Propranolol Activates the Orphan Nuclear Receptor TLX to Counteract Proliferation and Migration of Glioblastoma Cells

L-thyroxin and the non-classical thyroid hormone TETRAC are potent activators of PPARγ

(2020) Leonie Gellrich et al.   JOURNAL OF MEDICINAL CHEMISTRY

Nuclear receptor crosstalk — defining the mechanisms for therapeutic innovation

(2020) Karolien De Bosscher et al.   Nature Reviews Endocrinology

Chemical Starting Matter for HNF4α Ligand Discovery and Chemogenomics

(2020) Isabelle Meijer et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Computer-Aided Discovery of Small Molecule Inhibitors of Transcriptional Activity of TLX (NR2E1) Nuclear Receptor

(2018) Evgenia Dueva et al.   MOLECULES

Deletion of TLX and social isolation impairs exercise-induced neurogenesis in the adolescent hippocampus

(2017) Danka A. Kozareva et al.   HIPPOCAMPUS

Nonacidic Farnesoid X Receptor Modulators

(2017) Daniel Flesch et al.   JOURNAL OF MEDICINAL CHEMISTRY

DrugBank 5.0: a major update to the DrugBank database for 2018

(2017) David S Wishart et al.   NUCLEIC ACIDS RESEARCH

The nuclear receptor Tlx regulates motor, cognitive and anxiety-related behaviours during adolescence and adulthood

(2016) James D. O’Leary et al.   BEHAVIOURAL BRAIN RESEARCH

Regulation of behaviour by the nuclear receptor TLX

(2016) J. D. O'Leary et al.   GENES BRAIN AND BEHAVIOR

Synthesis, thermal degradation and dielectric properties of poly[2-hydroxy,3-(1-naphthyloxy)propyl methacrylate]

(2016) Fatih Biryan et al.   POLYMER BULLETIN

Downregulation of TLX induces TET3 expression and inhibits glioblastoma stem cell self-renewal and tumorigenesis

(2016) Qi Cui et al.   Nature Communications

Uncoupling Stress-Inducible Phosphorylation of Heat Shock Factor 1 from Its Activation

(2015) Marek A. Budzyński et al.   MOLECULAR AND CELLULAR BIOLOGY

NSAIDs Ibuprofen, Indometacin and Diclofenac do not interact with Farnesoid X Receptor

(2015) Jurema Schmidt et al.   Scientific Reports

The Human Orphan Nuclear Receptor Tailless (TLX, NR2E1) Is Druggable

(2014) Cindy Benod et al.   PLoS One

TLX activates MMP-2, promotes self-renewal of tumor spheres in neuroblastoma and correlates with poor patient survival

(2014) P L Chavali et al.   Cell Death & Disease

Tailless and Atrophin control Drosophila aggression by regulating neuropeptide signalling in the pars intercerebralis

(2014) Shaun M. Davis et al.   Nature Communications

The Nuclear Receptor TLX Is Required for Gliomagenesis within the Adult Neurogenic Niche

(2012) Y. Zou et al.   MOLECULAR AND CELLULAR BIOLOGY

The Oncoprotein BCL11A Binds to Orphan Nuclear Receptor TLX and Potentiates its Transrepressive Function

(2012) Sara B. Estruch et al.   PLoS One

Transcriptional activation of NAD+-dependent protein deacetylase SIRT1 by nuclear receptor TLX

(2009) Naotoshi Iwahara et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Initial association of NR2E1 with bipolar disorder and identification of candidate mutations in bipolar disorder, schizophrenia, and aggression through resequencing

(2008) Ravinesh A. Kumar et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

The nuclear receptor tailless is required for neurogenesis in the adult subventricular zone

(2008) H.-K. Liu et al.   GENES & DEVELOPMENT

Transrepressive Function of TLX Requires the Histone Demethylase LSD1

(2008) A. Yokoyama et al.   MOLECULAR AND CELLULAR BIOLOGY