Recent engineering advances of EVs for compounds, nucleic acids, and TCM delivery

Serum-derived extracellular vesicles from breast cancer patients contribute to differential regulation of T-cell-mediated immune-escape mechanisms in breast cancer subtypes

(2023) Rosalind Graham et al.   Frontiers in Immunology

Tumor-derived extracellular vesicles as messengers of natural products in cancer treatment

(2022) Yuanxin Xu et al.   Theranostics

Extracellular Vesicle Delivery of Neferine for the Attenuation of Neurodegenerative Disease Proteins and Motor Deficit in an Alzheimer’s Disease Mouse Model

(2022) Bin Tang et al.   Pharmaceuticals

Protective effect of Yangxue Jiedu Soup against psoriasis-like lesions by regulating TLR4/NF-κB signaling pathway mediated by secretion of exosome HSP70

(2022) Jingjing Lv et al.   BIOMEDICINE & PHARMACOTHERAPY

Astragaloside IV drug-loaded exosomes (AS-IV EXOs) derived from endothelial progenitor cells improve the viability and tube formation in high-glucose impaired human endothelial cells by promoting miR-214 expression

(2022) Xiaoling Zou et al.   Endokrynologia Polska

Therapeutically harnessing extracellular vesicles

(2022) Lesley Cheng et al.   NATURE REVIEWS DRUG DISCOVERY

Selective isolation of extracellular vesicles from minimally processed human plasma as a translational strategy for liquid biopsies

(2022) Diogo Fortunato et al.   Biomarker Research

Advanced research on extracellular vesicles based oral drug delivery systems

(2022) Mengdi Song et al.   JOURNAL OF CONTROLLED RELEASE

Investigation of canine extracellular vesicles in diffuse large B-cell lymphomas

(2022) Marek Kulka et al.   PLoS One

High‐Yield Separation of Extracellular Vesicles Using Programmable Zwitterionic Coacervates

(2022) Carolina Paganini et al.   Small

Microfluidic Strategies for Extracellular Vesicle Isolation: Towards Clinical Applications

(2022) Alessio Meggiolaro et al.   Biosensors-Basel

Isolation and characterization of extracellular vesicle subpopulations from tissues

(2021) Rossella Crescitelli et al.   Nature Protocols

Extracellular vesicle therapeutics from plasma and adipose tissue

(2021) Dalila Iannotta et al.   Nano Today

Extracellular vesicles as a next-generation drug delivery platform

(2021) Inge Katrin Herrmann et al.   Nature Nanotechnology

The polysaccharide chitosan facilitates the isolation of small extracellular vesicles from multiple biofluids

(2021) Awanit Kumar et al.   Journal of Extracellular Vesicles

Active cargo loading into extracellular vesicles: Highlights the heterogeneous encapsulation behaviour

(2021) Chaoxiang Chen et al.   Journal of Extracellular Vesicles

Native and bioengineered extracellular vesicles for cardiovascular therapeutics

(2020) Ricardo Cerqueira de Abreu et al.   Nature Reviews Cardiology

Combination of Size-Exclusion Chromatography and Ultracentrifugation Improves the Proteomic Profiling of Plasma-Derived Small Extracellular Vesicles

(2020) Rui Wei et al.   BIOLOGICAL PROCEDURES ONLINE

Bu-Shen-Yi-Sui Capsule, an Herbal Medicine Formula, Promotes Remyelination by Modulating the Molecular Signals via Exosomes in Mice with Experimental Autoimmune Encephalomyelitis

(2020) Pei-Yuan Zhao et al.   Oxidative Medicine and Cellular Longevity

Zhen-Wu-Tang Protects IgA Nephropathy in Rats by Regulating Exosomes to Inhibit NF-κB/NLRP3 Pathway

(2020) Honglian Li et al.   Frontiers in Pharmacology

Exosome: A Review of Its Classification, Isolation Techniques, Storage, Diagnostic and Targeted Therapy Applications

(2020) Yi Zhang et al.   International Journal of Nanomedicine

Extracellular microvesicles/exosomes: discovery, disbelief, acceptance, and the future?

(2020) Mariusz Z. Ratajczak et al.   LEUKEMIA

Extracellular Vesicle-Associated Proteins in Tissue Repair

(2020) Marieke T. Roefs et al.   TRENDS IN CELL BIOLOGY

Modern isolation and separation techniques for extracellular vesicles

(2020) Thanaporn Liangsupree et al.   JOURNAL OF CHROMATOGRAPHY A

Engineering precision nanoparticles for drug delivery

(2020) Michael J. Mitchell et al.   NATURE REVIEWS DRUG DISCOVERY

Exosomes isolated from two different cell lines using three different isolation techniques show variation in physical and molecular characteristics

(2020) Manish Dash et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Improved loading of plasma derived-extracellular vesicles to encapsulate antitumor miRNAs

(2019) Margherita Alba Carlotta Pomatto et al.   Molecular Therapy-Methods & Clinical Development

Extracellular vesicles-mediated intercellular communication: roles in the tumor microenvironment and anti-cancer drug resistance

(2019) Selma Maacha et al.   Molecular Cancer

Development and comparative analysis of human urine exosome isolation strategies

(2019) Seongcheol Cho et al.   PROCESS BIOCHEMISTRY

Engineered extracellular vesicles with synthetic lipids via membrane fusion to establish efficient gene delivery

(2019) Yong-Yu Jhan et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Genetically Engineered Cell-Derived Nanoparticles for Targeted Breast Cancer Immunotherapy

(2019) Xiaojing Shi et al.   MOLECULAR THERAPY

Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation

(2019) Zhaogang Yang et al.   Nature Biomedical Engineering

Methotrexate-Loaded Extracellular Vesicles Functionalized with Therapeutic and Targeted Peptides for the Treatment of Glioblastoma Multiforme

(2018) Zhilan Ye et al.   ACS Applied Materials & Interfaces

Exosomes from Suxiao Jiuxin pill-treated cardiac mesenchymal stem cells decrease H3K27 demethylase UTX expression in mouse cardiomyocytes in vitro

(2018) Xiao-fen Ruan et al.   ACTA PHARMACOLOGICA SINICA

Suxiao Jiuxin pill promotes exosome secretion from mouse cardiac mesenchymal stem cells in vitro

(2018) Xiao-fen Ruan et al.   ACTA PHARMACOLOGICA SINICA

Surface functionalized exosomes as targeted drug delivery vehicles for cerebral ischemia therapy

(2018) Tian Tian et al.   BIOMATERIALS

NRP-1 targeted and cargo-loaded exosomes facilitate simultaneous imaging and therapy of glioma in vitro and in vivo

(2018) Gang Jia et al.   BIOMATERIALS

Engineered exosome-mediated delivery of functionally active miR-26a and its enhanced suppression effect in HepG2 cells

(2018) Gaofeng Liang et al.   International Journal of Nanomedicine

Shedding light on the cell biology of extracellular vesicles

(2018) Guillaume van Niel et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Anchor peptide captures, targets, and loads exosomes of diverse origins for diagnostics and therapy

(2018) Xianjun Gao et al.   Science Translational Medicine

Exosome-Liposome Hybrid Nanoparticles Deliver CRISPR/Cas9 System in MSCs

(2018) Yao Lin et al.   Advanced Science

Reprogramming Exosomes as Nanoscale Controllers of Cellular Immunity

(2018) Qinqin Cheng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Exosome–transmitted long non-coding RNA PTENP1 suppresses bladder cancer progression

(2018) Rui Zheng et al.   Molecular Cancer

3D Cellular Architecture Affects MicroRNA and Protein Cargo of Extracellular Vesicles

(2018) Sara Rocha et al.   Advanced Science

Tangential Flow Filtration for Highly Efficient Concentration of Extracellular Vesicles from Large Volumes of Fluid

(2018) Sara Busatto et al.   Cells

CD63-Mediated Antigen Delivery into Extracellular Vesicles via DNA Vaccination Results in Robust CD8+T Cell Responses

(2017) Tomohiro Kanuma et al.   JOURNAL OF IMMUNOLOGY

Extracellular vesicles as potential biomarkers of acute graft-vs-host disease

(2017) G Lia et al.   LEUKEMIA

Milk-derived exosomes for oral delivery of paclitaxel

(2017) Ashish K. Agrawal et al.   Nanomedicine-Nanotechnology Biology and Medicine

Higher functionality of extracellular vesicles isolated using size-exclusion chromatography compared to ultracentrifugation

(2017) Emma A. Mol et al.   Nanomedicine-Nanotechnology Biology and Medicine

Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer

(2017) Sushrut Kamerkar et al.   NATURE

Nanoparticle orientation to control RNA loading and ligand display on extracellular vesicles for cancer regression

(2017) Fengmei Pi et al.   Nature Nanotechnology

Isolation and characterization of urinary extracellular vesicles: implications for biomarker discovery

(2017) Michael L. Merchant et al.   Nature Reviews Nephrology

Neutral Sphingomyelinase-2 Deficiency Ameliorates Alzheimer's Disease Pathology and Improves Cognition in the 5XFAD Mouse

(2016) Michael B. Dinkins et al.   JOURNAL OF NEUROSCIENCE

Enrichment of extracellular vesicles from tissues of the central nervous system by PROSPR

(2016) Xavier Gallart-Palau et al.   Molecular Neurodegeneration

Engineering hybrid exosomes by membrane fusion with liposomes

(2016) Yuko T. Sato et al.   Scientific Reports

A novel affinity-based method for the isolation of highly purified extracellular vesicles

(2016) Wataru Nakai et al.   Scientific Reports

Efficient inhibition of infectious prions multiplication and release by targeting the exosomal pathway

(2015) Didier Vilette et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Exosomes as drug delivery vehicles for Parkinson's disease therapy

(2015) Matthew J. Haney et al.   JOURNAL OF CONTROLLED RELEASE

Using exosomes, naturally-equipped nanocarriers, for drug delivery

(2015) Elena V. Batrakova et al.   JOURNAL OF CONTROLLED RELEASE

Ultrafiltration with size-exclusion liquid chromatography for high yield isolation of extracellular vesicles preserving intact biophysical and functional properties

(2015) Joel Z. Nordin et al.   Nanomedicine-Nanotechnology Biology and Medicine

Surface Functionalization of Exosomes Using Click Chemistry

(2014) Tyson Smyth et al.   BIOCONJUGATE CHEMISTRY

Paclitaxel is incorporated by mesenchymal stromal cells and released in exosomes that inhibit in vitro tumor growth: A new approach for drug delivery

(2014) Luisa Pascucci et al.   JOURNAL OF CONTROLLED RELEASE

Bioinspired Exosome-Mimetic Nanovesicles for Targeted Delivery of Chemotherapeutics to Malignant Tumors

(2013) Su Chul Jang et al.   ACS Nano

Exosomes are natural carriers of exogenous siRNA to human cells in vitro

(2013) Tatyana A Shtam et al.   Cell Communication and Signaling

Extracellular vesicles: biology and emerging therapeutic opportunities

(2013) Samir EL Andaloussi et al.   NATURE REVIEWS DRUG DISCOVERY

The 2013 Nobel Prize in Physiology or Medicine

(2013) Annelie Hellvard et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Comparison of ultracentrifugation, density gradient separation, and immunoaffinity capture methods for isolating human colon cancer cell line LIM1863-derived exosomes

(2012) Bow J. Tauro et al.   METHODS

Plasma exosomes can deliver exogenous short interfering RNA to monocytes and lymphocytes

(2012) Jessica Wahlgren et al.   NUCLEIC ACIDS RESEARCH

Microvesicles and exosomes: Opportunities for cell-derived membrane vesicles in drug delivery

(2011) Susan M. van Dommelen et al.   JOURNAL OF CONTROLLED RELEASE

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

(2011) Lydia Alvarez-Erviti et al.   NATURE BIOTECHNOLOGY

A Novel Nanoparticle Drug Delivery System: The Anti-inflammatory Activity of Curcumin Is Enhanced When Encapsulated in Exosomes

(2010) Dongmei Sun et al.   MOLECULAR THERAPY

Microfluidic isolation and transcriptome analysis of serum microvesicles

(2009) Chihchen Chen et al.   LAB ON A CHIP