Elongation of the side chain by linear alkyl groups increases the potency of salacinol, a potent α-glucosidase inhibitor from the Ayurvedic traditional medicine “Salacia,” against human intestinal maltase

Practical Route to Neokotalanol and Its Natural Analogues: Sulfonium Sugars with Antidiabetic Activities

(2019) Yuhao Huang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Facile Synthesis of Neokotalanol, a Potent α-glycosidase Inhibitor Isolated from the Ayurvedic Traditional Medicine “Salacia”

(2019) Genzoh Tanabe et al.   ACS Omega

An Efficient Gram-Scale Total Synthesis of Neoponkoranol as Potent α-Glucosidase Inhibitor

(2018) Wang Zihao et al.   CURRENT ORGANIC CHEMISTRY

Diastereoselective Synthesis of Salacinol-Type α-Glucosidase Inhibitors

(2017) Fumihiro Ishikawa et al.   JOURNAL OF ORGANIC CHEMISTRY

Hydrophobic substituents increase the potency of salacinol, a potent α-glucosidase inhibitor from Ayurvedic traditional medicine ‘Salacia’

(2016) Genzoh Tanabe et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Highly Diastereoselective Route to α-Glucosidase Inhibitors, Neosalacinol and Neoponkoranol

(2016) Genzoh Tanabe et al.   JOURNAL OF ORGANIC CHEMISTRY

Salacinol and Related Analogs: New Leads for Type 2 Diabetes Therapeutic Candidates from the Thai Traditional Natural Medicine Salacia chinensis

(2015) Toshio Morikawa et al.   Nutrients

Naturally Occurring Sulfonium-Ion Glucosidase Inhibitors and Their Derivatives: A Promising Class of Potential Antidiabetic Agents

(2013) Sankar Mohan et al.   ACCOUNTS OF CHEMICAL RESEARCH

Deoxygenation at the C3 position of d- and l-arabinofuranose: stereospecific access to enantiomeric cordycepose derivatives

(2013) Fábio da Paixão Soares et al.   CARBOHYDRATE RESEARCH

Research Progress of Synthesis and Structure-activity Relationship Studies on Sulfonium-type α-glucosidase Inhibitors Isolated from Salacia Genus Plants

(2013) Weijia Xie et al.   MINI-REVIEWS IN ORGANIC CHEMISTRY

Synthetic study on neoponkoranol and its side chain epimer as potent α-glucosidase inhibitors, optimization of protecting group

(2013) Dan Liu et al.   TETRAHEDRON LETTERS

Role of the side chain stereochemistry in the α-glucosidase inhibitory activity of kotalanol, a potent natural α-glucosidase inhibitor. Part 2

(2012) Genzoh Tanabe et al.   BIOORGANIC & MEDICINAL CHEMISTRY

In silico design, synthesis and evaluation of 3′-O-benzylated analogs of salacinol, a potent α-glucosidase inhibitor isolated from an Ayurvedic traditional medicine “Salacia”

(2012) Genzoh Tanabe et al.   CHEMICAL COMMUNICATIONS

Isolation, structure identification and SAR studies on thiosugar sulfonium salts, neosalaprinol and neoponkoranol, as potent α-glucosidase inhibitors

(2011) Weijia Xie et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Role of the side chain stereochemistry in the α-glucosidase inhibitory activity of kotalanol, a potent natural α-glucosidase inhibitor

(2011) Weijia Xie et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Mapping the intestinal alpha-glucogenic enzyme specificities of starch digesting maltase-glucoamylase and sucrase-isomaltase

(2011) Kyra Jones et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Biological evaluation of 3′-O-alkylated analogs of salacinol, the role of hydrophobic alkyl group at 3′ position in the side chain on the α-glucosidase inhibitory activity

(2011) Genzoh Tanabe et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Study of the inhibition of two human maltase-glucoamylases catalytic domains by different α-glucosidase inhibitors

(2011) Limei Ren et al.   CARBOHYDRATE RESEARCH

Docking and SAR studies of salacinol derivatives as α-glucosidase inhibitors

(2010) Shinya Nakamura et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Structural Basis for Substrate Selectivity in Human Maltase-Glucoamylase and Sucrase-Isomaltase N-terminal Domains

(2010) Lyann Sim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quantitative analysis of neosalacinol and neokotalanol, another two potent α-glucosidase inhibitors from Salacia species, by LC-MS with ion pair chromatography

(2010) Osamu Muraoka et al.   Journal of Natural Medicines

Potent Glucosidase Inhibitors: De-O-sulfonated Ponkoranol and Its Stereoisomer

(2010) Razieh Eskandari et al.   ORGANIC LETTERS

New Glucosidase Inhibitors from an Ayurvedic Herbal Treatment for Type 2 Diabetes: Structures and Inhibition of Human Intestinal Maltase-Glucoamylase with Compounds fromSalacia reticulata

(2009) Lyann Sim et al.   BIOCHEMISTRY

Facile synthesis of de-O-sulfated salacinols: Revision of the structure of neosalacinol, a potent α-glucosidase inhibitor

(2009) Genzoh Tanabe et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Salaprionol and Ponkoranol with Thiosugar Sulfonium Sulfate Structure from Salacia prinoides and a-Glucosidase Inhibitory Activity of Ponkoranol and Kotalanol Desulfate

(2009) Masayuki Yoshikawa et al.   HETEROCYCLES

Structure Proof and Synthesis of Kotalanol and De-O-sulfonated Kotalanol, Glycosidase Inhibitors Isolated from an Herbal Remedy for the Treatment of Type-2 Diabetes

(2009) Kumarasamy Jayakanthan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Effect of five-membered sugar mimics on mammalian glycogen-degrading enzymes and various glucosidases

(2008) Yasuhiro Minami et al.   BIOORGANIC & MEDICINAL CHEMISTRY

α-Glucosidase Inhibitor from Kothala-himbutu (Salacia reticulataWIGHT)

(2008) Sei Ozaki et al.   JOURNAL OF NATURAL PRODUCTS

Studies Directed toward the Stereochemical Structure Determination of the Naturally Occurring Glucosidase Inhibitor, Kotalanol: Synthesis and Inhibitory Activities against Human Maltase Glucoamylase of Seven-Carbon, Chain-Extended Homologues of Salacinol

(2008) Ravindranath Nasi et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis and elucidation of absolute stereochemistry of salaprinol, another thiosugar sulfonium sulfate from the ayurvedic traditional medicine Salacia prinoides

(2008) Genzoh Tanabe et al.   TETRAHEDRON

On the structure of the bioactive constituent from ayurvedic medicine Salacia reticulata: revision of the literature

(2008) Osamu Muraoka et al.   TETRAHEDRON LETTERS