Polycystin-2-dependent transcriptome reveals early response of autosomal dominant polycystic kidney disease

A Comprehensive Immune Cell Atlas of Cystic Kidney Disease Reveals the Involvement of Adaptive Immune Cells in Injury-Mediated Cyst Progression in Mice

(2022) Cheng Song et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Genotype–phenotype correlates in Joubert syndrome: A review

(2022) Simone Gana et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS

A cAMP signalosome in primary cilia drives gene expression and kidney cyst formation

(2022) Jan N Hansen et al.   EMBO REPORTS

Channel Function of Polycystin-2 in the Endoplasmic Reticulum Protects against Autosomal Dominant Polycystic Kidney Disease

(2022) Biswajit Padhy et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Expression of active B-Raf proto-oncogene in kidney collecting ducts induces cyst formation in normal mice and accelerates cyst growth in mice with polycystic kidney disease

(2022) Stephen C. Parnell et al.   KIDNEY INTERNATIONAL

A Comprehensive Map of mRNAs and Their Isoforms across All 14 Renal Tubule Segments of Mouse

(2021) Lihe Chen et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Imaging evaluation of hereditary renal tumors: a pictorial review

(2021) Takashi Tanaka et al.   JAPANESE JOURNAL OF RADIOLOGY

Time-resolved proteomics profiling of the ciliary Hedgehog response

(2021) Elena A. May et al.   JOURNAL OF CELL BIOLOGY

Identification of pathological transcription in autosomal dominant polycystic kidney disease epithelia

(2021) Sebastian Friedrich et al.   Scientific Reports

c-Jun N-terminal kinase (JNK) signaling contributes to cystic burden in polycystic kidney disease

(2021) Abigail O. Smith et al.   PLoS Genetics

Doxycycline Changes the Transcriptome Profile of mIMCD3 Renal Epithelial Cells

(2021) Hyun Jun Jung et al.   Frontiers in Physiology

GLIS3: A Critical Transcription Factor in Islet β-Cell Generation

(2021) David W. Scoville et al.   Cells

Identification of ADPKD-Related Genes and Pathways in Cells Overexpressing PKD2

(2020) Zhe Zhang et al.   Genes

Cilia and polycystic kidney disease

(2020) Ming Ma   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Structure and function of polycystin channels in primary cilia

(2020) Chau My Ta et al.   CELLULAR SIGNALLING

IFT20 is critical for collagen biosynthesis in craniofacial bone formation

(2020) Hiroyuki Yamaguchi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cyclin-Dependent Kinase 1 Activity Is a Driver of Cyst Growth in Polycystic Kidney Disease

(2020) Chao Zhang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Widespread Repression of Gene Expression in Cancer by a Wnt/β-Catenin/MAPK Pathway

(2020) Nathan Harmston et al.   CANCER RESEARCH

Progress in the understanding of polycystic kidney disease

(2019) Vicente E. Torres et al.   Nature Reviews Nephrology

Acute Inhibition of Heterotrimeric Kinesin-2 Function Reveals Mechanisms of Intraflagellar Transport in Mammalian Cilia

(2019) Martin F. Engelke et al.   CURRENT BIOLOGY

Metascape provides a biologist-oriented resource for the analysis of systems-level datasets

(2019) Yingyao Zhou et al.   Nature Communications

Cell-Autonomous Hedgehog Signaling Is Not Required for Cyst Formation in Autosomal Dominant Polycystic Kidney Disease

(2019) Ming Ma et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Single-Cell Profiling Reveals Sex, Lineage, and Regional Diversity in the Mouse Kidney

(2019) Andrew Ransick et al.   DEVELOPMENTAL CELL

Proliferative signaling by ERBB proteins and RAF/MEK/ERK effectors in polycystic kidney disease

(2019) Mitchell I. Parker et al.   CELLULAR SIGNALLING

Role of the RNA-binding protein Bicaudal-C1 and interacting factors in cystic kidney diseases

(2019) Benjamin Rothé et al.   CELLULAR SIGNALLING

The Value of Genetic Testing in Polycystic Kidney Diseases Illustrated by a Family With PKD2 and COL4A1 Mutations

(2018) Emilie Cornec-Le Gall et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Dishevelled: A masterful conductor of complex Wnt signals

(2018) Monica Sharma et al.   CELLULAR SIGNALLING

A Boolean network of the crosstalk between IGF and Wnt signaling in aging satellite cells

(2018) Lea Siegle et al.   PLoS One

Direct binding of CEP85 to STIL ensures robust PLK4 activation and efficient centriole assembly

(2018) Yi Liu et al.   Nature Communications

Polycystin-2 is an essential ion channel subunit in the primary cilium of the renal collecting duct epithelium

(2018) Xiaowen Liu et al.   eLife

Structure of the human PKD1-PKD2 complex

(2018) Qiang Su et al.   SCIENCE

GLIS3 Transcriptionally Activates WNT Genes to Promote Differentiation of Human Embryonic Stem Cells into Posterior Neural Progenitors

(2018) Kilsoo Jeon et al.   STEM CELLS

Polycystic kidney disease

(2018) Carsten Bergmann et al.   Nature Reviews Disease Primers

Genetic Complexity of Autosomal Dominant Polycystic Kidney and Liver Diseases

(2017) Emilie Cornec-Le Gall et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Hepatocyte Nuclear Factor–1βRegulates Urinary Concentration and Response to Hypertonicity

(2017) Karam Aboudehen et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Ciliary Mechanisms of Cyst Formation in Polycystic Kidney Disease

(2017) Ming Ma et al.   Cold Spring Harbor Perspectives in Biology

DCDC2Mutations Cause Neonatal Sclerosing Cholangitis

(2016) Muriel Girard et al.   HUMAN MUTATION

The polycystin complex mediates Wnt/Ca2+ signalling

(2016) Seokho Kim et al.   NATURE CELL BIOLOGY

MKS5 and CEP290 Dependent Assembly Pathway of the Ciliary Transition Zone

(2016) Chunmei Li et al.   PLOS BIOLOGY

PIERCE1 is critical for specification of left-right asymmetry in mice

(2016) Young Hoon Sung et al.   Scientific Reports

DCDC2 Mutations Cause a Renal-Hepatic Ciliopathy by Disrupting Wnt Signaling

(2015) Markus Schueler et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Proteomics of Primary Cilia by Proximity Labeling

(2015) David U. Mick et al.   DEVELOPMENTAL CELL

A missense mutation in DCDC2 causes human recessive deafness DFNB66, likely by interfering with sensory hair cell and supporting cell cilia length regulation

(2015) M'hamed Grati et al.   HUMAN MOLECULAR GENETICS

A polycystin-centric view of cyst formation and disease: the polycystins revisited

(2015) Albert C.M. Ong et al.   KIDNEY INTERNATIONAL

TMEM107 recruits ciliopathy proteins to subdomains of the ciliary transition zone and causes Joubert syndrome

(2015) Nils J. Lambacher et al.   NATURE CELL BIOLOGY

TNFα Signaling Regulates Cystic Epithelial Cell Proliferation through Akt/mTOR and ERK/MAPK/Cdk2 Mediated Id2 Signaling

(2015) Julie X. Zhou et al.   PLoS One

Trimmomatic: a flexible trimmer for Illumina sequence data

(2014) Anthony M. Bolger et al.   BIOINFORMATICS

A review of crosstalk between MAPK and Wnt signals and its impact on cartilage regeneration

(2014) Ying Zhang et al.   CELL AND TISSUE RESEARCH

Downregulating Hedgehog Signaling Reduces Renal Cystogenic Potential of Mouse Models

(2014) P. V. Tran et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Cyst formation following disruption of intracellular calcium signaling

(2014) Ivana Y. Kuo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss of cilia suppresses cyst growth in genetic models of autosomal dominant polycystic kidney disease

(2013) Ming Ma et al.   NATURE GENETICS

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Dual specificity phosphatases 10 and 16 are positive regulators of EGF-stimulated ERK activity: Indirect regulation of ERK signals by JNK/p38 selective MAPK phosphatases

(2012) Ann R. Finch et al.   CELLULAR SIGNALLING

Tolvaptan in Patients with Autosomal Dominant Polycystic Kidney Disease

(2012) Vicente E. Torres et al.   NEW ENGLAND JOURNAL OF MEDICINE

Knockdown of Bardet-Biedl Syndrome Gene BBS9/PTHB1 Leads to Cilia Defects

(2012) Shobi Veleri et al.   PLoS One

TMEM237 Is Mutated in Individuals with a Joubert Syndrome Related Disorder and Expands the Role of the TMEM Family at the Ciliary Transition Zone

(2011) Lijia Huang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Putative roles of cilia in polycystic kidney disease

(2011) Paul Winyard et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Evc2 is a positive modulator of Hedgehog signalling that interacts with Evc at the cilia membrane and is also found in the nucleus

(2011) Helen J Blair et al.   BMC BIOLOGY

Increased Expression of the Dyslexia Candidate Gene DCDC2 Affects Length and Signaling of Primary Cilia in Neurons

(2011) Satu Massinen et al.   PLoS One

Pkd1 and Pkd2 Are Required for Normal Placental Development

(2010) Miguel A. Garcia-Gonzalez et al.   PLoS One

Cystic kidney disease: the role of Wnt signaling

(2010) Madeline A. Lancaster et al.   TRENDS IN MOLECULAR MEDICINE

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

(2009) Bryan T. MacDonald et al.   DEVELOPMENTAL CELL

Conditional Mutation of Pkd2 Causes Cystogenesis and Upregulates  -Catenin

(2009) I. Kim et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Glis3 Is Associated with Primary Cilia and Wwtr1/TAZ and Implicated in Polycystic Kidney Disease

(2009) H. S. Kang et al.   MOLECULAR AND CELLULAR BIOLOGY

Cyst formation and activation of the extracellular regulated kinase pathway after kidney specific inactivation of Pkd1

(2008) Sekiya Shibazaki et al.   HUMAN MOLECULAR GENETICS

Polycystin-1 C-terminal tail associates with β-catenin and inhibits canonical Wnt signaling

(2008) Mark Lal et al.   HUMAN MOLECULAR GENETICS

An efficient and versatile system for acute and chronic modulation of renal tubular function in transgenic mice

(2008) Milena Traykova-Brauch et al.   NATURE MEDICINE

Functional analysis of the zinc finger and activation domains of Glis3 and mutant Glis3(NDH1)

(2008) Ju Youn Beak et al.   NUCLEIC ACIDS RESEARCH