Nur77: a potential therapeutic target in cancer

Nuclear receptor Nr4a1 modulates both regulatory T-cell (Treg) differentiation and clonal deletion

(2012) M. S. Fassett et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cross-talk between NR4A orphan nuclear receptors and β-catenin signaling pathway in osteoblasts

(2011) Ann-Marie Rajalin et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

ERK1/2 deactivation enhances cytoplasmic Nur77 expression level and improves the apoptotic effect of fenretinide in human liver cancer cells

(2011) Hui Yang et al.   BIOCHEMICAL PHARMACOLOGY

Orphan receptor TR3 participates in cisplatin-induced apoptosis via Chk2 phosphorylation to repress intestinal tumorigenesis

(2011) Lu-ming Yao et al.   CARCINOGENESIS

Targeting NR4A1 (TR3) in cancer cells and tumors

(2011) Syng-Ook Lee et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Essential role for DNA-PK-mediated phosphorylation of NR4A nuclear orphan receptors in DNA double-strand break repair

(2011) M. Malewicz et al.   GENES & DEVELOPMENT

T cell receptor signal strength in Tregand iNKT cell development demonstrated by a novel fluorescent reporter mouse

(2011) Amy E. Moran et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Overexpression of the orphan receptor Nur77 and its translocation induced by PCH4 may inhibit malignant glioma cell growth and induce cell apoptosis

(2011) Li-Fu Chang et al.   JOURNAL OF SURGICAL ONCOLOGY

Orphan Receptor TR3 Enhances p53 Transactivation and Represses DNA Double-Strand Break Repair in Hepatoma Cells under Ionizing Radiation

(2011) Bi-xing Zhao et al.   MOLECULAR ENDOCRINOLOGY

The transcription factor NR4A1 (Nur77) controls bone marrow differentiation and the survival of Ly6C− monocytes

(2011) Richard N Hanna et al.   NATURE IMMUNOLOGY

Regulation of NR4A nuclear receptor expression by oncogenic BRAF in melanoma cells

(2011) Aaron G. Smith et al.   Pigment Cell & Melanoma Research

Orphan nuclear transcription factor TR3/Nur77 regulates microvessel permeability by targeting endothelial nitric oxide synthase and destabilizing endothelial junctions

(2011) D. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Orphan nuclear receptor Nur77 participates in human apolipoprotein A5 gene expression

(2010) Kwang-Hoon Song   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Regulation of Nur77 protein turnover through acetylation and deacetylation induced by p300 and HDAC1

(2010) Shin-Ae Kang et al.   BIOCHEMICAL PHARMACOLOGY

Inactivation of the Orphan Nuclear Receptor TR3/Nur77 Inhibits Pancreatic Cancer Cell and Tumor Growth

(2010) S.-O. Lee et al.   CANCER RESEARCH

A Unique Pharmacophore for Activation of the Nuclear Orphan Receptor Nur77 In vivo and In vitro

(2010) Jing-jing Liu et al.   CANCER RESEARCH

Protein kinase C regulates mitochondrial targeting of Nur77 and its family member Nor-1 in thymocytes undergoing apoptosis

(2010) Jennifer Thompson et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Regulation of Nur77 expression by β-catenin and its mitogenic effect in colon cancer cells

(2010) Hua Wu et al.   FASEB JOURNAL

Expression of Nur77 induced by an n-butylidenephthalide derivative promotes apoptosis and inhibits cell growth in oral squamous cell carcinoma

(2010) Po Yen Liu et al.   INVESTIGATIONAL NEW DRUGS

Dibutyryl-cAMP up-regulates nur77 expression via histone modification during neurite outgrowth in PC12 cells

(2010) H. Maruoka et al.   JOURNAL OF BIOCHEMISTRY

Minireview: Nuclear Hormone Receptor 4A Signaling: Implications for Metabolic Disease

(2010) Michael A. Pearen et al.   MOLECULAR ENDOCRINOLOGY

Orphan nuclear receptor Nur77 is required for the differentiation of C6 glioma cells induced by cholera toxin

(2009) Dong Xu et al.   ACTA PHARMACOLOGICA SINICA

Induction and intracellular localization of Nur77 dictate fenretinide-induced apoptosis of human liver cancer cells

(2009) Hui Yang et al.   BIOCHEMICAL PHARMACOLOGY

Inhibition of activation-induced death of dendritic cells and enhancement of vaccine efficacy via blockade of MINOR

(2009) T. Wang et al.   BLOOD

Paclitaxel Directly Binds to Bcl-2 and Functionally Mimics Activity of Nur77

(2009) C. Ferlini et al.   CANCER RESEARCH

The Orphan Nuclear Receptor Nur77 Suppresses Endothelial Cell Activation Through Induction of IκBα Expression

(2009) Bei You et al.   CIRCULATION RESEARCH

Nur77

(2009) Paul C. Evans   CIRCULATION RESEARCH

TIF1β/KAP-1 Is a Coactivator of the Orphan Nuclear Receptor NGFI-B/Nur77

(2009) Juliette Rambaud et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylation of Nur77 by the MEK-ERK-RSK Cascade Induces Mitochondrial Translocation and Apoptosis in T Cells

(2009) A. Wang et al.   JOURNAL OF IMMUNOLOGY

Activation of Nerve Growth Factor-Induced B  by Methylene-Substituted Diindolylmethanes in Bladder Cancer Cells Induces Apoptosis and Inhibits Tumor Growth

(2009) S. Dae Cho et al.   MOLECULAR PHARMACOLOGY

Cotreatment with BCL-2 antagonist sensitizes cutaneous T-cell lymphoma to lethal action of HDAC7-Nur77-based mechanism

(2008) J. Chen et al.   BLOOD

A Short Nur77-Derived Peptide Converts Bcl-2 from a Protector to a Killer

(2008) Siva Kumar Kolluri et al.   CANCER CELL

Modulation of Orphan Nuclear Receptor Nur77-Mediated Apoptotic Pathway by Acetylshikonin and Analogues

(2008) Jie Liu et al.   CANCER RESEARCH

Akt phosphorylates the TR3 orphan receptor and blocks its targeting to the mitochondria

(2008) H.-Z. Chen et al.   CARCINOGENESIS

Nur77 upregulates HIF-α by inhibiting pVHL-mediated degradation

(2008) Bu-Yeon Kim et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Alpha 1-antichymotrypsin/SerpinA3 is a novel target of orphan nuclear receptor Nur77

(2008) Yongjuan Zhao et al.   FEBS Journal

Transcriptional cooperation between NF-κB p50 and CCAAT/enhancer binding protein β regulates Nur77 transcription in Leydig cells

(2008) Bassam El-Asmar et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Orphan nuclear receptor, Nurr-77 was a possible target gene of butylidenephthalide chemotherapy on glioblastoma multiform brain tumor

(2008) Po-Cheng Lin et al.   JOURNAL OF NEUROCHEMISTRY

The Orphan Nuclear Receptor NUR77 Regulates Hormone-InducedStARTranscription in Leydig Cells through Cooperation with Ca2+/Calmodulin-Dependent Protein Kinase I

(2008) Luc J. Martin et al.   MOLECULAR ENDOCRINOLOGY

The Induction of Orphan Nuclear Receptor Nur77 Expression by n-Butylenephthalide as Pharmaceuticals on Hepatocellular Carcinoma Cell Therapy

(2008) Y.-L. Chen et al.   MOLECULAR PHARMACOLOGY

Cytosporone B is an agonist for nuclear orphan receptor Nur77

(2008) Yanyan Zhan et al.   Nature Chemical Biology

A feedback regulatory loop between methyltransferase PRMT1 and orphan receptor TR3

(2008) Na-zi Lei et al.   NUCLEIC ACIDS RESEARCH