AMP-activated protein kinase (AMPK) signaling in GnRH neurons links energy status and reproduction

Hyperactive LH pulses and elevated kisspeptin and NKB gene expression in the arcuate nucleus of a PCOS mouse model

(2020) Lourdes A Esparza et al.   ENDOCRINOLOGY

Novel mechanisms for the metabolic control of puberty: implications for pubertal alterations in early-onset obesity and malnutrition

(2019) M J Vazquez et al.   JOURNAL OF ENDOCRINOLOGY

The Effects of Kisspeptin on β-cell Function, Serum Metabolites and Appetite in Humans

(2018) Chioma Izzi-Engbeaya et al.   DIABETES OBESITY & METABOLISM

Connecting metabolism and gonadal function: Novel central neuropeptide pathways involved in the metabolic control of puberty and fertility

(2018) M. Manfredi-Lozano et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Hindbrain 5′-Adenosine Monophosphate-activated Protein Kinase Mediates Short-term Food Deprivation Inhibition of the Gonadotropin-releasing Hormone–Luteinizing Hormone Axis: Role of Nitric Oxide

(2018) Manita Shakya et al.   NEUROSCIENCE

SF1-Specific AMPKα1 Deletion Protects Against Diet-Induced Obesity

(2018) Patricia Seoane-Collazo et al.   DIABETES

Neuroanatomical Framework of the Metabolic Control of Reproduction

(2018) Jennifer W. Hill et al.   PHYSIOLOGICAL REVIEWS

Metabolic regulation of female puberty via hypothalamic AMPK–kisspeptin signaling

(2018) Juan Roa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SIRT1 mediates obesity- and nutrient-dependent perturbation of pubertal timing by epigenetically controlling Kiss1 expression

(2018) M. J. Vazquez et al.   Nature Communications

Disentangling puberty: novel neuroendocrine pathways and mechanisms for the control of mammalian puberty

(2017) M S Avendaño et al.   HUMAN REPRODUCTION UPDATE

Prevalence of ‘obesity-associated gonadal dysfunction’ in severely obese men and women and its resolution after bariatric surgery: a systematic review and meta-analysis

(2017) Hector F. Escobar-Morreale et al.   HUMAN REPRODUCTION UPDATE

Definition of the hypothalamic GnRH pulse generator in mice

(2017) Jenny Clarkson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AMPKα2 in Kiss1 Neurons Is Required for Reproductive Adaptations to Acute Metabolic Challenges in Adult Female Mice

(2016) Marcio A. Torsoni et al.   ENDOCRINOLOGY

The management of anovulatory infertility in women with polycystic ovary syndrome: an analysis of the evidence to support the development of global WHO guidance

(2016) Adam H. Balen et al.   HUMAN REPRODUCTION UPDATE

A microRNA switch regulates the rise in hypothalamic GnRH production before puberty

(2016) Andrea Messina et al.   NATURE NEUROSCIENCE

Control of puberty onset and fertility by gonadotropin-releasing hormone neurons

(2016) Allan E. Herbison   Nature Reviews Endocrinology

Hypothalamic AMPK: a canonical regulator of whole-body energy balance

(2016) Miguel López et al.   Nature Reviews Endocrinology

Direct Actions of Kisspeptins on GnRH Neurons Permit Attainment of Fertility but are Insufficient to Fully Preserve Gonadotropic Axis Activity

(2016) Silvia León et al.   Scientific Reports

Pharmacological and Morphological Evidence of AMPK-Mediated Energy Sensing in the Lower Brain Stem Ependymocytes to Control Reproduction in Female Rodents

(2015) Shiori Minabe et al.   ENDOCRINOLOGY

Developmental variations in environmental influences including endocrine disruptors on pubertal timing and neuroendocrine control: Revision of human observations and mechanistic insight from rodents

(2015) Anne-Simone Parent et al.   FRONTIERS IN NEUROENDOCRINOLOGY

60 YEARS OF NEUROENDOCRINOLOGY: MEMOIR: Harris' neuroendocrine revolution: of portal vessels and self-priming

(2015) George Fink   JOURNAL OF ENDOCRINOLOGY

AMPK: a master energy regulator for gonadal function

(2015) Michael J. Bertoldo et al.   Frontiers in Neuroscience

Estradiol Regulates Brown Adipose Tissue Thermogenesis via Hypothalamic AMPK

(2014) Pablo B. Martínez de Morentin et al.   Cell Metabolism

Metformin: From Mechanisms of Action to Therapies

(2014) Marc Foretz et al.   Cell Metabolism

Physiological Roles of Gonadotropin-Inhibitory Hormone Signaling in the Control of Mammalian Reproductive Axis: Studies in the NPFF1 Receptor Null Mouse

(2014) Silvia León et al.   ENDOCRINOLOGY

Evidence that Insulin Signalling in Gonadotrophin-Releasing Hormone and Kisspeptin Neurones does not Play an Essential Role in Metabolic Regulation of Fertility in Mice

(2014) M. C. Evans et al.   JOURNAL OF NEUROENDOCRINOLOGY

Connecting metabolism and reproduction: Roles of central energy sensors and key molecular mediators

(2014) Juan Roa et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Optogenetic activation of GnRH neurons reveals minimal requirements for pulsatile luteinizing hormone secretion

(2014) Pauline Campos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Development of a Methodology for and Assessment of Pulsatile Luteinizing Hormone Secretion in Juvenile and Adult Male Mice

(2013) F. J. Steyn et al.   ENDOCRINOLOGY

Dependence of fertility on kisspeptin–Gpr54 signaling at the GnRH neuron

(2013) Milen Kirilov et al.   Nature Communications

BMP8B Increases Brown Adipose Tissue Thermogenesis through Both Central and Peripheral Actions

(2012) Andrew J. Whittle et al.   CELL

Adiponectin inhibits KISS1 gene transcription through AMPK and specificity protein-1 in the hypothalamic GT1-7 neurons

(2012) Jun-Ping Wen et al.   JOURNAL OF ENDOCRINOLOGY

Role of Neurokinin B in the Control of Female Puberty and Its Modulation by Metabolic Status

(2012) V. M. Navarro et al.   JOURNAL OF NEUROSCIENCE

Kisspeptins and Reproduction: Physiological Roles and Regulatory Mechanisms

(2012) Leonor Pinilla et al.   PHYSIOLOGICAL REVIEWS

Kisspeptin Signaling Is Indispensable for Neurokinin B, but not Glutamate, Stimulation of Gonadotropin Secretion in Mice

(2011) David García-Galiano et al.   ENDOCRINOLOGY

Glucosensing by GnRH Neurons: Inhibition by Androgens and Involvement of AMP-Activated Protein Kinase

(2011) Alison V. Roland et al.   MOLECULAR ENDOCRINOLOGY

Neuroendocrine control by kisspeptins: role in metabolic regulation of fertility

(2011) Victor M. Navarro et al.   Nature Reviews Endocrinology

Early metformin therapy to delay menarche and augment height in girls with precocious pubarche

(2010) Lourdes Ibáñez et al.   FERTILITY AND STERILITY

Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells

(2010) Daisuke Nakada et al.   NATURE

The Mammalian Target of Rapamycin as Novel Central Regulator of Puberty Onset via Modulation of Hypothalamic Kiss1 System

(2009) J. Roa et al.   ENDOCRINOLOGY

Leptin Indirectly Regulates Gonadotropin-Releasing Hormone Neuronal Function

(2009) Janette H. Quennell et al.   ENDOCRINOLOGY

Regulation of Gonadotropin-Releasing Hormone Secretion by Kisspeptin/Dynorphin/Neurokinin B Neurons in the Arcuate Nucleus of the Mouse

(2009) V. M. Navarro et al.   JOURNAL OF NEUROSCIENCE

The Effect of AMP-Activated Kinase Activation on Gonadotrophin-Releasing Hormone Secretion in GT1-7 Cells and its Potential Role in Hypothalamic Regulation of the Oestrous Cyclicity in Rats

(2008) S. Coyral-Castel et al.   JOURNAL OF NEUROENDOCRINOLOGY