Kaposi’s sarcoma herpesvirus activates the hypoxia response to usurp HIF2α-dependent translation initiation for replication and oncogenesis

ARNT-dependent HIF-2 transcriptional activity is not sufficient to regulate downstream target genes in neuroblastoma

(2020) Camilla U. Persson et al.   EXPERIMENTAL CELL RESEARCH

Proteomics of SARS-CoV-2-infected host cells reveals therapy targets

(2020) Denisa Bojkova et al.   NATURE

A network of RNA-binding proteins controls translation efficiency to activate anaerobic metabolism

(2020) J. J. David Ho et al.   Nature Communications

Kaposi sarcoma

(2019) Ethel Cesarman et al.   Nature Reviews Disease Primers

Influenza A virus (H1N1) triggers a hypoxic response by stabilizing hypoxia-inducible factor-1α via inhibition of proteasome

(2019) Lehao Ren et al.   VIROLOGY

The KSHV ORF34 protein Interacts and Stabilizes HIF-2α via Binding to the HIF-2α bHLH and PAS Domains

(2019) Muzammel Haque et al.   JOURNAL OF VIROLOGY

KSHV lytic replication interferes with mTORC1 regulation of autophagy and viral protein synthesis

(2019) Eric S. Pringle et al.   JOURNAL OF VIROLOGY

Characterization of de novo lytic infection of dermal lymphatic microvascular endothelial cells by Kaposi's sarcoma-associated herpesvirus

(2019) Gavin Golas et al.   VIROLOGY

PDGFRA defines the mesenchymal stem cell Kaposi’s sarcoma progenitors by enabling KSHV oncogenesis in an angiogenic environment

(2019) Julian Naipauer et al.   PLoS Pathogens

A role of hypoxia-inducible factor 1 alpha in Murine Gammaherpesvirus 68 (MHV68) lytic replication and reactivation from latency

(2019) Darlah M. López-Rodríguez et al.   PLoS Pathogens

Translational Control in Virus-Infected Cells

(2018) Noam Stern-Ginossar et al.   Cold Spring Harbor Perspectives in Biology

KSHV-induced ligand mediated activation of PDGF receptor-alpha drives Kaposi's sarcomagenesis

(2018) Lucas E. Cavallin et al.   PLoS Pathogens

Translational control of ERK signaling through miRNA/4EHP-directed silencing

(2018) Seyed Mehdi Jafarnejad et al.   eLife

Induction of HIF-1α by HIV-1 Infection in CD4+ T Cells Promotes Viral Replication and Drives Extracellular Vesicle-Mediated Inflammation

(2018) Gabriel Duette et al.   mBio

Kaposi’s Sarcoma-Associated Herpesvirus-Encoded Viral IL-6 (vIL-6) Enhances Immunoglobulin Class-Switch Recombination

(2018) Santas A. Rosario et al.   Frontiers in Microbiology

Cap-binding protein 4EHP effects translation silencing by microRNAs

(2017) Clément Chapat et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypoxia-inducible factor-1 alpha as a therapeutic target for primary effusion lymphoma

(2017) Prabha Shrestha et al.   PLoS Pathogens

RNA Sequencing Reveals that Kaposi Sarcoma-Associated Herpesvirus Infection Mimics Hypoxia Gene Expression Signature

(2017) Coralie Viollet et al.   PLoS Pathogens

Human Cells Cultured under Physiological Oxygen Utilize Two Cap-binding Proteins to recruit Distinct mRNAs for Translation

(2016) Sara Timpano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Kaposi sarcoma–associated herpesvirus: immunobiology, oncogenesis, and therapy

(2016) Dirk P. Dittmer et al.   JOURNAL OF CLINICAL INVESTIGATION

A Cap for Every Occasion: Alternative eIF4F Complexes

(2016) J.J. David Ho et al.   TRENDS IN BIOCHEMICAL SCIENCES

Human Mesenchymal Stem Cells of Diverse Origins Support Persistent Infection with Kaposi’s Sarcoma-Associated Herpesvirus and Manifest Distinct Angiogenic, Invasive, and Transforming Phenotypes

(2016) Myung-Shin Lee et al.   mBio

Epigenetic re-expression of HIF-2α suppresses soft tissue sarcoma growth

(2016) Michael S. Nakazawa et al.   Nature Communications

Systemic Reprogramming of Translation Efficiencies on Oxygen Stimulus

(2016) J.J. David Ho et al.   Cell Reports

The E3 Ubiquitin Ligase ARIH1 Protects against Genotoxic Stress by Initiating a 4EHP-Mediated mRNA Translation Arrest

(2015) Louise von Stechow et al.   MOLECULAR AND CELLULAR BIOLOGY

Cancer Cells Exploit eIF4E2-Directed Synthesis of Hypoxia Response Proteins to Drive Tumor Progression

(2014) J. Uniacke et al.   CANCER RESEARCH

Human Viral Oncogenesis: A Cancer Hallmarks Analysis

(2014) Enrique A. Mesri et al.   Cell Host & Microbe

Human Papillomavirus 16 E6 Contributes HIF-1α Induced Warburg Effect by Attenuating the VHL-HIF-1α Interaction

(2014) Yi Guo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Inhibition of KAP1 Enhances Hypoxia-Induced Kaposi's Sarcoma-Associated Herpesvirus Reactivation through RBP-J 

(2014) L. Zhang et al.   JOURNAL OF VIROLOGY

Molecular and Cellular Mechanisms of KSHV Oncogenesis of Kaposi's Sarcoma Associated with HIV/AIDS

(2014) Lucas E. Cavallin et al.   PLoS Pathogens

Kaposi's Sarcoma Herpesvirus MicroRNAs Induce Metabolic Transformation of Infected Cells

(2014) Ohad Yogev et al.   PLoS Pathogens

Hypoxia-inducible Factor-1α (HIF-1α) Promotes Cap-dependent Translation of Selective mRNAs through Up-regulating Initiation Factor eIF4E1 in Breast Cancer Cells under Hypoxia Conditions

(2013) Tingfang Yi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phase II Trial of Imatinib in AIDS-Associated Kaposi's Sarcoma: AIDS Malignancy Consortium Protocol 042

(2013) Henry B. Koon et al.   JOURNAL OF CLINICAL ONCOLOGY

Differential Role for Host Translation Factors in Host and Viral Protein Synthesis during Human Cytomegalovirus Infection

(2013) E. M. Lenarcic et al.   JOURNAL OF VIROLOGY

S-nitrosoglutathione reductase (GSNOR) enhances vasculogenesis by mesenchymal stem cells

(2013) S. A. Gomes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Current Status of Vertebrate Cellular mRNA IRESs

(2013) R. J. Jackson   Cold Spring Harbor Perspectives in Biology

A Novel 4EHP-GIGYF2 Translational Repressor Complex Is Essential for Mammalian Development

(2012) M. Morita et al.   MOLECULAR AND CELLULAR BIOLOGY

An oxygen-regulated switch in the protein synthesis machinery

(2012) James Uniacke et al.   NATURE

Tinkering with Translation: Protein Synthesis in Virus-Infected Cells

(2012) D. Walsh et al.   Cold Spring Harbor Perspectives in Biology

Rapamycin With Antiretroviral Therapy in AIDS-Associated Kaposi Sarcoma

(2011) Susan E. Krown et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Generation of a doxycycline-inducible KSHV producer cell line of endothelial origin: Maintenance of tight latency with efficient reactivation upon induction

(2011) Jinjong Myoung et al.   JOURNAL OF VIROLOGICAL METHODS

Viral subversion of the host protein synthesis machinery

(2011) Derek Walsh et al.   NATURE REVIEWS MICROBIOLOGY

Amplification of the Angiogenic Signal through the Activation of the TSC/mTOR/HIF Axis by the KSHV vGPCR in Kaposi's Sarcoma

(2011) Bruno C. Jham et al.   PLoS One

Kaposi's sarcoma-associated herpesvirus ORF57 protein interacts with PYM to enhance translation of viral intronless mRNAs

(2010) James R Boyne et al.   EMBO JOURNAL

KSHV and the pathogenesis of Kaposi sarcoma: listening to human biology and medicine

(2010) Don Ganem   JOURNAL OF CLINICAL INVESTIGATION

Activation of Host Translational Control Pathways by a Viral Developmental Switch

(2009) Carolina Arias et al.   PLoS Pathogens

Kaposi's Sarcoma-Associated Herpesvirus Viral IFN Regulatory Factor 3 Stabilizes Hypoxia-Inducible Factor-1  to Induce Vascular Endothelial Growth Factor Expression

(2008) Y. C. Shin et al.   CANCER RESEARCH