Journal
CHEMICAL & PHARMACEUTICAL BULLETIN
Volume 57, Issue 2, Pages 198-203Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.57.198
Keywords
Sapindus rarak; anti-hyperlipidemic activity; triterpene oligoglycoside; rarasaponin; Sapindaceae
Funding
- Ministry of Education, Culture, Sports, Science and Technology of Japan (MEXT)
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The methanolic extract and its saponin fraction (methanol-eluted fraction) of the pericarps of Sapindus rarak DC. were found to suppress plasma triglyceride elevation in olive oil-treated mice. From the active fraction, three new acylated oleanane-type triterpene saponins, rarasaponins IV (1), V (2), and VI (3), were isolated. The structures of 1-3 were elucidated on the basis of chemical and spectroscopic evidence. The principle saponin constituents, hederagenin 3-O-alpha-L-arabinopyranosyl-(1 -> 3)-alpha-L-rhamnopyranosyl-(1 -> 2)-alpha-L-arabinopyranoside (4) and hederagenin 3-O-(3,4-di-O-acetyl-alpha-L-arabinopyranosyl)-(1 -> 3)-alpha-L-rhamnopyranosyl-(1 -> 2)-alpha-L-arabinopyranoside (5), showed inhibitory effects on plasma triglyceride elevation at a dose of 200 mg/kg, per os.
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