A cAMP signalosome in primary cilia drives gene expression and kidney cyst formation

CiliaQ: a simple, open-source software for automated quantification of ciliary morphology and fluorescence in 2D, 3D, and 4D images

(2021) Jan Niklas Hansen et al.   EUROPEAN PHYSICAL JOURNAL E

Vertebrate cells differentially interpret ciliary and extraciliary cAMP

(2021) Melissa E. Truong et al.   CELL

Time-resolved proteomics profiling of the ciliary Hedgehog response

(2021) Elena A. May et al.   JOURNAL OF CELL BIOLOGY

Smoothened transduces Hedgehog signals via activity-dependent sequestration of PKA catalytic subunits

(2021) Corvin D. Arveseth et al.   PLOS BIOLOGY

The cellular pathways and potential therapeutics of Polycystic Kidney Disease

(2021) Taylor Richards et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Discovery of ciliary G protein-coupled receptors regulating pancreatic islet insulin and glucagon secretion

(2021) Chien-Ting Wu et al.   GENES & DEVELOPMENT

Signal transduction in primary cilia – analyzing and manipulating GPCR and second messenger signaling

(2021) Dagmar Wachten et al.   PHARMACOLOGY & THERAPEUTICS

Signaling in the primary cilium through the lens of the Hedgehog pathway

(2020) Eduardo D. Gigante et al.   Wiley Interdisciplinary Reviews-Developmental Biology

Modulation of polycystic kidney disease by G-protein coupled receptors and cyclic AMP signaling

(2020) Caroline R. Sussman et al.   CELLULAR SIGNALLING

Ankmy2 Prevents Smoothened-Independent Hyperactivation of the Hedgehog Pathway via Cilia-Regulated Adenylyl Cyclase Signaling

(2020) Bandarigoda Nipunika Somatilaka et al.   DEVELOPMENTAL CELL

Nanobody-directed targeting of optogenetic tools to study signaling in the primary cilium

(2020) Jan N Hansen et al.   eLife

Ciliopathies and the Kidney: A Review

(2020) Dominique J. McConnachie et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Subcellular Organization of the cAMP Signaling Pathway

(2020) Manuela Zaccolo et al.   PHARMACOLOGICAL REVIEWS

Cellular signalling by primary cilia in development, organ function and disease

(2019) Zeinab Anvarian et al.   Nature Reviews Nephrology

Tolvaptan: A Review in Autosomal Dominant Polycystic Kidney Disease

(2019) Hannah A. Blair   DRUGS

Establishing and regulating the composition of cilia for signal transduction

(2019) Maxence V. Nachury et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Direct visualization of cAMP signaling in primary cilia reveals up-regulation of ciliary GPCR activity following Hedgehog activation

(2019) Jason Y. Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Small-molecule allosteric activators of PDE4 long form cyclic AMP phosphodiesterases

(2019) Faisa Omar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cilia in cystic kidney and other diseases

(2019) Gregory J. Pazour et al.   CELLULAR SIGNALLING

The molecular machines that traffic signaling receptors into and out of cilia

(2018) Maxence V Nachury   CURRENT OPINION IN CELL BIOLOGY

Subcellular localization of MC4R with ADCY3 at neuronal primary cilia underlies a common pathway for genetic predisposition to obesity

(2018) Jacqueline E. Siljee et al.   NATURE GENETICS

The prevalence of autosomal dominant polycystic kidney disease (ADPKD): A meta-analysis of European literature and prevalence evaluation in the Italian province of Modena suggest that ADPKD is a rare and underdiagnosed condition

(2018) Andrea Solazzo et al.   PLoS One

cAMP: From Long-Range Second Messenger to Nanodomain Signalling

(2018) Nshunge Musheshe et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Genetics of Autosomal Recessive Polycystic Kidney Disease and Its Differential Diagnoses

(2018) Carsten Bergmann   Frontiers in Pediatrics

Heavy-tailed prior distributions for sequence count data: removing the noise and preserving large differences

(2018) Anqi Zhu et al.   BIOINFORMATICS

G-Protein-Coupled Receptor Signaling in Cilia

(2017) Kirk Mykytyn et al.   Cold Spring Harbor Perspectives in Biology

Red fluorescent protein-based cAMP indicator applicable to optogenetics and in vivo imaging

(2017) Kazuki Harada et al.   Scientific Reports

Cyclic nucleotide phosphodiesterases in heart and vessels: A therapeutic perspective

(2016) Pierre Bobin et al.   Archives of Cardiovascular Diseases

The primary cilium as a cellular receiver: organizing ciliary GPCR signaling

(2016) Keren I Hilgendorf et al.   CURRENT OPINION IN CELL BIOLOGY

Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9

(2016) John G Doench et al.   NATURE BIOTECHNOLOGY

Near-optimal probabilistic RNA-seq quantification

(2016) Nicolas L Bray et al.   NATURE BIOTECHNOLOGY

Gpr161 anchoring of PKA consolidates GPCR and cAMP signaling

(2016) Verena A. Bachmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Primary Cilia and Mammalian Hedgehog Signaling

(2016) Fiona Bangs et al.   Cold Spring Harbor Perspectives in Biology

Proteomics of Primary Cilia by Proximity Labeling

(2015) David U. Mick et al.   DEVELOPMENTAL CELL

AQUA Cloning: A Versatile and Simple Enzyme-Free Cloning Approach

(2015) Hannes M. Beyer et al.   PLoS One

The cAMP phosphodiesterase-4D7 (PDE4D7) is downregulated in androgen-independent prostate cancer cells and mediates proliferation by compartmentalising cAMP at the plasma membrane of VCaP prostate cancer cells

(2014) D J P Henderson et al.   BRITISH JOURNAL OF CANCER

The Intraflagellar Transport Protein IFT27 Promotes BBSome Exit from Cilia through the GTPase ARL6/BBS3

(2014) Gerald M. Liew et al.   DEVELOPMENTAL CELL

IFT27 Links the BBSome to IFT for Maintenance of the Ciliary Signaling Compartment

(2014) Thibaut Eguether et al.   DEVELOPMENTAL CELL

Prostaglandin signalling regulates ciliogenesis by modulating intraflagellar transport

(2014) Daqing Jin et al.   NATURE CELL BIOLOGY

Improved vectors and genome-wide libraries for CRISPR screening

(2014) Neville E Sanjana et al.   NATURE METHODS

Full-length RNA-seq from single cells using Smart-seq2

(2014) Simone Picelli et al.   Nature Protocols

Gli Protein Activity Is Controlled by Multisite Phosphorylation in Vertebrate Hedgehog Signaling

(2014) Pawel Niewiadomski et al.   Cell Reports

The Ciliary G-Protein-Coupled Receptor Gpr161 Negatively Regulates the Sonic Hedgehog Pathway via cAMP Signaling

(2013) Saikat Mukhopadhyay et al.   CELL

Strategies Targeting cAMP Signaling in the Treatment of Polycystic Kidney Disease

(2013) V. E. Torres et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Animal Models for Human Polycystic Kidney Disease

(2012) Shizuko NAGAO et al.   EXPERIMENTAL ANIMALS

pcaGoPromoter - An R Package for Biological and Regulatory Interpretation of Principal Components in Genome-Wide Gene Expression Data

(2012) Morten Hansen et al.   PLoS One

Prostaglandin E2 stimulates cystogenesis through EP4 receptor in IMCD-3 cells

(2012) Dorit Elberg et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Ciliopathies

(2011) Friedhelm Hildebrandt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Polycystin-2 and phosphodiesterase 4C are components of a ciliary A-kinase anchoring protein complex that is disrupted in cystic kidney diseases

(2011) Y.-H. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cyclic AMP-mediated cyst expansion

(2010) Darren P. Wallace   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Primary cilia regulate mTORC1 activity and cell size through Lkb1

(2010) Christopher Boehlke et al.   NATURE CELL BIOLOGY

Compartmentalized signalling: spatial regulation of cAMP by the action of compartmentalized phosphodiesterases

(2009) George S. Baillie   FEBS Journal

Underpinning compartmentalised cAMP signalling through targeted cAMP breakdown

(2009) Miles D. Houslay   TRENDS IN BIOCHEMICAL SCIENCES