Development of a Potent Nurr1 Agonist Tool for In Vivo Applications

Scaffold Hopping from Amodiaquine to Novel Nurr1 Agonist Chemotypes via Microscale Analogue Libraries

(2022) Sabine Willems et al.   ChemMedChem

Recent advances of human dihydroorotate dehydrogenase inhibitors for cancer therapy: Current development and future perspectives

(2022) Lele Zhang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Nurr1 Modulation Mediates Neuroprotective Effects of Statins

(2022) Sabine Willems et al.   Advanced Science

Medicinal Chemistry and Chemical Biology of Nurr1 Modulators: An Emerging Strategy in Neurodegeneration

(2022) Sabine Willems et al.   JOURNAL OF MEDICINAL CHEMISTRY

Mechanistic Impact of Different Ligand Scaffolds on FXR Modulation Suggests Avenues to Selective Modulators

(2022) Jan Heering et al.   ACS Chemical Biology

A first in man study to evaluate the safety, pharmacokinetics and pharmacodynamics of RP7214, a dihydroorotate dehydrogenase inhibitor in healthy subjects

(2022) Ajit Nair et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Fragment-like Chloroquinolineamines Activate the Orphan Nuclear Receptor Nurr1 and Elucidate Activation Mechanisms

(2021) Sabine Willems et al.   JOURNAL OF MEDICINAL CHEMISTRY

Analogs of the Dopamine Metabolite 5,6-Dihydroxyindole Bind Directly to and Activate the Nuclear Receptor Nurr1

(2021) Svetlana A. Kholodar et al.   ACS Chemical Biology

Beam Search for Automated Design and Scoring of Novel ROR Ligands with Machine Intelligence**

(2021) Michael Moret et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Development and Profiling of Inverse Agonist Tools for the Neuroprotective Transcription Factor Nurr1

(2021) Daniel Zaienne et al.   JOURNAL OF MEDICINAL CHEMISTRY

L-thyroxin and the non-classical thyroid hormone TETRAC are potent activators of PPARγ

(2020) Leonie Gellrich et al.   JOURNAL OF MEDICINAL CHEMISTRY

PGE1 and PGA1 bind to Nurr1 and activate its transcriptional function

(2020) Sreekanth Rajan et al.   Nature Chemical Biology

Vidofludimus calcium, a next generation DHODH inhibitor for the Treatment of relapsing-remitting multiple sclerosis

(2020) Andreas Muehler et al.   Multiple Sclerosis and Related Disorders

The orphan nuclear receptor Nurr1 is responsive to non-steroidal anti-inflammatory drugs

(2020) Sabine Willems et al.   Communications Chemistry

Chemical Starting Matter for HNF4α Ligand Discovery and Chemogenomics

(2020) Isabelle Meijer et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Selective Vulnerability to Pyrimidine Starvation in Hematologic Malignancies Revealed by AG-636, a Novel Clinical-Stage Inhibitor of Dihydroorotate Dehydrogenase

(2020) Gabrielle McDonald et al.   MOLECULAR CANCER THERAPEUTICS

Assessment of NR4A Ligands That Directly Bind and Modulate the Orphan Nuclear Receptor Nurr1

(2020) Paola Munoz-Tello et al.   JOURNAL OF MEDICINAL CHEMISTRY

UniProt: the universal protein knowledgebase in 2021

(2020) et al.   NUCLEIC ACIDS RESEARCH

Applications of deuterium in medicinal chemistry

(2019) Tracey Pirali et al.   JOURNAL OF MEDICINAL CHEMISTRY

Computer-Assisted Discovery and Structural Optimization of a Novel Retinoid X Receptor Agonist Chemotype

(2019) Pascal Heitel et al.   ACS Medicinal Chemistry Letters

Tuning Nuclear Receptor Selectivity of Wy14,643 towards Selective Retinoid X Receptor Modulation

(2019) Julius Pollinger et al.   JOURNAL OF MEDICINAL CHEMISTRY

ASLAN003, a potent dihydroorotate dehydrogenase inhibitor for differentiation of acute myeloid leukemia

(2019) Jianbiao Zhou et al.   HAEMATOLOGICA

Targeting Myeloid Differentiation Using Potent 2-Hydroxypyrazolo[1,5-a]pyridine Scaffold-Based Human Dihydroorotate Dehydrogenase Inhibitors

(2018) Stefano Sainas et al.   JOURNAL OF MEDICINAL CHEMISTRY

Nurr1 (NR4A2) regulates Alzheimer’s disease-related pathogenesis and cognitive function in the 5XFAD mouse model

(2018) Minho Moon et al.   AGING CELL

Nonacidic Farnesoid X Receptor Modulators

(2017) Daniel Flesch et al.   JOURNAL OF MEDICINAL CHEMISTRY

Nurr1 reduction influences the onset of chronic EAE in mice

(2015) Francesca Montarolo et al.   INFLAMMATION RESEARCH

Uncoupling Stress-Inducible Phosphorylation of Heat Shock Factor 1 from Its Activation

(2015) Marek A. Budzyński et al.   MOLECULAR AND CELLULAR BIOLOGY

Nuclear receptor Nurr1 agonists enhance its dual functions and improve behavioral deficits in an animal model of Parkinson’s disease

(2015) Chun-Hyung Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NSAIDs Ibuprofen, Indometacin and Diclofenac do not interact with Farnesoid X Receptor

(2015) Jurema Schmidt et al.   Scientific Reports

Correlation between orphan nuclear receptor Nurr1 expression and amyloid deposition in 5XFAD mice, an animal model of Alzheimer's disease

(2014) Minho Moon et al.   JOURNAL OF NEUROCHEMISTRY

NURR1 in Parkinson disease—from pathogenesis to therapeutic potential

(2013) Mickael Decressac et al.   Nature Reviews Neurology