Hypoxia and hypoxia‐inducible factors in Kaposi sarcoma‐associated herpesvirus infection and disease pathogenesis

Echinomycin as a promising therapeutic agent against KSHV-related malignancies

(2023) Jungang Chen et al.   Journal of Hematology & Oncology

Targeting galectin-driven regulatory circuits in cancer and fibrosis

(2023) Karina V. Mariño et al.   NATURE REVIEWS DRUG DISCOVERY

Regulation of Erythropoiesis by the Hypoxia-Inducible Factor Pathway: Effects of Genetic and Pharmacological Perturbations

(2022) Gregg L. Semenza   Annual Review of Medicine

The ORF45 Protein of Kaposi’s Sarcoma-Associated Herpesvirus and Its Critical Role in the Viral Life Cycle

(2022) Natalie Atyeo et al.   Viruses-Basel

Epigenetic Reprogramming of Kaposi’s Sarcoma-Associated Herpesvirus during Hypoxic Reactivation

(2022) Rajnish Kumar Singh et al.   Cancers

KSHV-encoded vCyclin can modulate HIF1α levels to promote DNA replication in hypoxia

(2021) Rajnish Kumar Singh et al.   eLife

Hypoxia and HIF-1 Trigger Marek’s Disease Virus Reactivation in Lymphoma-Derived Latently Infected T Lymphocytes

(2021) Corentin Mallet et al.   JOURNAL OF VIROLOGY

Kaposi’s sarcoma herpesvirus activates the hypoxia response to usurp HIF2α-dependent translation initiation for replication and oncogenesis

(2021) Omayra Méndez-Solís et al.   Cell Reports

Viral interleukin-6 encoded by an oncogenic virus promotes angiogenesis and cellular transformation by enhancing STAT3-mediated epigenetic silencing of caveolin 1

(2020) Wan Li et al.   ONCOGENE

Pharmacologic Targeting of Hypoxia-Inducible Factors

(2019) Gregg L. Semenza   Annual Review of Pharmacology and Toxicology

An endothelial cell line infected by Kaposi’s sarcoma–associated herpes virus (KSHV) allows the investigation of Kaposi’s sarcoma and the validation of novel viral inhibitors in vitro and in vivo

(2019) Tatyana Dubich et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Kaposi sarcoma

(2019) Ethel Cesarman et al.   Nature Reviews Disease Primers

AIDS-Related Kaposi Sarcoma, Version 2.2019

(2019) Erin Reid et al.   Journal of the National Comprehensive Cancer Network

The transcriptional factors HIF-1 and HIF-2 and their novel inhibitors in cancer therapy

(2019) Najah Albadari et al.   Expert Opinion on Drug Discovery

Kaposi sarcoma–associated herpesvirus miRNAs suppress CASTOR1-mediated mTORC1 inhibition to promote tumorigenesis

(2019) Tingting Li et al.   JOURNAL OF CLINICAL INVESTIGATION

3-[(1S,2S,3R)-2,3-Difluoro-1-hydroxy-7-methylsulfonylindan-4-yl]oxy-5-fluorobenzonitrile (PT2977), a Hypoxia-Inducible Factor 2α (HIF-2α) Inhibitor for the Treatment of Clear Cell Renal Cell Carcinoma

(2019) Rui Xu et al.   JOURNAL OF MEDICINAL CHEMISTRY

The KSHV ORF34 protein Interacts and Stabilizes HIF-2α via Binding to the HIF-2α bHLH and PAS Domains

(2019) Muzammel Haque et al.   JOURNAL OF VIROLOGY

KSHV-encoded LANA protects the cellular replication machinery from hypoxia induced degradation

(2019) Rajnish Kumar Singh et al.   PLoS Pathogens

Characterization of de novo lytic infection of dermal lymphatic microvascular endothelial cells by Kaposi's sarcoma-associated herpesvirus

(2019) Gavin Golas et al.   VIROLOGY

Induction of Kaposi’s Sarcoma-Associated Herpesvirus-Encoded Thymidine Kinase (ORF21) by X-Box Binding Protein 1

(2019) Victoria Wang et al.   JOURNAL OF VIROLOGY

A role of hypoxia-inducible factor 1 alpha in Murine Gammaherpesvirus 68 (MHV68) lytic replication and reactivation from latency

(2019) Darlah M. López-Rodríguez et al.   PLoS Pathogens

miRNAs regulate the HIF switch during hypoxia: a novel therapeutic target

(2018) Marcin Serocki et al.   ANGIOGENESIS

Evolution of Kaposi sarcoma in the past 30 years in a tertiary hospital of the European Mediterranean basin

(2018) J. Marcoval et al.   CLINICAL AND EXPERIMENTAL DERMATOLOGY

HIV-Associated Cancers and Related Diseases

(2018) Robert Yarchoan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Hypoxia-inducible factor-1α plays roles in Epstein-Barr virus’s natural life cycle and tumorigenesis by inducing lytic infection through direct binding to the immediate-early BZLF1 gene promoter

(2017) Richard J. Kraus et al.   PLoS Pathogens

Hypoxia-inducible factor-1 alpha as a therapeutic target for primary effusion lymphoma

(2017) Prabha Shrestha et al.   PLoS Pathogens

RNA Sequencing Reveals that Kaposi Sarcoma-Associated Herpesvirus Infection Mimics Hypoxia Gene Expression Signature

(2017) Coralie Viollet et al.   PLoS Pathogens

Hypoxia-responsive miR-210 promotes self-renewal capacity of colon tumor-initiating cells by repressing ISCU and by inducing lactate production

(2016) Pit Ullmann et al.   Oncotarget

Clinical Features and Outcomes of Patients With Symptomatic Kaposi Sarcoma Herpesvirus (KSHV)-associated Inflammation: Prospective Characterization of KSHV Inflammatory Cytokine Syndrome (KICS)

(2015) Mark N. Polizzotto et al.   CLINICAL INFECTIOUS DISEASES

Induction of Kaposi's Sarcoma-Associated Herpesvirus-Encoded Viral Interleukin-6 by X-Box Binding Protein 1

(2015) Duosha Hu et al.   JOURNAL OF VIROLOGY

Rituximab plus liposomal doxorubicin in HIV-infected patients with KSHV-associated multicentric Castleman disease

(2014) T. S. Uldrick et al.   BLOOD

Hypoxia-inducible factor 1 and its role in viral carcinogenesis

(2014) Sean Cuninghame et al.   VIROLOGY

A Unique Herpesviral Transcriptional Program in KSHV-Infected Lymphatic Endothelial Cells Leads to mTORC1 Activation and Rapamycin Sensitivity

(2013) Henry H Chang et al.   Cell Host & Microbe

Hypoxia: A master regulator of microRNA biogenesis and activity

(2013) Shriram Nallamshetty et al.   FREE RADICAL BIOLOGY AND MEDICINE

Regression of Fibrosis and Reversal of Cirrhosis in Rats by Galectin Inhibitors in Thioacetamide-Induced Liver Disease

(2013) Peter G. Traber et al.   PLoS One

AKTivation of PI3K/AKT/mTOR signaling pathway by KSHV

(2013) Aadra P. Bhatt et al.   Frontiers in Immunology

Recent advances in Kaposi sarcoma herpesvirus-associated multicentric Castleman disease

(2012) Thomas S. Uldrick et al.   CURRENT OPINION IN ONCOLOGY

Disrupting galectin-1 interactions with N-glycans suppresses hypoxia-driven angiogenesis and tumorigenesis in Kaposi’s sarcoma

(2012) Diego O. Croci et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Kaposi's Sarcoma-Associated Herpesvirus ORF34 Protein Binds to HIF-1  and Causes Its Degradation via the Proteasome Pathway

(2012) M. Haque et al.   JOURNAL OF VIROLOGY

Hypoxia promotes ligand-independent EGF receptor signaling via hypoxia-inducible factor-mediated upregulation of caveolin-1

(2012) Y. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Passing the baton: the HIF switch

(2012) Mei Yee Koh et al.   TRENDS IN BIOCHEMICAL SCIENCES

Molecular mechanisms mediating metastasis of hypoxic breast cancer cells

(2012) Gregg L. Semenza   TRENDS IN MOLECULAR MEDICINE

The KSHV viral IL-6 homolog is sufficient to induce blood to lymphatic endothelial cell differentiation

(2012) Valerie A. Morris et al.   VIROLOGY

Clinical Manifestations of Kaposi Sarcoma Herpesvirus Lytic Activation: Multicentric Castleman Disease (KSHV–MCD) and the KSHV Inflammatory Cytokine Syndrome

(2012) Mark N. Polizzotto et al.   Frontiers in Microbiology

A novel approach to cancer therapy using PX-478 as a HIF-1α inhibitor

(2011) Kyeong Lee et al.   ARCHIVES OF PHARMACAL RESEARCH

High-dose zidovudine plus valganciclovir for Kaposi sarcoma herpesvirus-associated multicentric Castleman disease: a pilot study of virus-activated cytotoxic therapy

(2011) T. S. Uldrick et al.   BLOOD

Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen Induction by Hypoxia and Hypoxia-Inducible Factors

(2011) R. P. Veeranna et al.   JOURNAL OF VIROLOGY

Deep Sequencing Reveals Direct Targets of Gammaherpesvirus-Induced mRNA Decay and Suggests That Multiple Mechanisms Govern Cellular Transcript Escape

(2011) Karen Clyde et al.   PLoS One

Amplification of the Angiogenic Signal through the Activation of the TSC/mTOR/HIF Axis by the KSHV vGPCR in Kaposi's Sarcoma

(2011) Bruno C. Jham et al.   PLoS One

Global mRNA Degradation during Lytic Gammaherpesvirus Infection Contributes to Establishment of Viral Latency

(2011) Justin M. Richner et al.   PLoS Pathogens

MicroRNA miR-210 modulates cellular response to hypoxia through the MYC antagonist MNT

(2010) Zhan Zhang et al.   CELL CYCLE

An Interleukin‐6–Related Systemic Inflammatory Syndrome in Patients Co‐Infected with Kaposi Sarcoma–Associated Herpesvirus and HIV but without Multicentric Castleman Disease

(2010) Thomas S. Uldrick et al.   CLINICAL INFECTIOUS DISEASES

HIF-1 and HIF-2 transcription factors — Similar but not identical

(2010) Agnieszka Loboda et al.   MOLECULES AND CELLS

Characterization of the Activation of Protein Tyrosine Phosphatase, Receptor-Type, Z Polypeptide 1 (PTPRZ1) by Hypoxia Inducible Factor-2 Alpha

(2010) Victoria Wang et al.   PLoS One

MicroRNA-210 Regulates Mitochondrial Free Radical Response to Hypoxia and Krebs Cycle in Cancer Cells by Targeting Iron Sulfur Cluster Protein ISCU

(2010) Elena Favaro et al.   PLoS One

Induction of the Warburg effect by Kaposi's sarcoma herpesvirus is required for the maintenance of latently infected endothelial cells

(2010) T. Delgado et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The carbohydrate-binding domain on galectin-1 is more extensive for a complex glycan than for simple saccharides: implications for galectin–glycan interactions at the cell surface

(2009) Michelle C. Miller et al.   BIOCHEMICAL JOURNAL

Hypoxia-Inducible mir-210 Regulates Normoxic Gene Expression Involved in Tumor Initiation

(2009) Xin Huang et al.   MOLECULAR CELL

Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization

(2009) K. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

LANA-1, Bcl-2, Mcl-1 and HIF-1α protein expression in HIV-associated Kaposi sarcoma

(2009) E Long et al.   VIRCHOWS ARCHIV

Regulation of gene expression by hypoxia

(2008) Niall Steven Kenneth et al.   BIOCHEMICAL JOURNAL

Kaposi's Sarcoma-Associated Herpesvirus Viral IFN Regulatory Factor 3 Stabilizes Hypoxia-Inducible Factor-1  to Induce Vascular Endothelial Growth Factor Expression

(2008) Y. C. Shin et al.   CANCER RESEARCH

Regulation of gene expression by hypoxia: Integration of the HIF-transduced hypoxic signal at the hypoxia-responsive element

(2008) Stefan Kaluz et al.   CLINICA CHIMICA ACTA

Differential Dependence of Hypoxia-inducible Factors 1α and 2α on mTORC1 and mTORC2

(2008) Alfredo Toschi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Digoxin and other cardiac glycosides inhibit HIF-1  synthesis and block tumor growth

(2008) H. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA