Review
Biochemistry & Molecular Biology
Chunli Wang, Lingzu Kong, Seokmin Kim, Sunyoung Lee, Sechan Oh, Seona Jo, Inhwan Jang, Tae-Don Kim
Summary: This review summarizes the roles of IL-7 and IL-7R alpha in immunity and cancer, and discusses their recent advances and potential as immunotherapy tools.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Anja Meyer, Prashant J. Parmar, Shiva Shahrara
Summary: While physiological levels of IL-7 are essential for T cell function, elevated levels of IL-7 in Rheumatoid arthritis (RA) can contribute to disease activity and joint inflammation. IL-7 promotes immune cell differentiation and secretion of inflammatory factors, aggravating the inflammatory response. Blocking IL-7/IL-7R signaling can effectively suppress joint inflammation, osteoclast formation, and neovascularization.
AUTOIMMUNITY REVIEWS
(2022)
Review
Biochemistry & Molecular Biology
Sizhen Su, Yimiao Zhao, Na Zeng, Xiaoxing Liu, Yongbo Zheng, Jie Sun, Yi Zhong, Shuilin Wu, Shuyu Ni, Yimiao Gong, Zhibo Zhang, Nan Gao, Kai Yuan, Wei Yan, Le Shi, Arun V. Ravindran, Thomas Kosten, Jie Shi, Yanping Bao, Lin Lu
Summary: The increasing number of COVID-19 infections have brought attention to the long-term consequences of SARS-CoV-2 infection, known as long COVID. This review summarizes the published epidemiology, symptoms, and risk factors of long COVID, as well as the potential pathophysiological mechanisms and biomarkers for its prevention, diagnosis, and treatment. Evidence-based guidelines for the comprehensive evaluation and management of long COVID are also suggested, aiming to improve treatment strategies, preventive measures, and public health policy making.
MOLECULAR PSYCHIATRY
(2023)
Article
Immunology
Haiyan Xu, Li Cai, Zijian Li, Lili Zhang, Guojue Wang, Rongli Xie, Yongshuai Jiang, Yuanyang Yuan, Hong Nie
Summary: The IL-7/IL-7R pathway has a dual effect on osteoclastogenesis in RA, by inhibiting osteoclast formation and inducing inflammatory remission, making it a potential novel therapeutic target for autoimmune diseases like RA.
Article
Clinical Neurology
Heather Angus-Leppan, Angelica E. Guiloff, Karen Bensons, Roberto J. Guiloff
Summary: The treatment gap for migraine has widened during the COVID-19 pandemic as attention has shifted to the international emergency. Telemedicine has been effective for migraine follow-up, with ongoing evaluation needed. It is important to avoid drug interactions and close contact procedures in acute COVID-19 cases, while also acknowledging the potential secondary effects of the virus on those with migraine.
JOURNAL OF NEUROLOGY
(2021)
Article
Oncology
Sung-Ill Jang, Jae-Hee Cho, So-Young Kim, In-Young Hong, Joon-Seong Park, Hye-Sun Lee, Goeun Park, Jong-Kyoung Kim, Hyung-Keun Lee, Dong-Ki Lee
Summary: This study identified IL-7R as a potential early diagnostic biomarker for PDAC and demonstrated that the combination of IL-7R and CA19-9 can improve diagnostic performance.
Article
Cell Biology
Lei Lei, Xiaofeng Yang, Yanhong Su, Huiqiang Zheng, Jun Liu, Haiyan Liu, Yujing Zou, Anjun Jiao, Xin Wang, Cangang Zhang, Xingzhe Zhang, Jiahui Zhang, Dan Zhang, Xiaobo Zhou, Lin Shi, Enqi Liu, Liang Bai, Chenming Sun, Baojun Zhang
Summary: Med1 plays an important role in maintaining CD8(+) T cells through IL-7R alpha/STAT5 pathway-mediated cell survival. Med1 deficiency leads to increased cell death, decreased expression of IL-7R alpha, and down-regulation of pSTAT5 in CD8(+) T cells.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Environmental Sciences
Albert Nienhaus
Summary: The report provides an update on COVID-19 cases among health and social welfare workers in Germany. The majority of claims are from nursing homes (39.5%) and hospitals (37.6%), with the highest claim rate for hospitals. By May 3rd, 2021, 77 workers had died and 375 were hospitalized.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Public, Environmental & Occupational Health
Alexandra Jaye Zimmer, Joel Shyam Klinton, Charity Oga-Omenka, Petra Heitkamp, Carol Nawina Nyirenda, Jennifer Furin, Madhukar Pai
Summary: The COVID-19 pandemic has severely disrupted tuberculosis care and service delivery, setting back progress in the fight against TB. By drawing on the comprehensive approaches used to manage COVID-19, the TB community can strengthen the global TB response through multisectoral collaborations.
JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH
(2022)
Review
Biochemistry & Molecular Biology
Md Saidur Rahman, Khandkar Shaharina Hossain, Sharnali Das, Sushmita Kundu, Elikanah Olusayo Adegoke, Md Ataur Rahman, Md Abdul Hannan, Md Jamal Uddin, Myung-Geol Pang
Summary: Insulin, a polypeptide hormone secreted mainly by pancreatic beta cells, coordinates with glucagon to regulate blood glucose levels. It induces glucose storage in the liver, muscles, and adipose tissue, leading to overall weight gain. The modulation of physiological processes by insulin is crucial in the onset and progression of various diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
A. L. Ren, R. J. Digby, E. J. Needham
Summary: COVID-19 is primarily a respiratory disease, but can also lead to neurological complications. The main processes causing neurological damage include cerebrovascular disease, immunologically mediated neurological disorders, and the harmful effects of critical illness on the nervous system. While it is still uncertain if the virus directly invades the nervous system, the large number of infections at present suggests that nervous system infection may not be a significant issue.
JOURNAL OF NEUROLOGY
(2021)
Review
Pediatrics
Elmira Haji Esmaeli Memar, Reihaneh Mohsenipour, Seyedeh Taravat Sadrosadat, Parastoo Rostami
Summary: This article reviews the impact of SARS-CoV-2 infection on endocrine systems and the consequences of COVID-19 in children with underlying endocrine abnormalities. The study found that SARS-CoV-2 may have implications for glucose metabolism, hypothalamus and pituitary function, adrenal function, and mineral metabolism. Although children and adults share some risk factors for SARS-CoV-2 infection sequelae, pediatric responses are unique and cannot be simply generalized from adult study results.
WORLD JOURNAL OF PEDIATRICS
(2023)
Review
Respiratory System
Yochai Adir, Walid Saliba, Antoine Beurnier, Marc Humbert
Summary: Asthma patients may not be at increased risk of SARS-CoV-2 infection and disease severity. Different asthma phenotypes and comorbidities play important roles in evaluating the risk of SARS-CoV-2 infection and disease severity.
EUROPEAN RESPIRATORY REVIEW
(2021)
Article
Medicine, General & Internal
Emily R. Pfaff, Charisse Madlock-Brown, John M. Baratta, Abhishek Bhatia, Hannah Davis, Andrew Girvin, Elaine Hill, Elizabeth Kelly, Kristin Kostka, Johanna Loomba, Julie A. McMurry, Rachel Wong, Tellen D. Bennett, Richard Moffitt, Christopher G. Chute, Melissa Haendel
Summary: This study examined the heterogeneity in the adoption and use of the ICD-10-CM code for Post COVID-19 condition in the US. The findings showed demographic disparities among patients diagnosed with U09.9, as well as disparities in the diagnosis of long COVID. This work provides insights into potential subtypes of long COVID and highlights the need for further research and remedies for the existing disparities.
Review
Physiology
Carleigh Hebbard, Brooke Lee, Rajesh Katare, Venkata Naga Srikanth Garikipati
Summary: The novel coronavirus SARS-CoV-2 has been declared a pandemic by the WHO in March 2020, with over 220 countries affected and millions of confirmed cases and deaths worldwide. Studies are showing a potential link between SARS-CoV-2 infection and an increased incidence of new-onset heart disease and diabetes, regardless of disease severity. This trend could lead to a troubling increase in heart disease and diabetes in the future, with implications for patient care and future research areas.
FRONTIERS IN PHYSIOLOGY
(2021)
