Article
Dermatology
Jin-Yuan Ma, Jia-Wei Liu
Summary: This study reported a case of a 40-year-old man with AIDS-associated Kaposi sarcoma in the oral cavity, skin, and esophagus. After chemotherapy treatment, the lesions showed significant improvement.
CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY
(2022)
Article
Medicine, Research & Experimental
Bryan Valcarcel-Valdivia, Daniel Enriquez-Vera, Luis Enrique Piedra, Alexis Holguin, Gabriel De la Cruz Ku
Summary: This study retrospectively assessed the treatment approaches and outcomes of patients with KS in Peru. The majority of patients had a high severity status and received systemic chemotherapy. Paclitaxel was the most commonly used first-line drug and showed relatively high overall response rates for both AIDS-related KS and CKS. The 5-year OS rates were slightly lower for AIDS-related KS patients compared to CKS patients.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Article
Immunology
Qianlai Luo, Anna Satcher Johnson, H. Irene Hall, Elizabeth K. Cahoon, Meredith Shiels
Summary: Between 2008 and 2016, the incidence of Kaposi sarcoma among people living with HIV decreased nationally, but nondecreasing trends were observed in some states and among younger and black PLWH.
CLINICAL INFECTIOUS DISEASES
(2021)
Review
Oncology
Isabelle Poizot-Martin, Sylvie Bregigeon, Romain Palich, Anne-Genevieve Marcelin, Marc-Antoine Valantin, Caroline Solas, Marianne Veyri, Jean-Philippe Spano, Alain Makinson
Summary: Kaposi sarcoma-immune reconstitution inflammatory syndrome (KS-IRIS) is a common disease among people living with HIV, despite the improvement of KS with antiretroviral therapy (ART), the occurrence of KS-IRIS still exists and is associated with significant morbidity and mortality.
Article
Immunology
Kathryn Lurain, Mark N. Polizzotto, Laurie T. Krug, Griffin Shoemaker, Amrit Singh, Stig M. R. Jensen, Kathleen M. Wyvill, Ramya Ramaswami, Thomas S. Uldrick, Robert Yarchoan, Irini Sereti
Summary: The aim of this study was to evaluate the baseline differences and the impact of pomalidomide on lymphocyte counts and T-cell subsets in patients with Kaposi sarcoma. The results showed that pomalidomide can decrease T-cell senescence and increase T-cell activation, suggesting its immunomodulatory effects contribute to its activity against Kaposi sarcoma.
Article
Oncology
Andy Karabajakian, Isabelle Ray-Coquard, Jean-Yves Blay
Summary: Kaposi's sarcoma has multiple forms, with the HIV-related form being the most aggressive and involving different areas. Kaposi's sarcoma-associated herpes virus is the underlying cause of the disease, affecting host cell proliferation and angiogenesis, and also impacting immune response.
Review
Otorhinolaryngology
Kendyl Barron, Ariel Omiunu, Joseph Celidonio, Alexandra Cruz-Mullane, Corina Din-Lovinescu, Maria Manuela Chemas-Velez, Soly Baredes, Jean Anderson Eloy, Christina H. Fang
Summary: This study provides a comprehensive review of laryngeal Kaposi sarcoma, including patient characteristics, treatment, and clinical outcomes. The study found that long-term outcomes were generally unfavorable, with most cases occurring in advanced HIV disease patients.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2023)
Article
Oncology
Melitah Motlhale, Mazvita Muchengeti, Debbie Bradshaw, Wenlong Carl Chen, Mwiza Gideon Singini, Chantal Babb de Villiers, Cathryn M. M. Lewis, Noemi Bender, Christopher G. G. Mathew, Robert Newton, Tim Waterboer, Elvira Singh, Freddy Sitas
Summary: This study investigates the relationship between Kaposi sarcoma-associated herpesvirus (KSHV) infection, HIV-1 infection, and antiretroviral therapy (ART) rollout in South Africa. The findings show that KSHV seropositivity is higher in males and individuals with HIV, and lower in individuals with higher levels of education. KSHV seroprevalence decreases over time, coinciding with ART rollout and improvements in educational standards and hygiene.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Medicine, General & Internal
Yuhao Zeng, Rahul Prasad, Rachel D. King, Rajshri Joshi, Jason Lane, Sterling Shriber, Faris Shweikeh, Yani Zhang
Summary: This report presents two cases of AIDS-related Kaposi sarcoma (AIDS-KS) associated with severe steroid-unresponsive periorbital lymphedema that responded to chemotherapy. The association of periorbital edema with KS is important as it often leads to the misuse of steroids in HIV-infected patients.
AMERICAN JOURNAL OF CASE REPORTS
(2023)
Article
Immunology
David Severin, Faiza Bessaoud, Nadia Meftah, Aurelie Du Thanh, Brigitte Tretarre, Bernard Guillot, Alain Makinson
Summary: This study found that most cases of Kaposi sarcoma occurring in HIV-infected individuals are AIDS-KS, but Kaposi sarcoma can also occur in individuals with controlled viral load. Compared to CKS, Kaposi sarcoma in individuals with controlled viral load demonstrate similar clinical presentations, while individuals with viremic AIDS-KS present with more aggressive features.
Article
Immunology
Peter Julius, Guobin Kang, Stepfanie Siyumbwa, Jane Musumali, For Yue Tso, Owen Ngalamika, Trevor Kaile, Fred Maate, Phyllis Moonga, John T. West, Peter Angeletti, Charles Wood
Summary: This case report presents a rare occurrence of co-infection and co-localization of KSHV and EBV in KS arising from the conjunctiva. The possibility of interactions between these two viruses within the same lesion is indicated. Further study is needed to determine the prevalence of EBV co-infection in KS and its impact on KS development and progression.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Medicine, General & Internal
Noah Osei, Gerald Fletcher, Abosede Showunmi, Meena Ahluwalia
Summary: Kaposi sarcoma is a common malignancy in AIDS patients, usually presenting as pigmented papules and nodules on the skin. This case report describes a 31-year-old smoker with AIDS who developed a throat mass with hoarseness of voice, which was diagnosed as laryngeal Kaposi sarcoma. It highlights the importance of considering laryngeal involvement of Kaposi sarcoma in immunodeficient patients, especially when there are no skin lesions.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Review
Oncology
Blanca Iciar Indave Ruiz, Subasri Armon, Reiko Watanabe, Lesley Uttley, Valerie A. White, Alexander J. Lazar, Ian A. Cree
Summary: The current understanding of whether Kaposi's sarcoma is a clonal neoplasm or simply an aggressive reactive virus-driven lesion is insufficient, indicating the need for further research.
Article
Dermatology
Kristan Schiele, Priscilla Ly Kojder, Alex B. Haynes, Anthony Soldano, Anokhi Jambusaria-Pahlajani
Summary: Merkel cell carcinoma (MCC) is a rare, aggressive primary neuroendocrine carcinoma of the skin while Kaposi sarcoma (KS) is an indolent angioproliferative tumor associated with human herpesvirus 8 (HHV8). Concurrent occurrence of MCC and KS is rare, with limited reported cases. Treatment is still ongoing with pembrolizumab for both KS and MCC in this particular case.
JOURNAL OF CUTANEOUS PATHOLOGY
(2022)
Article
Pathology
Jose A. Plaza, Omar P. Sangueza, Alessio Giubellino, Alejandro A. Gru, Benjamin Kaffenberger, Paul E. Wakely, Martin J. Sangueza
Summary: This study reveals a new variant of KS that resembles well-differentiated angiosarcoma histologically. These tumors can be difficult to differentiate from KS without clinical guidance, posing significant diagnostic challenges. Awareness of this variant of KS is crucial for proper diagnosis and management of patients.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2022)
Review
Medical Laboratory Technology
Lee Ratner
SEMINARS IN DIAGNOSTIC PATHOLOGY
(2020)
Article
Virology
Aditi Malu, Tetiana Hutchison, Lacin Yapindi, Katie Smith, Katherine Nelson, Rachel Bergeson, Jordan Pope, Megan Romeo, Carolyn Harrod, Lee Ratner, Carine Van Lint, Robert Harrod
Article
Oncology
Nitya Nathwani, Sandra E. Kurtin, Brea Lipe, Supriya Gupta Mohile, Donna D. Catamero, Debra Wujcik, Kristy Birchard, Agnes Davis, William Dudley, Carrie Tompkins Stricker, Tanya Marya Wildes
JCO ONCOLOGY PRACTICE
(2020)
Article
Virology
Javan K. Kisaka, Lee Ratner, George B. Kyei
JOURNAL OF VIROLOGY
(2020)
Editorial Material
Hematology
Lee Ratner
Article
Oncology
Richard T. Hoppe, Ranjana H. Advani, Weiyun Z. Ai, Richard F. Ambinder, Philippe Armand, Celeste M. Bello, Cecil M. Benitez, Philip J. Bierman, Kirsten M. Boughan, Bouthaina Dabaja, Leo Gordon, Francisco J. Hernandez-Ilizaliturri, Alex F. Herrera, Ephraim P. Hochberg, Jiayi Huang, Patrick B. Johnston, Mark S. Kaminski, Vaishalee P. Kenkre, Nadia Khan, Ryan C. Lynch, Kami Maddocks, Jonathan McConathy, Matthew McKinney, Monika Metzger, David Morgan, Carolyn Mulroney, Rachel Rabinovitch, Karen C. Rosenspire, Stuart Seropian, Randa Tao, Jane N. Winter, Joachim Yahalom, Jennifer L. Burns, Ndiya Ogba
JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK
(2020)
Article
Virology
Daniel A. Rauch, Sydney L. Olson, John C. Harding, Hemalatha Sundaramoorthi, Youngsoo Kim, Tianyuan Zhou, A. Robert MacLeod, Grant Challen, Lee Ratner
Article
Hematology
Amrita Krishnan, Vikram Adhikarla, Erasmus K. Poku, Joycelynne Palmer, Ammar Chaudhry, Van Eric Biglang-awa, Nicole Bowles, Nitya Nathwani, Michael Rosenzweig, Firoozeh Sahebi, Chatchada Karanes, Jennifer Simpson, James F. Sanchez, Dave Yamauchi, Maria Parayno, Arnab Chowdhury, Enrico Caserta, Guido Marcucci, Russell Rockne, Anna M. Wu, Jeffrey Wong, Stephen J. Forman, David Colcher, Paul Yazaki, John Shively, Flavia Pichiorri
Article
Hematology
Peter M. Voorhees, Cesar Rodriguez, Brandi Reeves, Nitya Nathwani, Luciano J. Costa, Yana Lutska, Padma Bobba, Daniela Hoehn, Huiling Pei, Jon Ukropec, Ming Qi, Thomas S. Lin, Paul G. Richardson
Summary: The phase 2 GRIFFIN study explores the efficacy of D-RVd combination therapy in transplant-eligible newly diagnosed multiple myeloma patients. The study shows promising results in terms of high stringent complete response rate and minimal residual disease negativity at the end of maintenance therapy. The safety profile of the treatment regimen is consistent with previous studies, and with over 3 years of follow-up, D-RVd demonstrates durable responses that deepen with D-R maintenance.
Article
Microbiology
Xiaogang Cheng, Ancy Joseph, Victor Castro, Alice Chen-Liaw, Zachary Skidmore, Jacqueline E. Payton, Lee Ratner, John R. Edwards, Takaharu Ueno, Jun-ichi Fujisawa, Daniel A. Rauch, Grant A. Challen, Michael P. Martinez, Patrick Green, Malachi Griffith
Summary: HTLV-1 is a retrovirus that causes leukemia, lymphoma, and inflammatory disorders. CTCF binding to the virus plays a pivotal role in regulating gene expression, DNA, and histone modifications, affecting virus replication in infected cells.
Article
Oncology
Richard T. Hoppe, Ranjana H. Advani, Weiyun Z. Ai, Richard F. Ambinder, Philippe Armand, Celeste M. Bello, Cecil M. Benitez, Weina Chen, Bouthaina Dabaja, Megan E. Daly, Leo I. Gordon, Neil Hansen, Alex F. Herrera, Ephraim P. Hochberg, Patrick B. Johnston, Mark S. Kaminski, Christopher R. Kelsey, Vaishalee P. Kenkre, Nadia Khan, Ryan C. Lynch, Kami Maddocks, Jonathan McConathy, Monika Metzger, David Morgan, Carolyn Mulroney, Sheeja T. Pullarkat, Rachel Rabinovitch, Karen C. Rosenspire, Stuart Seropian, Randa Tao, Pallawi Torka, Jane N. Winter, Joachim Yahalom, Joanna C. Yang, Jennifer L. Burns, Mallory Campbell, Hema Sundar
Summary: This article discusses the classification and treatment options for Hodgkin lymphoma, focusing on radiation therapy dose constraints and the management of advanced-stage and relapsed or refractory Hodgkin lymphoma.
JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK
(2022)
Article
Microbiology
Yueqi Du, Ellen Wu, Xiang Gao, Jie Zhang, John C. Martin, Bruce A. Rosa, Makedonka Mitreva, Lee Ratner
Summary: This study provides a deeper understanding of the viral genetic determinants of coreceptor shift by combining single-genome sequence analysis and next-generation sequencing. It highlights the importance of low-frequency mutants in the development of drug resistance and the role of specific amino acid substitutions outside the V3 region. Additionally, it emphasizes the significance of residues in the V1/V2, V4, C3, and C4 domains in coreceptor shift.
MICROBIOLOGY SPECTRUM
(2022)
Article
Oncology
Matthew T. Villaume, Dilan Patel, Christine Lopez, Vivek Patel, Pauleatha Diggs, Hannah Harmsen, Mary Ann Thompson, David Morgan
WORLD JOURNAL OF ONCOLOGY
(2020)
Article
Hematology
Catherine S. Diefenbach, Fangxin Hong, Richard F. Ambinder, Jonathan B. Cohen, Michael J. Robertson, Kevin A. David, Ranjana H. Advani, Timothy S. Fenske, Stefan K. Barta, Neil D. Palmisiano, Jakob Svoboda, David S. Morgan, Reem Karmali, Elad Sharon, Howard Streicher, Brad S. Kahl, Stephen M. Ansell
LANCET HAEMATOLOGY
(2020)
Article
Biology
Song Cao, Kristine M. Wylie, Matt A. Wyczalkowski, Alla Karpova, Jessica Ley, Sam Sun, R. Jay Mashl, Wen-Wei Liang, Xiaowei Wang, Kimberly Johnson, John F. DiPersio, Hiram Gay, Lee Ratner, Feng Chen, Douglas R. Adkins, Li Ding
COMMUNICATIONS BIOLOGY
(2019)
