Article
Oncology
Gong Peng, Yin Wang, Pengfei Ge, Christopher Bailey, Peng Zhang, Di Zhang, Zhaoli Meng, Chong Qi, Qian Chen, Jingtao Chen, Junqi Niu, Pan Zheng, Yang Liu, Yan Liu
Summary: The study found that HIF1 alpha plays a crucial role in GBM by regulating the expression of PDGF-D and PDGFR alpha to maintain the constitutive activation of the AKT pathway, which is essential for GBM malignancy. Therapies targeting HIF1 alpha may provide effective treatment for GBM.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Virology
Dayvson Mauricio da Silva, Juliana Prado Goncales, Jose Valter Joaquim Silva Junior, Thaisa Regina Rocha Lopes, Luan Araujo Bezerra, Virginia Maria Barros de Lorena, Maria Rosangela Cunha Duarte Coelho
Summary: In HIV/HHV-8 coinfection, levels of cytokines IL-4, IL-6, and IL-10 are higher in patients compared to those infected with only HIV, potentially indicating the development of HHV-8-related diseases. On the other hand, levels of IL-2, TNF-alpha, and IFN-gamma show no significant difference between the two groups.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Wen-Ying Long, Guo-Hua Zhao, Yao Wu
Summary: Hesperetin induces apoptotic cell death in BCBL-1 cells in a dose-dependent manner. It also inhibits KSHV reactivation and reduces the production of progeny virus from KSHV-harbouring cells by suppressing HIF1 alpha expression. These findings suggest that hesperetin may be a novel strategy for treating KSHV infection and KSHV-associated lymphomas.
JOURNAL OF GENERAL VIROLOGY
(2021)
Review
Virology
Antony Idam Mamimandjiami, Augustin Mouinga-Ondeme, Jill-Lea Ramassamy, Delia Doreen Djuicy, Philippe Afonso, Antoine Mahe, Jean-Bernard Lekana-Douki, Olivier Cassar, Antoine Gessain
Summary: This study revealed a high seroprevalence of HHV-8 in rural adult populations in Gabon, with genetically diverse strains belonging to the B, A, and F genotypes.
Article
Immunology
Nedaa Alomari, Jennifer Totonchy
Summary: This study demonstrates that the differentiation of new plasma cells is involved in the early stages of KSHV infection in B cells, and that IL-21 signaling can potentiate this effect, thereby increasing the overall magnitude of KSHV infection at early timepoints. These results suggest that IL-21 signaling represents a host-level susceptibility factor for the establishment of KSHV infection.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Xiaonian Cao, Wei Wu, Dao Wang, Wei Sun, Senyan Lai
Summary: GSK3 alpha overexpression in non-small cell lung cancer (NSCLC) is associated with shorter survival time in patients. GSK3 alpha overexpression promotes proliferation, migration, invasion, and clone formation ability of NSCLC cells, while its inhibition has the opposite effect. GSK3 alpha regulates the HIF1/VEGFA signaling pathway independently through the PHDs-pVHL pathway, thereby influencing tumor angiogenesis in NSCLC.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Virology
Nedaa Alomari, Jennifer Totonchy
Summary: The study found that IFN-gamma has a strong inhibitory effect on KSHV infection in certain samples that are more susceptible to infection, contain higher proportions of naive B cells, and display increased levels of IRF1 and STAT1-pY701. This effect was associated with increased frequencies of germinal center B cells (GCB) and decreased infection of plasma cells, indicating that IFN-gamma-mediated modulation of viral dynamics in GC can inhibit the establishment of KSHV infection.
Review
Oncology
Perla El Zeinaty, Celeste Lebbe, Julie Delyon
Summary: Kaposi's sarcoma (KS) is a common neoplasm caused by human gammaherpesvirus-8 (HHV-8) in Eastern and Central Africa. The endemic KS subtype can be aggressive, with ulcerative skin lesions and soft tissue invasion. Treatment options include systemic chemotherapies, immunomodulators, immune checkpoint inhibitors, and antiangiogenic drugs.
Article
Cell Biology
Mao Shen, Runsang Pan, Shan Lei, Lu Zhang, Changhua Zhou, Zhirui Zeng, Yingjie Nie, Xiaobin Tian
Summary: This study found that the overexpression of potassium inwardly rectifying channel subfamily J member 2 (KCNJ2) is associated with advanced stage and high metastatic potential of osteosarcoma (OS), and poor prognosis. In OS cells, inhibition of KCNJ2 can suppress metastasis, while elevation of KCNJ2 has the opposite effects. KCNJ2 forms a positive feedback loop with HIF1 alpha, promoting the metastasis of OS cells. These findings may have significant implications for the diagnosis and treatment of OS.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Immunology
Katherine R. Sabourin, Ibrahim Daud, Sidney Ogolla, Nazzarena Labo, Wendell Miley, Molly Lamb, Robert Newton, Denise Whitby, Rosemary Rochford
Summary: The study found that children with malaria have an increased risk of KSHV seroconversion, especially in high malaria transmission areas. As the annualized rate of malaria in children increases, the risk of KSHV seropositivity also increases.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Multidisciplinary Sciences
Zhaoping Qiu, Weijie Guo, Bo Dong, Yu Wang, Pan Deng, Chi Wang, Jinpeng Liu, Qing Zhang, Rudolf Grosschedl, Zhiyong Yu, Jiong Deng, Yadi Wu
Summary: EBF1 is highly expressed in TNBC and plays a crucial role in tumorigenicity and progression; By forming a transcriptional complex with HIF1 alpha, EBF1 regulates cell mitophagy and prevents cell death; Targeting EBF1 pathway may offer alternative treatment strategies for TNBC.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Oncology
Cheng Wang, Wencheng Zhang, Wenjing Xu, Zhaoyu Liu, Kai Huang
Summary: This study found that hepatic AMPK alpha 1 plays an essential role in maintaining iron homeostasis by regulating hepcidin through its interaction with PHD2. This discovery provides a new potential approach for treating iron disturbances in chronic diseases.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Kunhua Hu, Yufeng Ding, Hongwen Zhu, Xiaoqian Jing, Weiling He, Hua Yu, Xiongjun Wang
Summary: Tumor cells surviving hypoxic stress acquire the ability to drive cancer progression. Glutamate dehydrogenase 1 (GDH1) plays a critical role in regulating colorectal cancer (CRC) cell survival under hypoxia. GDH1 deficiency inhibits CRC occurrence and impairs hypoxia-inducible factor 1-alpha (HIF-1a) stability, promoting CRC progression through the modulation of GDH1 acetylation at K503 and K527.
Article
Virology
Thomas Fricke, Anna K. Grosskopf, Armin Ensser, Marija Backovic, Alexander S. Hahn
Summary: Kaposi's sarcoma herpesvirus (KSHV) is associated with a significant disease burden, particularly in Sub-Sahara Africa. Immune sera can neutralize KSHV and inhibit its binding to cellular receptors. The glycoprotein H and L complex has been identified as a crucial target for the development of KSHV vaccines.
Article
Immunology
Shaoqiu Leng, Xiaoyu Zhang, Shuwen Wang, Jing Qin, Qiang Liu, Anli Liu, Zi Sheng, Qi Feng, Xiang Hu, Jun Peng
Summary: Altered microenvironmental stiffness, sensed by the mechanosensitive channel Piezo1 in macrophages, can induce immune responses. This study found that Piezo1-deficient macrophages have reduced aerobic glycolysis and impaired secretion of inflammatory cytokines. Activation of Piezo1 through agonist Yoda1 or cyclical hydrostatic pressure increases glycolytic activity and enhances cytokine secretion in response to liposaccharide. In vivo, Piezo1-deficient mice are less susceptible to dextran sulfate sodium-induced colitis, while Yoda1 treatment exacerbates colitis. Mechanistically, Piezo1 activation promotes aerobic glycolysis through the Ca2+-induced CaMKII-HIF1 alpha axis. Therefore, this study demonstrates the role of Piezo1-mediated mechanosensitive signals in enhancing macrophage metabolism and immune response.
FRONTIERS IN IMMUNOLOGY
(2022)