Exploring Fatty Acid Mimetics as NR4A Ligands

Development of a Potent Nurr1 Agonist Tool for In Vivo Applications

(2023) Jan Vietor et al.   Journal of Medicinal Chemistry

De Novo Design of Nurr1 Agonists via Fragment-Augmented Generative Deep Learning in Low-Data Regime

(2023) Marco Ballarotto et al.   Journal of Medicinal Chemistry

Nurr1 Modulation Mediates Neuroprotective Effects of Statins

(2022) Sabine Willems et al.   Advanced Science

Compilation and Evaluation of Fatty Acid Mimetics Screening Library

(2022) Johanna H. M. Ehrler et al.   BIOCHEMICAL PHARMACOLOGY

Druggability Evaluation of the Neuron Derived Orphan Receptor (NOR‐1) Reveals Inverse NOR‐1 Agonists

(2022) Daniel Zaienne et al.   ChemMedChem

Medicinal Chemistry and Chemical Biology of Nurr1 Modulators: An Emerging Strategy in Neurodegeneration

(2022) Sabine Willems et al.   JOURNAL OF MEDICINAL CHEMISTRY

Stability of the Retinoid X Receptor-α Homodimer in the Presence and Absence of Rexinoid and Coactivator Peptide

(2021) Zhengrong Yang et al.   BIOCHEMISTRY

Propranolol Activates the Orphan Nuclear Receptor TLX to Counteract Proliferation and Migration of Glioblastoma Cells

(2021) Giuseppe Faudone et al.   JOURNAL OF MEDICINAL CHEMISTRY

Targeting Nuclear Receptors in Neurodegeneration and Neuroinflammation

(2021) Sabine Willems et al.   JOURNAL OF MEDICINAL CHEMISTRY

L-thyroxin and the non-classical thyroid hormone TETRAC are potent activators of PPARγ

(2020) Leonie Gellrich et al.   JOURNAL OF MEDICINAL CHEMISTRY

PGE1 and PGA1 bind to Nurr1 and activate its transcriptional function

(2020) Sreekanth Rajan et al.   Nature Chemical Biology

The orphan nuclear receptor Nurr1 is responsive to non-steroidal anti-inflammatory drugs

(2020) Sabine Willems et al.   Communications Chemistry

Assessment of NR4A Ligands That Directly Bind and Modulate the Orphan Nuclear Receptor Nurr1

(2020) Paola Munoz-Tello et al.   JOURNAL OF MEDICINAL CHEMISTRY

Computer-Assisted Discovery and Structural Optimization of a Novel Retinoid X Receptor Agonist Chemotype

(2019) Pascal Heitel et al.   ACS Medicinal Chemistry Letters

Tuning Nuclear Receptor Selectivity of Wy14,643 towards Selective Retinoid X Receptor Modulation

(2019) Julius Pollinger et al.   JOURNAL OF MEDICINAL CHEMISTRY

Characteristics of Nur77 and its ligands as potential anticancer compounds (Review)

(2018) Lingjuan Wu et al.   Molecular Medicine Reports

Nonacidic Farnesoid X Receptor Modulators

(2017) Daniel Flesch et al.   JOURNAL OF MEDICINAL CHEMISTRY

Opportunities and Challenges for Fatty Acid Mimetics in Drug Discovery

(2017) Ewgenij Proschak et al.   JOURNAL OF MEDICINAL CHEMISTRY

Identification of a Binding Site for Unsaturated Fatty Acids in the Orphan Nuclear Receptor Nurr1

(2016) Ian Mitchelle S. de Vera et al.   ACS Chemical Biology

The interplay of NR4A receptors and the oncogene–tumor suppressor networks in cancer

(2015) Jordan A. Beard et al.   CELLULAR SIGNALLING

NSAIDs Ibuprofen, Indometacin and Diclofenac do not interact with Farnesoid X Receptor

(2015) Jurema Schmidt et al.   Scientific Reports

In Silico Identification and Pharmacological Evaluation of Novel Endocrine Disrupting Chemicals That Act via the Ligand-Binding Domain of the Estrogen Receptor α

(2014) Fiona M. McRobb et al.   TOXICOLOGICAL SCIENCES

Nur77: a potential therapeutic target in cancer

(2012) Sally KY To et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Cytosporone B is an agonist for nuclear orphan receptor Nur77

(2008) Yanyan Zhan et al.   Nature Chemical Biology