Therapeutic Targeting of Intestinal Fibrosis in Crohn’s Disease

IL-36 in chronic inflammation and fibrosis — bridging the gap?

(2021) Michael Elias et al.   JOURNAL OF CLINICAL INVESTIGATION

Soluble Fraction from Lysate of a High Concentration Multi-Strain Probiotic Formulation Inhibits TGF-β1-Induced Intestinal Fibrosis on CCD-18Co Cells

(2021) Francesca Lombardi et al.   Nutrients

Anti-TL1A Antibody PF-06480605 Safety and Efficacy for Ulcerative Colitis: A Phase 2a Single-Arm Study

(2021) Silvio Danese et al.   Clinical Gastroenterology and Hepatology

Biomarkers for the Prediction and Diagnosis of Fibrostenosing Crohn’s Disease: A Systematic Review

(2021) Calen A. Steiner et al.   Clinical Gastroenterology and Hepatology

Therapeutic Targeting of Nrf2 Signaling by Maggot Extracts Ameliorates Inflammation-Associated Intestinal Fibrosis in Chronic DSS-Induced Colitis

(2021) Rong Wang et al.   Frontiers in Immunology

Controversial Contribution of Th17/IL-17 Toward the Immune Response in Intestinal Fibrosis

(2020) Giovanni Latella et al.   DIGESTIVE DISEASES AND SCIENCES

Treatment with a probiotic combination reduces abdominal adhesion in rats by decreasing intestinal inflammation and restoring microbial composition

(2020) Xiaorong Deng et al.   ONCOLOGY REPORTS

Dissecting the Heterogeneity in T-Cell Mediated Inflammation in IBD

(2020) Irma Tindemans et al.   Cells

Systematic review: medical therapy for fibrostenosing Crohn’s disease

(2020) Cathy Lu et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

The Role of Citrullination in Inflammatory Bowel Disease: A Neglected Player in Triggering Inflammation and Fibrosis?

(2020) Gabriele Dragoni et al.   INFLAMMATORY BOWEL DISEASES

Pirfenidone Inhibits Cell Proliferation and Collagen I Production of Primary Human Intestinal Fibroblasts

(2020) Yingying Cui et al.   Cells

AXL Is a Potential Target for the Treatment of Intestinal Fibrosis

(2020) Calen A Steiner et al.   INFLAMMATORY BOWEL DISEASES

Could Pirfenidone Also be Effective in Treating Intestinal Fibrosis?

(2020) Giovanni Latella et al.   Cells

PAD4 Deficiency Improves Bleomycin-induced Neutrophil Extracellular Traps and Fibrosis in Mouse Lung

(2020) Masaki Suzuki et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Interleukin-17 as a Therapy Target in Intestinal Fibrosis

(2020) Bao-Lei Zhang et al.   DIGESTIVE DISEASES AND SCIENCES

Interleukin-36 Cytokine/Receptor Signaling: A New Target for Tissue Fibrosis

(2020) Elaina Melton et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Fibrosis: from mechanisms to medicines

(2020) Neil C. Henderson et al.   NATURE

Flagellin-mediated activation of IL-33-ST2 signaling by a pathobiont promotes intestinal fibrosis

(2019) Jin Imai et al.   Mucosal Immunology

Neutrophil Extracellular Traps Sustain Inflammatory Signals in Ulcerative Colitis

(2019) Vincenzo Dinallo et al.   Journal of Crohns & Colitis

Targeting anti-fibrotic pathways in Crohn’s disease – The final frontier?

(2019) Christopher Ma et al.   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

Assessment of Crohn’s disease-associated small bowel strictures and fibrosis on cross-sectional imaging: a systematic review

(2019) Dominik Bettenworth et al.   GUT

Cytokine Networks in the Pathophysiology of Inflammatory Bowel Disease

(2019) Matthias Friedrich et al.   IMMUNITY

Decellularized Human Gut as a Natural 3D Platform for Research in Intestinal Fibrosis

(2019) Paolo Giuffrida et al.   INFLAMMATORY BOWEL DISEASES

Autophagy inhibition-mediated epithelial–mesenchymal transition augments local myofibroblast differentiation in pulmonary fibrosis

(2019) Charlotte Hill et al.   Cell Death & Disease

Role of Interleukin-17 in Pathogenesis of Intestinal Fibrosis in Mice

(2019) Jian Li et al.   DIGESTIVE DISEASES AND SCIENCES

Thalidomide Prevented and Ameliorated Pathogenesis of Crohn’s Disease in Mice via Regulation of Inflammatory Response and Fibrosis

(2019) Hongjin Chen et al.   Frontiers in Pharmacology

An expert consensus to standardise definitions, diagnosis and treatment targets for anti-fibrotic stricture therapies in Crohn's disease

(2018) F. Rieder et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Pirfenidone prevents radiation-induced intestinal fibrosis in rats by inhibiting fibroblast proliferation and differentiation and suppressing the TGF-β1/Smad/CTGF signaling pathway

(2018) Yan-Wu Sun et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Identification of Endpoints for Development of Antifibrosis Drugs for Treatment of Crohn’s Disease

(2018) Silvio Danese et al.   GASTROENTEROLOGY

Inhibition of Fibroblast Activation Protein Restores a Balanced Extracellular Matrix and Reduces Fibrosis in Crohn’s Disease Strictures Ex Vivo

(2018) Marta Truffi et al.   INFLAMMATORY BOWEL DISEASES

Quality of Life in Inflammatory Bowel Disease: A Systematic Review and Meta-analyses—Part I

(2018) Simon R Knowles et al.   INFLAMMATORY BOWEL DISEASES

Inclusion of the Mesentery in Ileocolic Resection for Crohn’s Disease is Associated With Reduced Surgical Recurrence

(2018) Calvin J Coffey et al.   Journal of Crohns & Colitis

Fibrostenotic Phenotype of Myofibroblasts in Crohn’s Disease is Dependent on Tissue Stiffness and Reversed by LOX Inhibition

(2018) Jessica R de Bruyn et al.   Journal of Crohns & Colitis

REDD1/Autophagy Pathway Is Associated with Neutrophil-Driven IL-1β Inflammatory Response in Active Ulcerative Colitis

(2018) Iliana Angelidou et al.   JOURNAL OF IMMUNOLOGY

A probiotic complex, rosavin, zinc, and prebiotics ameliorate intestinal inflammation in an acute colitis mouse model

(2018) Jin-Sil Park et al.   Journal of Translational Medicine

The big five in fibrosis: Macrophages, myofibroblasts, matrix, mechanics, and miscommunication

(2018) Pardis Pakshir et al.   MATRIX BIOLOGY

Phase 2 Study of ABT-122, a TNF- and IL-17A-Targeted Dual Variable Domain Immunoglobulin, in Psoriatic Arthritis With Inadequate Methotrexate Response

(2018) Philip J. Mease et al.   Arthritis & Rheumatology

Paracrine signalling during ZEB1-mediated epithelial–mesenchymal transition augments local myofibroblast differentiation in lung fibrosis

(2018) Liudi Yao et al.   CELL DEATH AND DIFFERENTIATION

Activation of Toll-Like Receptor (TLR) 5 Induces a PRO-Fibrogenic Phenotype on Human Intestinal Myofibroblasts (HIF) – A Novel Pathway Mediated by Caspase 1

(2018) Florian Rieder et al.   GASTROENTEROLOGY

Pirfenidone suppresses TGF‑β1‑induced human intestinal fibroblasts activities by regulating proliferation and apoptosis via the inhibition of the Smad and PI3K/AKT signaling pathway

(2018) Yanwu Sun et al.   Molecular Medicine Reports

Neutrophil extracellular traps in pediatric inflammatory bowel disease

(2018) Yehonatan Gottlieb et al.   PATHOLOGY INTERNATIONAL

Inhibiting Interleukin 36 Receptor Signaling Reduces Fibrosis in Mice with Chronic Intestinal Inflammation

(2018) Kristina Scheibe et al.   GASTROENTEROLOGY

The Mesenteric Fat and Intestinal Muscle Interface: Creeping Fat Influencing Stricture Formation in Crohn’s Disease

(2018) Ren Mao et al.   INFLAMMATORY BOWEL DISEASES

Intestinal fibrosis

(2018) Marco Vincenzo Lenti et al.   MOLECULAR ASPECTS OF MEDICINE

Effects of the fibroblast activation protein inhibitor, PT100, in a murine model of pulmonary fibrosis

(2017) Christine Egger et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Treatment of Intestinal Fibrosis in Experimental Inflammatory Bowel Disease by the Pleiotropic Actions of a Local Rho Kinase Inhibitor

(2017) Tom Holvoet et al.   GASTROENTEROLOGY

Mechanisms, Management, and Treatment of Fibrosis in Patients With Inflammatory Bowel Diseases

(2017) Florian Rieder et al.   GASTROENTEROLOGY

Efficacy of adalimumab in patients with Crohn's disease and symptomatic small bowel stricture: a multicentre, prospective, observational cohort (CREOLE) study

(2017) Yoram Bouhnik et al.   GUT

Overview of the IL-1 family in innate inflammation and acquired immunity

(2017) Charles A. Dinarello   IMMUNOLOGICAL REVIEWS

A Pooled Analysis of Efficacy, Safety, and Long-term Outcome of Endoscopic Balloon Dilation Therapy for Patients with Stricturing Crohnʼs Disease

(2017) Dominik Bettenworth et al.   INFLAMMATORY BOWEL DISEASES

Efficacy of Endoscopic Balloon Dilation for Small Bowel Strictures in Patients With Crohn’s Disease: A Nationwide, Multi-centre, Open-label, Prospective Cohort Study

(2017) Fumihito Hirai et al.   Journal of Crohns & Colitis

Vedolizumab in IBD–Lessons From Real-world Experience; A Systematic Review and Pooled Analysis

(2017) Tal Engel et al.   Journal of Crohns & Colitis

miR-200b-containing microvesicles attenuate experimental colitis associated intestinal fibrosis by inhibiting epithelial-mesenchymal transition

(2017) Jia Yang et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Rho-kinase signaling pathway promotes the expression of PARP to accelerate cardiomyocyte apoptosis in ischemia/reperfusion

(2017) Hongjun Bian et al.   Molecular Medicine Reports

Epithelial–mesenchymal transition in Crohn’s disease

(2017) H Jiang et al.   Mucosal Immunology

IL-17-driven intestinal fibrosis is inhibited by Itch-mediated ubiquitination of HIC-5

(2017) J Paul et al.   Mucosal Immunology

Pirfenidone and Nintedanib for Treatment of Idiopathic Pulmonary Fibrosis

(2017) Gayathri Sathiyamoorthy et al.   SOUTHERN MEDICAL JOURNAL

Thalidomide is a therapeutic agent that is effective in inducing and maintaining endoscopic remission in adult CD patients

(2017) Zhenhua Zhu et al.   Clinics and Research in Hepatology and Gastroenterology

Safety, Tolerability, and Pharmacodynamics of ABT-122, a Tumor Necrosis Factor- and Interleukin-17-Targeted Dual Variable Domain Immunoglobulin, in Patients With Rheumatoid Arthritis

(2017) Roy M. Fleischmann et al.   Arthritis & Rheumatology

A Randomized, Double-Blind, Placebo-Controlled Phase 2 Study of Brodalumab in Patients With Moderate-to-Severe Crohn’s Disease

(2016) Stephan R Targan et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Oral pirfenidone protects against fibrosis by inhibiting fibroblast proliferation and TGF-β signaling in a murine colitis model

(2016) Guanwei Li et al.   BIOCHEMICAL PHARMACOLOGY

Novel PPARγ Modulator GED-0507-34 Levo Ameliorates Inflammation-driven Intestinal Fibrosis

(2016) Silvia Speca et al.   INFLAMMATORY BOWEL DISEASES

Smooth Muscle Hyperplasia/Hypertrophy is the Most Prominent Histological Change in Crohn’s Fibrostenosing Bowel Strictures: A Semiquantitative Analysis by Using a Novel Histological Grading Scheme

(2016) Wenqian Chen et al.   Journal of Crohns & Colitis

European Crohn’s and Colitis Organisation Topical Review on Prediction, Diagnosis and Management of Fibrostenosing Crohn’s Disease

(2016) Florian Rieder et al.   Journal of Crohns & Colitis

Phosphotidylserine exposure and neutrophil extracellular traps enhance procoagulant activity in patients with inflammatory bowel disease

(2016) Ruishuang Ma et al.   THROMBOSIS AND HAEMOSTASIS

Biomarkers of intestinal fibrosis – one step towards clinical trials for stricturing inflammatory bowel disease

(2016) Paolo Giuffrida et al.   United European Gastroenterology Journal

Losartan Reduces Trinitrobenzene Sulphonic Acid-Induced Colorectal Fibrosis in Rats

(2016) Dov Wengrower et al.   CANADIAN JOURNAL OF GASTROENTEROLOGY

Novel Antimesenteric Functional End-to-End Handsewn (Kono-S) Anastomoses for Crohn's Disease: A Report of Surgical Procedure and Short-Term Outcomes

(2015) Hidetoshi Katsuno et al.   DIGESTIVE SURGERY

Gas6/Axl pathway is activated in chronic liver disease and its targeting reduces fibrosis via hepatic stellate cell inactivation

(2015) Cristina Bárcena et al.   JOURNAL OF HEPATOLOGY

The global burden of IBD: from 2015 to 2025

(2015) Gilaad G. Kaplan   Nature Reviews Gastroenterology & Hepatology

Polyphosphate, an active molecule derived from probiotic Lactobacillus brevis, improves the fibrosis in murine colitis

(2015) Shin Kashima et al.   Translational Research

Robust bioengineered 3D functional human intestinal epithelium

(2015) Ying Chen et al.   Scientific Reports

Extracellular Matrix Reorganization During Wound Healing and Its Impact on Abnormal Scarring

(2015) Meilang Xue et al.   Advances in Wound Care

In Crohn's disease fibrosis-reduced expression of themiR-29family enhances collagen expression in intestinal fibroblasts

(2014) Anke Nijhuis et al.   CLINICAL SCIENCE

Neutrophil extracellular traps promote differentiation and function of fibroblasts

(2014) Akrivi Chrysanthopoulou et al.   JOURNAL OF PATHOLOGY

Inhibition of a novel fibrogenic factor Tl1a reverses established colonic fibrosis

(2014) D Q Shih et al.   Mucosal Immunology

Tools for endoscopic stricture dilation

(2013) Uzma D. Siddiqui et al.   GASTROINTESTINAL ENDOSCOPY

Matrix Stiffness Corresponding to Strictured Bowel Induces a Fibrogenic Response in Human Colonic Fibroblasts

(2013) Laura A. Johnson et al.   INFLAMMATORY BOWEL DISEASES

Increased Activation of Latent TGF-β1 by αVβ3 in Human Crohnʼs Disease and Fibrosis in TNBS Colitis Can Be Prevented by Cilengitide

(2013) Chao Li et al.   INFLAMMATORY BOWEL DISEASES

Novel Rho/MRTF/SRF Inhibitors Block Matrix-stiffness and TGF-β–Induced Fibrogenesis in Human Colonic Myofibroblasts

(2013) Laura A. Johnson et al.   INFLAMMATORY BOWEL DISEASES

The Gut Microbiome in Intestinal Fibrosis: Environmental Protector or Provocateur?

(2013) F. Rieder   Science Translational Medicine

Adipokines from local fat cells shape the macrophage compartment of the creeping fat in Crohn's disease

(2012) Lea Isabell Kredel et al.   GUT

Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: unexpected results of a randomised, double-blind placebo-controlled trial

(2012) Wolfgang Hueber et al.   GUT

miR-200b is involved in intestinal fibrosis of Crohn’s disease

(2012) YINGWEI CHEN et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Proinflammatory cytokines induce crosstalk between colonic epithelial cells and subepithelial myofibroblasts: Implication in intestinal fibrosis

(2012) Ioannis Drygiannakis et al.   Journal of Crohns & Colitis

Anti-fibrotic therapy: Lost in translation?

(2012) Detlef Schuppan et al.   JOURNAL OF HEPATOLOGY

Crohn's disease

(2012) Daniel C Baumgart et al.   LANCET

Cellular and molecular mechanisms of intestinal fibrosis

(2012) Silvia Speca   WORLD JOURNAL OF GASTROENTEROLOGY

Inflammation-Induced Endothelial-to-Mesenchymal Transition

(2011) Florian Rieder et al.   AMERICAN JOURNAL OF PATHOLOGY

Constitutive TL1A Expression under Colitogenic Conditions Modulates the Severity and Location of Gut Mucosal Inflammation and Induces Fibrostenosis

(2011) Robert Barrett et al.   AMERICAN JOURNAL OF PATHOLOGY

Intestinal fibrosis is reduced by early elimination of inflammation in a mouse model of IBD: Impact of a “Top-Down” approach to intestinal fibrosis in mice

(2011) Laura A. Johnson et al.   INFLAMMATORY BOWEL DISEASES

Recent advances in understanding Crohn’s disease

(2011) Antonio Di Sabatino et al.   Internal and Emergency Medicine

Transforming growth factor-beta type 1 receptor (ALK5) and Smad proteins mediate TIMP-1 and collagen synthesis in experimental intestinal fibrosis

(2011) Carlos Medina et al.   JOURNAL OF PATHOLOGY

The endogenous cannabinoid system in the gut of patients with inflammatory bowel disease

(2011) A Di Sabatino et al.   Mucosal Immunology

The role of the miR-200 family in epithelial-mesenchymal transition

(2010) Perry S. Mongroo et al.   CANCER BIOLOGY & THERAPY

Endocannabinoid biosynthesis and inactivation, from simple to complex

(2010) Giulio G. Muccioli   DRUG DISCOVERY TODAY

Fibroblast activation protein expression in Crohnʼs disease strictures

(2010) Laura Rovedatti et al.   INFLAMMATORY BOWEL DISEASES

Identification of Epithelial to Mesenchymal Transition as a Novel Source of Fibroblasts in Intestinal Fibrosis

(2010) Sarah N. Flier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endoscopic vs ultrasonographic findings related to Crohn's Disease recurrence: A prospective longitudinal study at 3years

(2010) S. Onali et al.   Journal of Crohns & Colitis

Interleukin-25 production is differently regulated by TNF-α and TGF-β1 in the human gut

(2010) D Fina et al.   Mucosal Immunology

PPARγ Downregulation by TGFß in Fibroblast and Impaired Expression and Function in Systemic Sclerosis: A Novel Mechanism for Progressive Fibrogenesis

(2010) Jun Wei et al.   PLoS One

Critical Role of Serum Response Factor in Pulmonary Myofibroblast Differentiation Induced by TGF-β

(2009) Nathan Sandbo et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Endocannabinoid chemical biology: a tool for the development of novel therapies

(2009) Stefania Petrosino et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Peroxisome proliferator-activated receptor-γ abrogates Smad-dependent collagen stimulation by targeting the p300 transcriptional coactivator

(2009) Asish K. Ghosh et al.   FASEB JOURNAL

Transforming growth factor   signalling and matrix metalloproteinases in the mucosa overlying Crohn's disease strictures

(2009) A Di Sabatino et al.   GUT

Wound repair at a glance

(2009) T. J. Shaw et al.   JOURNAL OF CELL SCIENCE

The Prolyl-Aminodipeptidases and their Inhibitors as Therapeutic Targets for Fibrogenic Disorders

(2009) Lucienne Juillerat-Jeanneret et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Intestinal fibrosis in IBD—a dynamic, multifactorial process

(2009) Florian Rieder et al.   Nature Reviews Gastroenterology & Hepatology

Chronic Enteric Salmonella Infection in Mice Leads to Severe and Persistent Intestinal Fibrosis

(2008) Guntram A. Grassl et al.   GASTROENTEROLOGY

Emerging role of cannabinoids in gastrointestinal and liver diseases: basic and clinical aspects

(2008) A A Izzo et al.   GUT

The role of matrix stiffness in regulating cell behavior

(2008) Rebecca G. Wells   HEPATOLOGY

Transanal delivery of angiotensin converting enzyme inhibitor prevents colonic fibrosis in a mouse colitis model: development of a unique mode of treatment

(2008) Hiroyuki Koga et al.   SURGERY