Role and Molecular Regulatory Mechanisms of Hippo Signaling Pathway in Caenorhabditis Elegans and Mammalian Cell Models of Alzheimer’s Disease

Impairment of the autophagy–lysosomal pathway in Alzheimer's diseases: Pathogenic mechanisms and therapeutic potential

(2022) Wei Zhang et al.   Acta Pharmaceutica Sinica B

Faulty autolysosome acidification in Alzheimer’s disease mouse models induces autophagic build-up of Aβ in neurons, yielding senile plaques

(2022) Ju-Hyun Lee et al.   NATURE NEUROSCIENCE

Autolysosomal acidification failure as a primary driver of Alzheimer disease pathogenesis

(2022) Ju-Hyun Lee et al.   Autophagy

Glucose enrichment impair neurotransmission and induce Aβ oligomerization that cannot be reversed by manipulating O-β-GlcNAcylation in the C. elegans model of Alzheimer's disease

(2022) Waqar Ahmad   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

WTS-1/LATS regulates endocytic recycling by restraining F-actin assembly in a synergistic manner

(2021) Hanchong Zhang et al.   JOURNAL OF CELL SCIENCE

YAP-dependent necrosis occurs in early stages of Alzheimer’s disease and regulates mouse model pathology

(2020) Hikari Tanaka et al.   Nature Communications

Mammalian Sterile 20-Like Kinase (MST) 1/2: Crucial Players in Nervous and Immune System and Neurological Disorders

(2020) Yating Qi et al.   JOURNAL OF MOLECULAR BIOLOGY

Increased expression of YAP is associated with decreased cell autophagy in the eutopic endometrial stromal cells of endometriosis

(2019) Tianjiao Pei et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Silymarin’s Inhibition and Treatment Effects for Alzheimer’s Disease

(2019) Hong Guo et al.   MOLECULES

The neuropathological diagnosis of Alzheimer’s disease

(2019) Michael A. DeTure et al.   Molecular Neurodegeneration

TOR Signaling in Caenorhabditis elegans Development, Metabolism, and Aging

(2019) T. Keith Blackwell et al.   GENETICS

The emerging role of Hippo signaling in neurodegeneration

(2019) Manas Ranjan Sahu et al.   JOURNAL OF NEUROSCIENCE RESEARCH

A systematic integrated analysis of brain expression profiles reveals YAP1 and other prioritized hub genes as important upstream regulators in Alzheimer's disease

(2018) Min Xu et al.   Alzheimers & Dementia

Lentivirus-Mediated HDAC3 Inhibition Attenuates Oxidative Stress in APPswe/PS1dE9 Mice

(2018) Linjie Yu et al.   JOURNAL OF ALZHEIMERS DISEASE

Signaling via Amyloid Precursor-Like Proteins APLP1 and APLP2

(2018) Mark E. Orcholski et al.   JOURNAL OF ALZHEIMERS DISEASE

Behavioral Phenotyping of a Transgenic Caenorhabditis Elegans Expressing Neuronal Amyloid-β

(2017) Laura E. Dosanjh et al.   JOURNAL OF ALZHEIMERS DISEASE

Targeting Tumor Necrosis Factor Alpha for Alzheimer’s Disease

(2016) Boris Decourt et al.   Current Alzheimer Research

Mechanisms of Hippo pathway regulation

(2016) Zhipeng Meng et al.   GENES & DEVELOPMENT

AMPK modulates Hippo pathway activity to regulate energy homeostasis

(2015) Wenqi Wang et al.   NATURE CELL BIOLOGY

MAP4K family kinases act in parallel to MST1/2 to activate LATS1/2 in the Hippo pathway

(2015) Zhipeng Meng et al.   Nature Communications

Dietary regulation of PI3K/AKT/GSK-3β pathway in Alzheimer’s disease

(2014) Yasuko Kitagishi et al.   Alzheimers Research & Therapy

Yes-associated protein homolog, YAP-1, is involved in the thermotolerance and aging in the nematode Caenorhabditis elegans

(2013) Hiroaki Iwasa et al.   EXPERIMENTAL CELL RESEARCH

What is the Hippo pathway? Is the Hippo pathway conserved in Caenorhabditis elegans?

(2013) Z. Yang et al.   JOURNAL OF BIOCHEMISTRY

Expression of A2V-mutated Aβ in Caenorhabditis elegans results in oligomer formation and toxicity

(2013) Luisa Diomede et al.   NEUROBIOLOGY OF DISEASE

YAP accelerates Aβ25–35-induced apoptosis through upregulation of Bax expression by interaction with p73

(2011) Heng Zhang et al.   APOPTOSIS

Slimming downfatmakes neuropathichippo: The Fat/Hippo tumor suppressor pathway protects adult neurons through regulation of autophagy

(2011) Piera Calamita et al.   Autophagy

Mammalian Hippo pathway: from development to cancer and beyond

(2011) Y. Bao et al.   JOURNAL OF BIOCHEMISTRY

The V-ATPase: small cargo, large effects

(2010) Karin Schumacher et al.   CURRENT OPINION IN PLANT BIOLOGY

Differential NDR/LATS Interactions with the Human MOB Family Reveal a Negative Role for Human MOB2 in the Regulation of Human NDR Kinases

(2010) R. S. Kohler et al.   MOLECULAR AND CELLULAR BIOLOGY

Lats kinase is involved in the intestinal apical membrane integrity in the nematode Caenorhabditis elegans

(2009) J. Kang et al.   DEVELOPMENT

Novel Mediators of Amyloid Precursor Protein Signaling

(2009) A. Swistowski et al.   JOURNAL OF NEUROSCIENCE

Mint3/X11γ Is an ADP-Ribosylation Factor-dependent Adaptor that Regulates the Traffic of the Alzheimer's Precursor Protein from the Trans-Golgi Network

(2007) Punya Shrivastava-Ranjan et al.   MOLECULAR BIOLOGY OF THE CELL