HDAC11 promotes both NLRP3/caspase-1/GSDMD and caspase-3/GSDME pathways causing pyroptosis via ERG in vascular endothelial cells

Endothelial ERG alleviates cardiac fibrosis via blocking endothelin-1-dependent paracrine mechanism

(2021) Xin Zhang et al.   CELL BIOLOGY AND TOXICOLOGY

Punching Holes in Cellular Membranes: Biology and Evolution of Gasdermins

(2021) Elke De Schutter et al.   TRENDS IN CELL BIOLOGY

Trimethylamine N‐oxide promotes apoE −/− mice atherosclerosis by inducing vascular endothelial cell pyroptosis via the SDHB/ROS pathway

(2020) Peng Wu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation

(2020) Jun Jacob Hu et al.   NATURE IMMUNOLOGY

GSDMD, an executor of pyroptosis, is involved in IL-1β secretion in Aspergillus fumigatus keratitis

(2020) Wenyi Zhao et al.   EXPERIMENTAL EYE RESEARCH

The Reducing Effects of Pyrogallol-Phloroglucinol-6,6-Bieckol on High-Fat Diet-Induced Pyroptosis in Endothelial and Vascular Smooth Muscle Cells of Mice Aortas

(2020) Seyeon Oh et al.   Marine Drugs

The Transcription Factor ERG Regulates Super-Enhancers Associated with an Endothelial-Specific Gene Expression Program

(2019) Viktoria Kalna et al.   CIRCULATION RESEARCH

Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation

(2019) Corey Rogers et al.   Nature Communications

ATP induces caspase-3/gasdermin E-mediated pyroptosis in NLRP3 pathway-blocked murine macrophages

(2019) Chen-Ying Zeng et al.   APOPTOSIS

Histone deacetylase 11 inhibition promotes breast cancer metastasis from lymph nodes

(2019) Patrick L. Leslie et al.   Nature Communications

Pharmacological inhibition of histone deacetylase reduces NADPH oxidase expression, oxidative stress and the progression of atherosclerotic lesions in hypercholesterolemic apolipoprotein E-deficient mice; potential implications for human atherosclerosis

(2019) Simona-Adriana Manea et al.   Redox Biology

Novel Mechanism for Nicotinamide Phosphoribosyltransferase Inhibition of TNF-α–mediated Apoptosis in Human Lung Endothelial Cells

(2018) Radu C. Oita et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

HDAC11 deletion reduces fructose-induced cardiac dyslipidemia, apoptosis and inflammation by attenuating oxidative stress injury

(2018) Xiao-Di Fan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Pyroptosis and its relationship to atherosclerosis

(2018) Yuan-Jun Xu et al.   CLINICA CHIMICA ACTA

Ultrasonicated Lespedeza cuneata extract prevents TNF-α-induced early atherosclerosis in vitro and in vivo

(2018) Su Jeong Ha et al.   Food & Function

Histone deacetylase 11 inhibits interleukin 10 in B cells of subjects with allergic rhinitis

(2018) Jian-Bo Shao et al.   International Forum of Allergy & Rhinology

DNMT and HDAC inhibitors together abrogate endotoxemia mediated macrophage death by STAT3-JMJD3 signaling

(2018) Saheli Samanta et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

HDAC11 regulates interleukin-13 expression in CD4+ T cells in the heart

(2018) Li Yuan et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Proteinase-Activated Receptor-2 Modulates Ve-Cadherin Expression to Affect Human Vascular Endothelial Barrier Function

(2017) Rui Zhang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Attenuation of TNF-α-Induced Inflammatory Injury in Endothelial Cells by Ginsenoside Rb1 via Inhibiting NF-κB, JNK and p38 Signaling Pathways

(2017) Ping Zhou et al.   Frontiers in Pharmacology

Necroptosis: A new way of dying?

(2016) Britt Hanson   CANCER BIOLOGY & THERAPY

TNF-α Induces Caspase-1 Activation Independently of Simultaneously Induced NLRP3 in 3T3-L1 Cells

(2016) Mana Furuoka et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

(2016) Xing Liu et al.   NATURE

Regulation of endothelial homeostasis, vascular development and angiogenesis by the transcription factor ERG

(2016) Aarti V. Shah et al.   VASCULAR PHARMACOLOGY

HDAC6 inhibition prevents TNF-α-induced caspase 3 activation in lung endothelial cell and maintains cell-cell junctions

(2016) Jinyan Yu et al.   Oncotarget

ETS-related Gene (ERG) Controls Endothelial Cell Permeability via Transcriptional Regulation of the Claudin 5 (CLDN5) Gene

(2012) Lei Yuan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Transcription Factor Erg Inhibits Vascular Inflammation by Repressing NF-κB Activation and Proinflammatory Gene Expression in Endothelial Cells

(2010) Andrea Sperone et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Antiinflammatory Effects of the ETS Factor ERG in Endothelial Cells Are Mediated Through Transcriptional Repression of the Interleukin-8 Gene

(2009) Lei Yuan et al.   CIRCULATION RESEARCH

Transcription factor Erg regulates angiogenesis and endothelial apoptosis through VE-cadherin

(2008) G. M. Birdsey et al.   BLOOD

The histone deacetylase HDAC11 regulates the expression of interleukin 10 and immune tolerance

(2008) Alejandro Villagra et al.   NATURE IMMUNOLOGY