Journal
DALTON TRANSACTIONS
Volume 41, Issue 19, Pages 5778-5781Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2dt30514c
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- Department of Science and Technology, New Delhi
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Twenty different triazoles were prepared to probe the antitubercular structure-activity relationships (SAR) within the beta-lactam-ferrocene-triazole conjugate family. The compounds have been synthesized by copper-catalyzed click chemistry. In vitro anti-tubercular activity was determined for each compound but the synthesized hybrids failed to inhibit Mycobacterium tuberculosis growth even at high doses. The manuscript assumes significance as this is the first report on the inclusion of ferrocene nucleus in the well established beta-lactam family via triazole linkers with reputed physicochemical profiles.
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