Article
Radiology, Nuclear Medicine & Medical Imaging
Kanav Goyal, Purnima Aggarwal, Monica Gupta
Summary: This study compared the CSA of the sural and tibial nerves in diabetic peripheral neuropathy patients, finding that the CSA of the tibial nerve had higher sensitivity in the DPN group for screening purposes. Ultrasound can be used as the initial diagnostic tool for detecting DPN, especially in cases where nerve conduction studies are negative.
EUROPEAN JOURNAL OF RADIOLOGY
(2021)
Article
Multidisciplinary Sciences
D'Juan T. Farmer, Hana Mlcochova, Yan Zhou, Nils Koelling, Guanlin Wang, Neil Ashley, Helena Bugacov, Hung-Jhen Chen, Riana Parvez, Kuo-Chang Tseng, Amy E. Merrill, Robert E. Maxson, Andrew O. M. Wilkie, J. Gage Crump, Stephen R. F. Twigg
Summary: The authors utilized scRNA-seq and expression validation to uncover the cellular diversity within the murine embryonic coronal suture, shedding light on possible mechanisms for its loss in craniosynostosis.
NATURE COMMUNICATIONS
(2021)
Article
Immunology
Lina Tang, Tingting Li, Jing Xie, Yanping Huo
Summary: The study found that adipose tissue adjacent to breast cancer tissues differs significantly from adipose tissue adjacent to normal breast tissues. Breast cancer affects the function and gene expression of adipocytes and induces inflammatory responses. These findings may contribute to the diagnosis and treatment of breast cancer.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Neurosciences
Ruirui Zhang, Sailing Chen, Xinghui Wang, Xiaosong Gu, Sheng Yi
Summary: The study used high-coverage single-cell sequencing to reveal the cell diversity and heterogeneity of Schwann cells in the peripheral nerves of neonatal rats. A total of 10 cell types were identified in SN and DRG with distinct cell-cell communication patterns.
Review
Environmental Sciences
Wolfgang Grisold, Valentina Alda Carozzi
Summary: Toxic neuropathies are caused by various substances through different mechanisms, with a wide range of toxic agents that can affect the nervous system in different ways. Clinically, the most common type is cumulative toxicities, presenting as axonal symmetric neuropathies.
Article
Medicine, General & Internal
Glauber Voltan, Fred Bernards Filho, Marcel Nani Leite, Natalia Aparecida De Paula, Jaci Maria Santana, Claudia Maria Lincoln Silva, Josafa Goncalves Barreto, Moises Batista Da Silva, Guilherme Conde, Claudio Guedes Salgado, Marco Andrey Cipriani Frade
Summary: This study aimed to establish objective diagnostic criteria for Hansen's disease neuropathy through high-resolution ultrasound examination of peripheral nerves. The results showed that the asymmetry and focality of thickened nerves had higher sensitivity and specificity for early diagnosis compared to laboratory tests.
FRONTIERS IN MEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Milad R. Vahid, Erin L. Brown, Chloe B. Steen, Wubing Zhang, Hyun Soo Jeon, Minji Kang, Andrew J. Gentles, Aaron M. Newman
Summary: CytoSPACE is an optimization method that maps individual cells from a reference single-cell RNA sequencing atlas to spatial transcriptomics data, enabling tissue cartography at single-cell resolution with improved noise tolerance and accuracy.
NATURE BIOTECHNOLOGY
(2023)
Article
Anesthesiology
Graeme A. McLeod, Alistair Cowie, Amy Sadler, Fiona Watson, Paul Wasik, Miguel Angel Reina
Summary: Using 40 MHz ultrasound, the study aimed to accurately locate the needle tip and measure injection pressure in different tissue layers. Needle tip position was not discernible, but injection compartments in the circumneurium and subcircumneural were observed.
REGIONAL ANESTHESIA AND PAIN MEDICINE
(2023)
Article
Immunology
Lynn Nazareth, Heidi Walkden, Anu Chacko, Ali Delbaz, Todd Shelper, Charles W. Armitage, Ronak Reshamwala, Logan K. Trim, James A. St John, Kenneth W. Beagley, Jenny A. K. Ekberg
Summary: Chlamydia pneumoniae can infect the brain through olfactory nerve invasion, as demonstrated in mice within 48 h. Glial cells of olfactory and trigeminal nerves show differential responses to C. muridarum infection, potentially influencing the bacteria's ability to evade immune functions and invade nerves.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Multidisciplinary Sciences
Federico Abascal, Luke M. R. Harvey, Emily Mitchell, Andrew R. J. Lawson, Stefanie V. Lensing, Peter Ellis, Andrew J. C. Russell, Raul E. Alcantara, Adrian Baez-Ortega, Yichen Wang, Eugene Jing Kwa, Henry Lee-Six, Alex Cagan, Tim H. H. Coorens, Michael Spencer Chapman, Sigurgeir Olafsson, Steven Leonard, David Jones, Heather E. Machado, Megan Davies, Nina F. Obro, Krishnaa T. Mahubani, Kieren Allinson, Moritz Gerstung, Kourosh Saeb-Parsy, David G. Kent, Elisa Laurenti, Michael R. Stratton, Raheleh Rahbari, Peter J. Campbell, Robert J. Osborne, Inigo Martincorena
Summary: The study developed a method to detect mutations in single cells or small clones, revealing that somatic mutations also occur in non-dividing cells and contribute significantly to somatic mutagenesis.
Review
Cell Biology
Babukrishna Maniyadath, Qianbin Zhang, Rana K. Gupta, Susanne Mandrup
Summary: Adipose tissue is highly plastic and can change in size and cellular composition. Single-cell transcriptomics has revolutionized our understanding of the diverse cell types and states in adipose tissues and revealed the impact of transcriptional changes on tissue plasticity.
Editorial Material
Biochemistry & Molecular Biology
Pengyi Yang, Patrick P. L. Tam
Summary: In this study, Chen et al. developed a DNA nanoball-based sample-capture technology to generate a spatial transcriptome analysis of mouse organogenesis at single-cell resolution.
Review
Biochemistry & Molecular Biology
David Eisenbarth, Y. Alan Wang
Summary: Glioblastoma (GBM) is a highly deadly and treatment-resistant cancer due to its heterogeneity at both cellular and microenvironmental levels. The recent advancements in sequencing technologies have revealed the diversity of cell states in GBM, which hampers accurate classification and effective treatments for the disease. Moreover, GBM heterogeneity is influenced by both intrinsic factors and differs between new and recurrent cases, as well as treatment-naive and experienced patients. Understanding and unraveling the complex cellular network underlying GBM heterogeneity is essential for developing new strategies to combat this deadly disease.
Article
Physiology
Federica Mangione, Rocco D'Antuono, Nicolas Tapon
Summary: Tissues consist of diverse cell populations and it is challenging to dissect the contributions of different cell types. This study presents a method using near infrared femtosecond laser pulses for precise cell ablation without harming neighboring tissues. The technique allows monitoring of cellular behavior and morphological responses to cell loss with high resolution.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Ecology
Robert M. Bowers, Stephen Nayfach, Frederik Schulz, Sean P. Jungbluth, Ilona A. Ruhl, Andriy Sheremet, Janey Lee, Danielle Goudeau, Emiley A. Eloe-Fadrosh, Ramunas Stepanauskas, Rex R. Malmstrom, Nikos C. Kyrpides, Peter F. Dunfield, Tanja Woyke
Summary: Advancements in single-cell genomics have enabled rapid and affordable sequencing of microbial communities, providing a comprehensive snapshot of community composition and function. This approach also allows for the direct linkage of mobile elements to hosts and analysis of population heterogeneity among dominant community members.
Review
Clinical Neurology
Cindy V. Ly, Timothy M. Miller
CURRENT OPINION IN NEUROLOGY
(2018)
Article
Biochemistry & Molecular Biology
Chi-Kuang Yao, Yong Qi Lin, Cindy V. Ly, Tomoko Ohyama, Claire M. Haueter, Vera Y. Moiseenkova-Bell, Theodore G. Wensel, Hugo J. Bellen
Article
Biochemistry & Molecular Biology
G. Gregory Neely, Andreas Hess, Michael Costigan, Alex C. Keene, Spyros Goulas, Michiel Langeslag, Robert S. Griffin, Inna Belfer, Feng Dai, Shad B. Smith, Luda Diatchenko, Vaijayanti Gupta, Cui-Ping Xia, Sabina Amann, Silke Kreitz, Cornelia Heindl-Erdmann, Susanne Wolz, Cindy V. Ly, Suchir Arora, Rinku Sarangi, Debasis Dan, Maria Novatchkova, Mark Rosenzweig, Dustin G. Gibson, Darwin Truong, Daniel Schramek, Tamara Zoranovic, Shane J. F. Cronin, Belinda Angjeli, Kay Brune, Georg Dietzl, William Maixner, Arabella Meixner, Winston Thomas, J. Andrew Pospisilik, Mattias Alenius, Michaela Kress, Sai Subramaniam, Paul A. Garrity, Hugo J. Bellen, Clifford J. Woolf, Josef M. Penninger
Article
Cell Biology
Cindy V. Ly, Chi-Kuang Yao, Patrik Verstreken, Tomoko Ohyama, Hugo J. Bellen
JOURNAL OF CELL BIOLOGY
(2008)
Article
Neurosciences
Eliana Romero, Guang-Ho Cha, Patrik Verstreken, Cindy V. Ly, Robert E. Hughes, Hugo J. Bellen, Juan Botas
Article
Neurosciences
Patrik Verstreken, Tonnoko Ohyama, Claire Haueter, Ron L. P. Habets, Yong Q. Lin, Laura E. Swan, Cindy V. Ly, Koen J. T. Venken, Pietro De Camilli, Hugo J. Bellen
Article
Cell Biology
Nikolaos Giagtzoglou, Cindy V. Ly, Hugo J. Bellen
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY
(2009)
Article
Clinical Neurology
C. V. Ly, L. Koenig, J. Christensen, B. Gordon, H. Beaumont, S. Dahiya, J. Chen, Y. Su, B. Nelson, J. Jockel-Balsarotti, C. Drain, G. Jerome, J. C. Morris, A. M. Fagan, M. B. Harms, T. L. S. Benzinger, T. M. Miller, B. M. Ances
EUROPEAN JOURNAL OF NEUROLOGY
(2019)
Article
Clinical Neurology
Alan Pestronk, Namita Sinha, Ziad Alhumayyd, Cindy Ly, Robert Schmidt, Robert Bucelli
Article
Biology
Antonietta Franco, Xiawei Dang, Emily K. Walton, Joshua N. Ho, Barbara Zablocka, Cindy Ly, Timothy M. Miller, Robert H. Baloh, Michael E. Shy, Andrew S. Yoo, Gerald W. Dorn
Article
Biochemistry & Molecular Biology
Payam Mohassel, Sandra Donkervoort, Museer A. Lone, Matthew Nalls, Kenneth Gable, Sita D. Gupta, A. Reghan Foley, Ying Hu, Jonas Alex Morales Saute, Ana Lucila Moreira, Fernando Kok, Alessandro Introna, Giancarlo Logroscino, Christopher Grunseich, Alec R. Nickolls, Naemeh Pourshafie, Sarah B. Neuhaus, Dimah Saade, Andrea Gangfuss, Heike Koelbel, Zoe Piccus, Claire E. Le Pichon, Chiara Fiorillo, Cindy V. Ly, Ana Topf, Lauren Brady, Sabine Specht, Aliza Zidell, Helio Pedro, Eric Mittelmann, Florian P. Thomas, Katherine R. Chao, Chamindra G. Konersman, Megan T. Cho, Tracy Brandt, Volker Straub, Anne M. Connolly, Ulrike Schara, Andreas Roos, Mark Tarnopolsky, Ahmet Hoke, Robert H. Brown, Chia-Hsueh Lee, Thorsten Hornemann, Teresa M. Dunn, Carsten G. Bonnemann
Summary: This study identifies SPTLC1 variants causing excessive sphingolipid biosynthesis as a monogenic form of ALS. Disruption of normal SPT regulation by ORMDL proteins leads to uncontrolled SPT activity and elevated levels of canonical SPT products. Custom-designed small interfering RNAs that selectively target the SPTLC1 ALS allele for degradation offer a potential therapeutic approach to normalize sphingolipid levels.
Article
Clinical Neurology
Cindy V. Ly, Margaret D. Ireland, Wade K. Self, James Bollinger, Jennifer Jockel-Balsarotti, Hillary Herzog, Peggy Allred, Leah Miller, Michael Doyle, Isabel Anez-Bruzual, Bhavesh Trikamji, Ted Hyman, Tyler Kung, Katherine Nicholson, Robert C. Bucelli, Bruce W. Patterson, Randall J. Bateman, Timothy M. Miller
Summary: Using stable isotope labeling and mass spectrometry, this study showed that SOD1 mutations affect the kinetics and stability of SOD1 protein, but similar changes were not observed in sporadic ALS patients. These findings highlight the potential of stable isotope labeling and peptide deamidation to optimize the design of gene and molecular therapies for neurological disorders.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2023)
Article
Cell Biology
Tomoko Ohyama, Patrik Verstreken, Cindy V. Ly, Tanja Rosenmund, Akhila Rajan, An-Chi Tien, Claire Haueter, Karen L. Schulze, Hugo J. Bellen
JOURNAL OF CELL BIOLOGY
(2007)