Journal
CELL METABOLISM
Volume 31, Issue 6, Pages 1052-1067Publisher
CELL PRESS
DOI: 10.1016/j.cmet.2020.04.022
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Funding
- Australian Research Council [DP150100206]
- National Health and Medical Research Council [GNT1120714]
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While metabolism was initially thought to play a passive role in cell biology by generating ATP to meet bio-energetic demands, recent studies have identified critical roles for metabolism in the generation of new biomass and provision of obligate substrates for the epigenetic modification of histones and DNA. This review details how metabolites generated through glycolysis and the tricarboxylic acid cycle are utilized by somatic stem cells to support cell proliferation and lineage commitment. Importantly, we also discuss the evolving hypothesis that histones can act as an energy reservoir during times of energy stress. Finally, we discuss how cells integrate both extrinsic metabolic cues and intrinsic metabolic machinery to regulate cell fate.
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