Compilation and Evaluation of Fatty Acid Mimetics Screening Library

Image-Based Annotation of Chemogenomic Libraries for Phenotypic Screening

(2022) Amelie Tjaden et al.   MOLECULES

Designing a Small Fluorescent Inhibitor to Investigate Soluble Epoxide Hydrolase Engagement in Living Cells

(2022) Steffen Brunst et al.   ACS Medicinal Chemistry Letters

Pharmacology of Free Fatty Acid Receptors and Their Allosteric Modulators

(2021) Manuel Grundmann et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Development and in vitro profiling of dual FXR/LTA4H modulators

(2021) Simone Schierle et al.   ChemMedChem

Demonstrating Ligandability of the LC3A and LC3B Adapter Interface

(2021) Markus Hartmann et al.   JOURNAL OF MEDICINAL CHEMISTRY

Exploring the Human Cytomegalovirus Core Nuclear Egress Complex as a Novel Antiviral Target: A New Type of Small Molecule Inhibitors

(2021) Sewar Alkhashrom et al.   Viruses-Basel

Heterodimer formation with retinoic acid receptor RXRα modulates coactivator recruitment by peroxisome proliferator-activated receptor PPARγ

(2021) Whitney Kilu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Focused Libraries for Epigenetic Drug Discovery: The Importance of Isosteres

(2021) Adam I. Green et al.   JOURNAL OF MEDICINAL CHEMISTRY

Second-Generation Dual FXR/sEH Modulators with Optimized Pharmacokinetics

(2021) Moritz Helmstädter et al.   JOURNAL OF MEDICINAL CHEMISTRY

HighVia—A Flexible Live-Cell High-Content Screening Pipeline to Assess Cellular Toxicity

(2020) Alison Howarth et al.   SLAS Discovery

Agonist binding directs dynamic competition among nuclear receptors for heterodimerization with retinoid X receptor

(2020) Lina Fadel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Design and Structural Optimization of Dual FXR/PPARδ Activators

(2020) Simone Schierle et al.   JOURNAL OF MEDICINAL CHEMISTRY

First Structure–Activity Relationship Study of Potent BLT2 Agonists as Potential Wound-Healing Promoters

(2020) Victor Hernandez-Olmos et al.   JOURNAL OF MEDICINAL CHEMISTRY

Systematic assessment of fragment identification for multi‐target drug design

(2020) Steffen Brunst et al.   ChemMedChem

Computer-Assisted Discovery and Structural Optimization of a Novel Retinoid X Receptor Agonist Chemotype

(2019) Pascal Heitel et al.   ACS Medicinal Chemistry Letters

Tuning Nuclear Receptor Selectivity of Wy14,643 towards Selective Retinoid X Receptor Modulation

(2019) Julius Pollinger et al.   JOURNAL OF MEDICINAL CHEMISTRY

A dual farnesoid X receptor/soluble epoxide hydrolase modulator treats non-alcoholic steatohepatitis in mice

(2019) Md. Abdul Hye Khan et al.   BIOCHEMICAL PHARMACOLOGY

Discovery of the First in Vivo Active Inhibitors of the Soluble Epoxide Hydrolase Phosphatase Domain

(2019) Jan S. Kramer et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Novel Biphenyl-based Chemotype of Retinoid X Receptor Ligands Enables Subtype and Heterodimer Preferences

(2019) Julius Pollinger et al.   ACS Medicinal Chemistry Letters

Structure optimization of a new class of PPARγ antagonists

(2019) Victor Hernandez-Olmos et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design of Dual Inhibitors of Soluble Epoxide Hydrolase and LTA4 Hydrolase

(2019) Kerstin Hiesinger et al.   ACS Medicinal Chemistry Letters

The MTH1 inhibitor TH588 is a microtubule-modulating agent that eliminates cancer cells by activating the mitotic surveillance pathway

(2019) Nadia Gul et al.   Scientific Reports

A coupled fluorescence-based assay for the detection of protein arginine N-methyltransferase 6 (PRMT6) enzymatic activity

(2018) Jan Kramer et al.   ANALYTICAL BIOCHEMISTRY

Discovery of Polar Spirocyclic Orally Bioavailable Urea Inhibitors of Soluble Epoxide Hydrolase

(2018) Alexey Lukin et al.   BIOORGANIC CHEMISTRY

Leukotriene biosynthetic enzymes as therapeutic targets

(2018) Jesper Z. Haeggström   JOURNAL OF CLINICAL INVESTIGATION

Polypharmacology by Design: A Medicinal Chemist’s Perspective on Multitargeting Compounds

(2018) Ewgenij Proschak et al.   JOURNAL OF MEDICINAL CHEMISTRY

Selective Optimization of Pranlukast to Farnesoid X Receptor Modulators

(2018) Simone Schierle et al.   ChemMedChem

A Dual Modulator of Farnesoid X Receptor and Soluble Epoxide Hydrolase To Counter Nonalcoholic Steatohepatitis

(2017) Jurema Schmidt et al.   JOURNAL OF MEDICINAL CHEMISTRY

Opportunities and Challenges for Fatty Acid Mimetics in Drug Discovery

(2017) Ewgenij Proschak et al.   JOURNAL OF MEDICINAL CHEMISTRY

Soluble epoxide hydrolase as a therapeutic target for pain, inflammatory and neurodegenerative diseases

(2017) Karen M. Wagner et al.   PHARMACOLOGY & THERAPEUTICS

Thermodynamic properties of leukotriene A 4 hydrolase inhibitors

(2016) Sandra K. Wittmann et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Optimized Sleeping Beauty transposons rapidly generate stable transgenic cell lines

(2015) Eric Kowarz et al.   Biotechnology Journal

PENG: A Neural Gas-Based Approach for Pharmacophore Elucidation. Method Design, Validation, and Virtual Screening for Novel Ligands of LTA4H

(2015) Daniel Moser et al.   Journal of Chemical Information and Modeling

DataWarrior: An Open-Source Program For Chemistry Aware Data Visualization And Analysis

(2015) Thomas Sander et al.   Journal of Chemical Information and Modeling

Peroxisome Proliferator-Activated Receptor γ (PPARγ) and Ligand Choreography: Newcomers Take the Stage

(2015) Santiago Garcia-Vallvé et al.   JOURNAL OF MEDICINAL CHEMISTRY

N-Benzylbenzamides: A Novel Merged Scaffold for Orally Available Dual Soluble Epoxide Hydrolase/Peroxisome Proliferator-Activated Receptor γ Modulators

(2015) René Blöcher et al.   JOURNAL OF MEDICINAL CHEMISTRY

LTB4 promotes insulin resistance in obese mice by acting on macrophages, hepatocytes and myocytes

(2015) Pingping Li et al.   NATURE MEDICINE

Optimized Sleeping Beauty transposons rapidly generate stable transgenic cell lines

(2015) Eric Kowarz et al.   Biotechnology Journal

The ChEMBL bioactivity database: an update

(2013) A. Patrícia Bento et al.   NUCLEIC ACIDS RESEARCH

Retinoid Receptors and Therapeutic Applications of RAR/RXR Modulators

(2012) Albane le Maire et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Comparative Study of the Fatty Acid Binding Process of a New FABP from Cherax quadricarinatus by Fluorescence Intensity, Lifetime and Anisotropy

(2012) Jiayao Li et al.   PLoS One

Naturally occurring monoepoxides of eicosapentaenoic acid and docosahexaenoic acid are bioactive antihyperalgesic lipids

(2010) Christophe Morisseau et al.   JOURNAL OF LIPID RESEARCH

Trends in Kinase Selectivity: Insights for Target Class-Focused Library Screening

(2010) Shana L. Posy et al.   JOURNAL OF MEDICINAL CHEMISTRY

Designing Focused Chemical Libraries Enriched in Protein-Protein Interaction Inhibitors using Machine-Learning Methods

(2010) Christelle Reynès et al.   PLoS Computational Biology

Discovery of 4-[(2S)-2-{[4-(4-Chlorophenoxy)phenoxy]methyl}-1-pyrrolidinyl]butanoic Acid (DG-051) as a Novel Leukotriene A4 Hydrolase Inhibitor of Leukotriene B4 Biosynthesis

(2009) Vincent Sandanayaka et al.   JOURNAL OF MEDICINAL CHEMISTRY

Arachidonic acid cytochrome P450 epoxygenase pathway

(2008) Arthur A. Spector   JOURNAL OF LIPID RESEARCH

Similarity Searching and Scaffold Hopping in Synthetically Accessible Combinatorial Chemistry Spaces

(2008) Markus Boehm et al.   JOURNAL OF MEDICINAL CHEMISTRY

Fatty acid-binding proteins: role in metabolic diseases and potential as drug targets

(2008) Masato Furuhashi et al.   NATURE REVIEWS DRUG DISCOVERY