Article
Gastroenterology & Hepatology
Hidenobu Kojima, Kentaro Kadono, Hirofumi Hirao, Kenneth J. Dery, Taylor Torgerson, Siyuan Yao, Fady M. Kaldas, Douglas G. Farmer, Richard S. Blumberg, Jerzy W. Kupiec-Weglinski
Summary: This study reveals the association between T cell-specific CC1 signaling and OLT injury, showing that promoting T cell-intrinsic TIM-3 through interaction with liver-associated CC1 can suppress NF-KB in Kupffer cells and alleviate OLT damage.
Article
Pharmacology & Pharmacy
Ran Zhang, Yun Liu, Wenhua Zhong, Zebo Hu, Chao Wu, Mengyao Ma, Yi Zhang, Xiangyun He, Lin Wang, Shu Li, Yun Hong
Summary: This study found that overexpression of SIK2 can alleviate neuronal damage and promote energy metabolism during cerebral ischemia-reperfusion, which is related to the regulation of the mTOR pathway and mitochondrial autophagy.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Dabao Yao, Shuo Zhang, Zhengwei Hu, Haiyang Luo, Chengyuan Mao, Yu Fan, Mibo Tang, Fen Liu, Si Shen, Liyuan Fan, Mengjie Li, Jingjing Shi, Jiadi Li, Dongrui Ma, Yuming Xu, Changhe Shi
Summary: The study showed that overexpression of CHIP may exert neuroprotective effects by attenuating necroptosis and inflammation during CIR injury.
Article
Medicine, Research & Experimental
Meixuan Chen, Shuo Wu, Bing Shen, Qingquan Fan, Ran Zhang, Yu Zhou, Pingping Zhang, Liecheng Wang, Lesha Zhang
Summary: Delta opioids have tissue-protective properties and may relieve ischemic injury through transactivation of EGFR. Pre-treatment with a delta opioid receptor agonist improved neurologic deficits and reduced infarct volume in a rat model of ischemic stroke, effects that were blocked by EGFR and MMP inhibitors. Activation of EGFR, Akt, and ERK1/2 and upregulation of EGFR expression by the delta opioid agonist were inhibited by AG1478 and GM6001, suggesting an essential role of MMP-mediated transactivation of EGFR in the neuroprotective effects of delta opioids.
Article
Biochemistry & Molecular Biology
Yamei Wang, Ting Feng, Hong Li, Ying Xiong, Yuhong Tao
Summary: CD4+ T cells play a crucial role in the pathogenesis of renal ischemia-reperfusion injury (IRI). The imbalance between Th17/ regulatory T cell (Treg) subsets has been suggested to be involved in the development of renal IRI. A recently discovered negative checkpoint protein, T cell immunoglobulin domain and mucin domain family 3 (Tim-3), inhibits the immune response through binding to its ligand, galectin-9 (Gal-9). However, the role of the Gal-9/Tim-3 signaling pathway in regulating CD4+ T cell subsets in renal IRI remains unclear. This study investigates the effect of the Gal-9/Tim-3 signaling pathway on Th17/Treg subsets in renal IRI using a mouse model.
MOLECULAR IMMUNOLOGY
(2023)
Article
Behavioral Sciences
Lichao Fan, Lichun Zhou
Summary: AG490 acts as a JAK antagonist showing both anti-apoptotic and neuroprotective effects in cerebral ischemia/reperfusion injury. It achieves the anti-apoptotic effect through regulating the JAK-STAT pathway and enhancing the expression of neurotrophins.
BRAIN AND BEHAVIOR
(2021)
Review
Oncology
Gerardo Cazzato, Eliano Cascardi, Anna Colagrande, Teresa Lettini, Alessandra Filosa, Francesca Arezzo, Carmelo Lupo, Nadia Casatta, Vera Loizzi, Cristina Pellegrini, Maria Concetta Fargnoli, Eugenio Maiorano, Gerolamo Cicco, Roberto Tamma, Giuseppe Ingravallo
Summary: T cell immunoglobulin and mucin domain 3 (TIM-3) is an inhibitory immunocheckpoint that has been investigated for its role in the tumour microenvironment of melanoma. This review provides the most up-to-date knowledge about TIM-3 in melanoma and discusses future prospects and potential applications.
Article
Microbiology
Xiaowei Zhang, Cuiqin Liang, Hanzhong Wang, Zhengyuan Guo, Heng Rong, Jingdi Pan, Wei Li, Rongjuan Pei, Xinwen Chen, Zhiping Zhang, Xian-En Zhang, Zongqiang Cui
Summary: The study identified T-cell immunoglobulin and mucin domain 1 (TIM-1) as a cellular entry factor for tick-borne encephalitis virus (TBEV), mediating virus uptake and cointernalization into cells. In mice, TIM-1 deficiency reduced viral burden and pathogenesis significantly. This finding provides a potential target for antiviral development against TBEV.
Article
Microbiology
Xiaowei Zhang, Cuiqin Liang, Hanzhong Wang, Zhengyuan Guo, Heng Rong, Jingdi Pan, Wei Li, Rongjuan Pei, Xinwen Chen, Zhiping Zhang, Xian-En Zhang, Zongqiang Cui
Summary: This study identified T-cell immunoglobulin and mucin domain 1 (TIM-1) as a cellular entry factor for tick-borne encephalitis virus (TBEV), mediating the uptake of TBEV into cells. TIM-1 deficiency significantly reduced viral burden and pathogenesis, highlighting its importance in TBEV infection. This discovery provides a potential target for antiviral intervention and improves understanding of virus infection.
Review
Immunology
Huihui Chen, Jie Zha, Runyan Tang, Guochun Chen
Summary: Research has shown that dysfunctional immune cells play a role in the development of autoimmune diseases. The T cell immunoglobulin and mucin domaincontaining protein 3 (TIM-3) is expressed on the surfaces of various immune cells and is involved in regulating important biological processes. Understanding the structure and signaling pathways of TIM-3 and its interactions with ligands can provide insights into the pathogenesis and potential treatment of autoimmune diseases.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Cell Biology
Jared Kirui, Yara Abidine, Annasara Lenman, Koushikul Islam, Yong-Dae Gwon, Lisa Lasswitz, Magnus Evander, Marta Bally, Gisa Gerold
Summary: Chikungunya virus (CHIKV) is a mosquito-transmitted RNA virus characterized by acute and chronic arthritis. The transmembrane proteins T-cell immunoglobulin and mucin domain 1 (TIM-1) and Axl receptor tyrosine kinase (Axl) play important roles in the entry of enveloped viruses such as CHIKV.
Article
Parasitology
Hongbing Xie, Zhidan Li, Guangmei Zheng, Chunyan Yang, Xianbing Liu, Xiaoyan Xu, Yushan Ren, Chao Wang, Xuemei Hu
Summary: The study showed that Toxoplasma gondii infection can significantly downregulate the expression of Tim-3 on dDCs, leading to aberrant expression of functional molecules, ultimately resulting in dDC dysfunction and abnormal pregnancy outcomes.
PARASITES & VECTORS
(2022)
Article
Neurosciences
Dazhuang Yi, Qunhui Wang, Yuhao Zhao, Yu Song, Hong You, Jian Wang, Renjie Liu, Zhongqiang Shi, Xuan Chen, Qi Luo
Summary: The study identified alterations in the m6A modification profile in cerebral ischemia-reperfusion injury model rats, leading to differential gene expression associated with inflammation and neuronal pathways. Among m6A regulators, FTO was specifically downregulated in neurons after MCAO/R, providing new insights into the mechanisms of cerebral ischemia-reperfusion injury.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Genetics & Heredity
Xia Liu, Miao Ren, Anqi Zhang, Changshun Huang, Junlu Wang
Summary: This study investigated the potential role of ciprofol in cerebral ischemia-reperfusion injury (CIRI) and found that it can alleviate neurological deficits and reduce damage through the Nrf2-xCT-GPX4 signaling pathway.
FUNCTIONAL & INTEGRATIVE GENOMICS
(2023)
Article
Environmental Sciences
Miao Chen, Limin Fan, Guoping Wu, Hairong Wang, Shuo Gu
Summary: This study investigated the role of EZH2 and H3K27me3 in cerebral ischemia-reperfusion injury using rat models and primary cortical neuron models. The expression levels of EZH2 and H3K27me3 were upregulated under oxygen-glucose deprivation conditions and further enhanced by GSK-J4, but reduced by EPZ-6438 and AKT inhibitor. Inhibition of EZH2 or AKT effectively counteracted cell apoptosis and reduced infarct size in vivo. These findings suggest that EZH2 inhibition protects against ischemic brain injury through modulation of the H3K27me3/PI3K/AKT/mTOR signaling pathway.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Ophthalmology
Jian Hu, Yueyue Li, Qian Li, Liqiang Wang, Yifei Huang
Summary: This retrospective study evaluated the effectiveness of tailored surgical treatment based on the mechanical balance principle in treating involutional entropion in the lower eyelid. It was found that the surgical plans were safe and effective, with no recurrence cases during the follow-up period.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Jie Wu, Tengyun Wu, Shuo Zheng, Yifei Huang, Liqiang Wang
Summary: Repeated low-dose exposure to DC on the ocular surface caused significant impairments on the structure and viability of the corneal epithelium by inhibiting epithelial proliferation and inducing apoptosis. This study provides a foundation for understanding the harmful effects of daily exposure to cleaning products on the ocular surface.
EXPERIMENTAL EYE RESEARCH
(2021)
Article
Ophthalmology
Jie Wu, Junyi Wang, Liqiang Wang, Yifei Huang
Summary: This study showed that retinoic acid can increase corneal stiffness by upregulating TG2 expression for crosslinking. Experimental and microscopic results confirmed that retinoic acid increased collagen density in the cornea and increased its elastic modulus.
EXPERIMENTAL EYE RESEARCH
(2022)
Letter
Ophthalmology
Liqiang Wang, Zongyuan Li, Tengyun Wu, Anqi Liu, Xiezhou He, Shuo Zheng, Tao Ye, Liyuan Rong, Yifei Huang
Article
Nanoscience & Nanotechnology
Anqi Liu, Chunjing Liang, Ji Liu, Yifei Huang, Ming Wang, Liqiang Wang
Summary: This study reports the design of a novel ROS-responsive lipid nanoparticle for enhanced RNAi in CNV treatment. The lipid nanoparticles efficiently deliver siRNA into cells and release siRNA in response to the upregulated ROS in CNV.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Integrative & Complementary Medicine
Yumei Zhou, Weiwei Xu, Anqi Liu, Ye Tao, Qun Wang, Yanfeng Yang, Liqiang Wang, Yifei Huang
Summary: Salvianolic acids (Sal A) have a protective effect on retinal degeneration (RD) by antioxidant and antiapoptotic mechanisms, as demonstrated in both in vivo and in vitro experiments.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Article
Ophthalmology
Qing-Hua Yang, Hong-Tao Zhang, Xiao-Qi Li, Bing Chen, Zhao-Hui Li, Yi-Fei Huang, Xin Jin, Ying Zhang, Li-Qiang Wang
Summary: The segmented measurement of axial length by immersion B-scan shows comparable accuracy with that of IOLMaster 500 in ultra-high myopia patients with severe cataract secondary to silicone oil filling, leading to ideal postoperative refractive outcomes.
INTERNATIONAL JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Liyuan Rong, Yan Fu, Qiyou Li, Xinji Yang, Yueyue Li, Liang Yan, Liqiang Wang, Wei Wu
Summary: In this study, the effect of surface charge of PEG-GO on ocular compatibility was comprehensively investigated through in vitro and in vivo studies. The results showed that the surface charge of PEG-GO had negligible effect on its ocular compatibility, except for the cellular uptake. These findings contribute to our understanding of the relationship between surface charge and biocompatibility of GO derivatives.
Article
Immunology
Min Zhang, Lingling Wu, Yiyao Deng, Fei Peng, Tiantian Wang, Yinghua Zhao, Pu Chen, Jiaona Liu, Guangyan Cai, Liqiang Wang, Jie Wu, Xiangmei Chen
Summary: Using single-cell RNA sequencing, the researchers systematically studied the cellular atlas of the microenvironment in acute kidney injury (AKI) and discovered the dynamics of immune cell infiltration during AKI progression. They identified new subtypes of proximal tubule cells (PTCs) and investigated the cellular interactions between PTC-S1-new and PTC-injured cells, as well as their interactions with infiltrating immune cells through the CXCL and TNF signaling pathways.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Clinical Neurology
Kaixiu Li, Qun Wang, Liqiang Wang, Yifei Huang
Summary: Visual impairment and cognitive impairment are related to high myopia, but the specific pathogenesis and neural structure damage are not well understood.
FRONTIERS IN NEUROLOGY
(2022)
Article
Medicine, General & Internal
Zhao Li, Qun Wang, Shi-Feng Zhang, Yi-Fei Huang, Li-Qiang Wang
Summary: The purpose of this study was to summarize and discuss the treatment and timing of glaucoma in patients with MICOF keratoprosthesis implantation. The data analysis showed that patients with preexisting glaucoma were more likely to undergo corneal transplants, while there was a difference in the efficacy between surgical and medical treatment in patients with de novo glaucoma.
FRONTIERS IN MEDICINE
(2022)
Article
Neurosciences
Kaixiu Li, Xiaoqi Li, Qun Wang, Liqiang Wang, Yifei Huang
Summary: This study compared the kinetic pupillary changes between high myopia and low/moderate myopia using Pentacam. The results showed that in certain scanning periods, the pupillary changes in high myopia patients were slower compared to low/moderate myopia patients.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Medicine, General & Internal
Zongyuan Li, Kunkun Yang, Yannan Zhou, Tengyun Wu, Hongtao Zhang, Qinghua Yang, Qun Wang, Yifei Huang, Liqiang Wang
Summary: KLAL-DALK is an effective option for restoring a stable ocular surface and rapidly improving visual acuity in patients with bilateral severe LSCD.
FRONTIERS IN MEDICINE
(2022)
Article
Ophthalmology
Zhicha Hu, Wenqin Xu, Xinji Yang, Yueyue Li, Rui Ma, Yan Hei, Jian Hu, Zifeng Zhang, Liqiang Wang, Yusheng Wang
Summary: Despite extensive research, the exact mechanism of retinopathy of prematurity (ROP) is still unclear. In this study, the role of Sirt2, involved in both angiogenesis and inflammation, was investigated in a ROP animal model. The study found that Sirt2 was overexpressed and co-located with microglia in the model. Additionally, the study demonstrated that Sirt2 levels were upregulated in hypoxic microglia BV-2 in vitro.
EXPERIMENTAL EYE RESEARCH
(2023)
Article
Medicine, General & Internal
Zhibang Zhao, Wenliang Fan, Liqiang Wang, Qingbo Chu
Summary: This study aimed to explore the association between lipids and the survival and walking ability of hip fractures in geriatric patients after surgery. Restricted cubic spline was used to establish the nonlinear relationship, and the patients were divided into low, middle, and high levels of LDL-c. The results showed that patients with middle levels of LDL-c had a significantly higher survival probability, and low and high levels of LDL-c were associated with poor prognosis in terms of mortality and free walking ability.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2023)