IGF1 gene therapy in middle-aged female rats delays reproductive senescence through its effects on hypothalamic GnRH and kisspeptin neurons

IGF1 Gene Therapy Modifies Microglia in the Striatum of Senile Rats

(2019) Eugenia Falomir-Lockhart et al.   Frontiers in Aging Neuroscience

Kisspeptin and the control of emotions, mood and reproductive behaviour

(2018) Edouard Ga Mills et al.   JOURNAL OF ENDOCRINOLOGY

The role of kisspeptin neurons in reproduction and metabolism

(2018) Campbell J L Harter et al.   JOURNAL OF ENDOCRINOLOGY

Hypothalamic stem cells control ageing speed partly through exosomal miRNAs

(2017) Yalin Zhang et al.   NATURE

Age-related alterations in hypothalamic kisspeptin, neurokinin B, and dynorphin neurons and in pulsatile LH release in female and male rats

(2017) Yuyu Kunimura et al.   NEUROBIOLOGY OF AGING

Kisspeptin across the human lifespan:evidence from animal studies and beyond

(2016) Sophie A Clarke et al.   JOURNAL OF ENDOCRINOLOGY

Microglial M1/M2 polarization and metabolic states

(2015) Ruben Orihuela et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cognitive impairment and morphological changes in the dorsal hippocampus of very old female rats

(2015) G.R. Morel et al.   NEUROSCIENCE

Alternatively activated microglia and macrophages in the central nervous system

(2015) Rafael Franco et al.   PROGRESS IN NEUROBIOLOGY

Are Microglial Cells the Regulators of Lymphocyte Responses in the CNS?

(2015) Beatriz Almolda et al.   Frontiers in Cellular Neuroscience

Microglia are polarized to M1 type in high-anxiety inbred mice in response to lipopolysaccharide challenge

(2014) Zhilin Li et al.   BRAIN BEHAVIOR AND IMMUNITY

Hypothalamic Kiss1 and RFRP gene expressions are changed by a high dose of lipopolysaccharide in female rats

(2014) Takeshi Iwasa et al.   HORMONES AND BEHAVIOR

Neuroinflammation and M2 microglia: the good, the bad, and the inflamed

(2014) Jonathan D Cherry et al.   Journal of Neuroinflammation

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Hypothalamic IGF-I Gene Therapy Prolongs Estrous Cyclicity and Protects Ovarian Structure in Middle-Aged Female Rats

(2013) Silvia S. Rodríguez et al.   ENDOCRINOLOGY

Insulin-like growth factor 1 and 2 (IGF1, IGF2) expression in human microglia: differential regulation by inflammatory mediators

(2013) Hyeon-Sook Suh et al.   Journal of Neuroinflammation

Hypothalamic programming of systemic ageing involving IKK-β, NF-κB and GnRH

(2013) Guo Zhang et al.   NATURE

Aging-related changes in RP3V kisspeptin neurons predate the reduced activation of GnRH neurons during the early reproductive decline in female mice

(2013) Jing Zhang et al.   NEUROBIOLOGY OF AGING

Disruption of neurogenesis by hypothalamic inflammation in obesity or aging

(2013) Sudarshana Purkayastha et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

Insulin-like growth factor-I gene delivery to astrocytes reduces their inflammatory response to lipopolysaccharide

(2011) Maria J Bellini et al.   Journal of Neuroinflammation

Restorative effect of intracerebroventricular insulin-like growth factor-I gene therapy on motor performance in aging rats

(2011) F. Nishida et al.   NEUROSCIENCE

Acute inflammation reduces kisspeptin immunoreactivity at the arcuate nucleus and decreases responsiveness to kisspeptin independently of its anorectic effects

(2010) J. M. Castellano et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Minireview: Kisspeptin/Neurokinin B/Dynorphin (KNDy) Cells of the Arcuate Nucleus: A Central Node in the Control of Gonadotropin-Releasing Hormone Secretion

(2010) Michael N. Lehman et al.   ENDOCRINOLOGY

Kisspeptin Signaling in the Brain

(2009) Amy E. Oakley et al.   ENDOCRINE REVIEWS

Regulation of GPR54 Signaling by GRK2 and β-Arrestin

(2009) Macarena Pampillo et al.   MOLECULAR ENDOCRINOLOGY

The Multifaceted Profile of Activated Microglia

(2009) Marina A. Lynch   MOLECULAR NEUROBIOLOGY

The Female Rat Reproductive Cycle: A Practical Histological Guide to Staging

(2008) F. Russell Westwood   TOXICOLOGIC PATHOLOGY

Kisspeptins: a multifunctional peptide system with a role in reproduction, cancer and the cardiovascular system

(2007) E J Mead et al.   BRITISH JOURNAL OF PHARMACOLOGY