Germline mechanisms of immunotherapy toxicities in the era of genome‐wide association studies

15 years of GWAS discovery: Realizing the promise

(2023) Abdel Abdellaoui et al.   AMERICAN JOURNAL OF HUMAN GENETICS

FinnGen provides genetic insights from a well-phenotyped isolated population

(2023) Mitja I. Kurki et al.   NATURE

Polygenic architecture of rare coding variation across 394,783 exomes

(2023) Daniel J. Weiner et al.   NATURE

Neoadjuvant–Adjuvant or Adjuvant-Only Pembrolizumab in Advanced Melanoma

(2023) Sapna P. Patel et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genetic correlates of vitamin D-binding protein and 25-hydroxyvitamin D in neonatal dried blood spots

(2023) Clara Albiñana et al.   Nature Communications

Pervasiveness of HLA allele-specific expression loss across tumor types

(2023) Ioan Filip et al.   Genome Medicine

Steroid Dose and Duration, Immortal Time Bias, and Survival After High-grade Immune-Related Adverse Events

(2023) Pankti Reid et al.   JAMA Oncology

Accounting for age of onset and family history improves power in genome-wide association studies

(2022) Emil M. Pedersen et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Long-acting recombinant human interleukin-7, NT-I7, increases cytotoxic CD8+ T cells and enhances survival in mouse glioma models

(2022) Jian L. Campian et al.   CLINICAL CANCER RESEARCH

Germline HLA landscape does not predict efficacy of pembrolizumab monotherapy across solid tumor types

(2022) Aparna Chhibber et al.   IMMUNITY

Phenome-Wide Association Studies

(2022) Lisa Bastarache et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Immune-checkpoint inhibitors: long-term implications of toxicity

(2022) Douglas B. Johnson et al.   Nature Reviews Clinical Oncology

Expanded COVID-19 phenotype definitions reveal distinct patterns of genetic association and protective effects

(2022) Genevieve H. L. Roberts et al.   NATURE GENETICS

Validation of prediction models in the presence of competing risks: a guide through modern methods

(2022) Nan van Geloven et al.   BMJ-British Medical Journal

Recombinant human interleukin-7 reverses T cell exhaustion ex vivo in critically ill COVID-19 patients

(2022) Frank Bidar et al.   Annals of Intensive Care

Coming of Age: Human Genomics and the Cancer–Immune Set Point

(2022) Christian Hammer et al.   Cancer Immunology Research

IL22RA1/JAK/STAT Signaling Acts As a Cancer Target Through Pan-Cancer Analysis

(2022) Shuai Zhang et al.   Frontiers in Immunology

Ancestry-driven recalibration of tumor mutational burden and disparate clinical outcomes in response to immune checkpoint inhibitors

(2022) Amin H. Nassar et al.   CANCER CELL

Efficient and accurate frailty model approach for genome-wide survival association analysis in large-scale biobanks

(2022) Rounak Dey et al.   Nature Communications

African Ancestry–Associated Gene Expression Profiles in Triple-Negative Breast Cancer Underlie Altered Tumor Biology and Clinical Outcome in Women of African Descent

(2022) Rachel Martini et al.   Cancer Discovery

Association of Body Mass Index With the Safety Profile of Nivolumab With or Without Ipilimumab

(2022) Jennifer L. McQuade et al.   JAMA Oncology

Germline genetic variation and predicting immune checkpoint inhibitor induced toxicity

(2022) Ik Shin Chin et al.   npj Genomic Medicine

IL-7 and IL-7R in health and disease: An update through COVID times

(2022) Marta B. Fernandes et al.   Advances in Biological Regulation

Efficient phasing and imputation of low-coverage sequencing data using large reference panels

(2021) Simone Rubinacci et al.   NATURE GENETICS

Meta-analysis of tumor- and T cell-intrinsic mechanisms of sensitization to checkpoint inhibition

(2021) Kevin Litchfield et al.   CELL

Germline genetic contribution to the immune landscape of cancer

(2021) Rosalyn W. Sayaman et al.   IMMUNITY

Immortal Time Bias in Observational Studies

(2021) Kabir Yadav et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19

(2021)   NEW ENGLAND JOURNAL OF MEDICINE

The changing landscape of atherosclerosis

(2021) Peter Libby   NATURE

Use of deep learning to develop continuous-risk models for adverse event prediction from electronic health records

(2021) Nenad Tomašev et al.   Nature Protocols

Predicting treatment response from longitudinal images using multi-task deep learning

(2021) Cheng Jin et al.   Nature Communications

Electronic patient-reported outcomes and machine learning in predicting immune-related adverse events of immune checkpoint inhibitor therapies

(2021) Sanna Iivanainen et al.   BMC Medical Informatics and Decision Making

Immunotherapy-Mediated Thyroid Dysfunction: Genetic Risk and Impact on Outcomes with PD-1 Blockade in Non–Small Cell Lung Cancer

(2021) Jia Luo et al.   CLINICAL CANCER RESEARCH

Uniting biobank resources reveals novel genetic pathways modulating susceptibility for atopic dermatitis

(2021) Eeva Sliz et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Mapping the human genetic architecture of COVID-19

(2021)   NATURE

Genetic variation associated with thyroid autoimmunity shapes the systemic immune response to PD-1 checkpoint blockade

(2021) Zia Khan et al.   Nature Communications

Deep Survival Machines: Fully Parametric Survival Regression and Representation Learning for Censored Data With Competing Risks

(2021) Chirag Nagpal et al.   IEEE Journal of Biomedical and Health Informatics

Association Between a Common, Benign Genotype and Unnecessary Bone Marrow Biopsies Among African American Patients

(2021) Sara L. Van Driest et al.   JAMA Internal Medicine

Consensus disease definitions for neurologic immune-related adverse events of immune checkpoint inhibitors

(2021) Amanda C Guidon et al.   Journal for ImmunoTherapy of Cancer

IL-7 expands lymphocyte populations and enhances immune responses to sipuleucel-T in patients with metastatic castration-resistant prostate cancer (mCRPC)

(2021) Russell K Pachynski et al.   Journal for ImmunoTherapy of Cancer

HLA-A*03 and response to immune checkpoint blockade in cancer: an epidemiological biomarker study

(2021) Vivek Naranbhai et al.   LANCET ONCOLOGY

Exome sequencing and analysis of 454,787 UK Biobank participants

(2021) Joshua D. Backman et al.   NATURE

Rare variant analysis in eczema identifies exonic variants in DUSP1, NOTCH4 and SLC9A4

(2021) Sarah Grosche et al.   Nature Communications

Constructing germline research cohorts from the discarded reads of clinical tumor sequences

(2021) Alexander Gusev et al.   Genome Medicine

The added value of multi‐state modelling in a randomized controlled trial: The HOVON 102 study re‐analyzed

(2021) Katerina Bakunina et al.   Cancer Medicine

Low peripheral blood derived neutrophil-to-lymphocyte ratio (dNLR) is associated with increased tumor T-cell infiltration and favorable outcomes to first-line pembrolizumab in non-small cell lung cancer

(2021) Joao V Alessi et al.   Journal for ImmunoTherapy of Cancer

Fast Algorithms for Conducting Large-Scale GWAS of Age-at-Onset Traits Using Cox Mixed-Effects Models

(2020) Liang He et al.   GENETICS

B cells and tertiary lymphoid structures promote immunotherapy response

(2020) Beth A. Helmink et al.   NATURE

Peripheral CD8+ T cell characteristics associated with durable responses to immune checkpoint blockade in patients with metastatic melanoma

(2020) Benjamin P. Fairfax et al.   NATURE MEDICINE

Germline Features Associated with Immune Infiltration in Solid Tumors

(2020) Sahar Shahamatdar et al.   Cell Reports

Variable prediction accuracy of polygenic scores within an ancestry group

(2020) Hakhamanesh Mostafavi et al.   eLife

Association Between Immune-Related Adverse Events and Recurrence-Free Survival Among Patients With Stage III Melanoma Randomized to Receive Pembrolizumab or Placebo

(2020) Alexander M. M. Eggermont et al.   JAMA Oncology

Trans-biobank analysis with 676,000 individuals elucidates the association of polygenic risk scores of complex traits with human lifespan

(2020) Saori Sakaue et al.   NATURE MEDICINE

Polygenic risk for skin autoimmunity impacts immune checkpoint blockade in bladder cancer

(2020) Zia Khan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immune Checkpoint Inhibitor Rechallenge After Immune-Related Adverse Events in Patients With Cancer

(2020) Charles Dolladille et al.   JAMA Oncology

A Fast and Accurate Method for Genome-Wide Time-to-Event Data Analysis and Its Application to UK Biobank

(2020) Wenjian Bi et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Vitamin D, autoimmunity and immune-related adverse events of immune checkpoint inhibitors

(2020) Lillian Sun et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

Vitamin D intake is associated with decreased risk of immune checkpoint inhibitor‐induced colitis

(2020) Shilpa Grover et al.   CANCER

Cutaneous Immune-Related Adverse Events (irAEs) to Immune Checkpoint Inhibitors: A Dermatology Perspective on Management

(2020) Anastasiya Muntyanu et al.   JOURNAL OF CUTANEOUS MEDICINE AND SURGERY

Tutorial: a guide to performing polygenic risk score analyses

(2020) Shing Wan Choi et al.   Nature Protocols

Genomewide Association Study of Severe Covid-19 with Respiratory Failure

(2020) David Ellinghaus et al.   NEW ENGLAND JOURNAL OF MEDICINE

Acute kidney injury associated with immune checkpoint inhibitor therapy: incidence, risk factors and outcomes

(2020) Alejandro Meraz-Muñoz et al.   Journal for ImmunoTherapy of Cancer

The Polygenic and Monogenic Basis of Blood Traits and Diseases

(2020) Dragana Vuckovic et al.   CELL

Functionally informed fine-mapping and polygenic localization of complex trait heritability

(2020) Omer Weissbrod et al.   NATURE GENETICS

Decreased Absolute Lymphocyte Count and Increased Neutrophil/Lymphocyte Ratio With Immune Checkpoint Inhibitor–Associated Myocarditis

(2020) Zsofia D. Drobni et al.   Journal of the American Heart Association

Immortal time bias in the association between toxicity and response for immune checkpoint inhibitors: a meta-analysis

(2020) Filippo Gustavo Dall'Olio et al.   Immunotherapy

Clinical use of current polygenic risk scores may exacerbate health disparities

(2019) Alicia R. Martin et al.   NATURE GENETICS

PD-L1 expression, tumor mutational burden and cancer gene mutations are stronger predictors of benefit from immune checkpoint blockade than HLA class I genotype in non-small cell lung cancer

(2019) Marcelo V. Negrao et al.   Journal of Thoracic Oncology

Adverse effects of immune-checkpoint inhibitors: epidemiology, management and surveillance

(2019) Filipe Martins et al.   Nature Reviews Clinical Oncology

How genome-wide association studies (GWAS) made traditional candidate gene studies obsolete

(2019) Laramie E. Duncan et al.   NEUROPSYCHOPHARMACOLOGY

Genome-wide association study of medication-use and associated disease in the UK Biobank

(2019) Yeda Wu et al.   Nature Communications

Genome-wide association analysis of 350 000 Caucasians from the UK Biobank identifies novel loci for asthma, hay fever and eczema.

(2019) Åsa Johansson et al.   HUMAN MOLECULAR GENETICS

Genetic analyses of diverse populations improves discovery for complex traits

(2019) Genevieve L. Wojcik et al.   NATURE

Mechanisms of immune-related adverse events associated with immune checkpoint blockade: using germline genetics to develop a personalized approach

(2019) Zia Khan et al.   Genome Medicine

Extreme Polygenicity of Complex Traits Is Explained by Negative Selection

(2019) Luke J. O'Connor et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A global overview of pleiotropy and genetic architecture in complex traits

(2019) Kyoko Watanabe et al.   NATURE GENETICS

Flip the coin: IL-7 and IL-7R in health and disease

(2019) João T. Barata et al.   NATURE IMMUNOLOGY

Evolutionary divergence of HLA class I genotype impacts efficacy of cancer immunotherapy

(2019) Diego Chowell et al.   NATURE MEDICINE

Rare-variant collapsing analyses for complex traits: guidelines and applications

(2019) Gundula Povysil et al.   NATURE REVIEWS GENETICS

Context-specific regulation of surface and soluble IL7R expression by an autoimmune risk allele

(2019) Hussein Al-Mossawi et al.   Nature Communications

The role of PD-L1 expression as a predictive biomarker: an analysis of all US Food and Drug Administration (FDA) approvals of immune checkpoint inhibitors

(2019) Andrew A. Davis et al.   Journal for ImmunoTherapy of Cancer

Dynamic-DeepHit: A Deep Learning Approach for Dynamic Survival Analysis With Competing Risks Based on Longitudinal Data

(2019) Changhee Lee et al.   IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING

Are drug targets with genetic support twice as likely to be approved? Revised estimates of the impact of genetic support for drug mechanisms on the probability of drug approval

(2019) Emily A. King et al.   PLoS Genetics

Use of Immune Checkpoint Inhibitors in the Treatment of Patients With Cancer and Preexisting Autoimmune Disease

(2018) Noha Abdel-Wahab et al.   ANNALS OF INTERNAL MEDICINE

Scalable Joint Models for Reliable Uncertainty-Aware Event Prediction

(2018) Hossein Soleimani et al.   IEEE TRANSACTIONS ON PATTERN ANALYSIS AND MACHINE INTELLIGENCE

Efficacy and safety of fezakinumab (an IL-22 monoclonal antibody) in adults with moderate-to-severe atopic dermatitis inadequately controlled by conventional treatments: A randomized, double-blind, phase 2a trial

(2018) Emma Guttman-Yassky et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Association of body-mass index and outcomes in patients with metastatic melanoma treated with targeted therapy, immunotherapy, or chemotherapy: a retrospective, multicohort analysis

(2018) Jennifer L McQuade et al.   LANCET ONCOLOGY

Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis

(2018) Johannes Waage et al.   NATURE GENETICS

Heritability enrichment of specifically expressed genes identifies disease-relevant tissues and cell types

(2018) Hilary K. Finucane et al.   NATURE GENETICS

The personal and clinical utility of polygenic risk scores

(2018) Ali Torkamani et al.   NATURE REVIEWS GENETICS

Immune Checkpoint Inhibitor‐Associated Myocarditis

(2018) Sarju Ganatra et al.   ONCOLOGIST

Enhancing responses to cancer immunotherapy

(2018) Pia Kvistborg et al.   SCIENCE

Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians

(2018) Neil M Davies et al.   BMJ-British Medical Journal

Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians

(2018) Neil M Davies et al.   BMJ-British Medical Journal

Immune-checkpoint inhibitor-induced diarrhea and colitis in patients with advanced malignancies: retrospective review at MD Anderson

(2018) Yinghong Wang et al.   Journal for ImmunoTherapy of Cancer

Anti-IL-7 receptor α monoclonal antibody (GSK2618960) in healthy subjects - a randomised, double-blind placebo-controlled study

(2018) Joanne Ellis et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Application of multi-state models in cancer clinical trials

(2018) Jennifer G Le-Rademacher et al.   Clinical Trials

Functional architecture of low-frequency variants highlights strength of negative selection across coding and non-coding annotations

(2018) Steven Gazal et al.   NATURE GENETICS

Neoadjuvant versus adjuvant ipilimumab plus nivolumab in macroscopic stage III melanoma

(2018) Christian U. Blank et al.   NATURE MEDICINE

LAG3 (CD223) as a cancer immunotherapy target

(2017) Lawrence P. Andrews et al.   IMMUNOLOGICAL REVIEWS

Elements of cancer immunity and the cancer–immune set point

(2017) Daniel S. Chen et al.   NATURE

Precision oncology for acute myeloid leukemia using a knowledge bank approach

(2017) Moritz Gerstung et al.   NATURE GENETICS

Genetic architecture: the shape of the genetic contribution to human traits and disease

(2017) Nicholas J. Timpson et al.   NATURE REVIEWS GENETICS

Evolocumab and Clinical Outcomes in Patients with Cardiovascular Disease

(2017) Marc S. Sabatine et al.   NEW ENGLAND JOURNAL OF MEDICINE

Patient HLA class I genotype influences cancer response to checkpoint blockade immunotherapy

(2017) Diego Chowell et al.   SCIENCE

Practical recommendations for reporting Fine-Gray model analyses for competing risk data

(2017) Peter C. Austin et al.   STATISTICS IN MEDICINE

Reversal of cancer gene expression correlates with drug efficacy and reveals therapeutic targets

(2017) Bin Chen et al.   Nature Communications

Large scale meta-analysis characterizes genetic architecture for common psoriasis associated variants

(2017) Lam C. Tsoi et al.   Nature Communications

AACR Project GENIE: Powering Precision Medicine through an International Consortium

(2017)   Cancer Discovery

A Prospective, Multi-institutional, Pathologist-Based Assessment of 4 Immunohistochemistry Assays for PD-L1 Expression in Non–Small Cell Lung Cancer

(2017) David L. Rimm et al.   JAMA Oncology

Anti-interleukin and interleukin therapies for psoriasis: current evidence and clinical usefulness

(2017) Ya-Chu Tsai et al.   Therapeutic Advances in Musculoskeletal Disease

The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease

(2016) William J. Astle et al.   CELL

Introduction to the Analysis of Survival Data in the Presence of Competing Risks

(2016) Peter C. Austin et al.   CIRCULATION

Rapid genotype imputation from sequence without reference panels

(2016) Robert W Davies et al.   NATURE GENETICS

Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci

(2016) David Ellinghaus et al.   NATURE GENETICS

Detection and interpretation of shared genetic influences on 42 human traits

(2016) Joseph K Pickrell et al.   NATURE GENETICS

Developing and evaluating polygenic risk prediction models for stratified disease prevention

(2016) Nilanjan Chatterjee et al.   NATURE REVIEWS GENETICS

Improved Efficacy of Neoadjuvant Compared to Adjuvant Immunotherapy to Eradicate Metastatic Disease

(2016) J. Liu et al.   Cancer Discovery

Adjusting for Heritable Covariates Can Bias Effect Estimates in Genome-Wide Association Studies

(2015) Hugues Aschard et al.   AMERICAN JOURNAL OF HUMAN GENETICS

ELYPSE-7: a randomized placebo-controlled phase IIa trial with CYT107 exploring the restoration of CD4+ lymphocyte count in lymphopenic metastatic breast cancer patients

(2015) O. Trédan et al.   ANNALS OF ONCOLOGY

On the restricted mean survival time curve in survival analysis

(2015) Lihui Zhao et al.   BIOMETRICS

Immune related adverse events associated with anti-CTLA-4 antibodies: systematic review and meta-analysis

(2015) Anne Bertrand et al.   BMC Medicine

Concepts and Misconceptions about the Polygenic Additive Model Applied to Disease

(2015) Peter M. Visscher et al.   HUMAN HEREDITY

Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression

(2015) J. Bowden et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Genetic studies of body mass index yield new insights for obesity biology

(2015) Adam E. Locke et al.   NATURE

The support of human genetic evidence for approved drug indications

(2015) Matthew R Nelson et al.   NATURE GENETICS

Partitioning heritability by functional annotation using genome-wide association summary statistics

(2015) Hilary K Finucane et al.   NATURE GENETICS

An atlas of genetic correlations across human diseases and traits

(2015) Brendan Bulik-Sullivan et al.   NATURE GENETICS

TYK2 Protein-Coding Variants Protect against Rheumatoid Arthritis and Autoimmunity, with No Evidence of Major Pleiotropic Effects on Non-Autoimmune Complex Traits

(2015) Dorothée Diogo et al.   PLoS One

Partitioning Heritability of Regulatory and Cell-Type-Specific Variants across 11 Common Diseases

(2014) Alexander Gusev et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The role of the IL-22/IL-22R1 axis in cancer

(2014) Chrissie Lim et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Methodological Challenges in Mendelian Randomization

(2014) Tyler J. VanderWeele et al.   EPIDEMIOLOGY

Mendelian randomization: genetic anchors for causal inference in epidemiological studies

(2014) G. Davey Smith et al.   HUMAN MOLECULAR GENETICS

Restricted mean survival time: an alternative to the hazard ratio for the design and analysis of randomized trials with a time-to-event outcome

(2013) Patrick Royston et al.   BMC Medical Research Methodology

Interleukin-7: Fuel for the autoimmune attack

(2013) Hans Dooms   JOURNAL OF AUTOIMMUNITY

Genetics of rheumatoid arthritis contributes to biology and drug discovery

(2013) Yukinori Okada et al.   NATURE

The Genotype-Tissue Expression (GTEx) project

(2013) John Lonsdale et al.   NATURE GENETICS

Validating therapeutic targets through human genetics

(2013) Robert M. Plenge et al.   NATURE REVIEWS DRUG DISCOVERY

The heritability of human disease: estimation, uses and abuses

(2013) Albert Tenesa et al.   NATURE REVIEWS GENETICS

Power and Predictive Accuracy of Polygenic Risk Scores

(2013) Frank Dudbridge   PLoS Genetics

Estimation of pleiotropy between complex diseases using single-nucleotide polymorphism-derived genomic relationships and restricted maximum likelihood

(2012) S.H. Lee et al.   BIOINFORMATICS

Interleukin-7 receptor blockade suppresses adaptive and innate inflammatory responses in experimental colitis

(2012) Cynthia R Willis et al.   Journal of Inflammation-London

Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study

(2012) Benjamin F Voight et al.   LANCET

Use of genome-wide association studies for drug repositioning

(2012) Philippe Sanseau et al.   NATURE BIOTECHNOLOGY

Extremely low-coverage sequencing and imputation increases power for genome-wide association studies

(2012) Bogdan Pasaniuc et al.   NATURE GENETICS

Chromatin marks identify critical cell types for fine mapping complex trait variants

(2012) Gosia Trynka et al.   NATURE GENETICS

Anti-IL-7 receptor-  reverses established type 1 diabetes in nonobese diabetic mice by modulating effector T-cell function

(2012) L.-F. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GCTA: A Tool for Genome-wide Complex Trait Analysis

(2010) Jian Yang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Blockade of the interleukin-7 receptor inhibits collagen-induced arthritis and is associated with reduction of T cell activity and proinflammatory mediators

(2010) Sarita A. Y. Hartgring et al.   ARTHRITIS AND RHEUMATISM

A novel role for IL-22R1 as a driver of inflammation

(2010) R. Savan et al.   BLOOD

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

(2010) F. Stephen Hodi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Competing Risk Regression Models for Epidemiologic Data

(2009) B. Lau et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Adjuvant IL-7 antagonizes multiple cellular and molecular inhibitory networks to enhance immunotherapies

(2009) Marc Pellegrini et al.   NATURE MEDICINE

Anti-CTLA-4 antibody therapy associated autoimmune hypophysitis: serious immune related adverse events across a spectrum of cancer subtypes

(2009) Troy Dillard et al.   Pituitary

Designing Genome-Wide Association Studies: Sample Size, Power, Imputation, and the Choice of Genotyping Chip

(2009) Chris C. A. Spencer et al.   PLoS Genetics

Administration of rhIL-7 in humans increases in vivo TCR repertoire diversity by preferential expansion of naive T cell subsets

(2008) Claude Sportès et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Heritability in the genomics era — concepts and misconceptions

(2008) Peter M. Visscher et al.   NATURE REVIEWS GENETICS

Polymorphisms Associated with Cholesterol and Risk of Cardiovascular Events

(2008) Sekar Kathiresan et al.   NEW ENGLAND JOURNAL OF MEDICINE