Development of 4-((3-oxo-3-phenylpropyl)amino)benzenesulfonamide derivatives utilizing tail/dual-tail approaches as novel carbonic anhydrase inhibitors

Identification of N-phenyl-2-(phenylsulfonyl)acetamides/propanamides as new SLC-0111 analogues: Synthesis and evaluation of the carbonic anhydrase inhibitory activities

(2021) Mostafa M. Elbadawi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Development of novel benzofuran-based SLC-0111 analogs as selective cancer-associated carbonic anhydrase isoform IX inhibitors

(2021) Moataz Shaldam et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Genome-wide synthetic lethal screen unveils novel CAIX-NFS1/xCT axis as a targetable vulnerability in hypoxic solid tumors

(2021) Shawn C. Chafe et al.   Science Advances

Sulfonamide-based ring-fused analogues for CAN508 as novel carbonic anhydrase inhibitors endowed with antitumor activity: Design, synthesis, and in vitro biological evaluation

(2020) Mohamed A. Said et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Potent Dual-Tailed Benzenesulfonamide Inhibitors of Human Carbonic Anhydrases Implicated in Glaucoma and in Vivo Profiling of Their Intraocular Pressure-Lowering Action

(2020) Mohamed Fares et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Phase 1 Study of SLC-0111, a Novel Inhibitor of Carbonic Anhydrase IX, in Patients With Advanced Solid Tumors

(2020) Paul C. McDonald et al.   AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS

Novel oxindole/benzofuran hybrids as potential dual CDK2/GSK-3β inhibitors targeting breast cancer: design, synthesis, biological evaluation, and in silico studies

(2020) Wagdy M. Eldehna et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Dual-tail arylsulfone-based benzenesulfonamides differently match the hydrophobic and hydrophilic halves of human carbonic anhydrases active sites: Selective inhibitors for the tumor-associated hCA IX isoform

(2018) Hany S. Ibrahim et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

SLC-0111 enaminone analogs, 3/4-(3-aryl-3-oxopropenyl) aminobenzenesulfonamides, as novel selective subnanomolar inhibitors of the tumor-associated carbonic anhydrase isoform IX

(2018) Wagdy M. Eldehna et al.   BIOORGANIC CHEMISTRY

Amido/ureidosubstituted benzenesulfonamides-isatin conjugates as low nanomolar/subnanomolar inhibitors of the tumor-associated carbonic anhydrase isoform XII

(2016) Wagdy M. Eldehna et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Thylakoid luminal θ-carbonic anhydrase critical for growth and photosynthesis in the marine diatomPhaeodactylum tricornutum

(2016) Sae Kikutani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intrinsic thermodynamics of 4-substituted-2,3,5,6-tetrafluorobenzenesulfonamide binding to carbonic anhydrases by isothermal titration calorimetry

(2015) Asta Zubrienė et al.   BIOPHYSICAL CHEMISTRY

Carbonic Anhydrase Inhibitors with Dual-Tail Moieties To Match the Hydrophobic and Hydrophilic Halves of the Carbonic Anhydrase Active Site

(2015) Rajendra P. Tanpure et al.   JOURNAL OF MEDICINAL CHEMISTRY

Efficient Expression and Crystallization System of Cancer-Associated Carbonic Anhydrase Isoform IX

(2015) Janis Leitans et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design of tRNALys3Ligands: Fragment Evolution and Linker Selection Guided by NMR Spectroscopy

(2009) Florence Chung et al.   CHEMISTRY-A EUROPEAN JOURNAL

Carbonic Anhydrase as a Model for Biophysical and Physical-Organic Studies of Proteins and Protein−Ligand Binding

(2008) Vijay M. Krishnamurthy et al.   CHEMICAL REVIEWS