Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 14, Issue 35, Pages 39819-39829Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.2c10612
Keywords
tetrahedral framework nucleic acid; albumin; triple-negative breast cancer; long circulation; drug delivery system
Funding
- National Key R&D Program of China [2019YFA0110600]
- National Natural Science Founda-tion of China [81970916]
- Sichuan Province Youth Science and Technology Innovation Team [2022JDTD0021]
- West China School/Hospital of Stomatology Sichuan University [RCDWJS2021-20]
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In this study, bovine serum albumin (BSA) was used as a protective film to extend the circulation time of the tetrahedral framework nucleic acid (tFNA) delivery system and improve the targeted treatment of triple-negative breast cancer (TNBC). This optimized system exhibited effective tumor growth inhibition in the TNBC mice model, showing great potential for clinical translation.
Triple-negative breast cancer (TNBC) is a subtype of breast cancer, and it has aggressive and more frequent tissue metastases than other breast cancer subtypes. Because the proliferation of TNBC tumor cells does not depend on estrogen receptor (ER), progesterone accurate drug targets, conventional chemotherapy is challenging to be effective, and adverse reactions are severe. At present, the treatment strategy for TNBC generally depends on a combination of surgery, radiotherapy, and chemotherapy. Conventional administration methods have minimal effects on TNBC and cause severe damage to normal tissues. Therefore, it is an urgent task to develop an efficient and practical way of drug delivery and open up a new horizon of targeted therapy for TNBC. In our work, bovine serum albumin (BSA) acted as the protective film to prolong the circulation time of the tetrahedral framework nucleic acid (tFNA) delivery system and resist immune clearance in vivo. tFNA was used as a carrier loaded with DOX and AS1411 aptamers for the targeted treatment of triple-negative breast cancer. Compared with existing approaches, this optimized system exhibits stronger tumor-targeting so that tFNAs can be more concentrated around the tumor tissue, reducing DOX toxicity to other organs. This bionic delivery system exhibited effective tumor growth inhibition in the TNBC mice model, offering the clinical potential to promote the treatment of TNBC with great potential for clinical translation.
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