Medicinal chemistry of non-peptidomimetic dipeptidyl peptidase IV (DPP IV) inhibitors for treatment of Type-2 diabetes mellitus: Insights on recent development

Therapeutic Outcomes of Isatin and Its Derivatives against Multiple Diseases: Recent Developments in Drug Discovery

(2022) Rameshwar S. Cheke et al.   Pharmaceuticals

Synthesis, Characterization, and Evaluation of in vitro Antidiabetic Activity of Novel Pyrrolidine Sulphonamide Derivative

(2021) Megha Tukaram Salve et al.   International Journal of Pharmaceutical Investigation

The optimization of xanthine derivatives leading to HBK001 hydrochloride as a potent dual ligand targeting DPP-IV and GPR119

(2020) Gang Li et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Phytochemicals in Garlic Extract Inhibit Therapeutic Enzyme DPP-4 and Induce Skeletal Muscle Cell Proliferation: A Possible Mechanism of Action to Benefit the Treatment of Diabetes Mellitus

(2020) Poonam Kalhotra et al.   Biomolecules

In silico strategies for probing novel DPP-IV inhibitors as anti-diabetic agents

(2020) Shweta Sharma et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Anti-hyperglycaemic activity of H. rosa-sinensis leaves is partly mediated by inhibition of carbohydrate digestion and absorption, and enhancement of insulin secretion

(2020) Prawej Ansari et al.   JOURNAL OF ETHNOPHARMACOLOGY

Design, Synthesis and Evaluation of a Series of Novel Super-long Acting DPP-4 Inhibitors for the Treatment of Type 2 Diabetes

(2020) Chen Zhang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Phenanthridine Sulfonamide Derivatives as Potential DPP-IV Inhibitors: Design, Synthesis and Biological Evaluation

(2020) Reema Abu Khalaf et al.   Current Computer-Aided Drug Design

Inhibitory effect of chestnut (Castanea mollissima Blume) inner skin extract on the activity of α-amylase, α-glucosidase, dipeptidyl peptidase IV and in vitro digestibility of starches

(2020) Yuyang Zhang et al.   FOOD CHEMISTRY

Synthesis, in vitro evaluation, and computational simulations studies of 1,2,3-triazole analogues as DPP-4 inhibitors

(2020) Duy-Viet Vo et al.   BIOORGANIC & MEDICINAL CHEMISTRY

2. Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes—2021

(2020)   DIABETES CARE

Structural optimization of pyrazolo[1,5-a]pyrimidine derivatives as potent and highly selective DPP-4 inhibitors

(2020) Jian Shen et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and anti-diabetic activity of novel 1, 2, 3-triazole-5-carboximidamide derivatives as dipeptidyl peptidase-4 inhibitors

(2020) Hossein Fasihi Dastjerdi et al.   JOURNAL OF MOLECULAR STRUCTURE

Glucagon-like peptide 1 (GLP-1)

(2019) T.D. Müller et al.   Molecular Metabolism

Rapid generation of novel benzoic acid–based xanthine derivatives as highly potent, selective and long acting DPP-4 inhibitors: Scaffold-hopping and prodrug study

(2019) Qing Li et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Benzimidazole-based dual dipeptidyl peptidase-4 and xanthine oxidase inhibitors

(2019) Katarina Tomovic et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Dual Inhibition of DPP-4 and Cholinesterase Enzymes by the Phytoconstituents of the Ethanolic Extract of Prosopis cineraria Pods: Therapeutic Implications for the Treatment of Diabetes-associated Neurological Impairments

(2019) Heera Ram et al.   Current Alzheimer Research

Surrogating and redirection of pyrazolo[1,5- a ]pyrimidin-7(4 H )-one core, a novel class of potent and selective DPP-4 inhibitors

(2018) Xinxian Deng et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design, synthesis and biological evaluation of novel pyrimidinedione derivatives as DPP-4 inhibitors

(2018) Ning Li et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design and synthesis of aminocoumarin derivatives as DPP-IV inhibitors and anticancer agents

(2018) Rina Soni et al.   BIOORGANIC CHEMISTRY

Synthesis, Structural Characterization and Docking Studies of Sulfamoyl- Phenyl Acid Esters as Dipeptidyl Peptidase-IV Inhibitors

(2018) Reema Abu Khalaf et al.   Current Computer-Aided Drug Design

Synthesis, pharmacological evaluation and molecular docking studies of pyrimidinedione based DPP-4 inhibitors as antidiabetic agents

(2018) Vibhu Jha et al.   JOURNAL OF MOLECULAR STRUCTURE

Rational design and synthesis of new tetralin-sulfonamide derivatives as potent anti-diabetics and DPP-4 inhibitors: 2D & 3D QSAR, in vivo radiolabeling and bio distribution studies

(2018) Somaia S. Abd El-Karim et al.   BIOORGANIC CHEMISTRY

1,2-Benzisoxazole-3-acetamide derivatives as dual agents for DPP-IV inhibition and anticancer activity

(2018) Shubhendu Karandikar et al.   SYNTHETIC COMMUNICATIONS

Rapid generation of a novel DPP-4 inhibitor with long-acting properties: SAR study and PK/PD evaluation

(2017) Hui Xie et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Inter-regulation of gastric emptying and incretin hormone secretion: implications for postprandial glycemic control

(2016) Tongzhi Wu et al.   Biomarkers in Medicine

Discovery of novel xanthine compounds targeting DPP-IV and GPR119 as anti-diabetic agents

(2016) Gang Li et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and biological evaluation of triazole based uracil derivatives as novel DPP-4 inhibitors

(2016) Qing Li et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Design, synthesis and anti-diabetic activity of chromen-2-one derivatives

(2016) Rina Soni et al.   Arabian Journal of Chemistry

Sulfonamide-1,3,5-triazine–thiazoles: discovery of a novel class of antidiabetic agents via inhibition of DPP-4

(2016) Hai-De Gao et al.   RSC Advances

Complications of Diabetes 2016

(2016) Konstantinos Papatheodorou et al.   Journal of Diabetes Research

Overview of clinically approved oral antidiabetic agents for the treatment of type 2 diabetes mellitus

(2015) Zhi-Xu He et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Teneligliptin: A Review in Type 2 Diabetes

(2015) Lesley J. Scott   CLINICAL DRUG INVESTIGATION

Evogliptin: First Global Approval

(2015) Paul L. McCormack   DRUGS

Saxagliptin: A Review in Type 2 Diabetes

(2015) Sohita Dhillon   DRUGS

Alogliptin: A Review of Its Use in Patients with Type 2 Diabetes Mellitus

(2015) Gillian M. Keating   DRUGS

First novel once-weekly DPP-4 inhibitor, trelagliptin, for the treatment of type 2 diabetes mellitus

(2015) Kohei Kaku   EXPERT OPINION ON PHARMACOTHERAPY

The Place of Dipeptidyl Peptidase-4 Inhibitors in Type 2 Diabetes Therapeutics: A “Me Too” or “the Special One” Antidiabetic Class?

(2015) Ricardo Godinho et al.   Journal of Diabetes Research

Vildagliptin: A Review of Its Use in Type 2 Diabetes Mellitus

(2014) Gillian M. Keating   DRUGS

Recent approaches to medicinal chemistry and therapeutic potential of dipeptidyl peptidase-4 (DPP-4) inhibitors

(2014) Bhumika D. Patel et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

DPP-4 inhibitors: pharmacological differences and their clinical implications

(2014) Antonio Ceriello et al.   Expert Opinion On Drug Safety

Omarigliptin (MK-3102): A Novel Long-Acting DPP-4 Inhibitor for Once-Weekly Treatment of Type 2 Diabetes

(2014) Tesfaye Biftu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Gemigliptin, a novel dipeptidyl peptidase 4 inhibitor: first new anti-diabetic drug in the history of Korean pharmaceutical industry

(2013) Sung-Ho Kim et al.   ARCHIVES OF PHARMACAL RESEARCH

Dipeptidyl Peptidase IV and Its Inhibitors: Therapeutics for Type 2 Diabetes and What Else?

(2013) Lucienne Juillerat-Jeanneret   JOURNAL OF MEDICINAL CHEMISTRY

Structure Based Lead Optimization Approach in Discovery of Selective DPP4 Inhibitors

(2013) Manjunath Ghate et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Recent Advances in Non-Peptidomimetic Dipeptidyl Peptidase 4 Inhibitors: Medicinal Chemistry and Preclinical Aspects

(2012) Y. Liu et al.   CURRENT MEDICINAL CHEMISTRY

A review of the efficacy and safety of oral antidiabetic drugs

(2012) Stephanie Aleskow Stein et al.   Expert Opinion On Drug Safety

Use of the dipeptidyl peptidase-4 inhibitor linagliptin in combination therapy for type 2 diabetes

(2012) Rosemarie Lajara   EXPERT OPINION ON PHARMACOTHERAPY

Identification of diverse dipeptidyl peptidase IV inhibitors via structure-based virtual screening

(2012) Cui Li et al.   JOURNAL OF MOLECULAR MODELING

Current Advances and Therapeutic Potential of Agents Targeting Dipeptidyl Peptidases-IV, -II, 8/9 and Fibroblast Activation Protein

(2011) Shu-Jen Chen et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Management of type 2 diabetes: new and future developments in treatment

(2011) Abd A Tahrani et al.   LANCET

Type 2 diabetes mellitus—current therapies and the emergence of surgical options

(2011) Harold E. Lebovitz   Nature Reviews Endocrinology

Nutrient detection by incretin hormone secreting cells

(2011) Eleftheria Diakogiannaki et al.   PHYSIOLOGY & BEHAVIOR

The Glucagonostatic and Insulinotropic Effects of Glucagon-Like Peptide 1 Contribute Equally to Its Glucose-Lowering Action

(2010) K. J. Hare et al.   DIABETES

The dipeptidyl peptidase IV family in cancer and cell biology

(2010) Denise M. T. Yu et al.   FEBS Journal

GIP and GLP-1, the two incretin hormones: Similarities and differences

(2010) Yutaka Seino et al.   Journal of Diabetes Investigation

Medicinal Chemistry of Incretin Mimetics and DPP-4 Inhibitors

(2009) Heiko Zettl et al.   ChemMedChem

Type 2 Diabetes and Oral Antihyperglycemic Drugs

(2008) Mitchell Avery et al.   CURRENT MEDICINAL CHEMISTRY

(R)-8-(3-Amino-piperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydro-purine-2,6-dione (BI 1356), a Novel Xanthine-Based Dipeptidyl Peptidase 4 Inhibitor, Has a Superior Potency and Longer Duration of Action Compared with Other Dipeptidyl Peptidase-4 Inhibitors

(2008) L. Thomas et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS