sen et al. JOURNAL OF NEUROSCIENCE
- Tauroursodeoxycholate—Bile Acid with Chaperoning Activity: Molecular and Cellular Effects and Therapeutic Perspectives
- (2019) Magdalena Kusaczuk Cells
- Innate Immune Response to Cytoplasmic DNA: Mechanisms and Diseases
- (2019) Ming-Ming Hu et al. Annual Review of Immunology
- The luminal domain of the ER stress sensor protein PERK binds misfolded proteins and thereby triggers PERK oligomerization
- (2018) Peng Wang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- STING-dependent translation inhibition restricts RNA virus replication
- (2018) Kate M. Franz et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- cGAS–STING and Cancer: Dichotomous Roles in Tumor Immunity and Development
- (2018) Kevin W. Ng et al. TRENDS IN IMMUNOLOGY
- Role of eIF2α Kinases in Translational Control and Adaptation to Cellular Stress
- (2018) Ronald C. Wek Cold Spring Harbor Perspectives in Biology
- Translational Control in Cancer
- (2018) Nathaniel Robichaud et al. Cold Spring Harbor Perspectives in Biology
- Analysis of Drosophila STING Reveals an Evolutionarily Conserved Antimicrobial Function
- (2018) Marina Martin et al. Cell Reports
- Expression of STING Is Increased in Liver Tissues From Patients With NAFLD and Promotes Macrophage-Mediated Hepatic Inflammation and Fibrosis in Mice
- (2018) Xianjun Luo et al. GASTROENTEROLOGY
- A human gain-of-function STING mutation causes immunodeficiency and gammaherpesvirus-induced pulmonary fibrosis in mice
- (2018) Brock G. Bennion et al. JOURNAL OF VIROLOGY
- Endoplasmic reticulum stress is activated in post-ischemic kidneys to promote chronic kidney disease
- (2018) Shaoqun Shu et al. EBioMedicine
- Disease-associated mutations identify a novel region in human STING necessary for the control of type I interferon signaling
- (2017) Isabelle Melki et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Intrinsic antiproliferative activity of the innate sensor STING in T lymphocytes
- (2017) Silvia Cerboni et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Local Inhibition of PERK Enhances Memory and Reverses Age-Related Deterioration of Cognitive and Neuronal Properties
- (2017) Vijendra Sharma et al. JOURNAL OF NEUROSCIENCE
- Cytoplasmic chromatin triggers inflammation in senescence and cancer
- (2017) Zhixun Dou et al. NATURE
- Hippo signalling governs cytosolic nucleic acid sensing through YAP/TAZ-mediated TBK1 blockade
- (2017) Qian Zhang et al. NATURE CELL BIOLOGY
- Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence
- (2017) Selene Glück et al. NATURE CELL BIOLOGY
- Chronic innate immune activation of TBK1 suppresses mTORC1 activity and dysregulates cellular metabolism
- (2017) Maroof Hasan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- 4-PBA inhibits LPS-induced inflammation through regulating ER stress and autophagy in acute lung injury models
- (2017) Meichun Zeng et al. TOXICOLOGY LETTERS
- The STING agonist DMXAA triggers a cooperation between T lymphocytes and myeloid cells that leads to tumor regression
- (2017) Julia M. Weiss et al. OncoImmunology
- Agonist-Mediated Activation of STING Induces Apoptosis in Malignant B Cells
- (2016) Chih-Hang Anthony Tang et al. CANCER RESEARCH
- Recognition of Endogenous Nucleic Acids by the Innate Immune System
- (2016) Axel Roers et al. IMMUNITY
- Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing
- (2016) Qi Chen et al. NATURE IMMUNOLOGY
- The Circadian Protein BMAL1 Regulates Translation in Response to S6K1-Mediated Phosphorylation
- (2015) Jonathan O. Lipton et al. CELL
- STING Activation by Translocation from the ER Is Associated with Infection and Autoinflammatory Disease
- (2015) Nicole Dobbs et al. Cell Host & Microbe
- STING activation of tumor endothelial cells initiates spontaneous and therapeutic antitumor immunity
- (2015) Olivier Demaria et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation
- (2015) S. Liu et al. SCIENCE
- Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity
- (2015) Leticia Corrales et al. Cell Reports
- RIG-I-like receptor regulation in virus infection and immunity
- (2015) Ying Kai Chan et al. Current Opinion in Virology
- The Integrated Stress Response in Lung Disease
- (2014) Emily F. A. van 't Wout et al. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
- The Scanning Mechanism of Eukaryotic Translation Initiation
- (2014) Alan G. Hinnebusch Annual Review of Biochemistry
- STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors
- (2014) Liufu Deng et al. IMMUNITY
- Innate Antiviral Host Defense Attenuates TGF-β Function through IRF3-Mediated Suppression of Smad Signaling
- (2014) Pinglong Xu et al. MOLECULAR CELL
- Full-length RNA-seq from single cells using Smart-seq2
- (2014) Simone Picelli et al. Nature Protocols
- Activated STING in a Vascular and Pulmonary Syndrome
- (2014) Yin Liu et al. NEW ENGLAND JOURNAL OF MEDICINE
- Cyclic [G(2′,5′)pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase
- (2013) Pu Gao et al. CELL
- The eIF2α kinases: their structures and functions
- (2013) Neysan Donnelly et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Spontaneous activation of RNA-sensing pathways in autoimmune disease
- (2013) Steve P Crampton et al. CURRENT OPINION IN IMMUNOLOGY
- EIF2AK4 mutations cause pulmonary veno-occlusive disease, a recessive form of pulmonary hypertension
- (2013) Mélanie Eyries et al. NATURE GENETICS
- Genome engineering using the CRISPR-Cas9 system
- (2013) F Ann Ran et al. Nature Protocols
- Organization of the ER–Golgi interface for membrane traffic control
- (2013) Federica Brandizzi et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- STING-IRF3 pathway links endoplasmic reticulum stress with hepatocyte apoptosis in early alcoholic liver disease
- (2013) J. Petrasek et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Membrane lipid saturation activates endoplasmic reticulum unfolded protein response transducers through their transmembrane domains
- (2013) R. Volmer et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Extracellular M. tuberculosis DNA Targets Bacteria for Autophagy by Activating the Host DNA-Sensing Pathway
- (2012) Robert O. Watson et al. CELL
- Autoimmunity Initiates in Nonhematopoietic Cells and Progresses via Lymphocytes in an Interferon-Dependent Autoimmune Disease
- (2012) Alevtina Gall et al. IMMUNITY
- STING manifests self DNA-dependent inflammatory disease
- (2012) J. Ahn et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA
- (2012) J. Wu et al. SCIENCE
- Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway
- (2012) L. Sun et al. SCIENCE
- STING Specifies IRF3 Phosphorylation by TBK1 in the Cytosolic DNA Signaling Pathway
- (2012) Y. Tanaka et al. Science Signaling
- STING is a direct innate immune sensor of cyclic di-GMP
- (2011) Dara L. Burdette et al. NATURE
- I B kinase and TANK-binding kinase 1 activate AKT by direct phosphorylation
- (2011) X. Xie et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Phosphorylation of the Autophagy Receptor Optineurin Restricts Salmonella Growth
- (2011) P. Wild et al. SCIENCE
- Pattern Recognition Receptors and Inflammation
- (2010) Osamu Takeuchi et al. CELL
- The mechanism of eukaryotic translation initiation and principles of its regulation
- (2010) Richard J. Jackson et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- mTOR: from growth signal integration to cancer, diabetes and ageing
- (2010) Roberto Zoncu et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- PKR-like endoplasmic reticulum kinase (PERK) activation following brain ischemia is independent of unfolded nascent proteins
- (2010) T.H. Sanderson et al. NEUROSCIENCE
- Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets
- (2009) Nahum Sonenberg et al. CELL
- Ureteral obstruction as a model of renal interstitial fibrosis and obstructive nephropathy
- (2009) Robert L. Chevalier et al. KIDNEY INTERNATIONAL
- STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity
- (2009) Hiroki Ishikawa et al. NATURE
- Adaptive suppression of the ATF4–CHOP branch of the unfolded protein response by toll-like receptor signalling
- (2009) Connie W. Woo et al. NATURE CELL BIOLOGY
- SUnSET, a nonradioactive method to monitor protein synthesis
- (2009) Enrico K Schmidt et al. NATURE METHODS
- Molecular mechanisms of mTOR-mediated translational control
- (2009) Xiaoju Max Ma et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response
- (2009) T. Saitoh et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization
- (2009) W. Sun et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Epithelial Endoplasmic Reticulum Stress and Apoptosis in Sporadic Idiopathic Pulmonary Fibrosis
- (2008) Martina Korfei et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- Trex1 Prevents Cell-Intrinsic Initiation of Autoimmunity
- (2008) Daniel B. Stetson et al. CELL
- The Adaptor Protein MITA Links Virus-Sensing Receptors to IRF3 Transcription Factor Activation
- (2008) Bo Zhong et al. IMMUNITY
- STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling
- (2008) Hiroki Ishikawa et al. NATURE
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