Dual roles for autophagy: Degradation and secretion of Alzheimer's disease Aβ peptide

Latrepirdine (Dimebon®), a potential Alzheimer therapeutic, regulates autophagy and neuropathology in an Alzheimer mouse model

(2013) John W. Steele et al.   Autophagy

Non-autophagic roles of autophagy-related proteins

(2013) Suresh Subramani et al.   EMBO REPORTS

Human APOE genotype affects intraneuronal A 1-42 accumulation in a lentiviral gene transfer model

(2013) W. Zhao et al.   HUMAN MOLECULAR GENETICS

Tubulin Polymerization-promoting Protein (TPPP/p25α) Promotes Unconventional Secretion of α-Synuclein through Exophagy by Impairing Autophagosome-Lysosome Fusion

(2013) Patrick Ejlerskov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy and microtubules - new story, old players

(2013) R. Mackeh et al.   JOURNAL OF CELL SCIENCE

Autophagosomes form at ER–mitochondria contact sites

(2013) Maho Hamasaki et al.   NATURE

Emerging regulation and functions of autophagy

(2013) Patricia Boya et al.   NATURE CELL BIOLOGY

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

(2013) Jean-Charles Lambert et al.   NATURE GENETICS

Autophagy regulates endothelial cell processing, maturation and secretion of von Willebrand factor

(2013) Takehiro Torisu et al.   NATURE MEDICINE

The role of autophagy in neurodegenerative disease

(2013) Ralph A Nixon   NATURE MEDICINE

Alzheimer disease therapy—moving from amyloid-β to tau

(2013) Ezio Giacobini et al.   Nature Reviews Neurology

Autophagy in Human Health and Disease

(2013) Augustine M.K. Choi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Adaptor complex AP2/PICALM, through interaction with LC3, targets Alzheimer's APP-CTF for terminal degradation via autophagy

(2013) Y. Tian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy and apoptosis dysfunction in neurodegenerative disorders

(2013) Saeid Ghavami et al.   PROGRESS IN NEUROBIOLOGY

Unconventional Secretion, Unconventional Solutions

(2013) M. Zhang et al.   SCIENCE

Lysosomal NEU1 deficiency affects amyloid precursor protein levels and amyloid-β secretion via deregulated lysosomal exocytosis

(2013) Ida Annunziata et al.   Nature Communications

Aβ Secretion and Plaque Formation Depend on Autophagy

(2013) Per Nilsson et al.   Cell Reports

Trafficking and Proteolytic Processing of APP

(2013) C. Haass et al.   Cold Spring Harbor Perspectives in Medicine

Caspase activation regulates the extracellular export of autophagic vacuoles

(2012) Isabelle Sirois et al.   Autophagy

Endocytosis and autophagy: Shared machinery for degradation

(2012) Christopher A. Lamb et al.   BIOESSAYS

Mechanisms of Autophagosome Biogenesis

(2012) David C. Rubinsztein et al.   CURRENT BIOLOGY

The Exosome Secretory Pathway Transports Amyloid Precursor Protein Carboxyl-terminal Fragments from the Cell into the Brain Extracellular Space

(2012) Rocio Perez-Gonzalez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transgenic Expression of Intraneuronal A 42 But Not A 40 Leads to Cellular A  Lesions, Degeneration, and Functional Impairment without Typical Alzheimer's Disease Pathology

(2012) D. Abramowski et al.   JOURNAL OF NEUROSCIENCE

Genetic insights in Alzheimer's disease

(2012) Karolien Bettens et al.   LANCET NEUROLOGY

Intraneuronal Aβ accumulation and neurodegeneration: Lessons from transgenic models

(2012) Oliver Wirths et al.   LIFE SCIENCES

Macroautophagy deficiency mediates age-dependent neurodegeneration through a phospho-tau pathway

(2012) Keiichi Inoue et al.   Molecular Neurodegeneration

Amyloid precursor protein (APP) traffics from the cell surface via endosomes for amyloid β (Aβ) production in thetrans-Golgi network

(2012) Regina Wai-Yan Choy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy intersections with conventional and unconventional secretion in tissue development, remodeling and inflammation

(2012) Vojo Deretic et al.   TRENDS IN CELL BIOLOGY

Unconventional protein secretion

(2012) Yu Ding et al.   TRENDS IN PLANT SCIENCE

Intracellular distribution of amyloid beta peptide and its relationship to the lysosomal system

(2012) Lin Zheng et al.   Translational Neurodegeneration

The Role of Atg Proteins in Autophagosome Formation

(2011) Noboru Mizushima et al.   Annual Review of Cell and Developmental Biology

Strategic Role for Mitochondria in Alzheimer's Disease and Cancer

(2011) Louise Hedskog et al.   ANTIOXIDANTS & REDOX SIGNALING

Macroautophagy-generated increase of lysosomal amyloid β-protein mediates oxidant-induced apoptosis of cultured neuroblastoma cells

(2011) Lin Zheng et al.   Autophagy

Rescue of ΔF508-CFTR Trafficking via a GRASP-Dependent Unconventional Secretion Pathway

(2011) Heon Yung Gee et al.   CELL

Autophagy Proteins Regulate the Secretory Component of Osteoclastic Bone Resorption

(2011) Carl J. DeSelm et al.   DEVELOPMENTAL CELL

Autophagy-based unconventional secretory pathway for extracellular delivery of IL-1β

(2011) Nicolas Dupont et al.   EMBO JOURNAL

A small-molecule enhancer of autophagy decreases levels of Aβ and APP-CTF via Atg5-dependent autophagy pathway

(2011) Yuan Tian et al.   FASEB JOURNAL

Biogenesis of a novel compartment for autophagosome-mediated unconventional protein secretion

(2011) Caroline Bruns et al.   JOURNAL OF CELL BIOLOGY

Impaired  -Amyloid Secretion in Alzheimer's Disease Pathogenesis

(2011) D. Tampellini et al.   JOURNAL OF NEUROSCIENCE

Lysosomal Proteolysis Inhibition Selectively Disrupts Axonal Transport of Degradative Organelles and Causes an Alzheimer's-Like Axonal Dystrophy

(2011) S. Lee et al.   JOURNAL OF NEUROSCIENCE

Potent amyloidogenicity and pathogenicity of Aβ43

(2011) Takashi Saito et al.   NATURE NEUROSCIENCE

Control of autophagy as a therapy for neurodegenerative disease

(2011) Harry Harris et al.   Nature Reviews Neurology

Inducing Autophagy by Rapamycin Before, but Not After, the Formation of Plaques and Tangles Ameliorates Cognitive Deficits

(2011) Smita Majumder et al.   PLoS One

Spatial Coupling of mTOR and Autophagy Augments Secretory Phenotypes

(2011) M. Narita et al.   SCIENCE

Towards the global understanding of the autophagy regulatory network

(2010) Marta M. Lipinski   Autophagy

Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits

(2010) Dun-Sheng Yang et al.   BRAIN

Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations

(2010) Ju-Hyun Lee et al.   CELL

Novel synthetic small-molecule activators of AMPK as enhancers of autophagy and amyloid-β peptide degradation

(2010) Valérie Vingtdeux et al.   FASEB JOURNAL

Macroautophagy Is Not Directly Involved in the Metabolism of Amyloid Precursor Protein

(2010) Barry Boland et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Interplay between Mammalian Target of Rapamycin (mTOR), Amyloid-β, and Tau

(2010) Antonella Caccamo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Unconventional secretion of Acb1 is mediated by autophagosomes

(2010) Juan M. Duran et al.   JOURNAL OF CELL BIOLOGY

Unconventional secretion ofPichia pastorisAcb1 is dependent on GRASP protein, peroxisomal functions, and autophagosome formation

(2010) Ravi Manjithaya et al.   JOURNAL OF CELL BIOLOGY

Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease

(2010) Patricia Spilman et al.   PLoS One

Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease

(2010) M. M. Lipinski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism of amyloid plaque formation suggests an intracellular basis of A  pathogenicity

(2010) R. P. Friedrich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Review: Donepezil in Severe Alzheimer's Disease

(2009) Bengt Winblad   American Journal of Alzheimers Disease and Other Dementias

Loss of Autophagy Diminishes Pancreatic β Cell Mass and Function with Resultant Hyperglycemia

(2008) Hye Seung Jung et al.   Cell Metabolism

Sequence analyses of presenilin mutations linked to familial Alzheimer’s disease

(2008) Sun Don Kim et al.   CELL STRESS & CHAPERONES

Autophagy Induction and Autophagosome Clearance in Neurons: Relationship to Autophagic Pathology in Alzheimer's Disease

(2008) B. Boland et al.   JOURNAL OF NEUROSCIENCE

A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells

(2008) Ken Cadwell et al.   NATURE

Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease

(2008) Heng Du et al.   NATURE MEDICINE