Glucose enrichment impair neurotransmission and induce Aβ oligomerization that cannot be reversed by manipulating O-β-GlcNAcylation in the C. elegans model of Alzheimer's disease

O-GlcNAcylation ameliorates the pathological manifestations of Alzheimer’s disease by inhibiting necroptosis

(2021) Jinsu Park et al.   Science Advances

Metabolic disorder in Alzheimer’s disease

(2021) Mrinal K. Poddar et al.   METABOLIC BRAIN DISEASE

Precision Nutrition for Alzheimer’s Prevention in ApoE4 Carriers

(2021) Nicholas G. Norwitz et al.   Nutrients

Scavenging amyloid oligomers from neurons with silica nanobowls: Implications for amyloid diseases

(2021) Vrinda Sant et al.   BIOPHYSICAL JOURNAL

Structural and mechanistic insights into amyloid‐β and α‐synuclein fibril formation and polyphenol inhibitor efficacy in phospholipid bilayers

(2021) Henry M. Sanders et al.   FEBS Journal

Coupling relationship between glucose and oxygen metabolisms to differentiate preclinical Alzheimer's disease and normal individuals

(2021) Changchang Ding et al.   HUMAN BRAIN MAPPING

From reaction kinetics to dementia: A simple dimer model of Alzheimer’s disease etiology

(2021) Michael R. Lindstrom et al.   PLoS Computational Biology

Squalamine and Its Derivatives Modulate the Aggregation of Amyloid-β and α-Synuclein and Suppress the Toxicity of Their Oligomers

(2021) Ryan Limbocker et al.   Frontiers in Neuroscience

Bibliometric Analysis Study on the Mechanisms of Brain Energy Metabolism Disorders in Alzheimer's Disease From 2000 to 2020

(2021) Yi-Hong Du et al.   Frontiers in Neurology

Pathological mechanisms and therapeutic strategies for Alzheimer’s disease

(2021) KinYip Tam et al.   Neural Regeneration Research

O-GlcNAcylation as a Therapeutic Target for Alzheimer’s Disease

(2020) Jinsu Park et al.   NEUROMOLECULAR MEDICINE

Lifestyle Modifications and Nutritional Interventions in Aging-Associated Cognitive Decline and Alzheimer’s Disease

(2020) Gurjit Kaur Bhatti et al.   Frontiers in Aging Neuroscience

Prediction of human tau 3D structure, and interplay between O-β-GlcNAc and phosphorylation modifications in Alzheimer’s disease: C. elegans as a suitable model to study these interactions in vivo

(2020) Waqar Ahmad et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

High-glucose diets induce mitochondrial dysfunction in Caenorhabditis elegans

(2019) Jonathan Alcántar-Fernández et al.   PLoS One

The Structural Basis of Amyloid Strains in Alzheimer’s Disease

(2019) Lee Makowski   ACS Biomaterials-Science & Engineering

Evidence for brain glucose dysregulation in Alzheimer's disease

(2018) Yang An et al.   Alzheimers & Dementia

5-Methoxyindole-2-carboxylic acid (MICA) suppresses Aβ-mediated pathology in C. elegans

(2018) Waqar Ahmad et al.   EXPERIMENTAL GERONTOLOGY

Caloric restriction ameliorates acrolein-induced neurotoxicity in rats

(2018) Ying-Juan Huang et al.   NEUROTOXICOLOGY

Caenorhabditis elegans respond to high-glucose diets through a network of stress-responsive transcription factors

(2018) Jonathan Alcántar-Fernández et al.   PLoS One

Down-Regulation of Energy Metabolism in Alzheimer's Disease is a Protective Response of Neurons to the Microenvironment

(2018) Jiya Sun et al.   JOURNAL OF ALZHEIMERS DISEASE

Dihydrolipoamide dehydrogenase suppression induces human tau phosphorylation by increasing whole body glucose levels in a C. elegans model of Alzheimer’s Disease

(2018) Waqar Ahmad   EXPERIMENTAL BRAIN RESEARCH

A high glucose diet induces autophagy in a HLH-30/TFEB-dependent manner and impairs the normal lifespan of C. elegans

(2018) Berenice Franco-Juárez et al.   Aging-US

Molecular imaging of serotonin degeneration in mild cognitive impairment

(2017) Gwenn S. Smith et al.   NEUROBIOLOGY OF DISEASE

Serotonin improves glucose metabolism by Serotonylation of the small GTPase Rab4 in L6 skeletal muscle cells

(2017) Ramona Al-Zoairy et al.   Diabetology & Metabolic Syndrome

Glucose Metabolism: A Sweet Relief of Alzheimer’s Disease

(2016) Claudia Duran-Aniotz et al.   CURRENT BIOLOGY

Metformin Attenuates Aβ Pathology Mediated Through Levamisole Sensitive Nicotinic Acetylcholine Receptors in a C. elegans Model of Alzheimer’s Disease

(2016) Waqar Ahmad et al.   MOLECULAR NEUROBIOLOGY

Roles of O-GlcNAcylation on amyloid-β precursor protein processing, tau phosphorylation, and hippocampal synapses dysfunction in Alzheimer’s disease

(2016) Bo-Wen Zheng et al.   NEUROLOGICAL RESEARCH

Neuroproteomic tools for battling Alzheimer's disease

(2016) Timothy D. Veenstra   PROTEOMICS

Elevated glucose and oligomeric β-amyloid disrupt synapses via a common pathway of aberrant protein S-nitrosylation

(2016) Mohd Waseem Akhtar et al.   Nature Communications

The Role of Amyloid-β Oligomers in Toxicity, Propagation, and Immunotherapy

(2016) Urmi Sengupta et al.   EBioMedicine

Intracellular protein glycosylation modulates insulin mediated lifespan in C. elegans

(2016) Mohammad M. Rahman et al.   Aging-US

Amyloid β oligomers in Alzheimer’s disease pathogenesis, treatment, and diagnosis

(2015) Kirsten L. Viola et al.   ACTA NEUROPATHOLOGICA

Sporadic inclusion-body myositis: A degenerative muscle disease associated with aging, impaired muscle protein homeostasis and abnormal mitophagy

(2015) Valerie Askanas et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Effect of High Glucose Levels on Amyloid β Production in Retinas of Spontaneous Diabetes Mellitus Otsuka Long-Evans Tokushima Fatty Rats

(2015) Noriaki Nagai et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Alzheimer-associated A  oligomers impact the central nervous system to induce peripheral metabolic deregulation

(2015) J. R. Clarke et al.   EMBO Molecular Medicine

Nutrition and neurodegeneration: epidemiological evidence and challenges for future research

(2015) Sophie Gillette-Guyonnet et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Alzheimer disease: Epidemiology, diagnostic criteria, risk factors and biomarkers

(2014) Christiane Reitz et al.   BIOCHEMICAL PHARMACOLOGY

High Glucose-inducedO-GlcNAcylated Carbohydrate Response Element-binding Protein (ChREBP) Mediates Mesangial Cell Lipogenesis and Fibrosis

(2014) Min-Jung Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabolic impact of the glycerol channels AQP7 and AQP9 in adipose tissue and liver

(2014) Janne Lebeck   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Deoxyglucose prevents neurodegeneration in culture by eliminating microglia

(2014) Anna Vilalta et al.   Journal of Neuroinflammation

Pharmacological inhibition of O-GlcNAcase (OGA) prevents cognitive decline and amyloid plaque formation in bigenic tau/APP mutant mice

(2014) Scott A Yuzwa et al.   Molecular Neurodegeneration

Enhancement of β-amyloid oligomer accumulation after intracerebroventricular injection of streptozotocin, which involves central insulin signaling in a transgenic mouse model

(2014) Fangju Lin et al.   NEUROREPORT

Conserved Nutrient Sensor O-GlcNAc Transferase Is Integral to C. elegans Pathogen-Specific Immunity

(2014) Michelle R. Bond et al.   PLoS One

Specific Dietary Carbohydrates Differentially Influence the Life Span and Fecundity of Drosophila melanogaster

(2013) Oleh V. Lushchak et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Glucose delays age-dependent proteotoxicity

(2012) Arnaud Tauffenberger et al.   AGING CELL

Metabolic Alterations Induced by Sucrose Intake and Alzheimer’s Disease Promote Similar Brain Mitochondrial Abnormalities

(2012) Cristina Carvalho et al.   DIABETES

An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease–associated Aβ oligomers

(2012) Theresa R. Bomfim et al.   JOURNAL OF CLINICAL INVESTIGATION

Utility of an improved model of amyloid-beta (Aβ1-42) toxicity in Caenorhabditis elegans for drug screening for Alzheimer’s disease

(2012) Gawain McColl et al.   Molecular Neurodegeneration

Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation

(2012) Scott A Yuzwa et al.   Nature Chemical Biology

The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes

(2012) Iryna Benilova et al.   NATURE NEUROSCIENCE

WormScan: A Technique for High-Throughput Phenotypic Analysis of Caenorhabditis elegans

(2012) Mark D. Mathew et al.   PLoS One

Rabx-5 Regulates RAB-5 Early Endosomal Compartments and Synaptic Vesicles in C. elegans

(2012) Sharon B. Sann et al.   PLoS One

Differential Effects of an O-GlcNAcase Inhibitor on Tau Phosphorylation

(2012) Yang Yu et al.   PLoS One

Reserpine modulates neurotransmitter release to extend lifespan and alleviate age-dependent Aβ proteotoxicity in Caenorhabditis elegans

(2011) Kopal Saharia et al.   EXPERIMENTAL GERONTOLOGY

Copper Reduces A  Oligomeric Species and Ameliorates Neuromuscular Synaptic Defects in a C. elegans Model of Inclusion Body Myositis

(2011) D. L. Rebolledo et al.   JOURNAL OF NEUROSCIENCE

Structure of human O-GlcNAc transferase and its complex with a peptide substrate

(2011) Michael B. Lazarus et al.   NATURE

2-Deoxy-D-Glucose Treatment Induces Ketogenesis, Sustains Mitochondrial Function, and Reduces Pathology in Female Mouse Model of Alzheimer's Disease

(2011) Jia Yao et al.   PLoS One

C. elegans Positive Butanone Learning, Short-term, and Long-term Associative Memory Assays

(2011) Amanda Kauffman et al.   Jove-Journal of Visualized Experiments

The selfish brain: Competition for energy resources

(2010) Achim Peters   AMERICAN JOURNAL OF HUMAN BIOLOGY

Reduced O-GlcNAcylation links lower brain glucose metabolism and tau pathology in Alzheimer's disease

(2009) F. Liu et al.   BRAIN

Glucose Shortens the Life Span of C. elegans by Downregulating DAF-16/FOXO Activity and Aquaporin Gene Expression

(2009) Seung-Jae Lee et al.   Cell Metabolism

C. elegans as Model for the Study of High Glucose- Mediated Life Span Reduction

(2009) A. Schlotterer et al.   DIABETES

Intracellular amyloid formation in muscle cells of Aβ-transgenic Caenorhabditis elegans: determinants and physiological role in copper detoxification

(2009) Alicia N Minniti et al.   Molecular Neurodegeneration

A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo

(2008) Scott A Yuzwa et al.   Nature Chemical Biology

Amyloid beta oligomers induce impairment of neuronal insulin receptors

(2007) Wei-Qin Zhao et al.   FASEB JOURNAL