Review
Microbiology
Anil Pant, Lara Dsouza, Zhilong Yang
Summary: This article summarizes how viruses alter major cellular metabolic pathways to support their replication needs, emphasizing the utilization of cellular signaling cascades and the changes in cellular nutrition and metabolism during viral infections. Studying these changes enhances understanding of fundamental metabolic regulation processes and offers potential for combatting viral diseases, metabolic disorders, and cancer.
Article
Multidisciplinary Sciences
Srinivas Allanki, Boris Strilic, Lilly Scheinberger, Yeszamin L. Onderwater, Alora Marks, Stefan Guenther, Jens Preussner, Khrievono Kikhi, Mario Looso, Didier Y. R. Stainier, Sven Reischauer
Summary: Il-11/Stat3 signaling in zebrafish has a dual function of limiting fibrosis and promoting tissue regeneration. The research shows that Il-11 signaling can drive cellular reprogramming and antagonize scar formation in adult mammals. This reveals novel targets for regenerative therapies.
Review
Pharmacology & Pharmacy
Syeda Momna Ishtiaq, Muhammad Imran Arshad, Junaid Ali Khan
Summary: Liver cancer is a major cause of cancer-related deaths worldwide. Modulating immune check-points and the PPAR gamma signaling pathway are important therapeutic approaches for chronic liver disease-associated liver cancers. PPAR gamma plays a crucial role in balancing inflammatory and anti-inflammatory cytokines, as well as in the interaction between PPAR gamma, hepatic stellate cells, and the fibrogenic niche in hepatocarcinogenesis. PPAR gamma also has a significant impact on the pre-malignant microenvironment, promoting growth arrest, cell senescence, and cell clearance in liver cancer pathophysiology.
PHARMACOLOGY & THERAPEUTICS
(2022)
Review
Neurosciences
Chao Zhou, Wanyan Ni, Taiyang Zhu, Shuyu Dong, Ping Sun, Fang Hua
Summary: Alzheimer's disease is a common age-related dementia that currently has no cure. The underlying mechanisms of the disease, such as amyloid-beta deposition and tau hyperphosphorylation, are complex. Cellular reprogramming techniques offer a potential new approach for AD therapy by restoring functional neurons and integrating myelin.
FRONTIERS IN NEUROSCIENCE
(2022)
Review
Developmental Biology
Sydney Leaman, Nicolas Marichal, Benedikt Berninger
Summary: Cellular identity can be reprogrammed through gene regulatory networks, and recent research suggests that this reprogramming can mitigate disease phenotypes.
Article
Biology
Jack Greiner, Thomas Glonek
Summary: The lens and muscle tissues have high concentrations of ATP despite low metabolic requirements, suggesting a non-metabolic function of ATP in cellular and tissue function evolution.
Review
Oncology
Daniel J. Simpson, Nelly N. Olova, Tamir Chandra
Summary: Ageing is inevitable, but recent research has shown that slowing down and reversing the ageing process may be possible through induced pluripotent stem cells and epigenetic rejuvenation. Reprogramming-induced rejuvenation strategies offer promising candidates for safely reducing biological age.
CLINICAL EPIGENETICS
(2021)
Review
Biochemistry & Molecular Biology
Byung-Chul Oh
Summary: Intracellular calcium and phosphoinositides are vital for regulating cellular activities, and their interplay is linked to cancer, metabolic diseases, and insulin resistance. Dysregulation of PIP signaling in cancer cells can lead to membrane localization and activation of PIP-binding proteins. Excessive intracellular calcium levels negatively impact the membrane localization of PIP-binding proteins, contributing to insulin resistance and metabolic diseases.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2023)
Article
Plant Sciences
Sakiko Ishida, Hidemasa Suzuki, Aya Iwaki, Shogo Kawamura, Shohei Yamaoka, Mikiko Kojima, Yumiko Takebayashi, Katsushi Yamaguchi, Shuji Shigenobu, Hitoshi Sakakibara, Takayuki Kohchi, Ryuichi Nishihama
Summary: In this study, it was demonstrated that in the liverwort Marchantia polymorpha, the decrease in endogenous auxin level at the cut surface of decapitated explants induced the expression of a key transcription factor gene, MpLAXR. The expression of MpLAXR was able to overcome the inhibition of regeneration by exogenously applied auxin, and ectopic expression of MpLAXR promoted cell proliferation in normally quiescent tissues. These findings provide insights into stem cell regulation and apical dominance establishment in land plants.
PLANT AND CELL PHYSIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Ying Hua Su, Li Ping Tang, Xiang Yu Zhao, Xian Sheng Zhang
Summary: Plant cells have a strong capacity for reproduction, as a single plant cell can give rise to a whole plant via somatic embryogenesis without fertilization. Reprogramming somatic cells into totipotent cells is a critical step in somatic embryogenesis, inducible by stimuli such as plant hormones, transcriptional regulators and stress. Key molecular regulators and associated networks that control cell fate transition from somatic to totipotent cells are highlighted, with several outstanding questions proposed for further understanding of plant cell totipotency mechanisms.
JOURNAL OF INTEGRATIVE PLANT BIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Yun-Jian Yu, Jian-Hua Yan, Qi-Wen Chen, Ji-Yan Qiao, Si-Yuan Peng, Han Cheng, Meiwan Chen, Xian-Zheng Zhang
Summary: A cellular infectious microenvironment-activatable polymeric nano-system is designed for targeted intracellular drug delivery, macrophage reprogramming, and intracellular MRSA eradication. The nano-system is composed of a ferrocene-decorated polymeric nanovesicle with co-encapsulation of clofazimine and interferon-gamma. The system shows specific internalization by macrophages, triggers endosomal escape and on-site cytosolic drug delivery upon infection, reverses the immunosuppressive status of infected macrophages, and contributes to increased hydroxyl radical generation.
JOURNAL OF CONTROLLED RELEASE
(2023)
Editorial Material
Plant Sciences
Ralf Welsch, Alisher Touraev, Klaus Palme
Summary: The fertilized egg is the starting point for multicellular organism development, plant cells have the ability to regenerate, and the fate of regenerating tissues is regulated by plant hormones.
JOURNAL OF EXPERIMENTAL BOTANY
(2021)
Editorial Material
Biotechnology & Applied Microbiology
Joao Pedro de Magalhaes, Alejandro Ocampo
Summary: Cells can be rejuvenated and biological clocks reset through cellular reprogramming, and many companies are now developing therapies using this technique to rejuvenate human beings. However, the current research in rejuvenation is mostly based on in vitro studies, and it remains to be seen if it can be translated into clinical applications.
TRENDS IN BIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Veronika M. Shoba, Dhanushka N. P. Munkanatta Godage, Santosh K. Chaudhary, Arghya Deb, Sachini U. Siriwardena, Amit Choudhary
Summary: Phosphorylation-inducing chimeric small molecules (PHICS) can enable protein kinase C (PKC) to have new activities, such as inducing inhibitory neo-phosphorylations on a variant and phosphorylating cytosol-based neo-substrates. PKC with PHICS can also induce death of chronic myeloid leukemia cells. Synthetic chemistry has the power to expand the chemical and functional diversity of proteins in cells using bifunctional molecules.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Cell Biology
Jae-Hyun Yang, Christopher A. Petty, Thomas Dixon-McDougall, Maria Vina Lopez, Alexander Tyshkovskiy, Sun Maybury-Lewis, Xiao Tian, Nabilah Ibrahim, Zhili Chen, Patrick T. Griffin, Matthew Arnold, Jien Li, Oswaldo A. Martinez, Alexander Behn, Ryan Rogers-Hammond, Suzanne Angeli, Vadim N. Gladyshev, David A. Sinclair
Summary: A hallmark of eukaryotic aging is a loss of epigenetic information, a process that can be reversed. By ectopically inducing the Yamanaka factors OCT4, SOX2, and KLF4 (OSK) in mammals, we can restore youthful characteristics without changing cellular identity. Through high-throughput cell-based assays, we have identified six chemical cocktails that can reverse cellular aging and rejuvenate human cells without altering the genome.
Article
Veterinary Sciences
Rei Nakano, Kazuya Edamura, Tomohiro Nakayama, Kenji Teshima, Kazushi Asano, Takanori Narita, Ken Okabayashi, Hiroshi Sugiya
JOURNAL OF VETERINARY MEDICAL SCIENCE
(2015)
Article
Immunology
Hisashi Tsuchiya, Rei Nakano, Tadayoshi Konno, Ken Okabayashi, Takanori Narita, Hiroshi Sugiya
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY
(2015)
Article
Multidisciplinary Sciences
Taku Kitanaka, Rei Nakano, Nanako Kitanaka, Taro Kimura, Ken Okabayashi, Takanori Narita, Hiroshi Sugiya
SCIENTIFIC REPORTS
(2017)
Article
Multidisciplinary Sciences
Rei Nakano, Taku Kitanaka, Shinichi Namba, Nanako Kitanaka, Hiroshi Sugiya
SCIENTIFIC REPORTS
(2018)
Article
Veterinary Sciences
Kazuya Edamura, Takashi Kurosawa, Rei Nakano, Kenji Teshima, Kazushi Asano, Shigeo Tanaka
JOURNAL OF VETERINARY MEDICAL SCIENCE
(2012)
Article
Veterinary Sciences
Kazuya Edamura, Rei Nakano, Kyohei Fujimoto, Kenji Teshima, Kazushi Asano, Shigeo Tanaka
JOURNAL OF VETERINARY MEDICAL SCIENCE
(2014)
Article
Multidisciplinary Sciences
Rei Nakano, Kazuya Edamura, Tomohiro Nakayama, Takanori Narita, Ken Okabayashi, Hiroshi Sugiya
Article
Multidisciplinary Sciences
Tadayoshi Konno, Rei Nakano, Ryo Mamiya, Hisashi Tsuchiya, Taku Kitanaka, Shinichi Namba, Nanako Kitanaka, Ken Okabayashi, Takanori Narita, Hiroshi Sugiya
Article
Multidisciplinary Sciences
Shinichi Namba, Rei Nakano, Taku Kitanaka, Nanako Kitanaka, Tomohiro Nakayama, Hiroshi Sugiya
Article
Multidisciplinary Sciences
Rei Nakano, Taku Kitanaka, Shinichi Namba, Nanako Kitanaka, Masaki Sato, Yoshiyuki Shibukawa, Yoshikazu Masuhiro, Koichiro Kano, Taro Matsumoto, Hiroshi Sugiya
Article
Multidisciplinary Sciences
R. Yoshitake, K. Saeki, S. Eto, M. Shinada, R. Nakano, H. Sugiya, Y. Endo, N. Fujita, R. Nishimura, T. Nakagawa
SCIENTIFIC REPORTS
(2020)
Article
Immunology
Masashi Mizuno, Rei Nakano, Saki Nose, Moeka Matsumura, Yasuyuki Nii, Kentaro Kurogochi, Hiroshi Sugiya, Masami Uechi
Summary: In this study, it was found that interleukin 1 beta (IL-1 beta) induces the expression of interleukin 8 (IL-8) in canine cardiac fibroblasts through the activation of nuclear factor (NF)-kappa B p65.
FRONTIERS IN IMMUNOLOGY
(2022)
Correction
Multidisciplinary Sciences
Ryohei Yoshitake, Kohei Saeki, Shotaro Eto, Masahiro Shinada, Rei Nakano, Hiroshi Sugiya, Yoshifumi Endo, Naoki Fujita, Ryohei Nishimura, Takayuki Nakagawa
SCIENTIFIC REPORTS
(2020)
Article
Veterinary Sciences
Rei Nakano, Kazuya Edamura, Hiroshi Sugiya, Takanori Narita, Ken Okabayashi, Tadaaki Moritomo, Kenji Teshima, Kazushi Asano, Tomohiro Nakayama
AMERICAN JOURNAL OF VETERINARY RESEARCH
(2013)
