Co-exposure of avermectin and imidacloprid induces DNA damage, pyroptosis, and immune dysfunction in epithelioma papulosum cyprini cells via ROS-mediated Keap1/Nrf2/TXNIP axis

DNA damage and oxidative stress in gill cells of Cnesterodon decemmaculatus exposed to pesticides by runoff source in an agricultural basin

(2023) Pautasso Néstor Abel et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Ferroptosis contribute to neonicotinoid imidacloprid-evoked pyroptosis by activating the HMGB1-RAGE/TLR4-NF-κB signaling pathway

(2023) Dongfang Zhang et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

PM2.5 induce myocardial injury in hyperlipidemic mice through ROS-pyroptosis signaling pathway

(2023) Ruxue Jia et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Involvements of Nrf2 and oxidative stress in the ozone-elicited exacerbation in an allergic rhinitis model

(2023) Na Sun et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Polystyrene microplastics-induced macrophage extracellular traps contributes to liver fibrotic injury by activating ROS/TGF-β/Smad2/3 signaling axis

(2023) Shengchen Wang et al.   ENVIRONMENTAL POLLUTION

ROS mediated pyroptosis-M1 polarization crosstalk participates in inflammation of chicken liver induced by bisphenol A and selenium deficiency

(2023) Xu Shi et al.   ENVIRONMENTAL POLLUTION

Pyroptosis orchestrates immune responses in endometriosis

(2023) Q. Guo et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Polystyrene-microplastics and DEHP co-exposure induced DNA damage, cell cycle arrest and necroptosis of ovarian granulosa cells in mice by promoting ROS production

(2023) Hao Wu et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Baicalin suppressed necroptosis and inflammation against chlorpyrifos toxicity; involving in ER stress and oxidative stress in carp gills

(2023) Xiaojing Li et al.   FISH & SHELLFISH IMMUNOLOGY

Involvement of NLRP3/Caspase-1/GSDMD-Dependent pyroptosis in BPA-Induced apoptosis of human neuroblastoma cells

(2022) Congcong Wang et al.   BIOCHEMICAL PHARMACOLOGY

Albicanol modulates oxidative stress and the p53 axis to suppress profenofos induced genotoxicity in grass carp hepatocytes

(2022) Xuan Lihui et al.   FISH & SHELLFISH IMMUNOLOGY

PM2.5 induced lung injury through upregulating ROS-dependent NLRP3 Inflammasome-Mediated Pyroptosis

(2022) Fei Ren et al.   IMMUNOBIOLOGY

Identification of a novel mechanism for reversal of doxorubicin-induced chemotherapy resistance by TXNIP in triple-negative breast cancer via promoting reactive oxygen-mediated DNA damage

(2022) Yiting Chen et al.   Cell Death & Disease

Assessment of Avermectins-Induced Toxicity in Animals

(2022) Muhammad Salman et al.   Pharmaceuticals

HDAC11 promotes both NLRP3/caspase-1/GSDMD and caspase-3/GSDME pathways causing pyroptosis via ERG in vascular endothelial cells

(2022) Feng Yao et al.   Cell Death Discovery

Inorganic mercury induces liver oxidative stress injury in quails by inhibiting Akt/Nrf2 signal pathway

(2022) Yuge Liao et al.   INORGANIC CHEMISTRY COMMUNICATIONS

Mechanism of mitigating effect of wheat germ peptides on lead-induced oxidative damage in PC12 cells

(2022) Ning Li et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Acute ammonia stress-induced oxidative and heat shock responses modulated by transcription factors in Litopenaeus vannamei

(2022) Yanting Cui et al.   FISH & SHELLFISH IMMUNOLOGY

Microplastics and di (2-ethylhexyl) phthalate synergistically induce apoptosis in mouse pancreas through the GRP78/CHOP/Bcl-2 pathway activated by oxidative stress

(2022) Yuqi Wang et al.   FOOD AND CHEMICAL TOXICOLOGY

Acute toxicity of atrazine, alachlor, and chlorpyrifos mixtures to honey bees

(2022) Christopher J. Fellows et al.   PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY

ROS/ER stress contributes to trimethyltin chloride-mediated hepatotoxicity; Tea polyphenols alleviate apoptosis and immunosuppression

(2022) Huijun Zhu et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY

Tannic acid antagonizes atrazine exposure-induced autophagy and DNA damage crosstalk in grass carp hepatocytes via NO/iNOS/NF-κB signaling pathway to maintain stable immune function

(2022) Meichen Gao et al.   FISH & SHELLFISH IMMUNOLOGY

Melatonin alleviates lead-induced intestinal epithelial cell pyroptosis in the common carps (Cyprinus carpio) via miR-17-5p/TXNIP axis

(2022) Zhiying Miao et al.   FISH & SHELLFISH IMMUNOLOGY

Combined negative effects of microplastics and plasticizer DEHP: The increased release of Nets delays wound healing in mice

(2022) Xu Shi et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Monitoring and risk assessment of pesticide residue in plant-soil-groundwater systxem about medlar planting in Golmud

(2021) Xiuyan Jing et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

The piperine derivative HJ105 inhibits Aβ1–42-induced neuroinflammation and oxidative damage via the Keap1-Nrf2-TXNIP axis

(2021) Xiping Yang et al.   PHYTOMEDICINE

Avermectin induced DNA damage to the apoptosis and autophagy in human lung epithelial A549 cells

(2021) Lin Diao et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

New insights into crosstalk between apoptosis and necroptosis co-induced by chlorothalonil and imidacloprid in Ctenopharyngodon idellus kidney cells

(2021) Xiaojing Li et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Deoxynivalenol induces carp neutrophil apoptosis and necroptosis via CYP450s/ROS/PI3K/AKT pathway

(2021) Chang Ding et al.   AQUACULTURE

Toxicity of avermectin to Eriocheir sinensis and the isolation of a avermectin-degrading bacterium, Ochrobactrum sp. AVM-2

(2021) Yubo Ma et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Exposure to imidacloprid induce oxidative stress, mitochondrial dysfunction, inflammation, apoptosis and mitophagy via NF-kappaB/JNK pathway in grass carp hepatocytes

(2021) Zhiruo Miao et al.   FISH & SHELLFISH IMMUNOLOGY

Chlorpyrifos triggers epithelioma papulosum cyprini cell pyroptosis via miR-124-3p/CAPN1 axis

(2021) Zhiying Miao et al.   JOURNAL OF HAZARDOUS MATERIALS

Combined toxicity of imidacloprid, acetochlor, and tebuconazole to zebrafish (Danio rerio): acute toxicity and hepatotoxicity assessment

(2020) Yiming Chang et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Abamectin at environmentally-realistic concentrations cause oxidative stress and genotoxic damage in juvenile fish (Schizothorax prenanti)

(2020) Yuhang Hong et al.   AQUATIC TOXICOLOGY

The effects of the neurotoxic agent emamectin benzoate on the expression of immune and stress-related genes and blood serum profiles in the Rainbow trout

(2020) Serdar Kilercioglu et al.   MOLECULAR BIOLOGY REPORTS

Insights into the Toxicity and Degradation Mechanisms of Imidacloprid Via Physicochemical and Microbial Approaches

(2020) Shimei Pang et al.   Toxics

Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation

(2019) Corey Rogers et al.   Nature Communications

Genome-wide identification, evolution, and mRNA expression of complement genes in common carp (Cyprinus carpio)

(2019) Hongzao Lv et al.   FISH & SHELLFISH IMMUNOLOGY

Dietary biotin deficiency decreased growth performance and impaired the immune function of the head kidney, spleen and skin in on-growing grass carp (Ctenopharyngodon idella)

(2019) Peng He et al.   FISH & SHELLFISH IMMUNOLOGY

Nrf2-Keap1 signaling in oxidative and reductive stress

(2018) Ilaria Bellezza et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

DNA damage and oxidative stress induced by imidacloprid exposure in different tissues of the Neotropical fish Prochilodus lineatus

(2018) Carlos Eduardo Delfino Vieira et al.   CHEMOSPHERE

Single and mixture toxicity of strobilurin and SDHI fungicides to Xenopus tropicalis embryos

(2018) Siyu Wu et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

How Inflammasomes Inform Adaptive Immunity

(2018) Charles L. Evavold et al.   JOURNAL OF MOLECULAR BIOLOGY

Berberine, an isoquinoline alkaloid suppresses TXNIP mediated NLRP3 inflammasome activation in MSU crystal stimulated RAW 264.7 macrophages through the upregulation of Nrf2 transcription factor and alleviates MSU crystal induced inflammation in rats

(2017) Palani Dinesh et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The Nrf2-ARE signaling pathway: An update on its regulation and possible role in cancer prevention and treatment

(2017) Violetta Krajka-Kuźniak et al.   Pharmacological Reports

Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death

(2017) Jianjin Shi et al.   TRENDS IN BIOCHEMICAL SCIENCES

Eco-toxicological effects of the avermectin family with a focus on abamectin and ivermectin

(2016) Shahla Hosseini Bai et al.   CHEMOSPHERE

Ternary toxicological interactions of insecticides, herbicides, and a heavy metal on the earthworm Eisenia fetida

(2015) Yanhua Wang et al.   JOURNAL OF HAZARDOUS MATERIALS

Abamectin induces rapid and reversible hypoactivity within early zebrafish embryos

(2015) Tara D. Raftery et al.   NEUROTOXICOLOGY AND TERATOLOGY

Critical role of TXNIP in oxidative stress, DNA damage and retinal pericyte apoptosis under high glucose: Implications for diabetic retinopathy

(2013) Takhellambam S. Devi et al.   EXPERIMENTAL CELL RESEARCH

Thymoquinone ameliorates the immunological and histological changes induced by exposure to imidacloprid insecticide

(2012) Mohamed Mohany et al.   JOURNAL OF TOXICOLOGICAL SCIENCES