Insulin and Leptin Signaling Interact in the Mouse Kiss1 Neuron during the Peripubertal Period

Estradiol modulates Kiss1 neuronal response to ghrelin

(2014) Renata Frazao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Glucagon Regulates Hepatic Kisspeptin to Impair Insulin Secretion

(2014) Woo-Jin Song et al.   Cell Metabolism

Insulin Excites Anorexigenic Proopiomelanocortin Neurons via Activation of Canonical Transient Receptor Potential Channels

(2014) Jian Qiu et al.   Cell Metabolism

Obesity-Induced Hypogonadism in the Male: Premature Reproductive Neuroendocrine Senescence and Contribution of Kiss1-Mediated Mechanisms

(2014) Miguel Angel Sánchez-Garrido et al.   ENDOCRINOLOGY

Impaired kisspeptin signaling decreases metabolism and promotes glucose intolerance and obesity

(2014) Kristen P. Tolson et al.   JOURNAL OF CLINICAL INVESTIGATION

Evidence that Insulin Signalling in Gonadotrophin-Releasing Hormone and Kisspeptin Neurones does not Play an Essential Role in Metabolic Regulation of Fertility in Mice

(2014) M. C. Evans et al.   JOURNAL OF NEUROENDOCRINOLOGY

LIM-Homeodomain Transcription Factor Isl-1 Mediates Kisspeptin's Effect on Insulin Secretion in Mice

(2014) Juan Chen et al.   MOLECULAR ENDOCRINOLOGY

Kisspeptin inhibits a slow afterhyperpolarization current via protein kinase C and reduces spike frequency adaptation in GnRH neurons

(2013) Chunguang Zhang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Molecular mechanisms that drive estradiol-dependent burst firing of Kiss1 neurons in the rostral periventricular preoptic area

(2013) Chunguang Zhang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Leptin Engages a Hypothalamic Neurocircuitry to Permit Survival in the Absence of Insulin

(2013) Teppei Fujikawa et al.   Cell Metabolism

Obesity-Induced Infertility and Hyperandrogenism Are Corrected by Deletion of the Insulin Receptor in the Ovarian Theca Cell

(2013) S. Wu et al.   DIABETES

Delayed Puberty but Normal Fertility in Mice With Selective Deletion of Insulin Receptors FromKiss1Cells

(2013) Xiaoliang Qiu et al.   ENDOCRINOLOGY

Estrous Cycle Plasticity in the Hyperpolarization-Activated Current Ih Is Mediated by Circulating 17 -Estradiol in Preoptic Area Kisspeptin Neurons

(2013) R. Piet et al.   JOURNAL OF NEUROSCIENCE

Cellular Insulin Resistance Disrupts Leptin-Mediated Control of Neuronal Signaling and Transcription

(2013) Anaies Nazarians-Armavil et al.   MOLECULAR ENDOCRINOLOGY

Epigenetic control of female puberty

(2013) Alejandro Lomniczi et al.   NATURE NEUROSCIENCE

Leptin Signaling in Kiss1 Neurons Arises after Pubertal Development

(2013) Roberta M. Cravo et al.   PLoS One

Arcuate Kisspeptin/Neurokinin B/Dynorphin (KNDy) Neurons Mediate the Estrogen Suppression of Gonadotropin Secretion and Body Weight

(2012) Melinda A. Mittelman-Smith et al.   ENDOCRINOLOGY

Adiposity and sex hormones across the menstrual cycle: the BioCycle Study

(2012) E H Yeung et al.   INTERNATIONAL JOURNAL OF OBESITY

Direct leptin action on POMC neurons regulates glucose homeostasis and hepatic insulin sensitivity in mice

(2012) Eric D. Berglund et al.   JOURNAL OF CLINICAL INVESTIGATION

Distinct Roles for Specific Leptin Receptor Signals in the Development of Hypothalamic Feeding Circuits

(2012) S. G. Bouret et al.   JOURNAL OF NEUROSCIENCE

The complex interaction between obesity, metabolic syndrome and reproductive axis: A narrative review

(2012) Konstantinos Michalakis et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

InactivatingKISS1Mutation and Hypogonadotropic Hypogonadism

(2012) A. Kemal Topaloglu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Hypogonadotropic Hypogonadism in Morbidly Obese Males Is Reversed After Bariatric Surgery

(2012) Silvia Pellitero et al.   OBESITY SURGERY

Molecular Mapping of the Neural Pathways Linking Leptin to the Neuroendocrine Reproductive Axis

(2011) Gwendolyn W. Louis et al.   ENDOCRINOLOGY

Maternal Diabetes Compromises the Organization of Hypothalamic Feeding Circuits and Impairs Leptin Sensitivity in Offspring

(2011) Sophie M. Steculorum et al.   ENDOCRINOLOGY

Molecular Properties of Kiss1 Neurons in the Arcuate Nucleus of the Mouse

(2011) Michelle L. Gottsch et al.   ENDOCRINOLOGY

Leptin Deficiency and Diet-Induced Obesity Reduce Hypothalamic Kisspeptin Expression in Mice

(2011) Janette H. Quennell et al.   ENDOCRINOLOGY

Update: Hypogonadotropic Hypogonadism in Type 2 Diabetes and Obesity

(2011) Paresh Dandona et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Kisspeptin expression in guinea pig hypothalamus: Effects of 17β-estradiol

(2011) Martha A. Bosch et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Rescue of Obesity-Induced Infertility in Female Mice due to a Pituitary-Specific Knockout of the Insulin Receptor

(2010) Kathryn J. Brothers et al.   Cell Metabolism

Direct Insulin and Leptin Action on Pro-opiomelanocortin Neurons Is Required for Normal Glucose Homeostasis and Fertility

(2010) Jennifer W. Hill et al.   Cell Metabolism

Functional Hypothalamic Amenorrhea Due to Increased CRH Tone inMelanocortin Receptor 2-Deficient Mice

(2010) Takashi Matsuwaki et al.   ENDOCRINOLOGY

Kisspeptin Cells in the Ewe Brain Respond to Leptin and Communicate with Neuropeptide Y and Proopiomelanocortin Cells

(2010) Kathryn Backholer et al.   ENDOCRINOLOGY

Disruption of hypothalamic leptin signaling in mice leads to early-onset obesity, but physiological adaptations in mature animals stabilize adiposity levels

(2010) Laurence E. Ring et al.   JOURNAL OF CLINICAL INVESTIGATION

Leptin’s effect on puberty in mice is relayed by the ventral premammillary nucleus and does not require signaling in Kiss1 neurons

(2010) Jose Donato et al.   JOURNAL OF CLINICAL INVESTIGATION

Frequency-Dependent Release of Substance P Mediates Heterosynaptic Potentiation of Glutamatergic Synaptic Responses in the Rat Visual Thalamus

(2010) Sean P. Masterson et al.   JOURNAL OF NEUROPHYSIOLOGY

Kisspeptin Directly Excites Anorexigenic Proopiomelanocortin Neurons but Inhibits Orexigenic Neuropeptide Y Cells by an Indirect Synaptic Mechanism

(2010) L.-Y. Fu et al.   JOURNAL OF NEUROSCIENCE

Segregation of Acute Leptin and Insulin Effects in Distinct Populations of Arcuate Proopiomelanocortin Neurons

(2010) K. W. Williams et al.   JOURNAL OF NEUROSCIENCE

Leptin Rapidly Improves Glucose Homeostasis in Obese Mice by Increasing Hypothalamic Insulin Sensitivity

(2010) C. Koch et al.   JOURNAL OF NEUROSCIENCE

Hypothesis: Kisspeptin Mediates Male Hypogonadism in Obesity and Type 2 Diabetes

(2010) Jyothis T. George et al.   NEUROENDOCRINOLOGY

Hypothalamic Sites of Leptin Action Linking Metabolism and Reproduction

(2010) José Donato et al.   NEUROENDOCRINOLOGY

Characterization of Kiss1 neurons using transgenic mouse models

(2010) R.M. Cravo et al.   NEUROSCIENCE

Dominant Role of the p110β Isoform of PI3K over p110α in Energy Homeostasis Regulation by POMC and AgRP Neurons

(2009) Hind Al-Qassab et al.   Cell Metabolism

Insulin Signaling in α Cells Modulates Glucagon Secretion In Vivo

(2009) Dan Kawamori et al.   Cell Metabolism

Phosphatidyl Inositol 3-Kinase Signaling in Hypothalamic Proopiomelanocortin Neurons Contributes to the Regulation of Glucose Homeostasis

(2009) Jennifer W. Hill et al.   ENDOCRINOLOGY

The Mammalian Target of Rapamycin as Novel Central Regulator of Puberty Onset via Modulation of Hypothalamic Kiss1 System

(2009) J. Roa et al.   ENDOCRINOLOGY

Leptin Indirectly Regulates Gonadotropin-Releasing Hormone Neuronal Function

(2009) Janette H. Quennell et al.   ENDOCRINOLOGY

Regulation of Food Intake and Gonadotropin-Releasing Hormone/Luteinizing Hormone during Lactation: Role of Insulin and Leptin

(2009) Jing Xu et al.   ENDOCRINOLOGY

Lifelong Enhanced Diabetes Susceptibility and Obesity after Temporary Intrahypothalamic Hyperinsulinism during Brain Organization

(2009) A. Plagemann et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

Distribution of leptin-sensitive cells in the postnatal and adult mouse brain

(2009) Emilie Caron et al.   JOURNAL OF COMPARATIVE NEUROLOGY

17 -Estradiol Regulation of T-Type Calcium Channels in Gonadotropin-Releasing Hormone Neurons

(2009) C. Zhang et al.   JOURNAL OF NEUROSCIENCE

Metabolic control of puberty onset: New players, new mechanisms

(2009) Juan Roa et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Melanocortins Mimic the Effects of Leptin to Restore Reproductive Function in Lean Hypogonadotropic Ewes

(2009) Kathryn Backholer et al.   NEUROENDOCRINOLOGY

Effects of ghrelin on Kisspeptin mRNA expression in the hypothalamic medial preoptic area and pulsatile luteinising hormone secretion in the female rat

(2009) Sarah Forbes et al.   NEUROSCIENCE LETTERS

Hypothalamic IKKβ/NF-κB and ER Stress Link Overnutrition to Energy Imbalance and Obesity

(2008) Xiaoqing Zhang et al.   CELL

Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice

(2008) Jennifer W. Hill et al.   JOURNAL OF CLINICAL INVESTIGATION

The Creb1 coactivator Crtc1 is required for energy balance and fertility

(2008) Judith Y Altarejos et al.   NATURE MEDICINE

Ghrelin as a pleotrophic modulator of gonadal function and reproduction

(2008) Manuel Tena-Sempere   Nature clinical practice. Endocrinology & metabolism

KiSS-1 mRNA in adipose tissue is regulated by sex hormones and food intake

(2007) R.E. Brown et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY