Intestinal mucus and their glycans: A habitat for thriving microbiota

Mucin utilization by gut microbiota: recent advances on characterization of key enzymes

(2023) Grete Raba et al.   Essays in Biochemistry

Muc2-dependent microbial colonization of the jejunal mucus layer is diet sensitive and confers local resistance to enteric pathogen infection

(2023) George M.H. Birchenough et al.   Cell Reports

A bacterial sulfoglycosidase highlights mucin O-glycan breakdown in the gut ecosystem

(2023) Toshihiko Katoh et al.   Nature Chemical Biology

The intestinal MUC2 mucin C-terminus is stabilized by an extra disulfide bond in comparison to von Willebrand factor and other gel-forming mucins

(2023) Pablo Gallego et al.   Nature Communications

Sialidases and fucosidases of Akkermansia muciniphila are crucial for growth on mucin and nutrient sharing with mucus-associated gut bacteria

(2023) Bashar Shuoker et al.   Nature Communications

Diet leaves a genetic signature in a keystone member of the gut microbiota

(2022) Tanja Dapa et al.   Cell Host & Microbe

A gut-derived metabolite alters brain activity and anxiety behaviour in mice

(2022) Brittany D. Needham et al.   NATURE

Transglutaminase 3 crosslinks the secreted gel-forming mucus component Mucin-2 and stabilizes the colonic mucus layer

(2022) Jack D. A. Sharpen et al.   Nature Communications

Phenotypic and Genomic Diversification in Complex Carbohydrate-Degrading Human Gut Bacteria

(2022) Nicholas A. Pudlo et al.   mSystems

Carbohydrate-active enzymes (CAZymes) in the gut microbiome

(2022) Jacob F. Wardman et al.   NATURE REVIEWS MICROBIOLOGY

Sulfated glycan recognition by carbohydrate sulfatases of the human gut microbiota

(2022) Ana S Luis et al.   Nature Chemical Biology

The disulfide catalyst QSOX1 maintains the colon mucosal barrier by regulating Golgi glycosyltransferases

(2022) Tal Ilani et al.   EMBO JOURNAL

Clearance of small intestinal crypts involves goblet cell mucus secretion by intracellular granule rupture and enterocyte ion transport

(2022) Brendan Dolan et al.   Science Signaling

An intercrypt subpopulation of goblet cells is essential for colonic mucus barrier function

(2021) Elisabeth E. L. Nyström et al.   SCIENCE

New generation ENaC inhibitors detach cystic fibrosis airway mucus bundles via sodium/hydrogen exchanger inhibition

(2021) Melania Giorgetti et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Enterotoxigenic Escherichia coli Degrades the Host MUC2 Mucin Barrier To Facilitate Critical Pathogen-Enterocyte Interactions in Human Small Intestine

(2021) Alaullah Sheikh et al.   INFECTION AND IMMUNITY

A single sulfatase is required to access colonic mucin by a gut bacterium

(2021) Ana S. Luis et al.   NATURE

The carbohydrate-active enzyme database: functions and literature

(2021) Elodie Drula et al.   NUCLEIC ACIDS RESEARCH

The human gut symbiont Ruminococcus gnavus shows specificity to blood group A antigen during mucin glycan foraging: Implication for niche colonisation in the gastrointestinal tract

(2021) Haiyang Wu et al.   PLOS BIOLOGY

Metabolism of multiple glycosaminoglycans by Bacteroides thetaiotaomicron is orchestrated by a versatile core genetic locus

(2020) Didier Ndeh et al.   Nature Communications

Mucins and the Microbiome

(2020) Gunnar C. Hansson   Annual Review of Biochemistry

Spatially distinct physiology of Bacteroides fragilis within the proximal colon of gnotobiotic mice

(2020) Gregory P. Donaldson et al.   Nature Microbiology

Extracellular vesicles produced by Bifidobacterium longum export mucin-binding proteins

(2020) Keita Nishiyama et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Prominent members of the human gut microbiota express endo-acting O-glycanases to initiate mucin breakdown

(2020) Lucy I. Crouch et al.   Nature Communications

Assembly Mechanism of Mucin and von Willebrand Factor Polymers

(2020) Gabriel Javitt et al.   CELL

Mucin-derived O-glycans supplemented to diet mitigate diverse microbiota perturbations

(2020) K. M. Pruss et al.   ISME Journal

Proximal colon–derived O-glycosylated mucus encapsulates and modulates the microbiota

(2020) Kirk Bergstrom et al.   SCIENCE

Akkermansia muciniphila uses human milk oligosaccharides to thrive in the early life conditions in vitro

(2020) Ioannis Kostopoulos et al.   Scientific Reports

Comparison of gut microbiota in exclusively breast-fed and formula-fed babies: a study of 91 term infants

(2020) Jingran Ma et al.   Scientific Reports

A Novel Major Pilin Subunit Protein FimM Is Involved in Adhesion of Bifidobacterium longum BBMN68 to Intestinal Epithelial Cells

(2020) Yao Xiong et al.   Frontiers in Microbiology

Structural weakening of the colonic mucus barrier is an early event in ulcerative colitis pathogenesis

(2019) Sjoerd van der Post et al.   GUT

A Golgi-associated redox switch regulates catalytic activation and cooperative functioning of ST6Gal-I with B4GalT-I

(2019) Antti Hassinen et al.   Redox Biology

Complex N-glycan breakdown by gut Bacteroides involves an extensive enzymatic apparatus encoded by multiple co-regulated genetic loci

(2019) Justina Briliūtė et al.   Nature Microbiology

Elucidation of a sialic acid metabolism pathway in mucus-foraging Ruminococcus gnavus unravels mechanisms of bacterial adaptation to the gut

(2019) Andrew Bell et al.   Nature Microbiology

The continuing expansion of CAZymes and their families

(2019) Marie-Line Garron et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Bifidobacteria or Fiber Protects against Diet-Induced Microbiota-Mediated Colonic Mucus Deterioration

(2018) Bjoern O. Schroeder et al.   Cell Host & Microbe

Interactions of commensal and pathogenic microorganisms with the intestinal mucosal barrier

(2018) Eric C. Martens et al.   NATURE REVIEWS MICROBIOLOGY

The central exons of the human MUC2 and MUC6 mucins are highly repetitive and variable in sequence between individuals

(2018) Frida Svensson et al.   Scientific Reports

A surface endogalactanase in Bacteroides thetaiotaomicron confers keystone status for arabinogalactan degradation

(2018) Alan Cartmell et al.   Nature Microbiology

Gut microbiota functions: metabolism of nutrients and other food components

(2017) Ian Rowland et al.   EUROPEAN JOURNAL OF NUTRITION

Gut microbiota: Role in pathogen colonization, immune responses, and inflammatory disease

(2017) Joseph M. Pickard et al.   IMMUNOLOGICAL REVIEWS

The sialateO-acetylesterase EstA from gutBacteroidetesspecies enables sialidase-mediated cross-species foraging of 9-O-acetylated sialoglycans

(2017) Lloyd S. Robinson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Complex pectin metabolism by gut bacteria reveals novel catalytic functions

(2017) Didier Ndeh et al.   NATURE

How members of the human gut microbiota overcome the sulfation problem posed by glycosaminoglycans

(2017) Alan Cartmell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bifidobacterium bifidum Extracellular Sialidase Enhances Adhesion to the Mucosal Surface and Supports Carbohydrate Assimilation

(2017) Keita Nishiyama et al.   mBio

Unravelling the specificity and mechanism of sialic acid recognition by the gut symbiont Ruminococcus gnavus

(2017) C. David Owen et al.   Nature Communications

Unraveling the processes shaping mammalian gut microbiomes over evolutionary time

(2017) Mathieu Groussin et al.   Nature Communications

Interactions of Intestinal Bacteria with Components of the Intestinal Mucus

(2017) Jean-Félix Sicard et al.   Frontiers in Cellular and Infection Microbiology

Dietary pectic glycans are degraded by coordinated enzyme pathways in human colonic Bacteroides

(2017) Ana S. Luis et al.   Nature Microbiology

Are We Really Vastly Outnumbered? Revisiting the Ratio of Bacterial to Host Cells in Humans

(2016) Ron Sender et al.   CELL

A Dietary Fiber-Deprived Gut Microbiota Degrades the Colonic Mucus Barrier and Enhances Pathogen Susceptibility

(2016) Mahesh S. Desai et al.   CELL

The Reduction-insensitive Bonds of the MUC2 Mucin Are Isopeptide Bonds

(2016) Christian V. Recktenwald et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Diet-induced extinctions in the gut microbiota compound over generations

(2016) Erica D. Sonnenburg et al.   NATURE

A sentinel goblet cell guards the colonic crypt by triggering Nlrp6-dependent Muc2 secretion

(2016) G. M. H. Birchenough et al.   SCIENCE

Matching the Diversity of Sulfated Biomolecules: Creation of a Classification Database for Sulfatases Reflecting Their Substrate Specificity

(2016) Tristan Barbeyron et al.   PLoS One

Colitogenic Bacteroides thetaiotaomicron Antigens Access Host Immune Cells in a Sulfatase-Dependent Manner via Outer Membrane Vesicles

(2015) Christina A. Hickey et al.   Cell Host & Microbe

Dynamics and Stabilization of the Human Gut Microbiome during the First Year of Life

(2015) Fredrik Bäckhed et al.   Cell Host & Microbe

Normalization of Host Intestinal Mucus Layers Requires Long-Term Microbial Colonization

(2015) Malin E.V. Johansson et al.   Cell Host & Microbe

Small molecules from the human microbiota

(2015) M. S. Donia et al.   SCIENCE

Symbiotic Human Gut Bacteria with Variable Metabolic Priorities for Host Mucosal Glycans

(2015) N. A. Pudlo et al.   mBio

Discovery of intramolecular trans-sialidases in human gut microbiota suggests novel mechanisms of mucosal adaptation

(2015) Louise E. Tailford et al.   Nature Communications

Glycan complexity dictates microbial resource allocation in the large intestine

(2015) Artur Rogowski et al.   Nature Communications

Mucin glycan foraging in the human gut microbiome

(2015) Louise E. Tailford et al.   Frontiers in Genetics

Automatic prediction of polysaccharide utilization loci in Bacteroidetes species

(2014) Nicolas Terrapon et al.   BIOINFORMATICS

The composition of the gut microbiota shapes the colon mucus barrier

(2014) H. E. Jakobsson et al.   EMBO REPORTS

Reprograming of gut microbiome energy metabolism by the FUT2 Crohn’s disease risk polymorphism

(2014) Maomeng Tong et al.   ISME Journal

Membrane Protein Profiling of Human Colon Reveals Distinct Regional Differences

(2014) Sjoerd van der Post et al.   MOLECULAR & CELLULAR PROTEOMICS

Altered Mucus Glycosylation in Core 1 O-Glycan-Deficient Mice Affects Microbiota Composition and Intestinal Architecture

(2014) Felix Sommer et al.   PLoS One

Studies of mucus in mouse stomach, small intestine, and colon. III. Gastrointestinal Muc5ac and Muc2 mucin O-glycan patterns reveal a regiospecific distribution

(2013) Jessica M. Holmén Larsson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Studies of mucus in mouse stomach, small intestine, and colon. I. Gastrointestinal mucus layers have different properties depending on location as well as over the Peyer's patches

(2013) Anna Ermund et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Structural and biochemical characterization of the broad substrate specificity of Bacteroides thetaiotaomicron commensal sialidase

(2013) Kwang-Hyun Park et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis

(2013) Malin E V Johansson et al.   GUT

The Human Milk Metabolome Reveals Diverse Oligosaccharide Profiles

(2013) Jennifer T. Smilowitz et al.   JOURNAL OF NUTRITION

Microbiota-liberated host sugars facilitate post-antibiotic expansion of enteric pathogens

(2013) Katharine M. Ng et al.   NATURE

Bacterial colonization factors control specificity and stability of the gut microbiota

(2013) S. Melanie Lee et al.   NATURE

Diet rapidly and reproducibly alters the human gut microbiome

(2013) Lawrence A. David et al.   NATURE

The abundance and variety of carbohydrate-active enzymes in the human gut microbiota

(2013) Abdessamad El Kaoutari et al.   NATURE REVIEWS MICROBIOLOGY

Unraveling the Role of Surface Mucus-Binding Protein and Pili in Muco-Adhesion of Lactococcus lactis

(2013) Doan Thanh Lam Le et al.   PLoS One

Genetically dictated change in host mucus carbohydrate landscape exerts a diet-dependent effect on the gut microbiota

(2013) P. C. Kashyap et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of Extracellular Transaldolase from Bifidobacterium bifidum in Mucin Adhesion and Aggregation

(2012) Irene González-Rodríguez et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Insights into the recognition of the human glycome by microbial carbohydrate-binding modules

(2012) Elizabeth Ficko-Blean et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Detailed O-glycomics of the Muc2 mucin from colon of wild-type, core 1- and core 3-transferase-deficient mice highlights differences compared with human MUC2

(2012) Kristina A Thomsson et al.   GLYCOBIOLOGY

More than a marine propeller – the flagellum of the probiotic Escherichia coli strain Nissle 1917 is the major adhesin mediating binding to human mucus

(2012) Anja Troge et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Fucose sensing regulates bacterial intestinal colonization

(2012) Alline R. Pacheco et al.   NATURE

Human gut microbiome viewed across age and geography

(2012) Tanya Yatsunenko et al.   NATURE

How glycan metabolism shapes the human gut microbiota

(2012) Nicole M. Koropatkin et al.   NATURE REVIEWS MICROBIOLOGY

Fast Renewal of the Distal Colonic Mucus Layers by the Surface Goblet Cells as Measured by In Vivo Labeling of Mucin Glycoproteins

(2012) Malin E. V. Johansson   PLoS One

Calcium and pH-dependent packing and release of the gel-forming MUC2 mucin

(2012) D. Ambort et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An ex vivo method for studying mucus formation, properties, and thickness in human colonic biopsies and mouse small and large intestinal explants

(2011) Jenny K. Gustafsson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Bacteroides in the Infant Gut Consume Milk Oligosaccharides via Mucus-Utilization Pathways

(2011) Angela Marcobal et al.   Cell Host & Microbe

Control of mucin-type O-glycosylation: A classification of the polypeptide GalNAc-transferase gene family

(2011) E. P. Bennett et al.   GLYCOBIOLOGY

Loss of intestinal core 1–derived O-glycans causes spontaneous colitis in mice

(2011) Jianxin Fu et al.   JOURNAL OF CLINICAL INVESTIGATION

Mucin dynamics and enteric pathogens

(2011) Michael A. McGuckin et al.   NATURE REVIEWS MICROBIOLOGY

Oligosaccharide Binding Proteins from Bifidobacterium longum subsp. infantis Reveal a Preference for Host Glycans

(2011) Daniel Garrido et al.   PLoS One

Colonic mucosa-associated microbiota is influenced by an interaction of Crohn disease and FUT2 (Secretor) genotype

(2011) P. Rausch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diet Drives Convergence in Gut Microbiome Functions Across Mammalian Phylogeny and Within Humans

(2011) B. D. Muegge et al.   SCIENCE

Linking Long-Term Dietary Patterns with Gut Microbial Enterotypes

(2011) G. D. Wu et al.   SCIENCE

Microbial adhesins to gastrointestinal mucus

(2011) Nathalie Juge   TRENDS IN MICROBIOLOGY

Recognition and Degradation of Plant Cell Wall Polysaccharides by Two Human Gut Symbionts

(2011) Eric C. Martens et al.   PLOS BIOLOGY

Mucolytic Bacteria With Increased Prevalence in IBD Mucosa Augment In Vitro Utilization of Mucin by Other Bacteria

(2010) Chin Wen Png et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Structures and application of oligosaccharides in human milk

(2010) Akira KOBATA   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa

(2010) C. De Filippo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Succession of microbial consortia in the developing infant gut microbiome

(2010) J. E. Koenig et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nursing our microbiota: molecular linkages between bifidobacteria and milk oligosaccharides

(2010) David A. Sela et al.   TRENDS IN MICROBIOLOGY

Comparative genomic analysis of Lactobacillus rhamnosus GG reveals pili containing a human- mucus binding protein

(2009) M. Kankainen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mucosal Glycan Foraging Enhances Fitness and Transmission of a Saccharolytic Human Gut Bacterial Symbiont

(2008) Eric C. Martens et al.   Cell Host & Microbe

Diet-Induced Obesity Is Linked to Marked but Reversible Alterations in the Mouse Distal Gut Microbiome

(2008) Peter J. Turnbaugh et al.   Cell Host & Microbe

Worlds within worlds: evolution of the vertebrate gut microbiota

(2008) Ruth E. Ley et al.   NATURE REVIEWS MICROBIOLOGY

The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria

(2008) M. E. V. Johansson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA