Inhibition of Leishmania (Leishmania) amazonensis and Rat Arginases by Green Tea EGCG, (+)-Catechin and (−)-Epicatechin: A Comparative Structural Analysis of Enzyme-Inhibitor Interactions
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Title
Inhibition of Leishmania (Leishmania) amazonensis and Rat Arginases by Green Tea EGCG, (+)-Catechin and (−)-Epicatechin: A Comparative Structural Analysis of Enzyme-Inhibitor Interactions
Authors
Keywords
Enzyme inhibitors, Leishmania, Noncompetitive inhibitors, Leishmaniasis, Competitive inhibitors, Enzymes, Leishmania donovani, Tea
Journal
PLoS One
Volume 8, Issue 11, Pages e78387
Publisher
Public Library of Science (PLoS)
Online
2013-11-09
DOI
10.1371/journal.pone.0078387
References
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Note: Only part of the references are listed.- Dietary flavonoids fisetin, luteolin and their derived compounds inhibit arginase, a central enzyme in Leishmania (Leishmania) amazonensis infection
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- (2013) Tamrat Abebe et al. PLoS Neglected Tropical Diseases
- Mitochondrial damage contribute to epigallocatechin-3-gallate induced death in Leishmania amazonensis
- (2012) Job D.F. Inacio et al. EXPERIMENTAL PARASITOLOGY
- The leishmanicidal flavonols quercetin and quercitrin target Leishmania (Leishmania) amazonensis arginase
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- Polyamine metabolism in Leishmania: from arginine to trypanothione
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- (2010) C. Heiss et al. EUROPEAN HEART JOURNAL
- Trypanothione efficiently intercepts nitric oxide as a harmless iron complex in trypanosomatid parasites
- (2009) Alessio Bocedi et al. FASEB JOURNAL
- Cocoa flavanols lower vascular arginase activity in human endothelial cells in vitro and in erythrocytes in vivo
- (2008) Oliver Schnorr et al. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
- Molecular Docking Algorithms
- (2008) Raquel Dias et al. CURRENT DRUG TARGETS
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