Faulty autolysosome acidification in Alzheimer’s disease mouse models induces autophagic build-up of Aβ in neurons, yielding senile plaques

Engulfed by Glia: Glial Pruning in Development, Function, and Injury across Species

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Post-Golgi carriers, not lysosomes, confer lysosomal properties to pre-degradative organelles in normal and dystrophic axons

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Alzheimer disease

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Molecular Bases of Neurodegeneration and Cognitive Decline, the Major Burden of Sanfilippo Disease

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Hallmarks of Health

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Dying Neurons Utilize Innate Immune Signaling to Prime Glia for Phagocytosis during Development

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Lysosomal dysfunction in Down syndrome is APP-dependent and mediated by APP-βCTF (C99)

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Cytosolic glucosylceramide regulates endolysosomal function in Niemann-Pick type C disease

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Fluorescent Proteins for Investigating Biological Events in Acidic Environments

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Neuronal Cell Death

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Transgenic expression of a ratiometric autophagy probe specifically in neurons enables the interrogation of brain autophagy in vivo

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Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing

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Autophagosomes cooperate in the degradation of intracellular C-terminal fragments of the amyloid precursor protein via the MVB/lysosomal pathway

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Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities

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Amyloid plaque structure and cell surface interactions of β-amyloid fibrils revealed by electron tomography

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Intraneuronal aggregation of the β-CTF fragment of APP (C99) induces Aβ-independent lysosomal-autophagic pathology

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Disorders of lysosomal acidification—The emerging role of v-ATPase in aging and neurodegenerative disease

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Autophagy flux in CA1 neurons of Alzheimer hippocampus: Increased induction overburdens failing lysosomes to propel neuritic dystrophy

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Regulation of amyloid precursor protein processing by its KFERQ motif

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Presenilin 1 Maintains Lysosomal Ca2+ Homeostasis via TRPML1 by Regulating vATPase-Mediated Lysosome Acidification

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Intracellular amyloid and the neuronal origin of Alzheimer neuritic plaques

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Neuron loss in the 5XFAD mouse model of Alzheimer’s disease correlates with intraneuronal Aβ42 accumulation and Caspase-3 activation

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The role of autophagy in neurodegenerative disease

(2013) Ralph A Nixon   NATURE MEDICINE

The Inside-Out Amyloid Hypothesis and Synapse Pathology in Alzheimer's Disease

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Neuropathological Alterations in Alzheimer Disease

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Inhibition of Glycogen Synthase Kinase-3 Ameliorates β-Amyloid Pathology and Restores Lysosomal Acidification and Mammalian Target of Rapamycin Activity in the Alzheimer Disease Mouse Model

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Cholinergic Abnormalities, Endosomal Alterations and Up-Regulation of Nerve Growth Factor Signaling in Niemann-Pick Type C Disease

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A small-molecule enhancer of autophagy decreases levels of Aβ and APP-CTF via Atg5-dependent autophagy pathway

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Autophagy failure in Alzheimer's disease—locating the primary defect

(2011) Ralph A. Nixon et al.   NEUROBIOLOGY OF DISEASE

Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits

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Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations

(2010) Ju-Hyun Lee et al.   CELL

Autophagy in Alzheimer’s disease

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Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease

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Rapid appearance and local toxicity of amyloid-β plaques in a mouse model of Alzheimer’s disease

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Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE

Impairments in remote memory stabilization precede hippocampal synaptic and cognitive failures in 5XFAD Alzheimer mouse model

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Lysosomal membrane permeabilization in cell death

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