Recent progress and application of the tetrahedral framework nucleic acid materials on drug delivery

Functionalized DNA Nanomaterials Targeting Toll‐Like Receptor 4 Prevent Bisphosphonate‐Related Osteonecrosis of the Jaw via Regulating Mitochondrial Homeostasis in Macrophages

(2023) Tao Zhang et al.   ADVANCED FUNCTIONAL MATERIALS

Tetrahedral Framework Nucleic Acids: A Novel Strategy for Antibiotic Treating Drug-Resistant Infections

(2023) Yue Sun et al.   Biomacromolecules

A dynamic DNA tetrahedron framework for active targeting

(2023) Taoran Tian et al.   Nature Protocols

Antifibrotic Effects of Tetrahedral Framework Nucleic Acids by Inhibiting Macrophage Polarization and Macrophage–Myofibroblast Transition in Bladder Remodeling

(2023) Wei Wang et al.   Advanced Healthcare Materials

Liver-Targeted Delivery of Small Interfering RNA of C–C Chemokine Receptor 2 with Tetrahedral Framework Nucleic Acid Attenuates Liver Cirrhosis

(2023) Taoran Tian et al.   ACS Applied Materials & Interfaces

Typhaneoside-Tetrahedral Framework Nucleic Acids System: Mitochondrial Recovery and Antioxidation for Acute Kidney Injury treatment

(2023) Ran Yan et al.   ACS Nano

DNA-Based Nanomaterials as Drug Delivery Platforms for Increasing the Effect of Drugs in Tumors

(2023) Anastasiya N. Shishparenok et al.   Cancers

Antifibrotic and Antioxidant Effects of a Tetrahedral Framework Nucleic Acid-Based Chlorogenic Acid Delivery System

(2023) Lan Yao et al.   ACS Materials Letters

Framework Nucleic Acid-Based Multifunctional Tumor Theranostic Nanosystem for miRNA Fluorescence Imaging and Chemo/Gene Therapy

(2023) Haikun Luo et al.   ACS Applied Materials & Interfaces

Tetrahedral Framework Nucleic Acids Based Small Interfering RNA Targeting Receptor for Advanced Glycation End Products for Diabetic Complications Treatment

(2023) Zhengwen Cai et al.   ACS Nano

Amelioration of Osteoarthritis via Tetrahedral Framework Nucleic Acids Delivering Microrna‐124 for Cartilage Regeneration

(2023) Sirong Shi et al.   ADVANCED FUNCTIONAL MATERIALS

A Transdermal Drug Delivery System Based on Nucleic Acid Nanomaterials for Skin Photodamage Treatment

(2023) Yu Xie et al.   ADVANCED FUNCTIONAL MATERIALS

Modular DNA Tetrahedron Nanomachine-Guided Dual-Responsive Hybridization Chain Reactions for Discernible Bivariate Assay and Cell Imaging

(2023) Chunli Yang et al.   ANALYTICAL CHEMISTRY

ATP-responsive and functionalized framework nucleic acid for synergistic radio-immunotherapy

(2023) Yuxin Zhang et al.   Chemical Engineering Journal

The Current Progress of Tetrahedral DNA Nanostructure for Antibacterial Application and Bone Tissue Regeneration

(2023) Shebin Hong et al.   International Journal of Nanomedicine

Emerging Applications of Nanotechnology in Healthcare and Medicine

(2023) Shiza Malik et al.   MOLECULES

Dynamic matrices with DNA-encoded viscoelasticity for cell and organoid culture

(2023) Y.-H. Peng et al.   Nature Nanotechnology

Isothermal self-assembly of multicomponent and evolutive DNA nanostructures

(2023) Caroline Rossi-Gendron et al.   Nature Nanotechnology

Universal, label-free, single-molecule visualization of DNA origami nanodevices across biological samples using origamiFISH

(2023) Wendy Xueyi Wang et al.   Nature Nanotechnology

DNA framework-engineered chimeras platform enables selectively targeted protein degradation

(2023) Li Zhou et al.   Nature Communications

Tetrahedral-Framework Nucleic Acids Carry Small Interfering RNA to Downregulate Toll-Like Receptor 2 Gene Expression for the Treatment of Sepsis

(2022) Xiaolin Zhang et al.   ACS Applied Materials & Interfaces

Facilitating In Situ Tumor Imaging with a Tetrahedral DNA Framework‐Enhanced Hybridization Chain Reaction Probe

(2022) Bowen Zhang et al.   ADVANCED FUNCTIONAL MATERIALS

Biomimetic Nanoerythrosome‐Coated Aptamer–DNA Tetrahedron/Maytansine Conjugates: pH‐Responsive and Targeted Cytotoxicity for HER2‐Positive Breast Cancer

(2022) Wenjuan Ma et al.   ADVANCED MATERIALS

Treatment effect of DNA framework nucleic acids on diffuse microvascular endothelial cell injury after subarachnoid hemorrhage

(2022) Ruiqi Chen et al.   CELL PROLIFERATION

Tetrahedral Framework Nucleic Acids Can Alleviate Taurocholate-Induced Severe Acute Pancreatitis and Its Subsequent Multiorgan Injury in Mice

(2022) Yun Wang et al.   NANO LETTERS

Therapeutic Targeting of Intestinal Fibrosis in Crohn’s Disease

(2022) Giovanni Santacroce et al.   Cells

Interfacial DNA Framework-Enhanced Background-to-Signal Transition for Ultrasensitive and Specific Micro-RNA Detection

(2022) Tongtong Guo et al.   ACS Applied Materials & Interfaces

Tetrahedral Framework Nucleic Acids Inhibit Skin Fibrosis via the Pyroptosis Pathway

(2022) Yueying Jiang et al.   ACS Applied Materials & Interfaces

Tetrahedral Framework Nucleic Acids Connected with MicroRNA-126 Mimics for Applications in Vascular Inflammation, Remodeling, and Homeostasis

(2022) Yichen Ge et al.   ACS Applied Materials & Interfaces

Therapeutic Effects of Self-Assembled Tetrahedral Framework Nucleic Acids on Liver Regeneration in Acute Liver Failure

(2022) Yang Chen et al.   ACS Applied Materials & Interfaces

Modulation of the Crosstalk between Schwann Cells and Macrophages for Nerve Regeneration: A Therapeutic Strategy Based on a Multifunctional Tetrahedral Framework Nucleic Acids System

(2022) Jiajie Li et al.   ADVANCED MATERIALS

A Lysosome‐activated Tetrahedral Nanobox for Encapsulated siRNA Delivery

(2022) Yang Gao et al.   ADVANCED MATERIALS

Biological regulation on synovial fibroblast and the treatment of rheumatoid arthritis by nobiletin-loaded tetrahedral framework nucleic acids cargo tank

(2022) Yuting Wen et al.   CHINESE CHEMICAL LETTERS

Tetrahedral framework nucleic acid carrying angiogenic peptide prevents bisphosphonate-related osteonecrosis of the jaw by promoting angiogenesis

(2022) Dan Zhao et al.   International Journal of Oral Science

Inflammation-mediated Matrix Remodeling of Extracellular Matrix-mimicking Biomaterials in Tissue Engineering and Regenerative Medicine

(2022) Mimi Xu et al.   Acta Biomaterialia

A Tetrahedral Framework DNA‐Based Bioswitchable miRNA Inhibitor Delivery System: Application to Skin Anti‐Aging

(2022) Songhang Li et al.   ADVANCED MATERIALS

Tetrahedral framework nucleic acids‐based delivery promotes intracellular transfer of healing peptides and accelerates diabetic would healing

(2022) Shiyu Lin et al.   CELL PROLIFERATION

MiR‐26a‐tetrahedral framework nucleic acids mediated osteogenesis of adipose‐derived mesenchymal stem cells

(2022) Xiaoru Shao et al.   CELL PROLIFERATION

Gold nanoparticles conjugated DNA-tile nanomaterials for simultaneous delivery of morpholino antisense oligonucleotides and doxorubicin

(2022) Cansu Umran Tunc et al.   JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY

BACE1 Aptamer-Modified Tetrahedral Framework Nucleic Acid to Treat Alzheimer’s Disease in an APP-PS1 Animal Model

(2022) Yangyang Wang et al.   ACS Applied Materials & Interfaces

Albumin-Coated Framework Nucleic Acids as Bionic Delivery System for Triple-Negative Breast Cancer Therapy

(2022) Yuxin Zhang et al.   ACS Applied Materials & Interfaces

Tetrahedral framework nucleic acids linked CRISPR/Cas13a signal amplification system for rare tumor cell detection

(2022) Kerun Li et al.   TALANTA

Advances in regenerative medicine applications of tetrahedral framework nucleic acid-based nanomaterials: an expert consensus recommendation

(2022) Yunfeng Lin et al.   International Journal of Oral Science

Experimental Treatments for Spinal Cord Injury: A Systematic Review and Meta-Analysis

(2022) Farihah Iqbal Khan et al.   Cells

Tetrahedral DNA framework based CRISPR electrochemical biosensor for amplification-free miRNA detection

(2022) Yi Xu et al.   BIOSENSORS & BIOELECTRONICS

A tetrahedral framework nucleic acid based multifunctional nanocapsule for tumor prophylactic mRNA vaccination

(2022) Yuhao Liu et al.   CHINESE CHEMICAL LETTERS

Tetrahedral Framework Nucleic Acids Loaded with Aptamer AS1411 for siRNA Delivery and Gene Silencing in Malignant Melanoma

(2021) Dexuan Xiao et al.   ACS Applied Materials & Interfaces

Supercoiling and Looping Promote DNA Base Accessibility and Coordination among Distant Sites

(2021) Jonathan M. Fogg et al.   BIOPHYSICAL JOURNAL

Tetrahedral DNA nanostructure improves transport efficiency and anti‐fungal effect of histatin 5 against Candida albicans

(2021) Bowen Zhang et al.   CELL PROLIFERATION

Many Birds, One Stone: A Smart Nanodevice for Ratiometric Dual-Spectrum Assay of Intracellular MicroRNA and Multimodal Synergetic Cancer Therapy

(2021) Peng He et al.   ACS Nano

Tetrahedral Framework Nucleic Acids Induce Immune Tolerance and Prevent the Onset of Type 1 Diabetes

(2021) Shaojingya Gao et al.   NANO LETTERS

Tetrahedral Framework Nucleic Acids Ameliorate Insulin Resistance in Type 2 Diabetes Mellitus via the PI3K/Akt Pathway

(2021) Yanjing Li et al.   ACS Applied Materials & Interfaces

Tetrahedral Framework Nucleic Acids Reestablish Immune Tolerance and Restore Saliva Secretion in a Sjögren’s Syndrome Mouse Model

(2021) Shaojingya Gao et al.   ACS Applied Materials & Interfaces

Enhanced Penetrability of a Tetrahedral Framework Nucleic Acid by Modification with iRGD for DOX-Targeted Delivery to Triple-Negative Breast Cancer

(2021) Mengting Liu et al.   ACS Applied Materials & Interfaces

Angiogenic Aptamer-Modified Tetrahedral Framework Nucleic Acid Promotes Angiogenesis In Vitro and In Vivo

(2021) Dan Zhao et al.   ACS Applied Materials & Interfaces

Tetrahedral Framework Nucleic Acid Delivered RNA Therapeutics Significantly Attenuate Pancreatic Cancer Progression via Inhibition of CTR1-Dependent Copper Absorption

(2021) Guangqi Song et al.   ACS Applied Materials & Interfaces

The Neuroprotective Effect of MicroRNA‐22‐3p Modified Tetrahedral Framework Nucleic Acids on Damaged Retinal Neurons Via TrkB/BDNF Signaling Pathway

(2021) Jiajie Li et al.   ADVANCED FUNCTIONAL MATERIALS

Therapeutic siCCR2 Loaded by Tetrahedral Framework DNA Nanorobotics in Therapy for Intracranial Hemorrhage

(2021) Wei Fu et al.   ADVANCED FUNCTIONAL MATERIALS

The immune regulatory effects of tetrahedral framework nucleic acid on human T cells via the mitogen‐activated protein kinase pathway

(2021) Xuyang Liu et al.   CELL PROLIFERATION

Current Strategies for the Regeneration of Skeletal Muscle Tissue

(2021) Emine Alarcin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Erythromycin loaded by tetrahedral framework nucleic acids are more antimicrobial sensitive against Escherichia coli (E. coli)

(2021) Yue Sun et al.   Bioactive Materials

Biological Effect of Differently Sized Tetrahedral Framework Nucleic Acids: Endocytosis, Proliferation, Migration, and Biodistribution

(2021) Sirong Shi et al.   ACS Applied Materials & Interfaces

Functionalizing Framework Nucleic‐Acid‐Based Nanostructures for Biomedical Application

(2021) Tao Zhang et al.   ADVANCED MATERIALS

Mussel-inspired chemistry: A promising strategy for natural polysaccharides in biomedical applications

(2021) Fangfei Liu et al.   PROGRESS IN POLYMER SCIENCE

Bioswitchable Delivery of microRNA by Framework Nucleic Acids: Application to Bone Regeneration

(2021) Songhang Li et al.   Small

CRISPR/Cas12a Powered DNA Framework‐Supported Electrochemical Biosensing Platform for Ultrasensitive Nucleic Acid Analysis

(2021) Jing Su et al.   Small Methods

Tetrahedral framework nucleic acids-based delivery of microRNA-155 inhibits choroidal neovascularization by regulating the polarization of macrophages

(2021) Xin Qin et al.   Bioactive Materials

Antioxidative and Angiogenesis-Promoting Effects of Tetrahedral Framework Nucleic Acids in Diabetic Wound Healing with Activation of the Akt/Nrf2/HO-1 Pathway

(2020) Shiyu Lin et al.   ACS Applied Materials & Interfaces

Tetrahedral Framework Nucleic Acids Deliver Antimicrobial Peptides with Improved Effects and Less Susceptibility to Bacterial Degradation

(2020) Yuhao Liu et al.   NANO LETTERS

Nanomaterials and Aging

(2020) Chen-Chen Mao et al.   Current Stem Cell Research & Therapy

Tetrahedral Framework Nucleic Acids Loading Ampicillin Improve the Drug Susceptibility against Methicillin-Resistant Staphylococcus aureus

(2020) Yue Sun et al.   ACS Applied Materials & Interfaces

Design, fabrication and applications of tetrahedral DNA nanostructure-based multifunctional complexes in drug delivery and biomedical treatment

(2020) Tao Zhang et al.   Nature Protocols

Liver regeneration: biological and pathological mechanisms and implications

(2020) George K. Michalopoulos et al.   Nature Reviews Gastroenterology & Hepatology

Tetrahedral Framework Nucleic Acid Promotes the Treatment of Bisphosphonate-Related Osteonecrosis of the Jaws by Promoting Angiogenesis and M2 Polarization

(2020) Dan Zhao et al.   ACS Applied Materials & Interfaces

Tetrahedral framework nucleic acids act as antioxidants in acute kidney injury treatment

(2020) Qi Zhang et al.   CHEMICAL ENGINEERING JOURNAL

A DNA nanodevice-based vaccine for cancer immunotherapy

(2020) Shaoli Liu et al.   NATURE MATERIALS

Nucleic acid based tetrahedral framework DNA nanostructures for fibrotic diseases therapy

(2020) Tianxu Zhang et al.   Applied Materials Today

Tetrahedral Framework Nucleic Acid Inhibits Chondrocyte Apoptosis and Oxidative Stress through Activation of Autophagy

(2020) Sirong Shi et al.   ACS Applied Materials & Interfaces

The innate immune system and cell death in autoinflammatory and autoimmune disease

(2020) David E Place et al.   CURRENT OPINION IN IMMUNOLOGY

Neurodegenerative diseases and effective drug delivery: A review of challenges and novel therapeutics

(2020) Amna Akhtar et al.   JOURNAL OF CONTROLLED RELEASE

The protective effect of tetrahedral framework nucleic acids on periodontium under inflammatory conditions

(2020) Mi Zhou et al.   Bioactive Materials

Framework nucleic acids as programmable carrier for transdermal drug delivery

(2019) Christian Wiraja et al.   Nature Communications

From DNA Nanotechnology to Material Systems Engineering

(2019) Yong Hu et al.   ADVANCED MATERIALS

Create Nanoscale Patterns with DNA Origami

(2019) Sisi Fan et al.   Small

Carriers Break Barriers in Drug Delivery: Endocytosis and Endosomal Escape of Gene Delivery Vectors

(2019) Isabelle M. S. Degors et al.   ACCOUNTS OF CHEMICAL RESEARCH

PEGylated Protamine-Based Adsorbing Improves the Biological Properties and Stability of Tetrahedral Framework Nucleic Acids

(2019) Yichen Ge et al.   ACS Applied Materials & Interfaces

An Intelligent DNA Nanorobot with in Vitro Enhanced Protein Lysosomal Degradation of HER2

(2019) Wenjuan Ma et al.   NANO LETTERS

Tetrahedral Framework Nucleic Acids Promote Corneal Epithelial Wound Healing in Vitro and in Vivo

(2019) Nanxin Liu et al.   Small

Enhanced Efficacy of Temozolomide Loaded by a Tetrahedral Framework DNA Nanoparticle in the Therapy for Glioblastoma

(2019) Wei Fu et al.   ACS Applied Materials & Interfaces

Targeted Imaging of Brain Tumors with a Framework Nucleic Acid Probe

(2018) Tian Tian et al.   ACS Applied Materials & Interfaces

Systematic Study in Mammalian Cells Showing No Adverse Response to Tetrahedral DNA Nanostructure

(2018) Kai Xia et al.   ACS Applied Materials & Interfaces

Anti-inflammatory and Antioxidative Effects of Tetrahedral DNA Nanostructures via the Modulation of Macrophage Responses

(2018) Qi Zhang et al.   ACS Applied Materials & Interfaces

From Designing the Molecules of Life to Designing Life: Future Applications Derived from Advances in DNA Technologies

(2018) Richie E. Kohman et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

DNA Nanotechnology-Enabled Drug Delivery Systems

(2018) Qinqin Hu et al.   CHEMICAL REVIEWS

MUC1 aptamer-targeted DNA micelles for dual tumor therapy using doxorubicin and KLA peptide

(2018) Fahimeh Charbgoo et al.   Nanomedicine-Nanotechnology Biology and Medicine

Effect of tetrahedral DNA nanostructures on proliferation and osteo/odontogenic differentiation of dental pulp stem cells via activation of the notch signaling pathway

(2018) Mi Zhou et al.   Nanomedicine-Nanotechnology Biology and Medicine

A DNA nanorobot functions as a cancer therapeutic in response to a molecular trigger in vivo

(2018) Suping Li et al.   NATURE BIOTECHNOLOGY

Tetrahedral DNA Nanomaterial Regulates the Biological Behaviors of Adipose-Derived Stem Cells via DNA Methylation on Dlg3

(2018) Shiyu Lin et al.   ACS Applied Materials & Interfaces

Advances in biological applications of self-assembled DNA tetrahedral nanostructures

(2018) Songhang Li et al.   Materials Today

Inhibiting Methicillin-Resistant Staphylococcus aureus by Tetrahedral DNA Nanostructure-Enabled Antisense Peptide Nucleic Acid Delivery

(2018) Yuxin Zhang et al.   NANO LETTERS

DNA-based nanoscaffolds as vehicles for 5-fluoro-2′-deoxyuridine oligomers in colorectal cancer therapy

(2018) A. F. Jorge et al.   Nanoscale

The Clearance Effect of Tetrahedral DNA Nanostructures on Senescent Human Dermal Fibroblasts

(2018) Chenchen Mao et al.   ACS Applied Materials & Interfaces

Treatment of critical-sized bone defects: clinical and tissue engineering perspectives

(2017) Erika Roddy et al.   European Journal of Orthopaedic Surgery and Traumatology

Effect of tetrahedral DNA nanostructures on osteogenic differentiation of mesenchymal stem cells via activation of the Wnt/β-catenin signaling pathway

(2017) Xiao-Ru Shao et al.   Nanomedicine-Nanotechnology Biology and Medicine

Synthesis of an ethyleneimine/tetrahedral DNA nanostructure complex and its potential application as a multi-functional delivery vehicle

(2017) Taoran Tian et al.   Nanoscale

Programmable self-assembly of three-dimensional nanostructures from 10,000 unique components

(2017) Luvena L. Ong et al.   NATURE

Engineering nucleic acid structures for programmable molecular circuitry and intracellular biocomputation

(2017) Jiang Li et al.   Nature Chemistry

Tetrahedral DNA Nanostructure: A Potential Promoter for Cartilage Tissue Regeneration via Regulating Chondrocyte Phenotype and Proliferation

(2017) Xiaoru Shao et al.   Small

Oligolysine-based coating protects DNA nanostructures from low-salt denaturation and nuclease degradation

(2017) Nandhini Ponnuswamy et al.   Nature Communications

DNA nanotechnology

(2017) Nadrian C. Seeman et al.   Nature Reviews Materials

Multiple-Armed Tetrahedral DNA Nanostructures for Tumor-Targeting, Dual-Modality in Vivo Imaging

(2016) Dawei Jiang et al.   ACS Applied Materials & Interfaces

Receptor-Mediated Entry of Pristine Octahedral DNA Nanocages in Mammalian Cells

(2016) Giulia Vindigni et al.   ACS Nano

A pH-responsive DNA nanomachine-controlled catalytic assembly of gold nanoparticles

(2016) Dongbao Yao et al.   CHEMICAL COMMUNICATIONS

DNA hairpins promote temperature controlled cargo encapsulation in a truncated octahedral nanocage structure family

(2016) Oskar Franch et al.   Nanoscale

Coupling Gd-DTPA with a bispecific, recombinant protein anti-EGFR-iRGD complex improves tumor targeting in MRI

(2016) XIAOYAN XIN et al.   ONCOLOGY REPORTS

Macrophage polarization in experimental and clinical choroidal neovascularization

(2016) Yu Yang et al.   Scientific Reports

Fibrosis — A Common Pathway to Organ Injury and Failure

(2015) Don C. Rockey et al.   NEW ENGLAND JOURNAL OF MEDICINE

Programmable materials and the nature of the DNA bond

(2015) M. R. Jones et al.   SCIENCE

Nanotoxicity: An Interplay of Oxidative Stress, Inflammation and Cell Death

(2015) Puja Khanna et al.   Nanomaterials

Single-Particle Tracking and Modulation of Cell Entry Pathways of a Tetrahedral DNA Nanostructure in Live Cells

(2014) Le Liang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Temperature-responsive DNA-gated nanocarriers for intracellular controlled release

(2014) Zhengze Yu et al.   CHEMICAL COMMUNICATIONS

Drug delivery vehicles on a nano-engineering perspective

(2014) Betiana Felice et al.   Materials Science & Engineering C-Materials for Biological Applications

Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis

(2014) Wan Ling Wong et al.   Lancet Global Health

Functional DNA Nanostructures for Theranostic Applications

(2013) Hao Pei et al.   ACCOUNTS OF CHEMICAL RESEARCH

Narrative Review: Fibrotic Diseases: Cellular and Molecular Mechanisms and Novel Therapies

(2013) Joel Rosenbloom   ANNALS OF INTERNAL MEDICINE

A method to study in vivo stability of DNA nanostructures

(2013) Sunaina Surana et al.   METHODS

DNA nanostructure serum stability: greater than the sum of its parts

(2012) Justin W. Conway et al.   CHEMICAL COMMUNICATIONS

Acute kidney injury

(2012) Rinaldo Bellomo et al.   LANCET

Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA delivery

(2012) Hyukjin Lee et al.   Nature Nanotechnology

Loading and selective release of cargo in DNA nanotubes with longitudinal variation

(2010) Pik Kwan Lo et al.   Nature Chemistry

Hierarchical self-assembly of DNA into symmetric supramolecular polyhedra

(2008) Yu He et al.   NATURE

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

(2008) Jean-Philippe Coppé et al.   PLOS BIOLOGY

Cellular and molecular mechanisms of fibrosis

(2007) TA Wynn   JOURNAL OF PATHOLOGY