Silymarin’s Inhibition and Treatment Effects for Alzheimer’s Disease

Porphyromonas gingivalis in Alzheimer’s disease brains: Evidence for disease causation and treatment with small-molecule inhibitors

(2019) Stephen S. Dominy et al.   Science Advances

Assessing the role of Porphyromonas gingivalis in periodontitis to determine a causative relationship with Alzheimer’s disease

(2019) Sim K. Singhrao et al.   Journal of Oral Microbiology

Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease

(2019) D. Allan Butterfield et al.   NATURE REVIEWS NEUROSCIENCE

The amyloid cascade and Alzheimer’s disease therapeutics: theory versus observation

(2019) Rudy J. Castellani et al.   LABORATORY INVESTIGATION

Anti-inflammatory and cognitive effects of interferon-β1a (IFNβ1a) in a rat model of Alzheimer’s disease

(2019) Giuseppa Mudò et al.   Journal of Neuroinflammation

Impaired behavioural flexibility related to white matter microgliosis in the TgAPP21 rat model of Alzheimer disease

(2019) Alexander Levit et al.   BRAIN BEHAVIOR AND IMMUNITY

Amyloid growth and membrane damage: Current themes and emerging perspectives from theory and experiments on Aβ and hIAPP

(2018) Michele F.M. Sciacca et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The active role of Ca2+ ions in Aβ-mediated membrane damage

(2018) Michele F. M. Sciacca et al.   CHEMICAL COMMUNICATIONS

Cu and Zn coordination to amyloid peptides: From fascinating chemistry to debated pathological relevance

(2018) Elena Atrián-Blasco et al.   COORDINATION CHEMISTRY REVIEWS

Repurposing of Copper(II)-chelating Drugs for the Treatment of Neurodegenerative Diseases

(2018) Valeria Lanza et al.   CURRENT MEDICINAL CHEMISTRY

Phytochemical analysis, molecular docking and antiamnesic effects of methanolic extract of Silybum marianum (L.) Gaertn seeds in scopolamine induced memory impairment in mice

(2018) Nausheen Nazir et al.   JOURNAL OF ETHNOPHARMACOLOGY

Neuroinflammation and neurohormesis in the pathogenesis of Alzheimer’s disease and Alzheimer-linked pathologies: modulation by nutritional mushrooms

(2018) Angela Trovato Salinaro et al.   Immunity & Ageing

Phospholipids Critical Micellar Concentrations Trigger Different Mechanisms of Intrinsically Disordered Proteins Interaction with Model Membranes

(2018) Federica Scollo et al.   Journal of Physical Chemistry Letters

CSF biomarkers of neuroinflammation and cerebrovascular dysfunction in early Alzheimer disease

(2018) Shorena Janelidze et al.   NEUROLOGY

Silymarin prevents acetaminophen-induced hepatotoxicity via up-regulation of the glutathione conjugation capacity in mice

(2018) Young Chul Kim et al.   Journal of Functional Foods

Copper Redox Cycling Inhibits Aβ Fibre Formation and Promotes Fibre Fragmentation, while Generating a Dityrosine Aβ Dimer

(2018) Miao Gu et al.   Scientific Reports

Reduced Lipid Bilayer Thickness Regulates the Aggregation and Cytotoxicity of Amyloid-β

(2017) Kyle J. Korshavn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Silymarin ameliorates experimentally induced depressive like behavior in rats: Involvement of hippocampal BDNF signaling, inflammatory cytokines and oxidative stress response

(2017) Vishnu N. Thakare et al.   PHYSIOLOGY & BEHAVIOR

Common mechanisms involved in Alzheimer's disease and type 2 diabetes: a key role of chronic bacterial infection and inflammation

(2016) Judith Miklossy et al.   Aging-US

2016 Alzheimer's disease facts and figures

(2016)   Alzheimers & Dementia

Cerebrospinal Fluid Alzheimer’s Disease Biomarkers in Cerebral Amyloid Angiopathy-Related Inflammation

(2016) Dimitri Renard et al.   JOURNAL OF ALZHEIMERS DISEASE

Lipid-assisted protein transport: A diffusion-reaction model supported by kinetic experiments and molecular dynamics simulations

(2016) Carmelo La Rosa et al.   JOURNAL OF CHEMICAL PHYSICS

Silymarin Prevents Restraint Stress-Induced Acute Liver Injury by Ameliorating Oxidative Stress and Reducing Inflammatory Response

(2016) Sou Kim et al.   MOLECULES

Silymarin improved diet-induced liver damage and insulin resistance by decreasing inflammation in mice

(2016) Yu Guo et al.   PHARMACEUTICAL BIOLOGY

Potential antidepressant-like activity of silymarin in the acute restraint stress in mice: Modulation of corticosterone and oxidative stress response in cerebral cortex and hippocampus

(2016) Vishnu N. Thakare et al.   Pharmacological Reports

Oxidative stress: A major pathogenesis and potential therapeutic target of antioxidative agents in Parkinson’s disease and Alzheimer’s disease

(2016) Tianfang Jiang et al.   PROGRESS IN NEUROBIOLOGY

Redox modulation of cellular stress response and lipoxin A4 expression by Hericium Erinaceus in rat brain: relevance to Alzheimer’s disease pathogenesis

(2016) A. Trovato et al.   Immunity & Ageing

Involvement of inflammation in Alzheimer’s disease pathogenesis and therapeutic potential of anti-inflammatory agents

(2015) Sina Shadfar et al.   ARCHIVES OF PHARMACAL RESEARCH

Silibinin suppresses astroglial activation in a mouse model of acute Parkinson׳s disease by modulating the ERK and JNK signaling pathways

(2015) Yujeong Lee et al.   BRAIN RESEARCH

Silymarin Suppresses Cellular Inflammation By Inducing Reparative Stress Signaling

(2015) Erica S. Lovelace et al.   JOURNAL OF NATURAL PRODUCTS

Is interaction of amyloid β-peptides with metals involved in cognitive activity?

(2015) Haruna Tamano et al.   Metallomics

When astrocytes become harmful: Functional and inflammatory responses that contribute to Alzheimer's disease

(2014) Evangelina Avila-Muñoz et al.   AGEING RESEARCH REVIEWS

Redox proteomics analysis of HNE-modified proteins in Down syndrome brain: clues for understanding the development of Alzheimer disease

(2014) Fabio Di Domenico et al.   FREE RADICAL BIOLOGY AND MEDICINE

Monoclonal Antibodies against Aβ42 Fibrils Distinguish Multiple Aggregation State Polymorphismsin Vitroand in Alzheimer Disease Brain

(2014) Asa Hatami et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biometals and Their Therapeutic Implications in Alzheimer’s Disease

(2014) Scott Ayton et al.   Neurotherapeutics

Silymarin effect on amyloid-β plaque accumulation and gene expression of APP in an Alzheimer’s disease rat model

(2014) Parichehreh Yaghmaei et al.   DARU-Journal of Pharmaceutical Sciences

Quinones bearing non-steroidal anti-inflammatory fragments as multitarget ligands for Alzheimer’s disease

(2013) Federica Prati et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Structure–Activity Relationship for (+)-Taxifolin Isolated from Silymarin as an Inhibitor of Amyloid β Aggregation

(2013) Mizuho SATO et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease

(2013) Bin Zhang et al.   CELL

The role of inflammation in sporadic and familial Parkinson’s disease

(2013) Michela Deleidi et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

IFN-  Production by Amyloid  -Specific Th1 Cells Promotes Microglial Activation and Increases Plaque Burden in a Mouse Model of Alzheimer's Disease

(2013) T. C. Browne et al.   JOURNAL OF IMMUNOLOGY

Molecular mechanisms of dendrite stability

(2013) Anthony J. Koleske   NATURE REVIEWS NEUROSCIENCE

Pre-treatment with silymarin reduces brain myeloperoxidase activity and inflammatory cytokines in 6-OHDA hemi-parkinsonian rats

(2013) Rasool Haddadi et al.   NEUROSCIENCE LETTERS

Two-Step Mechanism of Membrane Disruption by Aβ through Membrane Fragmentation and Pore Formation

(2012) Michele F.M. Sciacca et al.   BIOPHYSICAL JOURNAL

Early intervention with a small molecule inhibitor for tumor nefosis factor-α prevents cognitive deficits in a triple transgenic mouse model of Alzheimer’s disease

(2012) S Prasad Gabbita et al.   Journal of Neuroinflammation

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

(2012) Michael T. Heneka et al.   NATURE

Silymarin prevents the toxicity induced by benzo(a)pyrene in human erythrocytes by preserving its membrane integrity: Anin vitrostudy

(2011) PV Kiruthiga et al.   ENVIRONMENTAL TOXICOLOGY

The contribution of activated astrocytes to Aβ production: Implications for Alzheimer's disease pathogenesis

(2011) Jie Zhao et al.   Journal of Neuroinflammation

Improvement of Cerebellum Redox States and Cholinergic Functions Contribute to the Beneficial Effects of Silymarin Against Manganese-Induced Neurotoxicity

(2011) Yassine Chtourou et al.   NEUROCHEMICAL RESEARCH

Oxidative Stress and β-Amyloid Protein in Alzheimer’s Disease

(2011) Zhiyou Cai et al.   NEUROMOLECULAR MEDICINE

PP1 Inhibition By Aβ Peptide And Aluminum As A Potential Pathological Mechanism In Alzheimer's Disease

(2010) Edgar F. da Cruz e Silva et al.   Alzheimers & Dementia

Identification of Hot Regions of the Aβ-IAPP Interaction Interface as High-Affinity Binding Sites in both Cross- and Self-Association

(2010) Erika Andreetto et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Evidence of Oxidative Stress in Alzheimer's Disease Brain and Antioxidant Therapy

(2010) Domenico Praticò   Annals of the New York Academy of Sciences

Silymarin Attenuated the Amyloid β Plaque Burden and Improved Behavioral Abnormalities in an Alzheimer’s Disease Mouse Model

(2010) Nakaba MURATA et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Silymarin protects spinal cord and cortical cells against oxidative stress and lipopolysaccharide stimulation

(2010) May-Jywan Tsai et al.   NEUROCHEMISTRY INTERNATIONAL

Silibinin: A novel inhibitor of Aβ aggregation

(2010) Fei Yin et al.   NEUROCHEMISTRY INTERNATIONAL

Linking type 2 diabetes and Alzheimer's disease

(2010) W. Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Silymarin protects PBMC against B(a)P induced toxicity by replenishing redox status and modulating glutathione metabolizing enzymes—An in vitro study

(2010) P.V. Kiruthiga et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The chemistry of Alzheimer’s disease

(2009) Arvi Rauk   CHEMICAL SOCIETY REVIEWS

Effect of silymarin on biochemical parameters of oxidative stress in aged and young rat brain

(2009) F. Galhardi et al.   FOOD AND CHEMICAL TOXICOLOGY

Natural Products and their Derivatives as Cholinesterase Inhibitors in the Treatment of Neurodegenerative Disorders: An Update

(2008) Monica Loizzo et al.   CURRENT MEDICINAL CHEMISTRY

Amyloid-cholinesterase interactions

(2008) Nibaldo C. Inestrosa et al.   FEBS Journal

Why Alzheimer’s is a disease of memory: The attack on synapses by Aß oligomers (ADDLs)

(2008) K. L. Viola et al.   Journal of Nutrition Health & Aging

Dendritic Spine Loss and Synaptic Alterations in Alzheimer’s Disease

(2008) Marlen Knobloch et al.   MOLECULAR NEUROBIOLOGY

Microtubule-associated protein tau in development, degeneration and protection of neurons

(2008) Jian-Zhi Wang et al.   PROGRESS IN NEUROBIOLOGY