Mathematical Modelling for Optimal Vaccine Dose Finding: Maximising Efficacy and Minimising Toxicity

Duration of Protection against Mild and Severe Disease by Covid-19 Vaccines

(2022) Nick Andrews et al.   NEW ENGLAND JOURNAL OF MEDICINE

Modeling comparative cost-effectiveness of SARS-CoV-2 vaccine dose fractionation in India

(2022) Zhanwei Du et al.   NATURE MEDICINE

Assessment of various continual reassessment method models for dose-escalation phase 1 oncology clinical trials: using real clinical data and simulation studies

(2021) G. D. James et al.   BMC CANCER

Optimising Vaccine Dose in Inoculation against SARS-CoV-2, a Multi-Factor Optimisation Modelling Study to Maximise Vaccine Safety and Efficacy

(2021) John Benest et al.   Vaccines

Vaccination and non-pharmaceutical interventions for COVID-19: a mathematical modelling study

(2021) Sam Moore et al.   LANCET INFECTIOUS DISEASES

Comparative systematic review and meta-analysis of reactogenicity, immunogenicity and efficacy of vaccines against SARS-CoV-2

(2021) Ian McDonald et al.   npj Vaccines

Using numerical modeling and simulation to assess the ethical burden in clinical trials and how it relates to the proportion of responders in a trial sample

(2021) Jean-Pierre Boissel et al.   PLoS One

Evaluation of non-linear-mixed-effect modeling to reduce the sample sizes of pediatric trials in type 2 diabetes mellitus

(2020) Clémence Rigaux et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

SciPy 1.0: fundamental algorithms for scientific computing in Python

(2020) Pauli Virtanen et al.   NATURE METHODS

Immunologic Dose-Response to Adenovirus-Vectored Vaccines in Animals and Humans: A Systematic Review of Dose-Response Studies of Replication Incompetent Adenoviral Vaccine Vectors when Given via an Intramuscular or Subcutaneous Route

(2020) Sara Afrough et al.   Vaccines

Response Type and Host Species may be Sufficient to Predict Dose-Response Curve Shape for Adenoviral Vector Vaccines

(2020) John Benest et al.   Vaccines

Bayesian optimization design for dose‐finding based on toxicity and efficacy outcomes in phase I/ II clinical trials

(2020) Ami Takahashi et al.   PHARMACEUTICAL STATISTICS

How to design a dose-finding study using the continual reassessment method

(2019) Graham M. Wheeler et al.   BMC Medical Research Methodology

Comparison between continuous and discrete doses for model based designs in cancer dose finding

(2019) Márcio Augusto Diniz et al.   PLoS One

Using simulation studies to evaluate statistical methods

(2019) Tim P. Morris et al.   STATISTICS IN MEDICINE

Dose finding for new vaccines: The role for immunostimulation/immunodynamic modelling

(2019) Sophie J. Rhodes et al.   JOURNAL OF THEORETICAL BIOLOGY

Adaptive designs in clinical trials: why use them, and how to run and report them

(2018) Philip Pallmann et al.   BMC Medicine

A tutorial on multiobjective optimization: fundamentals and evolutionary methods

(2018) Michael T. M. Emmerich et al.   Natural Computing

The establishment of surrogates and correlates of protection: Useful tools for the licensure of effective influenza vaccines?

(2018) Brian J. Ward et al.   Human Vaccines & Immunotherapeutics

A tutorial on multiobjective optimization: fundamentals and evolutionary methods

(2018) Michael T. M. Emmerich et al.   Natural Computing

Computing threshold antibody levels of protection in vaccine clinical trials: An assessment of methodological bias

(2018) Merryn Voysey et al.   PLoS One

Exploring the impact of inoculum dose on host immunity and morbidity to inform model-based vaccine design

(2018) Andreas Handel et al.   PLoS Computational Biology

A Bayesian adaptive design for cancer phase I trials using a flexible range of doses

(2017) Mourad Tighiouart et al.   Journal of Biopharmaceutical Statistics

Softmax exploration strategies for multiobjective reinforcement learning

(2017) Peter Vamplew et al.   NEUROCOMPUTING

Parameter Estimation in Softmax Decision-Making Models With Linear Objective Functions

(2016) Paul Reverdy et al.   IEEE Transactions on Automation Science and Engineering

The TB vaccine H56+IC31 dose-response curve is peaked not saturating: Data generation for new mathematical modelling methods to inform vaccine dose decisions

(2016) Sophie J. Rhodes et al.   VACCINE

Mathematical Model Reveals the Role of Memory CD8 T Cell Populations in Recall Responses to Influenza

(2016) Veronika I. Zarnitsyna et al.   Frontiers in Immunology

Multi-armed Bandit Models for the Optimal Design of Clinical Trials: Benefits and Challenges

(2015) Sofía S. Villar et al.   STATISTICAL SCIENCE

Disability weights for the Global Burden of Disease 2013 study

(2015) Joshua A Salomon et al.   Lancet Global Health

Dose-finding clinical trial design for ordinal toxicity grades using the continuation ratio model: an extension of the continual reassessment method

(2012) Emily M Van Meter et al.   Clinical Trials

A brief guide to model selection, multimodel inference and model averaging in behavioural ecology using Akaike’s information criterion

(2010) Matthew R. E. Symonds et al.   BEHAVIORAL ECOLOGY AND SOCIOBIOLOGY

Continual reassessment method with multiple toxicity constraints

(2010) S. M. Lee et al.   BIOSTATISTICS

A safety grading scale to support dose escalation and define stopping rules for healthy subject first-entry-into-man studies

(2010) Michel Sibille et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Dose Escalation Methods in Phase I Cancer Clinical Trials

(2009) Christophe Le Tourneau et al.   JNCI-Journal of the National Cancer Institute