Channel Function of Polycystin-2 in the Endoplasmic Reticulum Protects against Autosomal Dominant Polycystic Kidney Disease
Published 2022 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Channel Function of Polycystin-2 in the Endoplasmic Reticulum Protects against Autosomal Dominant Polycystic Kidney Disease
Authors
Keywords
-
Journal
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
Volume 33, Issue 8, Pages 1501-1516
Publisher
American Society of Nephrology (ASN)
Online
2022-07-14
DOI
10.1681/asn.2022010053
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- A polycystin-2 protein with modified channel properties leads to an increased diameter of renal tubules and to renal cysts
- (2021) Melanie Grosch et al. JOURNAL OF CELL SCIENCE
- Molecular dysregulation of ciliary polycystin-2 channels caused by variants in the TOP domain
- (2020) Thuy N. Vien et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Regulation of polycystin expression, maturation and trafficking
- (2020) Jinghua Hu et al. CELLULAR SIGNALLING
- Mineral bone disease in autosomal dominant polycystic kidney disease.
- (2020) Berenice Gitomer et al. KIDNEY INTERNATIONAL
- Structural basis for activity of TRIC counter-ion channels in calcium release
- (2019) Xiao-hui Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Tulp3 Is a Ciliary Trafficking Gene that Regulates Polycystic Kidney Disease
- (2019) Emilie Legué et al. CURRENT BIOLOGY
- TRIC-B: an under-explored druggable ion channel
- (2019) Zicheng Hu et al. NATURE REVIEWS DRUG DISCOVERY
- Holding open the door reveals a new view of polycystin channel function
- (2019) Michael J Caplan EMBO REPORTS
- Discovery and preclinical evaluation of anti-miR-17 oligonucleotide RGLS4326 for the treatment of polycystic kidney disease
- (2019) Edmund C. Lee et al. Nature Communications
- Polycystin 2: A calcium channel, channel partner, and regulator of calcium homeostasis in ADPKD
- (2019) Allison L. Brill et al. CELLULAR SIGNALLING
- TRIC-A Channel Maintains Store Calcium Handling by Interacting With Type 2 Ryanodine Receptor in Cardiac Muscle
- (2019) Xinyu Zhou et al. CIRCULATION RESEARCH
- Adenylyl cyclase 5 deficiency reduces renal cyclic AMP and cyst growth in an orthologous mouse model of polycystic kidney disease
- (2018) Qian Wang et al. KIDNEY INTERNATIONAL
- Hydrophobic pore gates regulate ion permeation in polycystic kidney disease 2 and 2L1 channels
- (2018) Wang Zheng et al. Nature Communications
- Polycystin-2 is an essential ion channel subunit in the primary cilium of the renal collecting duct epithelium
- (2018) Xiaowen Liu et al. eLife
- Cryo-EM structure of the polycystin 2-l1 ion channel
- (2018) Raymond E Hulse et al. eLife
- Genetic Complexity of Autosomal Dominant Polycystic Kidney and Liver Diseases
- (2017) Emilie Cornec-Le Gall et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Molecular insights into lipid-assisted Ca2+ regulation of the TRP channel Polycystin-2
- (2017) Martin Wilkes et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Ciliary Mechanisms of Cyst Formation in Polycystic Kidney Disease
- (2017) Ming Ma et al. Cold Spring Harbor Perspectives in Biology
- Molecular insights into lipid-assisted Ca2+ regulation of the TRP channel Polycystin-2
- (2017) Martin Wilkes et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- The Structure of the Polycystic Kidney Disease Channel PKD2 in Lipid Nanodiscs
- (2016) Peter S. Shen et al. CELL
- Progress in ciliary ion channel physiology
- (2016) Juan Lorenzo Pablo et al. JOURNAL OF GENERAL PHYSIOLOGY
- Structure of the polycystic kidney disease TRP channel Polycystin-2 (PC2)
- (2016) Mariana Grieben et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Function and regulation of TRPP2 ion channel revealed by a gain-of-function mutant
- (2016) Mahmud Arif Pavel et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mice lacking the intracellular cation channel TRIC-B have compromised collagen production and impaired bone mineralization
- (2016) Chengzhu Zhao et al. Science Signaling
- Structure of the polycystic kidney disease TRP channel Polycystin-2 (PC2)
- (2016) Mariana Grieben et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Absence of the ER Cation Channel TMEM38B/TRIC-B Disrupts Intracellular Calcium Homeostasis and Dysregulates Collagen Synthesis in Recessive Osteogenesis Imperfecta
- (2016) Wayne A. Cabral et al. PLoS Genetics
- Mice lacking the intracellular cation channel TRIC-B have compromised collagen production and impaired bone mineralization
- (2016) Chengzhu Zhao et al. Science Signaling
- Vasopressin and disruption of calcium signalling in polycystic kidney disease
- (2015) Fouad T. Chebib et al. Nature Reviews Nephrology
- Trimeric Intracellular Cation Channels and Sarcoplasmic/Endoplasmic Reticulum Calcium Homeostasis
- (2014) Xinyu Zhou et al. CIRCULATION RESEARCH
- Cyst formation following disruption of intracellular calcium signaling
- (2014) Ivana Y. Kuo et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Direct recording and molecular identification of the calcium channel of primary cilia
- (2013) Paul G. DeCaen et al. NATURE
- Loss of cilia suppresses cyst growth in genetic models of autosomal dominant polycystic kidney disease
- (2013) Ming Ma et al. NATURE GENETICS
- Genome engineering using the CRISPR-Cas9 system
- (2013) F Ann Ran et al. Nature Protocols
- Functional polycystin-1 dosage governs autosomal dominant polycystic kidney disease severity
- (2012) Katharina Hopp et al. JOURNAL OF CLINICAL INVESTIGATION
- TRIC channels supporting efficient Ca2+ release from intracellular stores
- (2012) Elisa Venturi et al. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
- Activation of PI3-Kinase Stimulates Endocytosis of ROMK via Akt1/SGK1-Dependent Phosphorylation of WNK1
- (2011) C.-J. Cheng et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- The ADPKD genes pkd1a/b and pkd2 regulate extracellular matrix formation
- (2010) S. Mangos et al. Disease Models & Mechanisms
- Embedding, serial sectioning and staining of zebrafish embryos using JB-4 resin
- (2010) Jessica Sullivan-Brown et al. Nature Protocols
- Pkd1 and Pkd2 Are Required for Normal Placental Development
- (2010) Miguel A. Garcia-Gonzalez et al. PLoS One
- Essential role of the TRIC-B channel in Ca2+ handling of alveolar epithelial cells and in perinatal lung maturation
- (2009) D. Yamazaki et al. DEVELOPMENT
- Polycystic Kidney Disease
- (2008) Peter C. Harris et al. Annual Review of Medicine
- An efficient and versatile system for acute and chronic modulation of renal tubular function in transgenic mice
- (2008) Milena Traykova-Brauch et al. NATURE MEDICINE
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started