Senescent Schwann cells induced by aging and chronic denervation impair axonal regeneration following peripheral nerve injury

Disentangling glial diversity in peripheral nerves at single-nuclei resolution

(2022) Aldrin K. Y. Yim et al.   NATURE NEUROSCIENCE

Failures of nerve regeneration caused by aging or chronic denervation are rescued by restoring Schwann cell c-Jun

(2021) Laura J Wagstaff et al.   eLife

Cellular aging beyond cellular senescence: Markers of senescence prior to cell cycle arrest in vitro and in vivo

(2021) Mikolaj Ogrodnik   AGING CELL

Transcriptional profiling of mouse peripheral nerves to the single-cell level to build a sciatic nerve ATlas (SNAT)

(2021) Daniel Gerber et al.   eLife

Evolving Techniques in Peripheral Nerve Regeneration

(2021) Steven T. Lanier et al.   JOURNAL OF HAND SURGERY-AMERICAN VOLUME

Targeting senescent cells improves functional recovery after spinal cord injury

(2021) Diogo Paramos-de-Carvalho et al.   Cell Reports

Nerve Growth Factor Enhances Tooth Mechanical Hyperalgesia Through C-C Chemokine Ligand 19 in Rats

(2021) Rui Guo et al.   Frontiers in Neurology

Loss of lamin‐B1 and defective nuclear morphology are hallmarks of astrocyte senescence in vitro and in the aging human hippocampus

(2021) Isadora Matias et al.   AGING CELL

Robust temporal changes of cellular senescence and proliferation after sciatic nerve injury

(2021) Shi-Ying Li et al.   Neural Regeneration Research

A proteomic atlas of senescence-associated secretomes for aging biomarker development

(2020) Nathan Basisty et al.   PLOS BIOLOGY

Translating IL-6 biology into effective treatments

(2020) Ernest H. Choy et al.   Nature Reviews Rheumatology

Acute and long-term costs of 268 peripheral nerve injuries in the upper extremity

(2020) Konstantin D. Bergmeister et al.   PLoS One

CNTF-STAT3-IL-6 Axis Mediates Neuroinflammatory Cascade across Schwann Cell-Neuron-Microglia

(2020) Zhongsheng Hu et al.   Cell Reports

Senolytic drugs: from discovery to translation

(2020) J. L. Kirkland et al.   JOURNAL OF INTERNAL MEDICINE

Biological Properties of JNK3 and Its Function in Neurons, Astrocytes, Pancreatic β-Cells and Cardiovascular Cells

(2020) Rei Nakano et al.   Cells

Schwann Cell Cultures: Biology, Technology and Therapeutics

(2020) Paula V. Monje   Cells

Senescence in Wound Repair: Emerging Strategies to Target Chronic Healing Wounds

(2020) Holly N. Wilkinson et al.   Frontiers in Cell and Developmental Biology

Cholesterol Depletion Regulates Axonal Growth and Enhances Central and Peripheral Nerve Regeneration

(2019) Cristina Roselló-Busquets et al.   Frontiers in Cellular Neuroscience

The Success and Failure of the Schwann Cell Response to Nerve Injury

(2019) Kristjan R. Jessen et al.   Frontiers in Cellular Neuroscience

Inhibition of T cell immunoglobulin and mucin-1 (TIM-1) protects against cerebral ischemia-reperfusion injury

(2019) Yueying Zheng et al.   Cell Communication and Signaling

Cellular senescence in development, regeneration and disease

(2019) Muriel Rhinn et al.   DEVELOPMENT

CXCL1 and CXCL2 Inhibit the Axon Outgrowth in a Time- and Cell-Type-Dependent Manner in Adult Rat Dorsal Root Ganglia Neurons

(2019) Antonia Teona Deftu et al.   NEUROCHEMICAL RESEARCH

Cellular Senescence: Defining a Path Forward

(2019) Vassilis Gorgoulis et al.   CELL

Mechanisms and functions of cellular senescence

(2018) Nicolás Herranz et al.   JOURNAL OF CLINICAL INVESTIGATION

Hallmarks of Cellular Senescence

(2018) Alejandra Hernandez-Segura et al.   TRENDS IN CELL BIOLOGY

Paracrine cellular senescence exacerbates biliary injury and impairs regeneration

(2018) Sofia Ferreira-Gonzalez et al.   Nature Communications

Inflammaging impairs peripheral nerve maintenance and regeneration

(2018) Robert Büttner et al.   AGING CELL

Macrophages Regulate Schwann Cell Maturation after Nerve Injury

(2018) Jo Anne Stratton et al.   Cell Reports

Regulation of iNOS on Immune Cells and Its Role in Diseases

(2018) Qingjie Xue et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

After Nerve Injury, Lineage Tracing Shows That Myelin and Remak Schwann Cells Elongate Extensively and Branch to Form Repair Schwann Cells, Which Shorten Radically on Remyelination

(2017) Jose A. Gomez-Sanchez et al.   JOURNAL OF NEUROSCIENCE

Graded Elevation of c-Jun in Schwann CellsIn Vivo: Gene Dosage Determines Effects on Development, Remyelination, Tumorigenesis, and Hypomyelination

(2017) Shaline V. Fazal et al.   JOURNAL OF NEUROSCIENCE

Irreversible changes occurring in long-term denervated Schwann cells affect delayed nerve repair

(2017) Giulia Ronchi et al.   JOURNAL OF NEUROSURGERY

Gentle Introduction to the Statistical Foundations of False Discovery Rate in Quantitative Proteomics

(2017) Thomas Burger   JOURNAL OF PROTEOME RESEARCH

Optimization of Experimental Parameters in Data-Independent Mass Spectrometry Significantly Increases Depth and Reproducibility of Results

(2017) Roland Bruderer et al.   MOLECULAR & CELLULAR PROTEOMICS

Cellular senescence mediates fibrotic pulmonary disease

(2017) Marissa J. Schafer et al.   Nature Communications

Multi-laboratory assessment of reproducibility, qualitative and quantitative performance of SWATH-mass spectrometry

(2017) Ben C. Collins et al.   Nature Communications

Changes in the Coding and Non-coding Transcriptome and DNA Methylome that Define the Schwann Cell Repair Phenotype after Nerve Injury

(2017) Peter J. Arthur-Farraj et al.   Cell Reports

Methods Used to Evaluate Pain Behaviors in Rodents

(2017) Jennifer R. Deuis et al.   Frontiers in Molecular Neuroscience

Impaired regeneration in aged nerves: Clearing out the old to make way for the new

(2016) Jami Scheib et al.   EXPERIMENTAL NEUROLOGY

The repair Schwann cell and its function in regenerating nerves

(2016) K. R. Jessen et al.   JOURNAL OF PHYSIOLOGY-LONDON

An attenuated immune response by Schwann cells and macrophages inhibits nerve regeneration in aged rats

(2016) Jami L. Scheib et al.   NEUROBIOLOGY OF AGING

Axonal Growth Arrests After an Increased Accumulation of Schwann Cells Expressing Senescence Markers and Stromal Cells in Acellular Nerve Allografts

(2016) Louis H. Poppler et al.   TISSUE ENGINEERING PART A

Schwann cell autophagy, myelinophagy, initiates myelin clearance from injured nerves

(2015) Jose A. Gomez-Sanchez et al.   JOURNAL OF CELL BIOLOGY

Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

(2015) Jianhui Chang et al.   NATURE MEDICINE

Cellular senescence in aging and age-related disease: from mechanisms to therapy

(2015) Bennett G Childs et al.   NATURE MEDICINE

An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA

(2014) Marco Demaria et al.   DEVELOPMENTAL CELL

Novel Roles for Osteopontin and Clusterin in Peripheral Motor and Sensory Axon Regeneration

(2014) M. C. Wright et al.   JOURNAL OF NEUROSCIENCE

Cellular senescence: from physiology to pathology

(2014) Daniel Muñoz-Espín et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Diminished Schwann Cell Repair Responses Underlie Age-Associated Impaired Axonal Regeneration

(2014) Michio W. Painter et al.   NEURON

Epigenetic induction of the Ink4a/Arf locus prevents Schwann cell overproliferation during nerve regeneration and after tumorigenic challenge

(2013) Jose Antonio Gomez-Sanchez et al.   BRAIN

Limited regeneration in long acellular nerve allografts is associated with increased Schwann cell senescence

(2013) Maryam Saheb-Al-Zamani et al.   EXPERIMENTAL NEUROLOGY

Schwann cell-derived exosomes enhance axonal regeneration in the peripheral nervous system

(2013) María Alejandra Lopez-Verrilli et al.   GLIA

A complex secretory program orchestrated by the inflammasome controls paracrine senescence

(2013) Juan Carlos Acosta et al.   NATURE CELL BIOLOGY

c-Jun Reprograms Schwann Cells of Injured Nerves to Generate a Repair Cell Essential for Regeneration

(2012) Peter J. Arthur-Farraj et al.   NEURON

Regulatory Mechanisms of Tumor Suppressor P16INK4Aand Their Relevance to Cancer

(2011) Junan Li et al.   BIOCHEMISTRY

Four faces of cellular senescence

(2011) Francis Rodier et al.   JOURNAL OF CELL BIOLOGY

Accelerating axonal growth promotes motor recovery after peripheral nerve injury in mice

(2011) Chi Him Eddie Ma et al.   JOURNAL OF CLINICAL INVESTIGATION

Influence of aging on peripheral nerve function and regeneration

(2010) Enrique Verdú et al.   JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM

ROLE OF CHRONIC SCHWANN CELL DENERVATION IN POOR FUNCTIONAL RECOVERY AFTER NERVE INJURIES AND EXPERIMENTAL STRATEGIES TO COMBAT IT

(2009) Olawale A.R. Sulaiman et al.   NEUROSURGERY

The role of neurotrophic factors in nerve regeneration

(2009) Tessa Gordon   Neurosurgical Focus

Role of Mitogen-Activated Protein Kinase Cascades in Inducible Nitric Oxide Synthase Expression by Lipopolysaccharide in a Rat Schwann Cell Line

(2008) Haibo Wang et al.   NEUROCHEMICAL RESEARCH