A quantitative clinical pharmacology-based framework for model-informed vaccine development

Mechanistic model for booster doses effectiveness in healthy, cancer, and immunosuppressed patients infected with SARS-CoV-2

(2023) Chrysovalantis Voutouri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MRI/PET multimodal imaging of the innate immune response in skeletal muscle and draining lymph node post vaccination in rats

(2023) Saaussan Madi et al.   Frontiers in Immunology

Successes and Opportunities during the Pandemic: Reflections and Revelations from a Vaccine Development Perspective

(2023) Penny M. Heaton et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Spatial dysregulation of T follicular helper cells impairs vaccine responses in aging

(2023) Alyssa Silva-Cayetano et al.   NATURE IMMUNOLOGY

Respiratory Syncytial Virus Prefusion F Protein Vaccine in Older Adults

(2023) Alberto Papi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Antigen presentation dynamics shape the antibody response to variants like SARS-CoV-2 Omicron after multiple vaccinations with the original strain

(2023) Leerang Yang et al.   Cell Reports

A modeling-based approach to optimize COVID-19 vaccine dosing schedules for improved protection

(2023) Prashant Dogra et al.   JCI Insight

Model‐Informed Drug Development: Steps Toward Harmonized Guidance

(2023) Scott Marshall et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Testing fractional doses of COVID-19 vaccines

(2022) Witold Więcek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanistic Models of COVID-19: Insights into Disease Progression, Vaccines, and Therapeutics

(2022) Rajat Desikan et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Could computer models be the key to better COVID vaccines?

(2022) Elie Dolgin   NATURE

COVID-19 vaccine dose sparing: strategies to improve vaccine equity and pandemic preparedness

(2022) Geert V T Roozen et al.   Lancet Global Health

Mathematical Modelling for Optimal Vaccine Dose Finding: Maximising Efficacy and Minimising Toxicity

(2022) John Benest et al.   Vaccines

Predicting effectiveness of the V114 vaccine against invasive pneumococcal disease in children

(2022) Josiah Ryman et al.   Expert Review of Vaccines

Pan-vaccine analysis reveals innate immune endotypes predictive of antibody responses to vaccination

(2022) Slim Fourati et al.   NATURE IMMUNOLOGY

Identifying COVID-19 optimal vaccine dose using mathematical immunostimulation/immunodynamic modelling

(2022) Sophie Rhodes et al.   VACCINE

Vaccine models predict rules for updating vaccines against evolving pathogens such as SARS-CoV-2 and influenza in the context of pre-existing immunity

(2022) Rajat Desikan et al.   Frontiers in Immunology

Accelerating model-informed decisions for COVID-19 vaccine candidates using a model-based meta-analysis approach

(2022) Bhargava Kandala et al.   EBioMedicine

The Correlated Beta Dose Optimisation Approach: Optimal Vaccine Dosing Using Mathematical Modelling and Adaptive Trial Design

(2022) John Benest et al.   Vaccines

Looking beyond COVID-19 vaccine phase 3 trials

(2021) Jerome H. Kim et al.   NATURE MEDICINE

Optimising Vaccine Dose in Inoculation against SARS-CoV-2, a Multi-Factor Optimisation Modelling Study to Maximise Vaccine Safety and Efficacy

(2021) John Benest et al.   Vaccines

Virus vaccines: proteins prefer prolines

(2021) Rogier W. Sanders et al.   Cell Host & Microbe

Single-dose administration and the influence of the timing of the booster dose on immunogenicity and efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine: a pooled analysis of four randomised trials

(2021) Merryn Voysey et al.   LANCET

Safety and immunogenicity of one versus two doses of the COVID-19 vaccine BNT162b2 for patients with cancer: interim analysis of a prospective observational study

(2021) Leticia Monin et al.   LANCET ONCOLOGY

Neutralizing antibody levels are highly predictive of immune protection from symptomatic SARS-CoV-2 infection

(2021) David S. Khoury et al.   NATURE MEDICINE

Emerging concepts in the science of vaccine adjuvants

(2021) Bali Pulendran et al.   NATURE REVIEWS DRUG DISCOVERY

Evaluating Vaccine Efficacy Against Severe Acute Respiratory Syndrome Coronavirus 2 Infection

(2021) Dan-Yu Lin et al.   CLINICAL INFECTIOUS DISEASES

Three Dose Levels of a Maternal Respiratory Syncytial Virus Vaccine Candidate Are Well Tolerated and Immunogenic in a Randomized Trial in Nonpregnant Women

(2021) Tino F Schwarz et al.   JOURNAL OF INFECTIOUS DISEASES

Reactogenicity and immunogenicity after a late second dose or a third dose of ChAdOx1 nCoV-19 in the UK: a substudy of two randomised controlled trials (COV001 and COV002)

(2021) Amy Flaxman et al.   LANCET

Systems vaccinology of the BNT162b2 mRNA vaccine in humans

(2021) Prabhu S. Arunachalam et al.   NATURE

Fractionation of COVID-19 vaccine doses could extend limited supplies and reduce mortality

(2021) Benjamin J. Cowling et al.   NATURE MEDICINE

mRNA vaccines for infectious diseases: principles, delivery and clinical translation

(2021) Namit Chaudhary et al.   NATURE REVIEWS DRUG DISCOVERY

Suboptimal Response to Coronavirus Disease 2019 Messenger RNA Vaccines in Patients With Hematologic Malignancies: A Need for Vigilance in the Postmasking Era

(2021) Mounzer E Agha et al.   Open Forum Infectious Diseases

Application of quantitative systems pharmacology to guide the optimal dosing of COVID‐19 vaccines

(2021) Mario Giorgi et al.   CPT-Pharmacometrics & Systems Pharmacology

Upper and lower respiratory tract correlates of protection against respiratory syncytial virus following vaccination of nonhuman primates

(2021) Tomer Zohar et al.   Cell Host & Microbe

Increased B Cell Selection Stringency In Germinal Centers Can Explain Improved COVID-19 Vaccine Efficacies With Low Dose Prime or Delayed Boost

(2021) Amar K. Garg et al.   Frontiers in Immunology

Forward and reverse translational approaches to predict efficacy of neutralizing respiratory syncytial virus (RSV) antibody prophylaxis

(2021) Brian M. Maas et al.   EBioMedicine

A method to estimate probability of disease and vaccine efficacy from clinical trial immunogenicity data

(2021) Julie Dudášová et al.   npj Vaccines

A quantitative systems pharmacology approach to support mRNA vaccine development and optimization

(2021) Gianluca Selvaggio et al.   CPT-Pharmacometrics & Systems Pharmacology

Improved Prediction of MHC II Antigen Presentation through Integration and Motif Deconvolution of Mass Spectrometry MHC Eluted Ligand Data

(2020) Birkir Reynisson et al.   JOURNAL OF PROTEOME RESEARCH

Recent Progress on the Versatility of Virus-Like Particles

(2020) Ciying Qian et al.   Vaccines

An mRNA Vaccine against SARS-CoV-2 — Preliminary Report

(2020) Lisa A. Jackson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Impact of Vaccines; Health, Economic and Social Perspectives

(2020) Charlene M. C. Rodrigues et al.   Frontiers in Microbiology

Multifaceted Effects of Antigen Valency on B Cell Response Composition and Differentiation In Vivo

(2020) Yu Kato et al.   IMMUNITY

Model-Informed Drug Development: Current U.S. Regulatory Practice and Future Considerations

(2019) Yaning Wang et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Dose finding for new vaccines: The role for immunostimulation/immunodynamic modelling

(2019) Sophie J. Rhodes et al.   JOURNAL OF THEORETICAL BIOLOGY

Successes and failures of the live-attenuated influenza vaccine: can we do better?

(2019) Laura Matrajt et al.   CLINICAL INFECTIOUS DISEASES

Predicting HLA class II antigen presentation through integrated deep learning

(2019) Binbin Chen et al.   NATURE BIOTECHNOLOGY

Injection of Antibodies against Immunodominant Epitopes Tunes Germinal Centers to Generate Broadly Neutralizing Antibodies

(2019) Michael Meyer-Hermann   Cell Reports

Preferential Presentation of High-Affinity Immune Complexes in Germinal Centers Can Explain How Passive Immunization Improves the Humoral Response

(2019) Amar K. Garg et al.   Cell Reports

Using vaccine Immunostimulation/Immunodynamic modelling methods to inform vaccine dose decision-making

(2018) Sophie J. Rhodes et al.   npj Vaccines

Sex differences in vaccine-induced humoral immunity

(2018) Stephanie Fischinger et al.   Seminars in Immunopathology

Basic principles of test-negative design in evaluating influenza vaccine effectiveness

(2017) Wakaba Fukushima et al.   VACCINE

The TB vaccine H56+IC31 dose-response curve is peaked not saturating: Data generation for new mathematical modelling methods to inform vaccine dose decisions

(2016) Sophie J. Rhodes et al.   VACCINE

Multi-epitope Models Explain How Pre-existing Antibodies Affect the Generation of Broadly Protective Responses to Influenza

(2016) Veronika I. Zarnitsyna et al.   PLoS Pathogens

Manipulating the Selection Forces during Affinity Maturation to Generate Cross-Reactive HIV Antibodies

(2015) Shenshen Wang et al.   CELL

The Efficacy of Influenza Vaccination is Reduced in Nursing Home Older Adults With Moderate to Severe Renal Impairment

(2012) Tuen Ching Chan et al.   Journal of the American Medical Directors Association

Advances in the vaccination of the elderly against influenza: role of a high-dose vaccine

(2010) Seth J Sullivan et al.   Expert Review of Vaccines

The Xs and Y of immune responses to viral vaccines

(2010) Sabra L Klein et al.   LANCET INFECTIOUS DISEASES

Age-related decline in immunity: implications for vaccine responsiveness

(2008) Rajesh Kumar et al.   Expert Review of Vaccines