Antigen presentation dynamics shape the antibody response to variants like SARS-CoV-2 Omicron after multiple vaccinations with the original strain

mRNA-based COVID-19 vaccine boosters induce neutralizing immunity against SARS-CoV-2 Omicron variant

(2022) Wilfredo F. Garcia-Beltran et al.   CELL

SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses

(2022) Wanwisa Dejnirattisai et al.   CELL

Association Between 3 Doses of mRNA COVID-19 Vaccine and Symptomatic Infection Caused by the SARS-CoV-2 Omicron and Delta Variants

(2022) Emma K. Accorsi et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Considerable escape of SARS-CoV-2 Omicron to antibody neutralization

(2022) Delphine Planas et al.   NATURE

Broadly neutralizing antibodies overcome SARS-CoV-2 Omicron antigenic shift

(2022) Elisabetta Cameroni et al.   NATURE

Omicron extensively but incompletely escapes Pfizer BNT162b2 neutralization

(2022) Sandile Cele et al.   NATURE

Omicron escapes the majority of existing SARS-CoV-2 neutralizing antibodies

(2022) Yunlong Cao et al.   NATURE

Effects of a Prolonged Booster Interval on Neutralization of Omicron Variant

(2022) Xin Zhao et al.   NEW ENGLAND JOURNAL OF MEDICINE

Effectiveness of a Third Dose of mRNA Vaccines Against COVID-19–Associated Emergency Department and Urgent Care Encounters and Hospitalizations Among Adults During Periods of Delta and Omicron Variant Predominance — VISION Network, 10 States, August 2021–January 2022

(2022) Mark G. Thompson et al.   MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT

SARS-CoV-2 Omicron-neutralizing memory B-cells are elicited by two doses of BNT162b2 mRNA vaccine

(2022) Ryutaro Kotaki et al.   Science Immunology

Analysis of memory B cells identifies conserved neutralizing epitopes on the N-terminal domain of variant SARS-Cov-2 spike proteins

(2022) Zijun Wang et al.   IMMUNITY

Increased memory B cell potency and breadth after a SARS-CoV-2 mRNA boost

(2022) Frauke Muecksch et al.   NATURE

Efficacy of a Fourth Dose of Covid-19 mRNA Vaccine against Omicron

(2022) Gili Regev-Yochay et al.   NEW ENGLAND JOURNAL OF MEDICINE

Clinical severity of, and effectiveness of mRNA vaccines against, covid-19 from omicron, delta, and alpha SARS-CoV-2 variants in the United States: prospective observational study

(2022) Adam S Lauring et al.   BMJ-British Medical Journal

COVID-19 vaccine booster dose needed to achieve Omicron-specific neutralisation in nursing home residents

(2022) David H. Canaday et al.   EBioMedicine

Antibodies from primary humoral responses modulate recruitment of naive B cells during secondary responses

(2022) Jeroen M.J. Tas et al.   IMMUNITY

Two complementary features of humoral immune memory confer protection against the same or variant antigens

(2022) Matthew Van Beek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SARS-CoV-2 Omicron variant emerged under immune selection

(2022) Chee Wah Tan et al.   Nature Microbiology

Combined PET and whole-tissue imaging of lymphatic-targeting vaccines in non-human primates

(2021) Jacob T. Martin et al.   BIOMATERIALS

SARS-CoV-2 mRNA vaccines induce persistent human germinal centre responses

(2021) Jackson S. Turner et al.   NATURE

Naturally enhanced neutralizing breadth against SARS-CoV-2 one year after infection

(2021) Zijun Wang et al.   NATURE

Expression of Foxp3 by T follicular helper cells in end-stage germinal centers

(2021) Johanne T. Jacobsen et al.   SCIENCE

Antibodies elicited by mRNA-1273 vaccination bind more broadly to the receptor binding domain than do those from SARS-CoV-2 infection

(2021) Allison J. Greaney et al.   Science Translational Medicine

Mapping mutations to the SARS-CoV-2 RBD that escape binding by different classes of antibodies

(2021) Allison J. Greaney et al.   Nature Communications

Anti-SARS-CoV-2 receptor-binding domain antibody evolution after mRNA vaccination

(2021) Alice Cho et al.   NATURE

Plasma Neutralization of the SARS-CoV-2 Omicron Variant

(2021) Fabian Schmidt et al.   NEW ENGLAND JOURNAL OF MEDICINE

mRNA vaccines induce durable immune memory to SARS-CoV-2 and variants of concern

(2021) Rishi R. Goel et al.   SCIENCE

Protection against SARS-CoV-2 Beta variant in mRNA-1273 vaccine–boosted nonhuman primates

(2021) Kizzmekia S. Corbett et al.   SCIENCE

Sequential immunization of macaques elicits heterologous neutralizing antibodies targeting the V3-glycan patch of HIV-1 Env

(2021) Amelia Escolano et al.   Science Translational Medicine

Affinity of anti-spike antibodies in SARS-CoV-2 patient plasma and its effect on COVID-19 antibody assays

(2021) Patrick J. Macdonald et al.   EBioMedicine

Naive human B cells engage the receptor binding domain of SARS-CoV-2, variants of concern, and related sarbecoviruses

(2021) Jared Feldman et al.   Science Immunology

Understanding the human antibody repertoire

(2020) Anthony R Rees   mAbs

Engineered immunogen binding to alum adjuvant enhances humoral immunity

(2020) Tyson J. Moyer et al.   NATURE MEDICINE

Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor

(2020) Jun Lan et al.   NATURE

Longitudinal Isolation of Potent Near-Germline SARS-CoV-2-Neutralizing Antibodies from COVID-19 Patients

(2020) Christoph Kreer et al.   CELL

Structures of Human Antibodies Bound to SARS-CoV-2 Spike Reveal Common Epitopes and Recurrent Features of Antibodies

(2020) Christopher O. Barnes et al.   CELL

Antibody Feedback Limits the Expansion of B Cell Responses to Malaria Vaccination but Drives Diversification of the Humoral Response

(2020) Hayley A. McNamara et al.   Cell Host & Microbe

Measuring SARS-CoV-2 neutralizing antibody activity using pseudotyped and chimeric viruses

(2020) Fabian Schmidt et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Convergent antibody responses to SARS-CoV-2 in convalescent individuals

(2020) Davide F. Robbiani et al.   NATURE

Potent neutralizing antibodies from COVID-19 patients define multiple targets of vulnerability

(2020) Philip J. M. Brouwer et al.   SCIENCE

Structural basis of a shared antibody response to SARS-CoV-2

(2020) Meng Yuan et al.   SCIENCE

Quantitative modeling of the effect of antigen dosage on B-cell affinity distributions in maturating germinal centers

(2020) Marco Molari et al.   eLife

Multifaceted Effects of Antigen Valency on B Cell Response Composition and Differentiation In Vivo

(2020) Yu Kato et al.   IMMUNITY

SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies

(2020) Christopher O. Barnes et al.   NATURE

Defining and Manipulating B Cell Immunodominance Hierarchies to Elicit Broadly Neutralizing Antibody Responses against Influenza Virus

(2020) Assaf Amitai et al.   Cell Systems

Modulating the quantity of HIV Env-specific CD4 T cell help promotes rare B cell responses in germinal centers

(2020) Jeong Hyun Lee et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Linking signaling and selection in the germinal center

(2019) Mark J. Shlomchik et al.   IMMUNOLOGICAL REVIEWS

Slow Delivery Immunization Enhances HIV Neutralizing Antibody and Germinal Center Responses via Modulation of Immunodominance

(2019) Kimberly M. Cirelli et al.   CELL

Outflanking immunodominance to target subdominant broadly neutralizing epitopes

(2019) Davide Angeletti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Germline-Encoded Affinity for Cognate Antigen Enables Vaccine Amplification of a Human Broadly Neutralizing Response against Influenza Virus

(2019) Maya Sangesland et al.   IMMUNITY

Restricted Clonality and Limited Germinal Center Reentry Characterize Memory B Cell Reactivation by Boosting

(2019) Luka Mesin et al.   CELL

Influenza Hemagglutinin Structures and Antibody Recognition

(2019) Nicholas C. Wu et al.   Cold Spring Harbor Perspectives in Medicine

B Cell Receptor and CD40 Signaling Are Rewired for Synergistic Induction of the c-Myc Transcription Factor in Germinal Center B Cells

(2018) Wei Luo et al.   IMMUNITY

Precursor Frequency and Affinity Determine B Cell Competitive Fitness in Germinal Centers, Tested with Germline-Targeting HIV Vaccine Immunogens

(2018) Robert K. Abbott et al.   IMMUNITY

When designing vaccines, consider the starting material: the human B cell repertoire

(2018) Colin Havenar-Daughton et al.   CURRENT OPINION IN IMMUNOLOGY

Memory B cells are reactivated in subcapsular proliferative foci of lymph nodes

(2018) Imogen Moran et al.   Nature Communications

The low spike density of HIV may have evolved because of the effects of T helper cell depletion on affinity maturation

(2018) Assaf Amitai et al.   PLoS Computational Biology

Subcapsular Sinus Macrophages: The Seat of Innate and Adaptive Memory in Murine Lymph Nodes

(2018) Imogen Moran et al.   TRENDS IN IMMUNOLOGY

Elicitation of Robust Tier 2 Neutralizing Antibody Responses in Nonhuman Primates by HIV Envelope Trimer Immunization Using Optimized Approaches

(2017) Matthias Pauthner et al.   IMMUNITY

Antigen Acquisition Enables Newly Arriving B Cells To Enter Ongoing Immunization-Induced Germinal Centers

(2017) Jackson S. Turner et al.   JOURNAL OF IMMUNOLOGY

The microanatomic segregation of selection by apoptosis in the germinal center

(2017) Christian T. Mayer et al.   SCIENCE

A Population Dynamics Model for Clonal Diversity in a Germinal Center

(2017) Assaf Amitai et al.   Frontiers in Microbiology

Epitope-Specific Suppression of IgG Responses by Passively Administered Specific IgG: Evidence of Epitope Masking

(2017) Joakim J. E. Bergström et al.   Frontiers in Immunology

Sequential Immunization Elicits Broadly Neutralizing Anti-HIV-1 Antibodies in Ig Knockin Mice

(2016) Amelia Escolano et al.   CELL

Complex Antigens Drive Permissive Clonal Selection in Germinal Centers

(2016) Masayuki Kuraoka et al.   IMMUNITY

Sustained antigen availability during germinal center initiation enhances antibody responses to vaccination

(2016) Hok Hei Tam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Visualizing antibody affinity maturation in germinal centers

(2016) J. M. J. Tas et al.   SCIENCE

Multi-epitope Models Explain How Pre-existing Antibodies Affect the Generation of Broadly Protective Responses to Influenza

(2016) Veronika I. Zarnitsyna et al.   PLoS Pathogens

Germinal Center Selection and the Antibody Response to Influenza

(2015) Gabriel D. Victora et al.   CELL

Manipulating the Selection Forces during Affinity Maturation to Generate Cross-Reactive HIV Antibodies

(2015) Shenshen Wang et al.   CELL

Expression kinetics of nucleoside-modified mRNA delivered in lipid nanoparticles to mice by various routes

(2015) Norbert Pardi et al.   JOURNAL OF CONTROLLED RELEASE

Clonal selection in the germinal centre by regulated proliferation and hypermutation

(2014) Alexander D. Gitlin et al.   NATURE

Germinal center B cells govern their own fate via antibody feedback

(2013) Yang Zhang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Antibodies in HIV-1 Vaccine Development and Therapy

(2013) F. Klein et al.   SCIENCE

A dynamic T cell–limited checkpoint regulates affinity-dependent B cell entry into the germinal center

(2011) Tanja A. Schwickert et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Germinal Center Dynamics Revealed by Multiphoton Microscopy with a Photoactivatable Fluorescent Reporter

(2010) Gabriel D. Victora et al.   CELL

Optimality of Mutation and Selection in Germinal Centers

(2010) Jingshan Zhang et al.   PLoS Computational Biology