Connecting nutritional deprivation and pubertal inhibition via GRK2-mediated repression of kisspeptin actions in GnRH neurons

AMP-activated protein kinase (AMPK) signaling in GnRH neurons links energy status and reproduction

(2020) D. Franssen et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

GPCR Signaling Regulation: The Role of GRKs and Arrestins

(2019) Vsevolod V. Gurevich et al.   Frontiers in Pharmacology

G Protein-Coupled Receptor Kinase 2 (GRK2) as a Potential Therapeutic Target in Cardiovascular and Metabolic Diseases

(2019) Cristina Murga et al.   Frontiers in Pharmacology

Antidiabetic and Cardioprotective Effects of Pharmacological Inhibition of GRK2 in db/db Mice

(2019) Ersilia Cipolletta et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Novel mechanisms for the metabolic control of puberty: implications for pubertal alterations in early-onset obesity and malnutrition

(2019) M J Vazquez et al.   JOURNAL OF ENDOCRINOLOGY

The Versatile Tanycyte: A Hypothalamic Integrator of Reproduction and Energy Metabolism

(2018) Vincent Prevot et al.   ENDOCRINE REVIEWS

Gonadotropin regulation by pulsatile GnRH: Signaling and gene expression

(2018) George A. Stamatiades et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Body mass index at the presentation of premature adrenarche is associated with components of metabolic syndrome at puberty

(2018) Gamze Kaya et al.   EUROPEAN JOURNAL OF PEDIATRICS

Metabolic regulation of female puberty via hypothalamic AMPK–kisspeptin signaling

(2018) Juan Roa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SIRT1 mediates obesity- and nutrient-dependent perturbation of pubertal timing by epigenetically controlling Kiss1 expression

(2018) M. J. Vazquez et al.   Nature Communications

Polycystic ovary syndrome: Understanding the role of the brain

(2017) Aleisha M. Moore et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Disentangling puberty: novel neuroendocrine pathways and mechanisms for the control of mammalian puberty

(2017) M S Avendaño et al.   HUMAN REPRODUCTION UPDATE

Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk

(2017) Felix R Day et al.   NATURE GENETICS

Association between Obesity and Puberty Timing: A Systematic Review and Meta-Analysis

(2017) Wenyan Li et al.   International Journal of Environmental Research and Public Health

Development and validation of a method for precise dating of female puberty in laboratory rodents: The puberty ovarian maturation score (Pub-Score)

(2017) Francisco Gaytan et al.   Scientific Reports

A microRNA switch regulates the rise in hypothalamic GnRH production before puberty

(2016) Andrea Messina et al.   NATURE NEUROSCIENCE

Control of puberty onset and fertility by gonadotropin-releasing hormone neurons

(2016) Allan E. Herbison   Nature Reviews Endocrinology

Feedback regulation of G protein-coupled receptor signaling by GRKs and arrestins

(2016) Joseph B. Black et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Direct Actions of Kisspeptins on GnRH Neurons Permit Attainment of Fertility but are Insufficient to Fully Preserve Gonadotropic Axis Activity

(2016) Silvia León et al.   Scientific Reports

Effects and Interactions of Tachykinins and Dynorphin on FSH and LH Secretion in Developing and Adult Rats

(2015) F. Ruiz-Pino et al.   ENDOCRINOLOGY

Reversal of diet-induced obesity and insulin resistance by inducible genetic ablation of GRK2

(2015) Rocio Vila-Bedmar et al.   Science Signaling

Reversal of diet-induced obesity and insulin resistance by inducible genetic ablation of GRK2

(2015) Rocio Vila-Bedmar et al.   Science Signaling

Puberty timing associated with diabetes, cardiovascular disease and also diverse health outcomes in men and women: the UK Biobank study

(2015) Felix R Day et al.   Scientific Reports

Development of a Methodology for and Assessment of Pulsatile Luteinizing Hormone Secretion in Juvenile and Adult Male Mice

(2013) F. J. Steyn et al.   ENDOCRINOLOGY

The Glial–Neuronal GRK2 Pathway Participates in the Development of Trigeminal Neuropathic Pain in Rats

(2013) Kyoung A. Won et al.   JOURNAL OF PAIN

Inhibitor of G Protein-Coupled Receptor Kinase 2 Normalizes Vascular Endothelial Function in Type 2 Diabetic Mice by Improving β-Arrestin 2 Translocation and Ameliorating Akt/eNOS Signal Dysfunction

(2012) Kumiko Taguchi et al.   ENDOCRINOLOGY

Increased Neurokinin B (Tac2) Expression in the Mouse Arcuate Nucleus Is an Early Marker of Pubertal Onset with Differential Sensitivity to Sex Steroid-Negative Feedback thanKiss1

(2012) John C. Gill et al.   ENDOCRINOLOGY

Alteration in Neonatal Nutrition Causes Perturbations in Hypothalamic Neural Circuits Controlling Reproductive Function

(2012) E. Caron et al.   JOURNAL OF NEUROSCIENCE

Role of Neurokinin B in the Control of Female Puberty and Its Modulation by Metabolic Status

(2012) V. M. Navarro et al.   JOURNAL OF NEUROSCIENCE

Secondary Sexual Characteristics in Boys: Data From the Pediatric Research in Office Settings Network

(2012) M. E. Herman-Giddens et al.   PEDIATRICS

Kisspeptins and Reproduction: Physiological Roles and Regulatory Mechanisms

(2012) Leonor Pinilla et al.   PHYSIOLOGICAL REVIEWS

GRK2: multiple roles beyond G protein-coupled receptor desensitization

(2012) Tama Evron et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Early Metabolic Programming of Puberty Onset: Impact of Changes in Postnatal Feeding and Rearing Conditions on the Timing of Puberty and Development of the Hypothalamic Kisspeptin System

(2011) Juan M. Castellano et al.   ENDOCRINOLOGY

Kisspeptin Signaling Is Indispensable for Neurokinin B, but not Glutamate, Stimulation of Gonadotropin Secretion in Mice

(2011) David García-Galiano et al.   ENDOCRINOLOGY

Neurobiological mechanisms underlying GnRH pulse generation by the hypothalamus

(2010) Kei-ichiro Maeda et al.   BRAIN RESEARCH

The complex G protein-coupled receptor kinase 2 (GRK2) interactome unveils new physiopathological targets

(2010) Petronila Penela et al.   BRITISH JOURNAL OF PHARMACOLOGY

Minireview: Kisspeptin/Neurokinin B/Dynorphin (KNDy) Cells of the Arcuate Nucleus: A Central Node in the Control of Gonadotropin-Releasing Hormone Secretion

(2010) Michael N. Lehman et al.   ENDOCRINOLOGY

Contribution of glial-neuronal interactions to the neuroendocrine control of female puberty

(2010) Sergio R. Ojeda et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Postnatal Development of an Estradiol-Kisspeptin Positive Feedback Mechanism Implicated in Puberty Onset

(2009) Jenny Clarkson et al.   ENDOCRINOLOGY

Regulation of Gonadotropin-Releasing Hormone Secretion by Kisspeptin/Dynorphin/Neurokinin B Neurons in the Arcuate Nucleus of the Mouse

(2009) V. M. Navarro et al.   JOURNAL OF NEUROSCIENCE

Regulation of GPR54 Signaling by GRK2 and β-Arrestin

(2009) Macarena Pampillo et al.   MOLECULAR ENDOCRINOLOGY

Recent Decline in Age at Breast Development: The Copenhagen Puberty Study

(2009) L. Aksglaede et al.   PEDIATRICS

Age at Puberty and the Emerging Obesity Epidemic

(2009) Lise Aksglaede et al.   PLoS One

TAC3 and TACR3 mutations in familial hypogonadotropic hypogonadism reveal a key role for Neurokinin B in the central control of reproduction

(2008) A Kemal Topaloglu et al.   NATURE GENETICS