Polystyrene-microplastics and DEHP co-exposure induced DNA damage, cell cycle arrest and necroptosis of ovarian granulosa cells in mice by promoting ROS production

The antagonistic effect of selenium on lead-induced apoptosis and necroptosis via P38/JNK/ERK pathway in chicken kidney

(2022) Zhiruo Miao et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Polystyrene nanoplastics induced cardiomyocyte apoptosis and myocardial inflammation in carp by promoting ROS production

(2022) Hao Wu et al.   FISH & SHELLFISH IMMUNOLOGY

Oxidative stress-CBP axis modulates MOB1 acetylation and activates the Hippo signaling pathway

(2022) Jiaqi Jin et al.   NUCLEIC ACIDS RESEARCH

Persistent activation of Nrf2 in a p62-dependent non-canonical manner aggravates lead-induced kidney injury by promoting apoptosis and inhibiting autophagy

(2022) Cai-Yu Lian et al.   Journal of Advanced Research

Eucalyptol relieves imidacloprid-induced autophagy through the miR-451/Cab39/AMPK axis in Ctenopharyngodon idellus kidney cells†

(2022) Xiaojing Li et al.   AQUATIC TOXICOLOGY

The endoplasmic reticulum-mitochondrial crosstalk is involved in the mitigation mechanism of eucalyptol on imidacloprid toxicity in Ctenopharyngodon idellus kidney cells

(2022) Xiaojing Li et al.   FISH & SHELLFISH IMMUNOLOGY

Polystyrene nanoplastics deteriorate LPS-modulated duodenal permeability and inflammation in mice via ROS drived-NF-κB/NLRP3 pathway

(2022) Yujiao He et al.   CHEMOSPHERE

Atrazine exposure induces necroptosis through the P450/ROS pathway and causes inflammation in the gill of common carp (Cyprinus carpio L.)

(2022) Tong Xu et al.   FISH & SHELLFISH IMMUNOLOGY

Paraquat induces apoptosis, programmed necrosis, and immune dysfunction in CIK cells via the PTEN/PI3K/AKT axis

(2022) Xu Shi et al.   FISH & SHELLFISH IMMUNOLOGY

Polystyrene microplastics-induced cardiotoxicity in chickens via the ROS-driven NF-κB-NLRP3-GSDMD and AMPK-PGC-1α axes

(2022) Yue Zhang et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Oxidative stress mediated by the TLR4/NOX2 signalling axis is involved in polystyrene microplastic-induced uterine fibrosis in mice

(2022) Hao Wu et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Cadmium exposure induces pyroptosis in testicular tissue by increasing oxidative stress and activating the AIM2 inflammasome pathway

(2022) Jinzhao Zhou et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Dose-effect of polystyrene microplastics on digestive toxicity in chickens (Gallus gallus): Multi-omics reveals critical role of gut-liver axis

(2022) Kai Yin et al.   Journal of Advanced Research

Combined negative effects of microplastics and plasticizer DEHP: The increased release of Nets delays wound healing in mice

(2022) Xu Shi et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Combined cytotoxicity of polystyrene nanoplastics and phthalate esters on human lung epithelial A549 cells and its mechanism

(2021) Qingying Shi et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Polystyrene microplastics lead to pyroptosis and apoptosis of ovarian granulosa cells via NLRP3/Caspase-1 signaling pathway in rats

(2021) Junyu Hou et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

ROS-Induced Hepatotoxicity under Cypermethrin: Involvement of the Crosstalk between Nrf2/Keap1 and NF-κB/iκB-α Pathways Regulated by Proteasome

(2021) Hongjing Zhao et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

New insights into crosstalk between apoptosis and necroptosis co-induced by chlorothalonil and imidacloprid in Ctenopharyngodon idellus kidney cells

(2021) Xiaojing Li et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Vinclozolin-induced mouse penile malformation and “small testis” via miR132, miR195a together with the Hippo signaling pathway

(2021) Haiming Yu et al.   TOXICOLOGY

Cadmium induces endoplasmic reticulum stress-mediated apoptosis in pig pancreas via the increase of Th1 cells

(2021) Hao Wu et al.   TOXICOLOGY

Pig lung fibrosis is active in the subacute CdCl2 exposure model and exerts cumulative toxicity through the M1/M2 imbalance

(2021) Shi Xu et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Exposure to imidacloprid induce oxidative stress, mitochondrial dysfunction, inflammation, apoptosis and mitophagy via NF-kappaB/JNK pathway in grass carp hepatocytes

(2021) Zhiruo Miao et al.   FISH & SHELLFISH IMMUNOLOGY

Cadmium exposure triggers oxidative stress, necroptosis, Th1/Th2 imbalance and promotes inflammation through the TNF-α/NF-κB pathway in swine small intestine

(2021) Xiaoming Chen et al.   JOURNAL OF HAZARDOUS MATERIALS

Epigenetic regulator BRD4 is involved in cadmium-induced acute kidney injury via contributing to lysosomal dysfunction, autophagy blockade and oxidative stress

(2021) Zhong-Gui Gong et al.   JOURNAL OF HAZARDOUS MATERIALS

The curcumin analogue WZ35 affects glycolysis inhibition of gastric cancer cells through ROS-YAP-JNK pathway

(2020) Tongke Chen et al.   FOOD AND CHEMICAL TOXICOLOGY

Aryl Hydrocarbon Receptor as a target for lycopene preventing DEHP-induced spermatogenic disorders

(2020) Yi Zhao et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Induction of SIRT1 by melatonin improves alcohol‐mediated oxidative liver injury by disrupting the CRBN‐YY1‐CYP2E1 signaling pathway

(2020) Sung‐Eun Lee et al.   JOURNAL OF PINEAL RESEARCH

It takes two to tango: coupling of Hippo pathway and redox signaling in biological process

(2020) Jianan Zheng et al.   CELL CYCLE

Polystyrene microplastics cause cardiac fibrosis by activating Wnt/β-catenin signaling pathway and promoting cardiomyocyte apoptosis in rats

(2020) Zekang Li et al.   ENVIRONMENTAL POLLUTION

Polystyrene microplastics induced male reproductive toxicity in mice

(2020) Haibo Jin et al.   JOURNAL OF HAZARDOUS MATERIALS

Enhanced reproductive toxicities induced by phthalates contaminated microplastics in male mice (Mus musculus)

(2020) Yongfeng Deng et al.   JOURNAL OF HAZARDOUS MATERIALS

Reactive oxygen species-evoked genotoxic stress mediates arsenic-induced suppression of male germ cell proliferation and decline in sperm quality

(2020) Xiao-Yi Zhang et al.   JOURNAL OF HAZARDOUS MATERIALS

Toxicity of polystyrene microplastics on juvenile Oncorhynchus mykiss (rainbow trout) after individual and combined exposure with chlorpyrifos‎

(2020) Samaneh Karbalaei et al.   JOURNAL OF HAZARDOUS MATERIALS

Polystyrene microplastics cause granulosa cells apoptosis and fibrosis in ovary through oxidative stress in rats

(2020) Ru An et al.   TOXICOLOGY

Rac-GTPase promotes fibrotic TGF-β1 signaling and chronic kidney disease via EGFR, p53, and Hippo/YAP/TAZ pathways

(2019) Samik Patel et al.   FASEB JOURNAL

Timely expression and activation of YAP1 in granulosa cells is essential for ovarian follicle development

(2019) Xiangmin Lv et al.   FASEB JOURNAL

CRBN knockdown mitigates lipopolysaccharide-induced acute lung injury by suppression of oxidative stress and endoplasmic reticulum (ER) stress associated NF-κB signaling

(2019) Huobao Yang et al.   BIOMEDICINE & PHARMACOTHERAPY

Polystyrene microplastic particles: In vitro pulmonary toxicity assessment

(2019) Cheng-Di Dong et al.   JOURNAL OF HAZARDOUS MATERIALS

Microplastics in aquatic environments: Occurrence, accumulation, and biological effects

(2019) Shen Xu et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Freshwater microplastics pollution: Detecting and visualizing emerging trends based on Citespace II

(2019) Liming Yao et al.   CHEMOSPHERE

Tri-ortho-cresyl phosphate (TOCP) induced ovarian failure in mice is related to the Hippo signaling pathway disruption

(2018) Liaoliao Hu et al.   REPRODUCTIVE TOXICOLOGY

Simulated digestion of polystyrene foam enhances desorption of diethylhexyl phthalate (DEHP) and In vitro estrogenic activity in a size-dependent manner

(2018) Scott Coffin et al.   ENVIRONMENTAL POLLUTION

The DNA damage-induced cell death response: a roadmap to kill cancer cells

(2016) Sonja Matt et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

TRAF2 functions as an activator switch in the reactive oxygen species-induced stimulation of MST1

(2016) Kyung-Hye Roh et al.   FREE RADICAL BIOLOGY AND MEDICINE

Microplastic exposure studies should be environmentally realistic

(2016) Robin Lenz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of cereblon by fenofibrate ameliorates alcoholic liver disease by enhancing AMPK

(2015) Yong Deuk Kim et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Leaching of the plasticizer di(2-ethylhexyl)phthalate (DEHP) from plastic containers and the question of human exposure

(2014) Hanno C. Erythropel et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Ubiquitous transcription factor YY1 promotes zebrafish liver steatosis and lipotoxicity by inhibiting CHOP-10 expression

(2013) Guor Mour Her et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The Ets Transcription Factor GABP Is a Component of the Hippo Pathway Essential for Growth and Antioxidant Defense

(2013) Hongtan Wu et al.   Cell Reports

The endocannabinoid N-arachidonoyl dopamine (NADA) selectively induces oxidative stress-mediated cell death in hepatic stellate cells but not in hepatocytes

(2012) Alexandra Wojtalla et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Cannabinoid 1 Receptor Promotes Cardiac Dysfunction, Oxidative Stress, Inflammation, and Fibrosis in Diabetic Cardiomyopathy

(2012) M. Rajesh et al.   DIABETES

Estrogen-related receptor γ controls hepatic CB1receptor-mediated CYP2E1 expression and oxidative liver injury by alcohol

(2012) Don-Kyu Kim et al.   GUT

Exposure to Di(2-ethyl-hexyl) phthalate (DEHP)in Uteroand during Lactation Causes Long-Term Pituitary-Gonadal Axis Disruption in Male and Female Mouse Offspring

(2011) Paola Pocar et al.   ENDOCRINOLOGY

The c-Abl-MST1 Signaling Pathway Mediates Oxidative Stress-Induced Neuronal Cell Death

(2011) L. Xiao et al.   JOURNAL OF NEUROSCIENCE

Oligomeric peroxiredoxin-I is an essential intermediate for p53 to activate MST1 kinase and apoptosis

(2011) A Morinaka et al.   ONCOGENE

CB1 receptor inhibition leads to decreased vascular AT1 receptor expression, inhibition of oxidative stress and improved endothelial function

(2010) Vedat Tiyerili et al.   BASIC RESEARCH IN CARDIOLOGY

CB1 cannabinoid receptors promote oxidative stress and cell death in murine models of doxorubicin-induced cardiomyopathy and in human cardiomyocytes

(2009) Partha Mukhopadhyay et al.   CARDIOVASCULAR RESEARCH