4.6 Review

Limb blastema formation: How much do we know at a genetic and epigenetic level?

Journal

JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 299, Issue 2, Pages -

Publisher

ELSEVIER
DOI: 10.1016/j.jbc.2022.102858

Keywords

-

Ask authors/readers for more resources

Regeneration of body parts is a remarkable ability found in many species, but its capacity varies across organisms. Urodeles, specifically salamanders, can completely regenerate limbs through blastema formation, a process involving undifferentiated progenitor cells that proliferate and rearrange to form internal tissues. Understanding limb blastema formation in salamanders can facilitate comparative studies with mammals and inspire therapeutic approaches in humans. This review focuses on the current knowledge about salamander limb blastema formation, exploring the potential role of epigenetic controls and highlighting research opportunities.
Regeneration of missing body parts is an incredible ability which is present in a wide number of species. However, this regenerative capability varies among different organisms. Urodeles (salamanders) are able to completely regenerate limbs after amputation through the essential process of blastema formation. The blastema is a collection of relatively undiffer-entiated progenitor cells that proliferate and repattern to form the internal tissues of a regenerated limb. Understanding blastema formation in salamanders may enable comparative studies with other animals, including mammals, with more limited regenerative abilities and may inspire future thera-peutic approaches in humans. This review focuses on the cur-rent state of knowledge about how limb blastemas form in salamanders, highlighting both the possible roles of epigenetic controls in this process as well as limitations to scientific un-derstanding that present opportunities for research.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.6
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

Article Biotechnology & Applied Microbiology

RNA-seq based transcriptomic map reveals new insights into mouse salivary gland development and maturation

Christian Gluck, Sangwon Min, Akinsola Oyelakin, Kirsten Smalley, Satrajit Sinha, Rose-Anne Romano

BMC GENOMICS (2016)

Article Biochemistry & Molecular Biology

ΔNp63 regulates IL-33 and IL-31 signaling in atopic dermatitis

J. M. Rizzo, A. Oyelakin, S. Min, K. Smalley, J. Bard, W. Luo, J. Nyquist, E. Guttman-Yassky, T. Yoshida, A. De Benedetto, L. A. Beck, S. Sinha, R-A Romano

CELL DEATH AND DIFFERENTIATION (2016)

Article Multidisciplinary Sciences

Functional characterization and genomic studies of a novel murine submandibular gland epithelial cell line

Sangwon Min, Eun-Ah Christine Song, Akinsola Oyelakin, Christian Gluck, Kirsten Smalley, Rose-Anne Romano

PLOS ONE (2018)

Article Biochemical Research Methods

Proteomic analysis of interactors for yeast protein arginine methyltransferase Hmt1 reveals novel substrate and insights into additional biological roles

Christopher A. Jackson, Neelu Yadav, Sangwon Min, Jun Li, Eric J. Milliman, Jun Qu, Yin-Chu Chen, Michael C. Yu

PROTEOMICS (2012)

Article Multidisciplinary Sciences

Genetic and scRNA-seq Analysis Reveals Distinct Cell Populations that Contribute to Salivary Gland Development and Maintenance

Eun-Ah Christine Song, Sangwon Min, Akinsola Oyelakin, Kirsten Smalley, Jonathan E. Bard, Lan Liao, Jianming Xu, Rose-Anne Romano

SCIENTIFIC REPORTS (2018)

Article Dentistry, Oral Surgery & Medicine

Transcriptomic and Single-Cell Analysis of the Murine Parotid Gland

A. Oyelakin, E. A. C. Song, S. Min, J. E. Bard, J. Kann, E. Horeth, K. Smalley, J. M. Kramer, S. Sinha, R. A. Romano

JOURNAL OF DENTAL RESEARCH (2019)

Article Multidisciplinary Sciences

p63 and Its Target Follistatin Maintain Salivary Gland Stem/Progenitor Cell Function through TGF-β/Activin Signaling

Sangwon Min, Akinsola Oyelakin, Christian Gluck, Jonathan E. Bard, Eun-Ah Christine Song, Kirsten Smalley, Monika Che, Elsa Flores, Satrajit Sinha, Rose-Anne Romano

ISCIENCE (2020)

Article Immunology

Transcriptomic and Network Analysis of Minor Salivary Glands of Patients With Primary Sjogren's Syndrome

Akinsola Oyelakin, Erich Horeth, Eun-Ah Christine Song, Sangwon Min, Monika Che, Brandon Marzullo, Christopher J. Lessard, Astrid Rasmussen, Lida Radfar, R. Hal Scofield, David M. Lewis, Donald U. Stone, Kiely Grundahl, Scott S. De Rossi, Zoya Kurago, A. Darise Farris, Kathy L. Sivils, Satrajit Sinha, Jill M. Kramer, Rose-Anne Romano

Summary: Primary Sjogren's syndrome is a systemic autoimmune disease primarily affecting women, leading to loss of saliva and tears. Currently, there is no effective cure due to limited understanding of disease etiology and pathology.

FRONTIERS IN IMMUNOLOGY (2021)

Article Dentistry, Oral Surgery & Medicine

A Global Vista of the Epigenomic State of the Mouse Submandibular Gland

C. Gluck, S. Min, A. Oyelakin, M. Che, E. Horeth, E. A. C. Song, J. Bard, N. Lamb, S. Sinha, R. A. Romano

Summary: This study identified critical enhancers and super-enhancers of the mouse submandibular salivary gland through chromatin immunoprecipitation sequencing experiments. Additionally, it uncovered transcription factors that are likely to play important roles in SMG biology.

JOURNAL OF DENTAL RESEARCH (2021)

Article Immunology

Transcriptomic and Single-Cell Analysis Reveals Regulatory Networks and Cellular Heterogeneity in Mouse Primary Sjogren's Syndrome Salivary Glands

Erich Horeth, Akinsola Oyelakin, Eun-Ah Christine Song, Monika Che, Jonathan Bard, Sangwon Min, Jeremy Kiripolsky, Jill M. Kramer, Satrajit Sinha, Rose-Anne Romano

Summary: Sjogren's Syndrome is a chronic autoimmune disease affecting salivary and lacrimal glands. RNA sequencing and single-cell RNA sequencing have revealed important pathways and regulatory networks in the pathobiology of SS, as well as the diversity in activated state of salivary gland epithelial cells.

FRONTIERS IN IMMUNOLOGY (2021)

Article Ophthalmology

Carbonic Anhydrase Inhibitors in Corneal Endothelial Transport

Thomas M. Malikowski, Jessica B. Bosch, Sangwon Min, Michael E. Duffey, Sangita P. Patel

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2014)

No Data Available