Central and peripheral mechanisms involved in the control of GnRH neuronal function by metabolic factors

Investigation of irisin's role in pubertal onset physiology in female rats

(2023) Esra Kutlu et al.   PEPTIDES

An update on peptide-based therapies for type 2 diabetes and obesity

(2023) Clifford J. Bailey et al.   PEPTIDES

Preconception weight loss improves fertility and maternal outcomes in obese mice

(2022) Natassia Rodrigo et al.   JOURNAL OF ENDOCRINOLOGY

Central and peripheral neuropeptide RFRP-3: A bridge linking reproduction, nutrition, and stress response

(2022) Padmasana Singh et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Connecting nutritional deprivation and pubertal inhibition via GRK2-mediated repression of kisspeptin actions in GnRH neurons

(2022) Cecilia Perdices-Lopez et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Liraglutide 3 mg on weight, body composition, and hormonal and metabolic parameters in women with obesity and polycystic ovary syndrome: a randomized placebo-controlled-phase 3 study

(2022) Karen E. Elkind-Hirsch et al.   FERTILITY AND STERILITY

IGF1 gene therapy in middle-aged female rats delays reproductive senescence through its effects on hypothalamic GnRH and kisspeptin neurons

(2022) Franco Juan Cruz Dolcetti et al.   Aging-US

The vital role of arcuate nociceptin/orphanin FQ neurones in mounting an oestradiol‐dependent adaptive response to negative energy balance via inhibition of nearby proopiomelanocortin neurones

(2022) Sarah Sayers et al.   JOURNAL OF PHYSIOLOGY-LONDON

Rapamycin treatment during development extends life span and health span of male mice and Daphnia magna

(2022) Anastasia V. Shindyapina et al.   Science Advances

The dendron and episodic neuropeptide release

(2021) Allan E. Herbison   JOURNAL OF NEUROENDOCRINOLOGY

Mouse Spexin: (II) Functional Role as a Satiety Factor inhibiting Food Intake by Regulatory Actions Within the Hypothalamus

(2021) Matthew K. H. Wong et al.   Frontiers in Endocrinology

MC3R links nutritional state to childhood growth and the timing of puberty

(2021) B. Y. H. Lam et al.   NATURE

Spexin: Its role, regulation, and therapeutic potential in the hypothalamus

(2021) Andy Tran et al.   PHARMACOLOGY & THERAPEUTICS

Obesity, polycystic ovary syndrome and infertility: a new avenue for GLP-1 receptor agonists

(2020) Hellas Cena et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

PNOCARC Neurons Promote Hyperphagia and Obesity upon High-Fat-Diet Feeding

(2020) Alexander Jais et al.   NEURON

Different dendritic domains of the GnRH neuron underlie the pulse and surge modes of GnRH secretion in female mice

(2020) Li Wang et al.   eLife

Long Chain Fatty Acids Differentially Regulate Sub-populations of Arcuate POMC and NPY Neurons

(2020) Natalie J. Michael et al.   NEUROSCIENCE

Time‐restricted feeding improves the reproductive function of female mice via liver fibroblast growth factor 21

(2020) Lun Hua et al.   Clinical and Translational Medicine

Insulin-like growth factor 1 (IGF-1) increases GABAergic neurotransmission to GnRH neurons via suppressing the retrograde tonic endocannabinoid signaling pathway in mice

(2020) Flora Balint et al.   NEUROENDOCRINOLOGY

Nociceptin/orphanin FQ neurons in the Arcuate Nucleus and Ventral Tegmental Area Act via Nociceptin Opioid Peptide Receptor Signaling to Inhibit Proopiomelanocortin and A10 Dopamine Neurons and Thereby Modulate Ingestion of Palatable Food

(2020) Jennifer Hernandez et al.   PHYSIOLOGY & BEHAVIOR

AMP-activated protein kinase (AMPK) signaling in GnRH neurons links energy status and reproduction

(2020) D. Franssen et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Nociceptin/orphanin FQ modulates energy homeostasis through inhibition of neurotransmission at VMN SF-1/ARC POMC synapses in a sex- and diet-dependent manner

(2019) Jennifer Hernandez et al.   Biology of Sex Differences

Irisin in the primate hypothalamus and its effect on GnRH in vitro

(2019) Fazal Wahab et al.   JOURNAL OF ENDOCRINOLOGY

Mechanistic target of rapamycin (mTOR) implicated in plasticity of the reproductive axis during social status transitions

(2019) Karen P. Maruska et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Activation of a classic hunger circuit slows luteinizing hormone pulsatility

(2019) Eulalia Coutinho et al.   NEUROENDOCRINOLOGY

Diabetes: a metabolic and reproductive disorder in women

(2019) Eleanor P Thong et al.   Lancet Diabetes & Endocrinology

Regulation of LH secretion by RFRP-3 – From the hypothalamus to the pituitary

(2018) Kai-Lun Hu et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Connecting metabolism and gonadal function: Novel central neuropeptide pathways involved in the metabolic control of puberty and fertility

(2018) M. Manfredi-Lozano et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Effects of N-carbamylglutamate and L-arginine on gonadotrophin-releasing hormone (GnRH) gene expression and secretion in GT1-7 cells

(2018) Y. Liu et al.   REPRODUCTION FERTILITY AND DEVELOPMENT

PACAP neurons in the ventral premammillary nucleus regulate reproductive function in the female mouse

(2018) Rachel A Ross et al.   eLife

Rapid sensing of l -leucine by human and murine hypothalamic neurons: Neurochemical and mechanistic insights

(2018) Nicholas Heeley et al.   Molecular Metabolism

Metabolic regulation of female puberty via hypothalamic AMPK–kisspeptin signaling

(2018) Juan Roa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SIRT1 mediates obesity- and nutrient-dependent perturbation of pubertal timing by epigenetically controlling Kiss1 expression

(2018) M. J. Vazquez et al.   Nature Communications

Obesity and female infertility: potential mediators of obesity's impact

(2017) Darcy E. Broughton et al.   FERTILITY AND STERILITY

AgRP to Kiss1 neuron signaling links nutritional state and fertility

(2017) Stephanie L. Padilla et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Systematic Morphometry of Catecholamine Nuclei in the Brainstem

(2017) Domenico Bucci et al.   Frontiers in Neuroanatomy

AMPKα2 in Kiss1 Neurons Is Required for Reproductive Adaptations to Acute Metabolic Challenges in Adult Female Mice

(2016) Marcio A. Torsoni et al.   ENDOCRINOLOGY

The management of anovulatory infertility in women with polycystic ovary syndrome: an analysis of the evidence to support the development of global WHO guidance

(2016) Adam H. Balen et al.   HUMAN REPRODUCTION UPDATE

Induction of Gnrh mRNA expression by the ω-3 polyunsaturated fatty acid docosahexaenoic acid and the saturated fatty acid palmitate in a GnRH-synthesizing neuronal cell model, mHypoA-GnRH/GFP

(2016) Dean Q. Tran et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Glucagon-Like Peptide-1 Excites Firing and Increases GABAergic Miniature Postsynaptic Currents (mPSCs) in Gonadotropin-Releasing Hormone (GnRH) Neurons of the Male Mice via Activation of Nitric Oxide (NO) and Suppression of Endocannabinoid Signaling Pathways

(2016) Imre Farkas et al.   Frontiers in Cellular Neuroscience

Fibroblast growth factor 21 has no direct role in regulating fertility in female mice

(2016) Garima Singhal et al.   Molecular Metabolism

Defining a novel leptin–melanocortin–kisspeptin pathway involved in the metabolic control of puberty

(2016) Maria Manfredi-Lozano et al.   Molecular Metabolism

European Consensus Statement on congenital hypogonadotropic hypogonadism—pathogenesis, diagnosis and treatment

(2015) Ulrich Boehm et al.   Nature Reviews Endocrinology

How Rainfall Variation Influences Reproductive Patterns of African Savanna Ungulates in an Equatorial Region Where Photoperiod Variation Is Absent

(2015) Joseph O. Ogutu et al.   PLoS One

Tissue-specific actions of the metabolic hormones FGF15/19 and FGF21

(2015) Bryn M. Owen et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Distribution and characterisation of Glucagon-like peptide-1 receptor expressing cells in the mouse brain

(2015) Simon C. Cork et al.   Molecular Metabolism

Insulin and Leptin Signaling Interact in the Mouse Kiss1 Neuron during the Peripubertal Period

(2015) Xiaoliang Qiu et al.   PLoS One

Physiological Roles of Gonadotropin-Inhibitory Hormone Signaling in the Control of Mammalian Reproductive Axis: Studies in the NPFF1 Receptor Null Mouse

(2014) Silvia León et al.   ENDOCRINOLOGY

Connecting metabolism and reproduction: Roles of central energy sensors and key molecular mediators

(2014) Juan Roa et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Delayed Puberty but Normal Fertility in Mice With Selective Deletion of Insulin Receptors FromKiss1Cells

(2013) Xiaoliang Qiu et al.   ENDOCRINOLOGY

FGF21 contributes to neuroendocrine control of female reproduction

(2013) Bryn M Owen et al.   NATURE MEDICINE

Dependence of fertility on kisspeptin–Gpr54 signaling at the GnRH neuron

(2013) Milen Kirilov et al.   Nature Communications

Direct Regulation of GnRH Neuron Excitability by Arcuate Nucleus POMC and NPY Neuron Neuropeptides in Female Mice

(2012) Juan Roa et al.   ENDOCRINOLOGY

RFamide-Related Peptide-3 Receptor Gene Expression in GnRH and Kisspeptin Neurons and GnRH-Dependent Mechanism of Action

(2012) Mohammed Z. Rizwan et al.   ENDOCRINOLOGY

Metabolic Actions of Insulin-Like Growth Factor-I in Normal Physiology and Diabetes

(2012) David R. Clemmons   ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA

Kisspeptins and Reproduction: Physiological Roles and Regulatory Mechanisms

(2012) Leonor Pinilla et al.   PHYSIOLOGICAL REVIEWS

Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity

(2012) D. W. Lamming et al.   SCIENCE

GRK2: multiple roles beyond G protein-coupled receptor desensitization

(2012) Tama Evron et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Gonadotropin-Releasing Hormone Neurons Extend Complex Highly Branched Dendritic Trees Outside the Blood-Brain Barrier

(2011) Michel K. Herde et al.   ENDOCRINOLOGY

Glucosensing by GnRH Neurons: Inhibition by Androgens and Involvement of AMP-Activated Protein Kinase

(2011) Alison V. Roland et al.   MOLECULAR ENDOCRINOLOGY

Regulation of gonadotropin-releasing hormone neurons by glucose

(2011) Alison V. Roland et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Characterization of the inhibitory roles of RFRP3, the mammalian ortholog of GnIH, in the control of gonadotropin secretion in the rat: in vivo and in vitro studies

(2010) R. Pineda et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Early metformin therapy to delay menarche and augment height in girls with precocious pubarche

(2010) Lourdes Ibáñez et al.   FERTILITY AND STERILITY

Divergent roles of growth factors in the GnRH regulation of puberty in mice

(2010) Sara A. DiVall et al.   JOURNAL OF CLINICAL INVESTIGATION

Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance

(2010) Miguel López et al.   NATURE MEDICINE

Characterization of Kiss1 neurons using transgenic mouse models

(2010) R.M. Cravo et al.   NEUROSCIENCE

The Mammalian Target of Rapamycin as Novel Central Regulator of Puberty Onset via Modulation of Hypothalamic Kiss1 System

(2009) J. Roa et al.   ENDOCRINOLOGY

Leptin Indirectly Regulates Gonadotropin-Releasing Hormone Neuronal Function

(2009) Janette H. Quennell et al.   ENDOCRINOLOGY

Alum Induces Innate Immune Responses through Macrophage and Mast Cell Sensors, But These Sensors Are Not Required for Alum to Act As an Adjuvant for Specific Immunity

(2009) A. S. McKee et al.   JOURNAL OF IMMUNOLOGY

Oleic Acid Directly Regulates POMC Neuron Excitability in the Hypothalamus

(2009) Young-Hwan Jo et al.   JOURNAL OF NEUROPHYSIOLOGY

Gonadotropin inhibitory hormone inhibits basal forebrain vGluT2-gonadotropin-releasing hormone neurons via a direct postsynaptic mechanism

(2009) Min Wu et al.   JOURNAL OF PHYSIOLOGY-LONDON

Regulation of GPR54 Signaling by GRK2 and β-Arrestin

(2009) Macarena Pampillo et al.   MOLECULAR ENDOCRINOLOGY

Sirolimus May Reduce Fertility in Male Renal Transplant Recipients

(2008) J. Zuber et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Rainfall influences on ungulate population abundance in the Mara-Serengeti ecosystem

(2008) J. O. Ogutu et al.   JOURNAL OF ANIMAL ECOLOGY

The Effect of AMP-Activated Kinase Activation on Gonadotrophin-Releasing Hormone Secretion in GT1-7 Cells and its Potential Role in Hypothalamic Regulation of the Oestrous Cyclicity in Rats

(2008) S. Coyral-Castel et al.   JOURNAL OF NEUROENDOCRINOLOGY

Norepinephrine Suppresses Gonadotropin-Releasing Hormone Neuron Excitability in the Adult Mouse

(2007) Seong-Kyu Han et al.   ENDOCRINOLOGY