Pharmaceutical Food Science: Search for Bio-Functional Molecules Obtained from Natural Resources to Prevent and Ameliorate Lifestyle Diseases

Medicinal chemistry of non-peptidomimetic dipeptidyl peptidase IV (DPP IV) inhibitors for treatment of Type-2 diabetes mellitus: Insights on recent development

(2023) Jaya P. Ambhore et al.   Journal of Molecular Structure

New biofunctional effects of oleanane-type triterpene saponins

(2023) Hisashi Matsuda et al.   Journal of Natural Medicines

Factors contributing to the adverse drug reactions associated with the dipeptidyl peptidase-4 (DPP-4) inhibitors: A scoping review

(2023) Swetha R. Reghunath et al.   Diabetes & Metabolic Syndrome-Clinical Research & Reviews

Ursane-type triterpene oligoglycosides with anti-hepatosteatosis and anti-hyperlipidemic activity from the leaves of Ilex paraguariensis A. St.-Hil.

(2022) Akifumi Nagatomo et al.   Journal of Natural Medicines

Research on the development and practical application of functional food materials that contribute to the improvement of QOL

(2022) Takashi Kometani   JOURNAL OF THE JAPANESE SOCIETY FOR FOOD SCIENCE AND TECHNOLOGY-NIPPON SHOKUHIN KAGAKU KOGAKU KAISHI

A Gedunin-Type Limonoid, 7-Deacetoxy-7-oxogedunin, from Andiroba (Carapa guianensis Aublet) Reduced Intracellular Triglyceride Content and Enhanced Autophagy in HepG2 Cells

(2022) Akifumi Nagatomo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A Mechanistic Review on Phytomedicine and Natural Products in the Treatment of Diabetes

(2022) Jyoti Nanda et al.   CURRENT DIABETES REVIEWS

A review of antidiabetic active thiosugar sulfoniums, salacinol and neokotalanol, from plants of the genus Salacia

(2021) Toshio Morikawa et al.   Journal of Natural Medicines

Aldose Reductase: a cause and a potential target for the treatment of diabetic complications

(2021) Sapna Thakur et al.   ARCHIVES OF PHARMACAL RESEARCH

A Basis for Pharmaceutical Sciences “Quality Assurance”: Quality Assurance of Health Foods, Foods with Health Claims, and Pharmaceutics

(2021) Yukihiro Goda   YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN

Quality Control and Quality Assurance for the Intermediate Zone between Food and Drug: Rational Use of Such Products and the Need to Modify the Pharmacy Education

(2021) Kiichiro Tsutani   YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN

Compliance of Clinical Trial Protocols for Foods with Function Claims (FFC) in Japan: Consistency between Clinical Trial Registrations and Published Reports

(2021) Hiroharu Kamioka et al.   Nutrients

Berberine Improves Glucose and Lipid Metabolism in HepG2 Cells Through AMPKα1 Activation

(2020) Gang Ren et al.   Frontiers in Pharmacology

Aldose reductase and protein tyrosine phosphatase 1B inhibitors as a promising therapeutic approach for diabetes mellitus

(2020) Antonios Kousaxidis et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Dose-Dependent Suppression of Postprandial Hyperglycemia and Improvement of Blood Glucose Parameters by Salacia chinensis Extract: Two Randomized, Double-Blind, Placebo-Controlled Studies

(2020) Masakazu Kobayashi et al.   JOURNAL OF MEDICINAL FOOD

Elongation of the side chain by linear alkyl groups increases the potency of salacinol, a potent α-glucosidase inhibitor from the Ayurvedic traditional medicine “Salacia,” against human intestinal maltase

(2020) Katsuki Takashima et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Salacia chinensis stem extract and its thiosugar sulfonium constituent, neokotalanol, improves HbA1c levels in ob/ob mice

(2019) Masakazu Kobayashi et al.   Journal of Natural Medicines

A Review of Biologically Active Natural Products from a Desert Plant Cistanche tubulosa

(2019) Toshio Morikawa et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Quality of Systematic Reviews of the Foods with Function Claims in Japan: Comparative Before- and After-Evaluation of Verification Reports by the Consumer Affairs Agency

(2019) Kamioka et al.   Nutrients

Glucose Tolerance-Improving Activity of Helichrysoside in Mice and Its Structural Requirements for Promoting Glucose and Lipid Metabolism

(2019) Morikawa et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Development of functional agricultural products utilizing the new health claim labeling system in Japan

(2018) Mari Maeda-Yamamoto et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Nobiletin Inhibits Hepatic Lipogenesis via Activation of AMP-Activated Protein Kinase

(2018) Taewon Yuk et al.   Evidence-based Complementary and Alternative Medicine

Health Claim Evidence Requirements in Japan

(2018) Kazuhiko Yamada et al.   JOURNAL OF NUTRITION

Lipid lowering agents of natural origin: An account of some promising chemotypes

(2017) Suriya P. Singh et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Diastereoselective Synthesis of Salacinol-Type α-Glucosidase Inhibitors

(2017) Fumihiro Ishikawa et al.   JOURNAL OF ORGANIC CHEMISTRY

Quality of systematic reviews of the Foods with Function Claims registered at the Consumer Affairs Agency Web site in Japan: a prospective systematic review

(2017) Hiroharu Kamioka et al.   NUTRITION RESEARCH

Reappraisal and perspectives of clinical drug–drug interaction potential of α-glucosidase inhibitors such as acarbose, voglibose and miglitol in the treatment of type 2 diabetes mellitus

(2017) Ranjeet Prasad Dash et al.   XENOBIOTICA

Major constituents of Cistanche tubulosa , echinacoside and acteoside, inhibit sodium-dependent glucose cotransporter 1-mediated glucose uptake by intestinal epithelial cells

(2017) Hiroaki Shimada et al.   Journal of Functional Foods

Hydrophobic substituents increase the potency of salacinol, a potent α-glucosidase inhibitor from Ayurvedic traditional medicine ‘Salacia’

(2016) Genzoh Tanabe et al.   BIOORGANIC & MEDICINAL CHEMISTRY

New biofunctional effects of the flower buds of Camellia sinensis and its bioactive acylated oleanane-type triterpene oligoglycosides

(2016) Hisashi Matsuda et al.   Journal of Natural Medicines

Therapeutic potential of α-glucosidase inhibitors in type 2 diabetes mellitus: an evidence-based review

(2015) Shashank R Joshi et al.   EXPERT OPINION ON PHARMACOTHERAPY

SH2 domain-containing inositol 5-phosphatase (SHIP2) inhibition ameliorates high glucose-induced de-novo lipogenesis and VLDL production through regulating AMPK/mTOR/SREBP1 pathway and ROS production in HepG2 cells

(2015) Sattar Gorgani-Firuzjaee et al.   FREE RADICAL BIOLOGY AND MEDICINE

Dipeptidyl peptidase-IV inhibitory activity of dimeric dihydrochalcone glycosides from flowers of Helichrysum arenarium

(2015) Toshio Morikawa et al.   Journal of Natural Medicines

Natural Products for the Treatment of Type 2 Diabetes Mellitus

(2015) José Ríos et al.   PLANTA MEDICA

Carapanolides M–S from seeds of andiroba (Carapa guianensis, Meliaceae) and triglyceride metabolism-promoting activity in high glucose-pretreated HepG2 cells

(2015) Takanobu Inoue et al.   TETRAHEDRON

Salacinol and Related Analogs: New Leads for Type 2 Diabetes Therapeutic Candidates from the Thai Traditional Natural Medicine Salacia chinensis

(2015) Toshio Morikawa et al.   Nutrients

Natural lipid-lowering agents and their effects: an update

(2014) Sultan Ayesh Mohammed Saghir et al.   EUROPEAN FOOD RESEARCH AND TECHNOLOGY

Obesity and Its Metabolic Complications: The Role of Adipokines and the Relationship between Obesity, Inflammation, Insulin Resistance, Dyslipidemia and Nonalcoholic Fatty Liver Disease

(2014) Un Jung et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Acylated phenylethanoid glycosides, echinacoside and acteoside from Cistanche tubulosa, improve glucose tolerance in mice

(2014) Toshio Morikawa et al.   Journal of Natural Medicines

Evaluation ofSalaciaSpecies as Anti-diabetic Natural Resources Based on Quantitative Analysis of Eight Sulphonium Constituents: A New Class of α-Glucosidase Inhibitors

(2014) Junji Akaki et al.   PHYTOCHEMICAL ANALYSIS

Flavonol glycosides with lipid accumulation inhibitory activity and simultaneous quantitative analysis of 15 polyphenols and caffeine in the flower buds of Camellia sinensis from different regions by LCMS

(2013) Toshio Morikawa et al.   FOOD CHEMISTRY

Research Progress of Synthesis and Structure-activity Relationship Studies on Sulfonium-type α-glucosidase Inhibitors Isolated from Salacia Genus Plants

(2013) Weijia Xie et al.   MINI-REVIEWS IN ORGANIC CHEMISTRY

Acylated dolabellane-type diterpenes from Nigella sativa seeds with triglyceride metabolism-promoting activity in high glucose-pretreated HepG2 cells

(2013) Toshio Morikawa et al.   Phytochemistry Letters

Aldose Reductase Inhibitors of Plant Origin

(2013) Ciddi Veeresham et al.   PHYTOTHERAPY RESEARCH

In silico design, synthesis and evaluation of 3′-O-benzylated analogs of salacinol, a potent α-glucosidase inhibitor isolated from an Ayurvedic traditional medicine “Salacia”

(2012) Genzoh Tanabe et al.   CHEMICAL COMMUNICATIONS

Novel aldose reductase inhibitors: a patent survey (2006 – present)

(2012) Maria Chatzopoulou et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Anti-hyperlipidemic constituents from the bark of Shorea roxburghii

(2012) Toshio Morikawa et al.   Journal of Natural Medicines

DPP-4 inhibitors in the treatment of type 2 diabetes

(2011) Hélène Duez et al.   BIOCHEMICAL PHARMACOLOGY

Mate Tea (Ilex paraguariensis) Promotes Satiety and Body Weight Lowering in Mice: Involvement of Glucagon-Like Peptide-1

(2011) Ghazi Mohamed Eisa Hussein et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Isolation, structure identification and SAR studies on thiosugar sulfonium salts, neosalaprinol and neoponkoranol, as potent α-glucosidase inhibitors

(2011) Weijia Xie et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Antidiabetogenic oligostilbenoids and 3-ethyl-4-phenyl-3,4-dihydroisocoumarins from the bark of Shorea roxburghii

(2011) Toshio Morikawa et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Medicinal Flowers. XXXII.

(2011) Toshio Morikawa et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Flavonol glycosides with lipid accumulation inhibitory activity from Sedum sarmentosum

(2011) Toshio Morikawa et al.   Phytochemistry Letters

Docking and SAR studies of salacinol derivatives as α-glucosidase inhibitors

(2010) Shinya Nakamura et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Medicinal Flowers. Part 29. Acylated Oleanane-Type Triterpene Bisdesmosides: Perennisaponins G, H, I, J, K, L, and M with Pancreatic Lipase Inhibitory Activity from the Flowers ofBellis perennis

(2010) Toshio Morikawa et al.   HELVETICA CHIMICA ACTA

Gliptins: A new class of oral antidiabetic agents

(2010) KG Seshadri et al.   INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES

Quantitative analysis of neosalacinol and neokotalanol, another two potent α-glucosidase inhibitors from Salacia species, by LC-MS with ion pair chromatography

(2010) Osamu Muraoka et al.   Journal of Natural Medicines

Quantitative determination of potent α-glucosidase inhibitors, salacinol and kotalanol, in Salacia species using liquid chromatography–mass spectrometry

(2010) Osamu Muraoka et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Characteristic alkaline catalyzed degradation of kotalanol, a potent α-glucosidase inhibitor isolated from Ayurvedic traditional medicine Salacia reticulata, leading to anhydroheptitols: another structural proof

(2010) Osamu Muraoka et al.   TETRAHEDRON

Synthesis of dipeptidyl peptidase-4 inhibitors: a brief overview

(2010) Naveen Mulakayala et al.   TETRAHEDRON

Search for TNF-α Sensitivity Degradation Principles from Medicinal Foods—Hepatoprotective Amide Constituents from Thai Natural Medicine Piper chaba—

(2010) Toshio MORIKAWA   YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN

Pharmaceutical Food Science: Search for Anti-obese Constituents from Medicinal Foods—Anti-hyperlipidemic Saponin Constituents from the Flowers of Bellis perennis—

(2010) Toshio MORIKAWA et al.   YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN

Structures of Acetylated Oleanane-Type Triterpene Saponins, Rarasaponins IV, V, and VI, and Anti-hyperlipidemic Constituents from the Pericarps of Sapindus rarak

(2009) Yasunobu Asao et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Medicinal Flowers. XXX. Eight New Glycosides, Everlastosides F—M, from the Flowers of Helichrysum arenarium

(2009) Toshio Morikawa et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Medicinal Flowers. XXVII. New Flavanone and Chalcone Glycosides, Arenariumosides I, II, III, and IV, and Tumor Necrosis Factor-α Inhibitors from Everlasting, Flowers of Helichrysum arenarium

(2009) Toshio Morikawa et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Foods with Health Claims in Japan

(2009) Junichi NAGATA et al.   FOOD SCIENCE AND TECHNOLOGY RESEARCH

Salaprionol and Ponkoranol with Thiosugar Sulfonium Sulfate Structure from Salacia prinoides and a-Glucosidase Inhibitory Activity of Ponkoranol and Kotalanol Desulfate

(2009) Masayuki Yoshikawa et al.   HETEROCYCLES

Medicinal Flowers. XXVIII. Structures of Five New Glycosides, Everlastosides A, B, C, D, and E, from the Flowers of Helichrysum arenarium

(2009) Masayuki Yoshikawa et al.   HETEROCYCLES

Voglibose for prevention of type 2 diabetes mellitus: a randomised, double-blind trial in Japanese individuals with impaired glucose tolerance

(2009) Ryuzo Kawamori et al.   LANCET

Oleanane-type triterpene oligoglycosides with pancreatic lipase inhibitory activity from the pericarps of Sapindus rarak

(2009) Toshio Morikawa et al.   PHYTOCHEMISTRY

Novel megastigmanes with lipid accumulation inhibitory and lipid metabolism-promoting activities in HepG2 cells from Sedum sarmentosum

(2009) Osamu Muraoka et al.   TETRAHEDRON

Bioactive Constituents from Chinese Natural Medicines. XXXII. Aminopeptidase N and Aldose Reductase Inhibitors from Sinocrassula indica: Structures of Sinocrassosides B4, B5, C1, and D1—D3

(2008) Toshio Morikawa et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Emerging dipeptidyl peptidase-4 inhibitors for the treatment of diabetes

(2008) Bo Ahrén   EXPERT OPINION ON EMERGING DRUGS

Perennisosides I−VII, Acylated Triterpene Saponins with Antihyperlipidemic Activities from the Flowers ofBellis perennis

(2008) Toshio Morikawa et al.   JOURNAL OF NATURAL PRODUCTS

Regulatory Sciences in Herbal Medicines and Dietary Supplements

(2008) Kiichiro TSUTANI et al.   YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN